Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesiotemporal lobe epilepsy and unilateral hippocampal sclerosis: post-operative facial emotion recognition abilities.

Abstract:

:Surgical treatment of mesial temporal lobe epilepsy (mTLE) patients involves the removal either of the left or the right hippocampus. Since the mesial temporal lobe is responsible for emotion recognition abilities, we aimed to assess facial emotion recognition (FER) in two homogeneous patient cohorts that differed only in the administered surgery design since anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SAH) were performed independently of the underlying electroclinical conditions. The patient selection for the two respective surgical procedures was carried out retrospectively between 2000 and 2009 by two independent epilepsy centres, the Kork Epilepsy Centre, Germany and the University Hospital of Strasbourg, France. All included patients had presented with unilateral hippocampus sclerosis (HS) without associated dysplasia or white matter blurring and had become seizure-free postoperatively. Psychometric evaluation was carried out with the Ekman 60 Faces Test and screened for depression and psychosomatic symptoms with the SCL-90 R and the BDI. Thirty healthy volunteers participated as control subjects. Sixty patients were included, 27 had undergone SAH and 33 ATL. Patients and controls obtained comparable scores in FER for surprise, happiness, anger and sadness. Concerning fear and disgust the patient group scored significantly worse. Left-sided operations led to the the most pronounced impairment. The ATL group scored significantly worse for recognition of fear compared with SAH patients. Inversely, after SAH scores for disgust were significantly lower than after ATL, independently of the side of resection. Unilateral temporal damage impairs FER. Different neurosurgical procedures may affect FER differently.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Wendling AS,Steinhoff BJ,Bodin F,Staack AM,Zentner J,Scholly J,Valenti MP,Schulze-Bonhage A,Hirsch E

doi

10.1016/j.eplepsyres.2015.01.002

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

26-32

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(15)00005-4

journal_volume

111

pub_type

杂志文章,多中心研究
  • Adenosine involvement in postictal events in amygdala-kindled rats.

    abstract::The actions of adenosine in modulating amygdala kindling were examined using the stable adenosine analog 5'-N'-ethylcarboxamidoadenosine (NECA) and caffeine, an adenosine antagonist. Systemically administered NECA was found to significantly reduce the rate of postictal spiking and to significantly increase the duratio...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(90)90070-c

    authors: Whitcomb K,Lupica CR,Rosen JB,Berman RF

    更新日期:1990-08-01 00:00:00

  • The influence of etiology upon ictal semiology, treatment decisions and long-term outcomes in infantile spasms and West syndrome.

    abstract::Studying infantile spasms is challenging because there are so many aspects of variation that introduce potential bias. These might relate to the many underlying etiologies, and variations in clinical semiology and electroencephalographic features that relate more to age or timing of investigation than to the underlyin...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2006.01.017

    authors: Lux AL,Osborne JP

    更新日期:2006-08-01 00:00:00

  • Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters.

    abstract::In the present study, L-pGlu-(1-benzyl)-L-His-L-ProNH(2) (NP-355), a newer CNS active thyrotropin-releasing hormone (TRH) analog was evaluated for its antiepileptic potential. NP-355 (5, 10 and 20 micromol/kg; i.v.) pretreatment significantly delayed onset and reduced the frequency of convulsions in pentylenetetrazole...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2009.09.007

    authors: Rajput SK,Singh JN,Ingole S,Jain G,Kaur N,Monga V,Meena CL,Jain R,Sharma SS

    更新日期:2009-12-01 00:00:00

  • Effects of levetiracetam as a monotherapy on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy.

    abstract:PURPOSE:Antiepileptic drugs (AEDs) may have adverse effects on bone metabolism and bone mineral density (BMD). The aim of this study is to determine the changes of bone metabolism and BMD in epilepsy patients who are undergoing levetiracetam (LEV) monotherapy. METHODS:Drug-naïve, sixty-one patients with recent onset e...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2012.09.002

    authors: Koo DL,Joo EY,Kim D,Hong SB

    更新日期:2013-03-01 00:00:00

  • A prospective study of serum sex hormones during carbamazepine therapy.

    abstract::This paper reports the results of a 12-month prospective follow-up study on the effects of carbamazepine (CBZ) medication on serum sex and pituitary hormone concentrations in 21 male patients with recently diagnosed epilepsy. The results of the present study indicate that a change occurs in the androgen balance during...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(91)90025-b

    authors: Isojärvi JI,Pakarinen AJ,Myllylä VV

    更新日期:1991-07-01 00:00:00

  • White matter abnormalities in patients with temporal lobe epilepsy and amygdala enlargement: Comparison with hippocampal sclerosis and healthy subjects.

