Persistent postictal hyperperfusion demonstrated with PET.

abstract：OBJECTIVE:The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. METHODS:Resting state fMR...

journal_title：Epilepsy research

authors： Zeng H,Ramos CG,Nair VA,Hu Y,Liao J,La C,Chen L,Gan Y,Wen F,Hermann B,Prabhakaran V

更新日期：2015-10-01 00:00:00

abstract：:There is strong evidence that epileptic seizures occur in diurnal or 24-h patterns. A study in rat models of partial epilepsy showed circadian seizure patterns, and in humans circadian rhythmicity in interictal discharges has been found, suggesting that circadian rhythm may play a role in epilepsy. Circadian influence...

journal_title：Epilepsy research

authors： Hofstra WA,Gordijn MC,van der Palen J,van Regteren R,Grootemarsink BE,de Weerd AW

更新日期：2011-05-01 00:00:00

abstract：:The present study examined the relationship between the patterns and densities of glutamate AMPA receptor sub-units GluR1 and GluR2/3 in the molecular layer of the fascia dentata and aberrant mossy fiber neoinnervation in human and kainate rat hippocampal epilepsy. Because AMPA sub-units modulate the fast glutamate sy...

journal_title：Epilepsy research

authors： Babb TL,Mathern GW,Leite JP,Pretorius JK,Yeoman KM,Kuhlman PA

更新日期：1996-12-01 00:00:00

abstract：:In the brain, injury-induced gliosis and axonal sprouting have been regarded as age-dependent repairing processes with, unfortunately, epileptogenic effects. The present study examines whether brains injured at different developmental stages become more or less susceptible to experimentally-induced status epilepticus....

journal_title：Epilepsy research

authors： Setkowicz Z,Janeczko K

更新日期：2003-03-01 00:00:00

abstract：:Post-stroke seizures occur in 5-20% of patients. Modeling of stroke-induced seizures in animals provides a useful tool for investigating the molecular basis of epileptogenesis and for developing therapies for stroke patients at increased risk for epileptogenesis. The questions addressed in the study were: (1) Do rats ...

journal_title：Epilepsy research

authors： Karhunen H,Pitkänen A,Virtanen T,Gureviciene I,Pussinen R,Ylinen A,Sivenius J,Nissinen J,Jolkkonen J

更新日期：2003-04-01 00:00:00

abstract：:This paper evaluates the patient-specific seizure prediction performance of pre-ictal changes in bivariate-synchrony between pairs of intracranial electroencephalographic (iEEG) signals within 15min of a seizure in patients with pharmacoresistant focal epilepsy. Prediction horizons under 15min reduce the durations of ...

journal_title：Epilepsy research

authors： Kuhlmann L,Freestone D,Lai A,Burkitt AN,Fuller K,Grayden DB,Seiderer L,Vogrin S,Mareels IM,Cook MJ

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate volumetric proton magnetic resonance spectroscopic imaging (MRSI) for localization of epileptogenic foci in neocortical epilepsy. METHODS:Twenty-five subjects reporting seizures considered to be of neocortical origin were recruited to take part in a 3-T MR study that inclu...

journal_title：Epilepsy research

authors： Maudsley AA,Domenig C,Ramsay RE,Bowen BC

更新日期：2010-02-01 00:00:00

abstract：:Seizures induced by the convulsant methionine sulfoximine (MSO) resemble human "grand mal" epilepsy, and brain glutamine synthetase is inhibited. We recently selected two inbred lines of mice: sensitive to MSO (MSO-Fast) and resistant (MSO-Slow). In the present study, the selection pressure was increased and consangui...

journal_title：Epilepsy research

authors： Boissonnet A,Hévor T,Cloix JF

更新日期：2012-01-01 00:00:00

abstract：:We studied the electrocorticogram (ECoG) before and immediately after transcortical selective amygdalo-hippocampectomy, prospectively in 13 consecutive patients and retrospectively in three others. ECoG was performed with surface and two depth electrodes inserted through T2 aimed at the amygdala and anterior hippocamp...

journal_title：Epilepsy research

authors： Cendes F,Dubeau F,Olivier A,Cukiert A,Andermann E,Quesney LF,Andermann F

更新日期：1993-12-01 00:00:00

abstract：:Valproate (VPA) and vigabatrin (gamma-vinyl GABA, GVG) are two novel antiepileptic drugs with a presumed GABAergic mechanism of action. However, for VPA, this aspect has been extensively debated. The aim of the present study was to investigate whether treatment of cultured neurons with clinically relevant concentratio...

journal_title：Epilepsy research

authors： Gram L,Larsson OM,Johnsen AH,Schousboe A

更新日期：1988-03-01 00:00:00

abstract：:Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [18F]fluorodeo...

journal_title：Epilepsy research

authors： Joutsa J,Rinne JO,Karrasch M,Hermann B,Johansson J,Anttinen A,Eskola O,Helin S,Shinnar S,Sillanpää M,TACOE study group.

