Scopolamine-induced convulsions in fasted animals after food intake: sensitivity of C57BL/6J mice and Sprague-Dawley rats.

abstract：:The genes of two group III metabotropic glutamate receptors, mGluR7 and 8, are candidate susceptibility genes for epilepsy. The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control association studies performe...

journal_title：Epilepsy research

authors： Goodwin H,Curran N,Chioza B,Blower J,Nashef L,Asherson P,Makoff AJ

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To assess subjective seizure anticipation in patients with focal and generalized epilepsy. METHODS:Five hundred consecutively recruited out-patients (251 male, 249 female, mean age 38.1 year) from three German tertiary epilepsy referral centres filled out questionnaires regarding subjective anticipation of sei...

journal_title：Epilepsy research

authors： Schulze-Bonhage A,Kurth C,Carius A,Steinhoff BJ,Mayer T

更新日期：2006-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of symptomatic epilepsy in young adults. This study examined physiological and anatomical epileptogenic consequences of a prior incident of TBI in rats. Rats were subjected to a fluid percussion brain injury one week prior to experimentation, and in vitro electrophysiolo...

journal_title：Epilepsy research

authors： Coulter DA,Rafiq A,Shumate M,Gong QZ,DeLorenzo RJ,Lyeth BG

更新日期：1996-12-01 00:00:00

abstract：:The Mongolian gerbil is known as an animal model that often exhibits spontaneous seizures that are characteristic of human epilepsy. Whereas there is much more information available relating this phenomenon to anatomical and electrophysiological characteristics of the hippocampal formation, the somatosensory cortex ha...

journal_title：Epilepsy research

authors： Kato M,Ito M,Seto-Ohshima A

更新日期：2000-07-01 00:00:00

abstract：:Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. In order to evaluate further the role of QUIN metabolism in genetic murine seizure models, the activities of its bi...

journal_title：Epilepsy research

authors： Eastman CL,Urbańska EM,Chapman AG,Schwarcz R

更新日期：1994-07-01 00:00:00

abstract：:Infantile spasms (IS) is a developmental and epileptic encephalopathy with heterogeneous etiologies including many genetic causes. Genetic studies have identified pathogenic variants in over 30 genes as causes of IS. Many of these genetic causes are extremely rare, with only one reported incidence in an individual wit...

journal_title：Epilepsy research

authors： Muir AM,Myers CT,Nguyen NT,Saykally J,Craiu D,De Jonghe P,Helbig I,Hoffman-Zacharska D,Guerrini R,Lehesjoki AE,Marini C,Møller RS,Serratosa J,Štěrbová K,Striano P,von Spiczak S,Weckhuysen S,Mefford HC,EuroEPINOMICS-RE

更新日期：2019-10-01 00:00:00

abstract：:This was an open-label study (N01281 [NCT00419393]) assessing the long-term safety of extended-release levetiracetam (LEV XR) in patients with partial-onset seizures (POS); the study was a follow-up to a double-blind, randomized, historical controlled, multicenter, conversion to monotherapy study (N01280 [NCT00419094]...

journal_title：Epilepsy research

authors： Chung S,Ceja H,Gawłowicz J,McShea C,Schiemann J,Lu S

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Epilepsy is associated with an increased mortality. This study estimates the effects of co-morbid disorders on short-term and long-term mortality and presents cause-specific mortality for children and young adults with epilepsy. METHODS:We established a population-based cohort of 1,855,946 children born in Den...

journal_title：Epilepsy research

authors： Christensen J,Pedersen CB,Sidenius P,Olsen J,Vestergaard M

更新日期：2015-08-01 00:00:00

abstract：:We examined the influence of seizures and carbamazepine (CBZ) on spiking rates in kindled cats. In the first experiment, spiking rates were measured before and after seizures, with and without CBZ. CBZ was administered immediately after seizures in order not to affect them. Spiking rates were measured over 9 h during ...

journal_title：Epilepsy research

authors： Gigli GL,Gotman J

更新日期：1991-04-01 00:00:00

abstract：:Interictal blood flow single photon emission computed tomography (SPECT) has been considered to be of limited value in the investigation of patients with partial epilepsies. Newer SPECT technologies using brain dedicated multiple detector systems have not been fully evaluated. To study the usefulness of an optimized S...

