Triheptanoin in acute mouse seizure models.

abstract：:Outbred rats are widely used in biomedical research studies. The genotypic variation, different housing and handling conditions during development, and gender of used rats can be expected to cause variations in behavior and epileptogenesis. We tested the hypothesis that adult female Wistar rats from different breeders...

journal_title：Epilepsy research

authors： Honndorf S,Lindemann C,Töllner K,Gernert M

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To improve the interpretability of figures containing an amplitude-integrated electroencephalogram (aEEG), we devised a color scale that allows us to incorporate spectral edge frequency (SEF) information into aEEG figures. Preliminary clinical assessment of this novel technique, which we call aEEG/SEF, was pe...

journal_title：Epilepsy research

authors： Kobayashi K,Mimaki N,Endoh F,Inoue T,Yoshinaga H,Ohtsuka Y

更新日期：2011-10-01 00:00:00

abstract：:Granule cell dispersion (GCD), a structural abnormality, is characteristic of temporal lobe epilepsy (TLE). Eugenol (EUG) is an essential component of medicinal herbs and is suggested to exert anticonvulsant activity. However, it is unclear whether EUG ameliorates the abnormal morphological changes in granule cells in...

journal_title：Epilepsy research

authors： Jeong KH,Lee DS,Kim SR

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:There have been no validated Medicare claims-based algorithms available to identify epilepsy by discrete etiology of stroke (e.g., post-stroke epilepsy, PSE) in community-dwelling elderly individuals, despite the increasing availability of large datasets. Our objective was to validate algorithms that detect w...

journal_title：Epilepsy research

authors： Moura LMVR,Smith JR,Blacker D,Vogeli C,Schwamm LH,Hsu J

更新日期：2019-03-01 00:00:00

abstract：:The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics including the spike-and-wave discharges (SWDs) in the EEG, some differences have been reported bet...

journal_title：Epilepsy research

authors： Akman O,Demiralp T,Ates N,Onat FY

更新日期：2010-05-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated in the pathogenesis of epilepsy and consequently as targets for anticonvulsant drugs. Consistent with this, broad-spectrum block of HCN-mediated current (Ih) reduces seizure susceptibility in a variety of epilepsy models. However, ...

journal_title：Epilepsy research

authors： Kharouf Q,Pinares-Garcia P,Romanelli MN,Reid CA

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Ictal magenetoencephalographic (MEG) discharges convey significant information about ictal onset and propagation, but there is no established method for analyzing ictal MEG. This study sought to clarify the usefulness of time-frequency analyses using short-time Fourier transform (STFT) for ictal onset and propa...

journal_title：Epilepsy research

authors： Yagyu K,Takeuchi F,Shiraishi H,Nakane S,Sueda K,Asahina N,Kohsaka S,Umeoka S,Usui N,Baba K,Saitoh S

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Prior research has shown that people with epilepsy are at risk for a poorer health-related quality of life (HRQOL). However, patients differ greatly in how well they adjust to their epilepsy. To better understand these differences, the present study examined the role of personality. More specifically, we e...

journal_title：Epilepsy research

authors： Rassart J,Luyckx K,Verdyck L,Mijnster T,Mark RE

更新日期：2020-01-01 00:00:00

abstract：:Interictal blood flow single photon emission computed tomography (SPECT) has been considered to be of limited value in the investigation of patients with partial epilepsies. Newer SPECT technologies using brain dedicated multiple detector systems have not been fully evaluated. To study the usefulness of an optimized S...

journal_title：Epilepsy research

authors： Schmitz EB,Costa DC,Jackson GD,Moriarty J,Duncan JS,Trimble MR,Ell PJ

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:Activation of the neurokinin-1 (NK1) receptor by neuropeptide substance P (SP) induces and maintains epileptic activity in various experimental models of epilepsy. The primary objective of this study was to investigate whether neurobiological changes linked to NK1-SP receptor system are associated with hyperexc...

journal_title：Epilepsy research

authors： Danfors T,Åhs F,Appel L,Linnman C,Fredrikson M,Furmark T,Kumlien E

更新日期：2011-11-01 00:00:00

abstract：:Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [18F]fluorodeo...

journal_title：Epilepsy research

authors： Joutsa J,Rinne JO,Karrasch M,Hermann B,Johansson J,Anttinen A,Eskola O,Helin S,Shinnar S,Sillanpää M,TACOE study group.