    abstract:PURPOSE:Cases of temporal lobe epilepsy (TLE) with ipsilateral amygdala enlargement (AE) have increasingly been reported. However, the white matter (WM) abnormalities of TLE patients with AE remain poorly investigated. Here we explored macrostructural and microstructural WM abnormalities in TLE patients with AE compare...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2016.09.011

    authors: Sone D,Ota M,Maikusa N,Kimura Y,Sumida K,Yokoyama K,Imabayashi E,Watanabe M,Watanabe Y,Okazaki M,Sato N,Matsuda H

    更新日期:2016-11-01 00:00:00

  • Subjective complaints compared to the results of neuropsychological assessment in patients with epilepsy: The influence of comorbid depression.

    abstract::The aim of the study was to compare subjective complaints of epilepsy patients with objective results of neuropsychological assessment and to investigate the possible influence of depression on self-reported complaints. 62 patients from the neurology clinic were included in the study. They were asked to fill the subje...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2009.02.006

    authors: Liik M,Vahter L,Gross-Paju K,Haldre S

    更新日期:2009-04-01 00:00:00

  • Grammar tests increase the ability to lateralize language function in the Wada test.

    abstract:INTRODUCTION:Grammar is a core component of the language system, yet it is rarely assessed during the Wada (intracarotid amobarbital) test. It is hypothesized that adding grammar tests to the recovery phase of the Wada test will increase our ability to lateralize language function. METHOD:Sixteen individuals (nine fem...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2014.09.014

    authors: Połczyńska M,Curtiss S,Walshaw P,Siddarth P,Benjamin C,Moseley BD,Vigil C,Jones M,Eliashiv D,Bookheimer S

    更新日期:2014-12-01 00:00:00

  • The uncommon causes of status epilepticus: a systematic review.

    abstract::This paper reports the first systematic review of uncommon causes of status epilepticus reported in the literature between 1990 and 2008. Uncommon causes are defined as those not listed in the main epidemiological studies of status epilepticus. 181 causes were identified. These were easily categorised into 5 specific ...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2010.07.015

    authors: Tan RY,Neligan A,Shorvon SD

    更新日期:2010-10-01 00:00:00

  • Antiepileptic drugs trials: neonates and infants.

    abstract::Special issues are related to AED testing in several populations. Pharmacokinetics, pharmacodynamics and underlying neurochemistry and developing systems require specific testing in appropriate infants with refractory seizures. EEG monitoring is an essential part of seizure definition and recognition, making it a nece...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2005.09.017

    authors: Pellock J

    更新日期:2006-01-01 00:00:00

  • Genetic heterogeneity in infantile spasms.

    abstract::Infantile spasms (IS) is a developmental and epileptic encephalopathy with heterogeneous etiologies including many genetic causes. Genetic studies have identified pathogenic variants in over 30 genes as causes of IS. Many of these genetic causes are extremely rare, with only one reported incidence in an individual wit...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2019.106181

    authors: Muir AM,Myers CT,Nguyen NT,Saykally J,Craiu D,De Jonghe P,Helbig I,Hoffman-Zacharska D,Guerrini R,Lehesjoki AE,Marini C,Møller RS,Serratosa J,Štěrbová K,Striano P,von Spiczak S,Weckhuysen S,Mefford HC,EuroEPINOMICS-RE

    更新日期:2019-10-01 00:00:00

  • Etiology and site of temporal lobe epilepsy influence postictal cytokine release.

    abstract::Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2009.05.009

    authors: Bauer S,Cepok S,Todorova-Rudolph A,Nowak M,Köller M,Lorenz R,Oertel WH,Rosenow F,Hemmer B,Hamer HM

    更新日期:2009-09-01 00:00:00

  • GC-MS-Based metabolomics discovers a shared serum metabolic characteristic among three types of epileptic seizures.

    abstract:OBJECTIVE:Understanding the overall and common metabolic changes of seizures can provide novel clues for their control and prevention. Here, we aim to investigate the global metabolic feature of serum for three types of seizures. METHODS:We recruited 27 patients who had experienced a seizure within 48h (including 11 w...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2016.07.003

    authors: Wang D,Wang X,Kong J,Wu J,Lai M

    更新日期:2016-10-01 00:00:00

  • Functional anatomy of limbic epilepsy: a proposal for central synchronization of a diffusely hyperexcitable network.

    abstract::The limbic/mesial temporal lobe epilepsy syndrome has been defined as a focal epilepsy, with the implication that there is a well defined focus of onset, traditionally centered around the hippocampus. The pathology of the hippocampus in this syndrome has been well described and a number of physiological abnormalities ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(98)00051-5

    authors: Bertram EH,Zhang DX,Mangan P,Fountain N,Rempe D

    更新日期:1998-09-01 00:00:00

  • Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy.