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To determine the relative bioavailability and tolerability of a topiramate (TPM) suspension after rectal administration. DESIGN/METHOD:Seven healthy men and five healthy non-pregnant women were enrolled. A 100 or 200 mg tablet of TPM was given orally and a 200 mg dose was given rectally in a randomized, open...

journal_title：Epilepsy research

authors： Conway JM,Birnbaum AK,Kriel RL,Cloyd JC

更新日期：2003-05-01 00:00:00

abstract：:The behavioral and EEG concomitants of kindling produced by daily electrical stimulation of the inferior colliculus have been recorded in three series of Wistar rats: (1) non epileptic controls (NE), (2) rats susceptible to audiogenic seizures (AS), (3) acoustically susceptible rats with prior kindling of audiogenic s...

journal_title：Epilepsy research

authors： Hirsch E,Maton B,Vergnes M,Depaulis A,Marescaux C

更新日期：1993-06-01 00:00:00

abstract：:A freezing probe was placed on the skull of postnatal day (PN) 1 rats to induce formation of a cerebrocortical microsulcus. Experimental studies were performed on PN days 21-24. At that time point, Nissl-stained sections revealed the presence of a microsulcus similar to that described in human dysplastic cortex. Immun...

journal_title：Epilepsy research

authors： Hablitz JJ,DeFazio T

更新日期：1998-09-01 00:00:00

abstract：:The intracarotid amobarbital procedure (IAP) was attempted in 22 pediatric epilepsy surgery candidates, ages 5-12 years old. With extra pre-test teaching and emotional preparation, adjusted amobarbital dosage for younger patients, and simplified test items tailored to the child's abilities, language and memory testing...

journal_title：Epilepsy research

authors： Szabó CA,Wyllie E

更新日期：1993-07-01 00:00:00

abstract：:A partially purified extract from American ginseng has been shown to have anticonvulsant activity. To identify the active components in this extract, the activities of the individual ginsenosides (Rb(1), Rb(3) and Rd), mixtures of the purified ginsenosides and a newly prepared Rb fraction were determined. One hour aft...

journal_title：Epilepsy research

authors： Lian XY,Zhang Z,Stringer JL

更新日期：2006-08-01 00:00:00

abstract：:Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

journal_title：Epilepsy research

authors： Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

更新日期：1990-07-01 00:00:00

abstract：:The ideal proof-of-principle study design provides a strong efficacy signal over the shortest duration, while exposing the fewest patients possible. Data from a large database (Pfizer Inc) which studied add-on pregabalin for the treatment of partial seizures was used to model how duration of baseline, post-randomizati...

journal_title：Epilepsy research

authors： French JA,Cabrera J,Emir B,Whalen E,Lu F

更新日期：2013-09-01 00:00:00

abstract：:The experimental antiepileptic drug, levetiracetam (UCB L059), a piracetam analogue has been investigated in photosensitive patients in the "photosensitivity model", an early phase II study. A total of 12 patients (10 females, 2 males) with a mean age of 21.5 years (range 13-38) were investigated during a 3 day period...

journal_title：Epilepsy research

authors： Kasteleijn-Nolst Trenité DG,Marescaux C,Stodieck S,Edelbroek PM,Oosting J

更新日期：1996-11-01 00:00:00

abstract：:An earlier pharmacodynamic study of the chiral antiepileptic drug stiripentol in an intravenous pentylenetetrazol-induced seizure model in the rat showed the development of a significant degree of tolerance to the anticonvulsant and neurotoxic effects following subacute treatment with the racemic compound. A more rece...