journal_title：Epilepsy research

authors： Schmitz EB,Costa DC,Jackson GD,Moriarty J,Duncan JS,Trimble MR,Ell PJ

更新日期：1995-06-01 00:00:00

abstract：INTRODUCTION:The anticonvulsant effects of melatonin (MT) have been demonstrated in several different experimental seizure models. Thus, the present study aimed to determine the anticonvulsant efficacy of MT, the optimum time for its administration prior to the induction of a seizure, and its effective dose in a rat mo...

journal_title：Epilepsy research

authors： Aydin L,Gundogan NU,Yazici C

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Grammar is a core component of the language system, yet it is rarely assessed during the Wada (intracarotid amobarbital) test. It is hypothesized that adding grammar tests to the recovery phase of the Wada test will increase our ability to lateralize language function. METHOD:Sixteen individuals (nine fem...

journal_title：Epilepsy research

authors： Połczyńska M,Curtiss S,Walshaw P,Siddarth P,Benjamin C,Moseley BD,Vigil C,Jones M,Eliashiv D,Bookheimer S

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussi...

journal_title：Epilepsy research

authors： Erdogan MA,Yusuf D,Erdogan A,Erbas O

更新日期：2019-02-01 00:00:00

abstract：:We have reported long-term clinical follow-up for two siblings with Lafora disease, a brother and sister, one of whom autopsied. Both siblings had repeated attacks of severe myoclonus, tonic and tonic-clonic convulsions, and intractable status epilepticus. The addition of orally administered zonisamide brought about s...

journal_title：Epilepsy research

authors： Yoshimura I,Kaneko S,Yoshimura N,Murakami T

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:This study aimed to test the hypothesis that high-dose prednisolone (4 mg/kg/day) may be more efficacious than usual-dose (2 mg/kg/day) prednisolone for spasm resolution at 14-days in children with infantile spasms. METHODS:This was a randomized, open-label-trial conducted at a tertiary-level-hospital from ...

journal_title：Epilepsy research

authors： Chellamuthu P,Sharma S,Jain P,Kaushik JS,Seth A,Aneja S

更新日期：2014-10-01 00:00:00

abstract：:The anticonvulsant activities of a noncompetitive (GYKI 52466) and a competitive (NBQX) AMPA/kainate antagonist were compared in the maximal electroshock (MES) seizure test and various chemoconvulsant models. Both antagonists were protective in the MES and pentylenetetrazol tests. GYKI 52466 was also protective agains...

journal_title：Epilepsy research

authors： Yamaguchi S,Donevan SD,Rogawski MA

更新日期：1993-07-01 00:00:00

abstract：:The mechanisms of paradoxical aggravation of epileptic seizures induced by selected antiepileptic drugs (AEDs) remain unclear. The present study addressed this issue by determining the seizure-threshold doses of carbamazepine (CBZ) and phenytoin (PHT), as well the dose-dependent effects of CBZ, PHT, and carbonic anhyd...

journal_title：Epilepsy research

authors： Yamamura S,Hamaguchi T,Ohoyama K,Sugiura Y,Suzuki D,Kanehara S,Nakagawa M,Motomura E,Matsumoto T,Tanii H,Shiroyama T,Okada M

更新日期：2009-04-01 00:00:00

abstract：:Freeze-lesion-induced focal cortical dysplasia in rats closely resembles human microgyria, a neuronal migration disorder associated with drug-resistant epilepsy. Alterations in expression of N-methyl-D-aspartate receptors (NMDARs) containing NR2B subunits have been suggested to play a role in the hyperexcitability see...

journal_title：Epilepsy research

authors： Bandyopadhyay S,Hablitz JJ

更新日期：2006-12-01 00:00:00

abstract：:The motivational consequences of kindling were examined in the conditioned place preference paradigm. In a distinctive environment, rats received stimulation of the amygdala that triggered afterdischarge (AD) alone or AD and generalized seizures. After 4 conditioning trials, preference for the conditioning environment...

journal_title：Epilepsy research

authors： Corcoran ME,Lanius R,Duren A

更新日期：1992-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate by a prospective, self-controlled method, whether treatment with carbamazepine (CBZ) and sodium valproate (VPA) monotherapy may alter serum lipoprotein (a) [Lp(a)] concentrations in epileptic children. METHODS:Serum Lp(a) concentrations have been determined in 18 epilep...