    abstract:PURPOSE:Recent analyses provided evidence that human adult cerebrospinal fluid (CSF) in addition to soluble proteins also contains membrane particles that moreover carry the somatic stem cell marker CD133. The significance of CD133 as a potential marker of cellular proliferation, including neurogenesis, remains unresol...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2011.10.029

    authors: Huttner HB,Corbeil D,Thirmeyer C,Coras R,Köhrmann M,Mauer C,Kuramatsu JB,Kloska SP,Doerfler A,Weigel D,Klucken J,Winkler J,Pauli E,Schwab S,Hamer HM,Kasper BS

    更新日期:2012-03-01 00:00:00

  • Massed amygdaloid kindling in encéphale isolé cats: its facilitation by naloxone.

    abstract::The effect of repetitive administration of naloxone on the development of massed amygdaloid kindling in 'encéphale isolé' cats was studied. Electrical amygdaloid kindling was carried out with a 15 min inter-stimulus interval (ISI) in a control situation with intravenous (i.v.) naloxone administration (2, 4, and 8 mg/k...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(89)90058-2

    authors: Fernández-Guardiola A,Rocha L,Pellicer F,Gutiérrez R,Calvo JM

    更新日期:1989-07-01 00:00:00

  • No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.

    abstract::Levetiracetam (LEV), a newer antiepileptic drug (AED) useful for several epilepsy syndromes, binds to SV2A. Identifying genetic variants that influence response to LEV may allow more tailored use of LEV. Obvious candidate genes are SV2A, SV2B and SV2C, which encode the only known binding site, synaptic vesicle protein...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2008.09.003

    authors: Lynch JM,Tate SK,Kinirons P,Weale ME,Cavalleri GL,Depondt C,Murphy K,O'Rourke D,Doherty CP,Shianna KV,Wood NW,Sander JW,Delanty N,Goldstein DB,Sisodiya SM

    更新日期:2009-01-01 00:00:00

  • Effects of adrenal dysfunction and high-dose adrenocorticotropic hormone on NMDA-induced spasm seizures in young Wistar rats.

    abstract::Infantile spasms (IS) is a devastating epilepsy syndrome treated with adrenocorticotropic hormone (ACTH). To demonstrate the effects of adrenal dysfunction, adrenalectomy (ADX) and N-methyl-d-aspartate (NMDA)-induced rat model studies of IS were performed. The latency of the seizure in the ADX group decreased and the ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2012.02.001

    authors: Wang YJ,Zhang Y,Liang XH,Yang G,Zou LP

    更新日期:2012-06-01 00:00:00

  • Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice.

    abstract::Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. In order to evaluate further the role of QUIN metabolism in genetic murine seizure models, the activities of its bi...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(94)90039-6

    authors: Eastman CL,Urbańska EM,Chapman AG,Schwarcz R

    更新日期:1994-07-01 00:00:00

  • Clorazepate in dogs: tolerance to the anticonvulsant effect and signs of physical dependence.

    abstract::Dogs were treated with clorazepate, which is known to be completely metabolized to desmethyldiazepam. 2 mg/kg t.i.d. were given orally for 5-6 weeks, a dose regimen providing plasma concentrations of desmethyldiazepam in the range known to be therapeutic in man. The rate of development of tolerance to the anticonvulsa...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(89)90042-9

    authors: Scherkl R,Kurudi D,Frey HH

    更新日期:1989-03-01 00:00:00

  • Somatic complications of epilepsy surgery over 25 years at a single center.

    abstract:INTRODUCTION:Epilepsy surgery is an effective treatment for refractory focal epilepsy. Risks of surgery need to be considered when advising individuals of treatment options. We describe the frequency and nature of physical adverse events associated with epilepsy surgery in a single center. MATERIAL AND METHODS:We revi...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2017.02.016

    authors: Gooneratne IK,Mannan S,de Tisi J,Gonzalez JC,McEvoy AW,Miserocchi A,Diehl B,Wehner T,Bell GS,Sander JW,Duncan JS

    更新日期:2017-05-01 00:00:00

  • Historical trend toward improved long-term outcome in childhood absence epilepsy.

    abstract::We retrospectively analyzed published studies to investigate historical trends in outcome of childhood absence epilepsy (CAE). We included patients based on onset of absence seizures in childhood, 3 Hz bilateral spike-wave discharges on EEG, and availability of seizure-free outcome data. The primary endpoint was seizu...

