Linkage and mutational analysis of CLCN2 in childhood absence epilepsy.

abstract：:There is strong evidence that epileptic seizures occur in diurnal or 24-h patterns. A study in rat models of partial epilepsy showed circadian seizure patterns, and in humans circadian rhythmicity in interictal discharges has been found, suggesting that circadian rhythm may play a role in epilepsy. Circadian influence...

journal_title：Epilepsy research

authors： Hofstra WA,Gordijn MC,van der Palen J,van Regteren R,Grootemarsink BE,de Weerd AW

更新日期：2011-05-01 00:00:00

abstract：:Several interacting genetic factors are likely to be involved in the epileptogenesis of idiopathic generalized epilepsies (IGE). Neurotransmitter transporters play a central role in the fine tuning of neurotransmission by removal of released neurotransmitters from the synaptic cleft. The present association study test...

journal_title：Epilepsy research

authors： Sander T,Berlin W,Ostapowicz A,Samochowiec J,Gscheidel N,Hoehe MR

更新日期：2000-08-01 00:00:00

abstract：:Glutamatergic ionotropic and metabotropic receptor modulators have been shown to produce anticonvulsant activity in a number of animal seizure models, e.g. maximal electroshock (MES) and DBA/2 sensory-induced seizures. The 6 Hz model of partial seizures is an alternative low frequency, long duration stimulation paradi...

journal_title：Epilepsy research

authors： Barton ME,Peters SC,Shannon HE

更新日期：2003-09-01 00:00:00

abstract：:CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of phenytoin to its primary inactive metabolite, (S)-pHPPH, by these mu...

journal_title：Epilepsy research

authors： Rettie AE,Haining RL,Bajpai M,Levy RH

更新日期：1999-07-01 00:00:00

abstract：:To clarify the mechanisms of the antiepileptic activity of phenytoin (PHI), the effects of PHT on extracellular and total levels of monoamines (dopamine and serotonin), in rat striatum and hippocampus were studied. The plasma concentrations of PHT associated with therapeutic activity did not affect striatal and hippoc...

journal_title：Epilepsy research

authors： Okada M,Kawata Y,Kiryu K,Mizuno K,Wada K,Inomata H,Tasaki H,Kaneko S

更新日期：1997-09-01 00:00:00

abstract：:Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. In order to evaluate further the role of QUIN metabolism in genetic murine seizure models, the activities of its bi...

journal_title：Epilepsy research

authors： Eastman CL,Urbańska EM,Chapman AG,Schwarcz R

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Due to pharmacoresistant seizures and the underutilization of surgical treatments, a large number of temporal lobe epilepsy (TLE) patients experience seizures for years or decades. The goal of this study was to generate a predictive model of duration of disease with the least number of parameters possible in...

journal_title：Epilepsy research

authors： Morgan VL,Conrad BN,Abou-Khalil B,Rogers BP,Kang H

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication. METHODS:The database of the therapeutic drug monitoring service of a large neurological hospital was searched to ident...

journal_title：Epilepsy research

authors： Fattore C,Messina S,Battino D,Croci D,Mamoli D,Perucca E

更新日期：2006-08-01 00:00:00

abstract：:The deletion of a sodium channel gene cluster located on chromosome 2q24.3 is associated with variable epilepsy phenotypes, including Dravet syndrome and migrating partial seizures of infancy. Although SCN1A is considered as the major contributor to the epilepsy phenotype, the role of other sodium channel genes that m...

journal_title：Epilepsy research

authors： Lim BC,Hwang H,Kim H,Chae JH,Choi J,Kim KJ,Hwang YS,Yum MS,Ko TS

更新日期：2015-01-01 00:00:00

abstract：:The characteristics of evoked potentials in patients with dentatorubral-pallidoluysian atrophy (DRPLA) were investigated. Twelve patients with DRPLA and three patients with progressive myoclonic epilepsy (PME) attributable to other causes participated in the study. In 11 out of the 12 patients, the diagnosis of DRPLA ...

journal_title：Epilepsy research

authors： Kasai K,Onuma T,Kato M,Kato T,Takeya J,Sekimoto M,Watanabe K,Minami N,Goto Y,Minabe Y