更新日期：2017-11-01 00:00:00

abstract：:The effect of repetitive administration of naloxone on the development of massed amygdaloid kindling in 'encéphale isolé' cats was studied. Electrical amygdaloid kindling was carried out with a 15 min inter-stimulus interval (ISI) in a control situation with intravenous (i.v.) naloxone administration (2, 4, and 8 mg/k...

journal_title：Epilepsy research

authors： Fernández-Guardiola A,Rocha L,Pellicer F,Gutiérrez R,Calvo JM

更新日期：1989-07-01 00:00:00

abstract：OBJECT:The use of T2 relaxometry was investigated to detect non-sclerotic epileptogenic abnormality of the hippocampus in presurgical evaluation of temporal lobe epilepsy (TLE). METHODS:This prospective study included 30 patients who underwent hippocampectomy as part of surgical treatment of refractory TLE. Ten patien...

journal_title：Epilepsy research

authors： Sato S,Iwasaki M,Suzuki H,Mugikura S,Jin K,Tominaga T,Takase K,Takahashi S,Nakasato N

更新日期：2016-10-01 00:00:00

abstract：:CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of phenytoin to its primary inactive metabolite, (S)-pHPPH, by these mu...

journal_title：Epilepsy research

authors： Rettie AE,Haining RL,Bajpai M,Levy RH

更新日期：1999-07-01 00:00:00

abstract：:Although memory, language, and executive functions have been extensively studied in patients with mesial temporal lobe epilepsy (MTLE), few investigations of the decision-making abilities of these patients have been performed. We studied implicit decision-making (decisions under ambiguity) in right and left MTLE patie...

journal_title：Epilepsy research

authors： Yamano M,Akamatsu N,Tsuji S,Kobayakawa M,Kawamura M

更新日期：2011-01-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common type of epilepsy with about one third of TLE patients being refractory to antiepileptic drugs. Knowledge about the mechanisms underlying seizure activity is fundamental to the discovery of new drug targets. Brain Na(+),K(+)-ATPase activity contributes to the maintenance ...

journal_title：Epilepsy research

authors： Funck VR,Ribeiro LR,Pereira LM,de Oliveira CV,Grigoletto J,Fighera MR,Royes LF,Furian AF,Oliveira MS

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:To identify consistent results of voxel-based morphometry (VBM) studies in unilateral refractory temporal lobe epilepsy (TLE). METHODS:Whole-brain VBM studies comparing refractory TLE patients with healthy controls (HC) were systematically searched in PubMed, ISI Web of Science, Embase, and Medline databases f...

journal_title：Epilepsy research

authors： Li J,Zhang Z,Shang H

更新日期：2012-02-01 00:00:00

abstract：:Cooling has been shown to terminate experimentally induced epileptiform activity in models of epilepsy without causing injury to the cooled brain, suggesting that cooling could represent an approach to seizure control in intractable focal epilepsies. Here we sought to determine the most effective way to apply cooling ...

journal_title：Epilepsy research

authors： Motamedi GK,Salazar P,Smith EL,Lesser RP,Webber WR,Ortinski PI,Vicini S,Rogawski MA

更新日期：2006-08-01 00:00:00

abstract：:Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying...

journal_title：Epilepsy research

authors： Bauer S,Cepok S,Todorova-Rudolph A,Nowak M,Köller M,Lorenz R,Oertel WH,Rosenow F,Hemmer B,Hamer HM

更新日期：2009-09-01 00:00:00

abstract：:It has been suggested that loss of the astrocytic water channel aquaporin-4 (AQP4) from perivascular endfeet in sclerotic hippocampi contributes to increased seizure propensity in human mesial temporal lobe epilepsy (MTLE). Whether this loss occurs prior to or as a consequence of epilepsy development remains to be res...

journal_title：Epilepsy research

authors： Alvestad S,Hammer J,Hoddevik EH,Skare Ø,Sonnewald U,Amiry-Moghaddam M,Ottersen OP

更新日期：2013-07-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenyl sulfone; DDS), an established anti-leprosy drug, showed anticonvulsive effects in the amygdaloid kindling model of epilepsy. Single doses of the drug in rats (6.25-12.5 mg/kg, i.p.) suppressed the kindled seizures in a dose-dependent manner without overt behavioral toxicity. With repeated...