    journal_title:Epilepsy research

    pub_type: 历史文章,杂志文章,meta分析

    doi:10.1016/j.eplepsyres.2019.02.013

    authors: Morse E,Giblin K,Chung MH,Dohle C,Berg AT,Blumenfeld H

    更新日期:2019-05-01 00:00:00

  • Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?

    abstract::Kindling, in the classical sense, involves progressively increasing responsivity to the intermittent repetition of the same 1-s subthreshold electrical stimulation over time, with the amygdala being the area most frequently studied. Such repeated subthreshold stimulation is associated with: lowering of the after-disch...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/s0920-1211(02)00081-5

    authors: Post RM

    更新日期:2002-06-01 00:00:00

  • Newly-diagnosed pediatric epilepsy is associated with elevated autoantibodies to glutamic acid decarboxylase but not cardiolipin.

    abstract::Glutamic acid decarboxylase autoantibodies (GADA) and anti-cardiolipin autoantibodies (ACA) have been detected in adult subjects with epilepsy, though the functional implications of these findings are a matter of debate. This study aimed to determine the prevalence of GADA and ACA and to investigate their clinical sig...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.02.009

    authors: Veri K,Uibo O,Talvik T,Talvik I,Metsküla K,Napa A,Vaher U,Õiglane-Šlik E,Rein R,Kolk A,Traat A,Uibo R

    更新日期:2013-07-01 00:00:00

  • Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trials.

    abstract::The purpose of this study was to determine the influence of levetiracetam on the steady-state serum concentrations of other commonly used antiepileptic drugs (AEDs). Serum AED concentrations were measured at baseline and after adjunctive therapy with levetiracetam (1000-4000 mg/day) or placebo in four phase III trials...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章,meta分析,随机对照试验

    doi:10.1016/j.eplepsyres.2005.01.005

    authors: Gidal BE,Baltès E,Otoul C,Perucca E

    更新日期:2005-03-01 00:00:00

  • Myoclonic astatic epilepsy: an age-dependent epileptic syndrome with favorable seizure outcome but variable cognitive evolution.

    abstract::The objective of the study was to explore clinical, electroencephalography (EEG), neuropsychological features and prognosis of myoclonic-astatic epilepsy (MAE). Of 327 children aged between 1 and 9 years with a diagnosis of generalized epilepsy followed between 2000 and 2008, 18 (5.5%) had MAE. Male significantly pred...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2011.07.021

    authors: Trivisano M,Specchio N,Cappelletti S,Di Ciommo V,Claps D,Specchio LM,Vigevano F,Fusco L

    更新日期:2011-11-01 00:00:00

  • Distinct absorption characteristics of oral formulations of valproic acid/divalproex available in the United States.

    abstract::Five oral formulations of valproic acid (VPA)/divalproex sodium are approved and commonly used in the US for treatment of epilepsy, mania/bipolar disorder and migraine prophylaxis. These formulations have unique pharmacokinetic and formulation characteristics and are designed to treat distinct patient populations. We ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.11.005

    authors: Dutta S,Reed RC

    更新日期:2007-03-01 00:00:00

  • Genetic seizure susceptibility underlying acute encephalopathies in childhood.

    abstract::We herein investigated risk factors of pediatric acute encephalopathy (AE) regarding the hitherto uncharacterized genetic background of seizure susceptibility underlying the pathogenesis of AE. The study included 15 patients with a history of various types of AE in childhood. We undertook the mutational analysis of th...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2010.07.005

    authors: Kobayashi K,Ouchida M,Okumura A,Maegaki Y,Nishiyama I,Matsui H,Ohtsuka Y,Ohmori I

    更新日期:2010-10-01 00:00:00

  • "It's good to know": experiences of gene identification and result disclosure in familial epilepsies.

    abstract::Recognition of the role of genetics in the epilepsies has increased dramatically, impacting on clinical practice across many epilepsy syndromes. There is limited research investigating the impact of gene identification on individuals and families with epilepsy. While research has focused on the impact of delivering ge...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2015.02.011

    authors: Vears DF,Dunn KL,Wake SA,Scheffer IE

    更新日期:2015-05-01 00:00:00

  • Stereoselective pharmacokinetics of stiripentol: an explanation for the development of tolerance to anticonvulsant effect.

    abstract::An earlier pharmacodynamic study of the chiral antiepileptic drug stiripentol in an intravenous pentylenetetrazol-induced seizure model in the rat showed the development of a significant degree of tolerance to the anticonvulsant and neurotoxic effects following subacute treatment with the racemic compound. A more rece...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(94)90001-9

    authors: Arends RH,Zhang K,Levy RH,Baillie TA,Shen DD

    更新日期:1994-06-01 00:00:00