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:The present study was undertaken to clarify the participation of the GABA-ergic system in epileptogenic activity induced by teicoplanin. METHODS:Under pentobarbital anesthesia, mice were fixed to a stereotaxic apparatus, and stainless steel electrodes were implanted into the frontal cortex (FCOR), hippocampus ...

journal_title：Epilepsy research

authors： Takechi K,Fujiwara A,Watanabe Y,Kamei C

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Clobazam (CLB, 1,5-benzodiazepine, 1,5-BZP) has been reported to show unique antiepileptic action profile distinguishing from standard 1,4-BZPs. To further elucidate the action profile of CLB, its effects on the abnormal circling fits (ACFs) and generalized tonic-clonic convulsions (GTCs) in Ihara epileptic rat...

journal_title：Epilepsy research

authors： Miura Y,Amano S,Torii R,Ihara N

更新日期：2002-05-01 00:00:00

abstract：INTRODUCTION:Tuberous sclerosis complex (TSC) is a multisystem genetic disorder affecting multiple organs, including the brain, and very often associated with epileptic activity. Language acquisition and development seems to be altered in a significant proportion of patients with TSC. In the present study, we used magn...

journal_title：Epilepsy research

authors： Gallagher A,Tanaka N,Suzuki N,Liu H,Thiele EA,Stufflebeam SM

更新日期：2013-03-01 00:00:00

abstract：:Activation of group I metabotropic glutamate receptors (mGluRs) produces a long-lasting change in hippocampal excitability that persists in the absence of an agonist. Exposure to the group I mGluR agonist dihydroxyphenylglycine (DHPG) results in the induction of spontaneously occurring epileptiform activity in the CA3...

journal_title：Epilepsy research

authors： Karr L,Rutecki PA

更新日期：2008-09-01 00:00:00

abstract：:Huperzine A (HupA) is a naturally occurring compound found in the firmoss Huperzia serrata. While HupA is a potent acetylcholinesterase inhibitor, its full pharmacologic profile is incompletely described. Since previous works suggested a capacity for HupA to prophylax against seizures, we tested the HupA antiepileptic...

journal_title：Epilepsy research

authors： Gersner R,Ekstein D,Dhamne SC,Schachter SC,Rotenberg A

更新日期：2015-11-01 00:00:00

abstract：:Although treatment of epilepsy easily evolves into a situation of overtreatment, reversing the process can be difficult and time consuming. Benefits of reducing overtreatment may include a decrease in side effects, better seizure control, a simplification in the medication regimen, improved compliance, and reduced cos...

journal_title：Epilepsy research

authors： Bourgeois BF

更新日期：2002-11-01 00:00:00

abstract：:The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. ...

journal_title：Epilepsy research

authors： Coppola G,Caliendo G,Veggiotti P,Romeo A,Tortorella G,De Marco P,Pascotto A

更新日期：2002-09-01 00:00:00

abstract：:The experimental antiepileptic drug, levetiracetam (UCB L059), a piracetam analogue has been investigated in photosensitive patients in the "photosensitivity model", an early phase II study. A total of 12 patients (10 females, 2 males) with a mean age of 21.5 years (range 13-38) were investigated during a 3 day period...

journal_title：Epilepsy research

authors： Kasteleijn-Nolst Trenité DG,Marescaux C,Stodieck S,Edelbroek PM,Oosting J

更新日期：1996-11-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of symptomatic epilepsy in young adults. This study examined physiological and anatomical epileptogenic consequences of a prior incident of TBI in rats. Rats were subjected to a fluid percussion brain injury one week prior to experimentation, and in vitro electrophysiolo...

journal_title：Epilepsy research

authors： Coulter DA,Rafiq A,Shumate M,Gong QZ,DeLorenzo RJ,Lyeth BG

更新日期：1996-12-01 00:00:00

abstract：:Freeze-lesion-induced focal cortical dysplasia in rats closely resembles human microgyria, a neuronal migration disorder associated with drug-resistant epilepsy. Alterations in expression of N-methyl-D-aspartate receptors (NMDARs) containing NR2B subunits have been suggested to play a role in the hyperexcitability see...