journal_title：Epilepsy research

authors： Hamada K,Hiyoshi T,Kobayashi S,Ishida S,Yagi K,Seino M

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Epilepsy is among the more stigmatising diseases, leading to a negative impact on the quality of life (QoL) of people with epilepsy (PWE). Assessment of the QoL and stigma in PWE reflects the outcome of their disease, and the findings can be used to improve the management of epilepsy. To fill a gap in the li...

journal_title：Epilepsy research

authors： Mroueh L,Boumediene F,Jost J,Ratsimbazafy V,Preux PM,Salameh P,Al-Hajje A

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:The NTRK2 gene encodes a member of the neurotrophic tyrosine kinase receptor family known as TrkB. It is a membrane-associated receptor with signaling and cellular differentiation properties that has been involved in neuropsychiatric disorders, including epilepsy. We report here the frequencies of NTRK2 allel...

journal_title：Epilepsy research

authors： Torres CM,Siebert M,Bock H,Mota SM,Krammer BR,Duarte JÁ,Bragatti JA,Castan JU,de Castro LA,Saraiva-Pereira ML,Bianchin MM

更新日期：2017-11-01 00:00:00

abstract：:Seizure forecasting would improve the quality of life of patients with refractory epilepsy. Although early findings were optimistic, no single feature has been found capable of individually characterizing brain dynamics during transition to seizure. Cross-frequency phase amplitude coupling has been recently proposed a...

journal_title：Epilepsy research

authors： Gagliano L,Bou Assi E,Nguyen DK,Rihana S,Sawan M

更新日期：2018-01-01 00:00:00

abstract：:Overexpression of multidrug efflux transporters such as P-glycoprotein (Pgp; ABCB1) or multidrug resistance proteins (MRPs; ABCC) in the blood-brain barrier has recently been suggested to explain, at least in part, pharmacoresistance in epilepsy, which affects about 30% of all patients with this common brain disorder....

journal_title：Epilepsy research

authors： Potschka H,Baltes S,Löscher W

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:The objectives of this study were to determine the inheritance pattern by which familial mesial temporal lobe epilepsy (FMTLE) is segregated in Mexican families, and to identify if there was an association between the clinical characteristics and the inheritance pattern. METHOD:We included a total of 25 famili...

journal_title：Epilepsy research

authors： Guzmán-Jiménez DE,Campos JB,Venegas-Vega CA,Sánchez MA,Velasco AL

更新日期：2020-11-01 00:00:00

abstract：:Polyamine (tissue) concentrations have been studied in hippocampus and temporal neocortex from patients with temporal lobe epilepsy. Depth electrode recordings demonstrated hippocampal origin of the seizures, the temporal neocortex being involved during the discharge propagation. Neuropathological examination of excis...

journal_title：Epilepsy research

authors： Laschet J,Trottier S,Grisar T,Leviel V

更新日期：1992-07-01 00:00:00

abstract：:Bupropion, a unique, non-nicotine smoking cessation aid and an effective antidepressant, is well known to produce seizures following overdosing in humans. However, the experimental background for the usefulness of antiepileptic drugs in the protection against bupropion-induced convulsions has not been established yet....

journal_title：Epilepsy research

authors： Tutka P,Mróz T,Klucha K,Piekarczyk M,Wielosz M

更新日期：2005-03-01 00:00:00

abstract：:The common features of all types of epilepsy are the synchronized and uncontrolled discharges of nerve cell assemblies. The reason for the pathologically synchronized discharges of the neuron is not exactly known yet. Recent reports claim that gap junctions have a critical role in neuronal synchronization. The present...

journal_title：Epilepsy research

authors： Bostanci MO,Bağirici F

更新日期：2006-10-01 00:00:00

abstract：:The development of epilepsy and a progressive increase in susceptibility to seizures may involve changes in inhibitory and excitatory systems from the beginning of the process. The present study was focused to analyze the opioid peptide changes induced by a chemical sub-convulsant stimulation. Experiments were carried...

journal_title：Epilepsy research

authors： Rocha L,Cano A,Cruz C,Omaña-Zapata I,Villalobos R,Maidment NT

更新日期：1999-11-01 00:00:00