journal_title：Epilepsy research

authors： Arends RH,Zhang K,Levy RH,Baillie TA,Shen DD

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:The NTRK2 gene encodes a member of the neurotrophic tyrosine kinase receptor family known as TrkB. It is a membrane-associated receptor with signaling and cellular differentiation properties that has been involved in neuropsychiatric disorders, including epilepsy. We report here the frequencies of NTRK2 allel...

journal_title：Epilepsy research

authors： Torres CM,Siebert M,Bock H,Mota SM,Krammer BR,Duarte JÁ,Bragatti JA,Castan JU,de Castro LA,Saraiva-Pereira ML,Bianchin MM

更新日期：2017-11-01 00:00:00

abstract：:Glutamatergic ionotropic and metabotropic receptor modulators have been shown to produce anticonvulsant activity in a number of animal seizure models, e.g. maximal electroshock (MES) and DBA/2 sensory-induced seizures. The 6 Hz model of partial seizures is an alternative low frequency, long duration stimulation paradi...

journal_title：Epilepsy research

authors： Barton ME,Peters SC,Shannon HE

更新日期：2003-09-01 00:00:00

abstract：:Epilepsy is a common neurological disease and encompasses a variety of disorders with paroxysms. Although there is a genetic component in the pathogenesis of epilepsy, the molecular mechanisms of this syndrome remains poorly understood. Linkage analysis and positional cloning have not been sufficient tools for determi...

journal_title：Epilepsy research

authors： Hirose S,Okada M,Kaneko S,Mitsudome A

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:Studies of adults who underwent temporal lobectomy for intractable temporal lobe epilepsy (TLE) demonstrated declining seizure free rates over time. Using seizure and social parameters, we followed patients who had temporal lobe surgery (TLS) in childhood to determine long-term outcomes. METHODS:We identified ...

journal_title：Epilepsy research

authors： Benifla M,Rutka JT,Otsubo H,Lamberti-Pasculli M,Elliott I,Sell E,RamachandranNair R,Ochi A,Weiss SK,Snead OC 3rd,Donner EJ

更新日期：2008-12-01 00:00:00

abstract：:The present study used Nissl stains and glutamate decarboxylase immunoreactivity (GAD-IR) to quantify the acute and chronic toxicity of kainic acid (KA) on focal and remote hippocampal principal neurons (i.e., pyramidal and granule cells) and on putative inhibitory neurons (GAD-IR or GABAergic) following intrahippocam...

journal_title：Epilepsy research

authors： Davenport CJ,Brown WJ,Babb TL

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Valproate is used widely for the treatment of epilepsy but has been associated with hyperandrogenism, hyperinsulinemia, and dyslipidemia. The mechanism for these associations is unknown, but they have been hypothesized to be secondary to valproate-associated weight gain. This study was conducted to test the ...

journal_title：Epilepsy research

authors： Morrell MJ,Isojärvi J,Taylor AE,Dam M,Ayala R,Gomez G,O'Neill F,Tennis P,Messenheimer J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway activato...

journal_title：Epilepsy research

authors： Singh N,Vijayanti S,Saha L,Bhatia A,Banerjee D,Chakrabarti A

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To characterize, in adolescents aged 12-17, the pharmacokinetic (PK) profile of perampanel, the impact of intrinsic and extrinsic factors on PK, and the relationships between perampanel exposure and cognitive function, seizure frequency, and responder status. METHODS:Population PK analysis used plasma concen...

journal_title：Epilepsy research

authors： Villanueva V,Majid O,Nabangchang C,Yang H,Laurenza A,Ferry J,Hussein Z

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:This was the first proof of principle clinical trial assessing the efficacy and safety of rufinamide as adjunctive therapy in epileptic patients. The pharmacokinetic (PK) profile of rufinamide was also determined. METHODS:Fifty patients with diagnoses of partial or primary generalized tonic-clonic seizures w...

journal_title：Epilepsy research

authors： Pålhagen S,Canger R,Henriksen O,van Parys JA,Rivière ME,Karolchyk MA

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Idiopathic epilepsy (IE) is a syndrome that comprises epilepsy only, with no underlying structural brain lesion or other neurological signs or symptoms. Numerous studies have shown that genetic factors play an important role in IE. IE is a common disease in the Chinese Han population. However, the genetic ep...

journal_title：Epilepsy research

authors： Li M,Heng X,Tao R,Liu J,Zhang L,Sun X,Wang L,Wu Q,Che F,Xue F

更新日期：2012-02-01 00:00:00