journal_title：Epilepsy research

authors： Bandyopadhyay S,Hablitz JJ

更新日期：2006-12-01 00:00:00

abstract：:The effect of magnesium-free medium on electrical and CaM kinase II activity in the rat hippocampal slice was examined. Experimental slices were incubated in 2 mM Mg, then exposed to magnesium-free medium for 1 h. Control slices were concurrently run in 2 mM Mg. Slices were then frozen and CaM kinase II activity was m...

journal_title：Epilepsy research

authors： Churn SB,Anderson WW,DeLorenzo RJ

更新日期：1991-09-01 00:00:00

abstract：:Women with epilepsy have different needs from men, particularly associated with childbearing. Despite clinical guidelines, the care of women with epilepsy remains suboptimal. The aim of this study was to establish whether women with epilepsy recall being given information on topics relating to childbearing. Design of ...

journal_title：Epilepsy research

authors： Bell GS,Nashef L,Kendall S,Solomon J,Poole K,Johnson AL,Moran NF,McCarthy M,McCormick D,Shorvon SD,Sander JW

更新日期：2002-12-01 00:00:00

abstract：:Zonisamide (Zonegran), a novel antiepileptic drug (AED) approved recently in Europe as adjunctive therapy for refractory partial seizures in adults, has been used extensively in Japan and the United States. A substantial body of clinical experience has accumulated over a 14-year period, allowing the properties and pha...

journal_title：Epilepsy research

authors： Baulac M

更新日期：2006-02-01 00:00:00

abstract：:Evidence-based treatment guidelines and practice parameters have been developed in most areas of medicine. They are important because insurance companies, formulary managers, and health maintenance organizations rely on guidelines for formulary and coverage decisions. The methodology for practice parameter development...

journal_title：Epilepsy research

authors： French JA

更新日期：2006-01-01 00:00:00

abstract：:To assess the efficacy of CM40907--a new antiepileptic drug--in suppressing inter-ictal spikes, 6 patients with severe intractable epilepsy and frequent spikes in their inter-ictal EEGs were entered in a double-blind placebo-controlled trial. The results show that CM40907 is efficacious in reducing spike counts in the...

journal_title：Epilepsy research

authors： Yepez-Lasso R,Duncan JS,Shorvon SD

更新日期：1990-04-01 00:00:00

abstract：:Post-stroke paroxysmal activity is a neurophysiological indicator of epileptogenesis and increase of seizure susceptibility, so treatments with neuroprotective activity and anti-paroxysmal activity can be more beneficial during post-ischemic period. The goal of this study was evaluation of levetiracetam (100 mg/kg, 7 ...

journal_title：Epilepsy research

authors： Litvinova SA,Kutepova IS,Voronina TA,Petrunina АА

更新日期：2020-11-01 00:00:00

abstract：:Mutations of the neuronal voltage-gated sodium channel alpha subunit type II (SCN2A) cause various epileptic syndromes, but have never been reported in association with acute encephalopathy. To validate the involvement of SCN2A mutations in acute encephalopathy, we screened 25 patients and found a novel missense mutat...

journal_title：Epilepsy research

authors： Kobayashi K,Ohzono H,Shinohara M,Saitoh M,Ohmori I,Ohtsuka Y,Mizuguchi M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:to determine how the duration of SE, the EEG findings during/after SE, the depth of coma at presentation and age impact on the prognosis of convulsive status epilepticus indepedent of aetiology and to analyse the outcome of status epilepticus with respect to mortality and morbidity (the latter measured in te...

journal_title：Epilepsy research

authors： Neligan A,Shorvon SD

更新日期：2011-01-01 00:00:00

abstract：:It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes. In patients, the onset of FS is likely due to the combined effect of temperature and i...

journal_title：Epilepsy research

authors： Warner TA,Liu Z,Macdonald RL,Kang JQ

更新日期：2017-08-01 00:00:00

abstract：:We hypothesized and found that the co-occurrence of migraine with aura (MA) with major depression (MD) or with suicide attempt (SA) increases the risk for developing unprovoked seizure more than these conditions alone. Number of conditions showed a linear relationship to seizure risk. This may reflect a new condition ...

journal_title：Epilepsy research

authors： Hesdorffer DC,Lúdvígsson P,Hauser WA,Olafsson E,Kjartansson O

更新日期：2007-07-01 00:00:00