journal_title：Epilepsy research

authors： Voudris KA,Attilakos A,Katsarou E,Drakatos A,Dimou S,Mastroyianni S,Skardoutsou A,Prassouli A,Garoufi A

更新日期：2006-08-01 00:00:00

abstract：:Prevention of epileptogenesis after brain insults, such as status epilepticus (SE), head trauma, or stroke, remains a challenge. Even if epilepsy cannot be prevented, it would be beneficial if the pathologic process could be modified to result in a less severe disease. We examined whether early discontinuation of SE r...

journal_title：Epilepsy research

authors： Pitkänen A,Kharatishvili I,Narkilahti S,Lukasiuk K,Nissinen J

更新日期：2005-01-01 00:00:00

abstract：:The effects of GABA uptake inhibitors, SKF 89976A and SKF 100330A, on recurrent inhibition were studied in the rat hippocampal slice preparation by the antidromic-orthodromic stimulation test. Population spikes evoked orthodromically by stimulation of the stratum radiatum and recorded in the CA1 pyramidal cell body la...

journal_title：Epilepsy research

authors： Capek R,Esplin B

更新日期：1993-10-01 00:00:00

abstract：:The efforts of the International League against Epilepsy (ILAE) to devise classifications of the epilepsies has greatly improved communication among epileptologists and influenced both basic and clinical research. Several classifications have been proposed since 1970; the most recent classification of epilepsy syndrom...

journal_title：Epilepsy research

authors： Engel J Jr

更新日期：2006-08-01 00:00:00

abstract：:Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cases. The degree of H...

journal_title：Epilepsy research

authors： Davies KG,Hermann BP,Dohan FC Jr,Foley KT,Bush AJ,Wyler AR

更新日期：1996-06-01 00:00:00

abstract：:This study was planned so as to evaluate whether magnetic field exposure has any significant effect on the pentylenetetrazol (PTZ)-induced seizures. Mice were exposed to 50 Hz, 2 G (0.2 mT) magnetic field in glass cages for 1 h. Sham exposure was produced by turning off the current while the animals were in the same e...

journal_title：Epilepsy research

authors： Keskil IS,Keskil ZA,Canseven AG,Seyhan N

更新日期：2001-04-01 00:00:00

abstract：:Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying...

journal_title：Epilepsy research

authors： Bauer S,Cepok S,Todorova-Rudolph A,Nowak M,Köller M,Lorenz R,Oertel WH,Rosenow F,Hemmer B,Hamer HM

更新日期：2009-09-01 00:00:00

abstract：:The ketogenic diet has been used to treat intractable epilepsy for many years, yet the mechanism(s) underlying its effectiveness have not been completely elucidated. However, emerging evidence indicates that the ketogenic diet may correct or otherwise alter a 'dystopic' gut microbiota that exhibits altered fecal micro...

journal_title：Epilepsy research

authors： Pittman QJ

更新日期：2020-10-01 00:00:00

abstract：:Audiogenic seizures in genetically susceptible rodents are provoked by intense acoustic stimulations which result in a tonic seizure associated with a short flattening of the EEG. These seizures have been shown to involve primarily brainstem structures. Daily exposure to sound for 30-40 days produced a permanent chang...

journal_title：Epilepsy research

authors： Hirsch E,Maton B,Vergnes M,Depaulis A,Marescaux C

更新日期：1992-05-01 00:00:00

abstract：:AWD 140-190 a potent new anticonvulsant was tested on several types of epileptiform activities in entorhinal cortex hippocampal slices. AWD 140-190 suppressed completely and in a dose-dependent manner spontaneous seizure-like events induced by lowering extracellular Ca2+. In the low magnesium model, AWD 140-190 applie...

journal_title：Epilepsy research

authors： Armand V,Rundfeldt C,Heinemann U

更新日期：1997-12-01 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS+) comprises a group of clinically and genetically heterogeneous epilepsy syndrome. Here, we provide the first report of clinical presentation and mutational analysis of SCN1A gene in 36 Malaysian GEFS+ patients. Mutational analysis of SCN1A gene revealed twenty sev...

journal_title：Epilepsy research

authors： Tan EH,Razak SA,Abdullah JM,Mohamed Yusoff AA

更新日期：2012-12-01 00:00:00