Abstract:
INTRODUCTION:Grammar is a core component of the language system, yet it is rarely assessed during the Wada (intracarotid amobarbital) test. It is hypothesized that adding grammar tests to the recovery phase of the Wada test will increase our ability to lateralize language function. METHOD:Sixteen individuals (nine females, fifteen right-handed, mean age 38.4 years, SD=10.7) with medically refractory temporal lobe epilepsy participated in the study. On EEG ten patients had seizures originating in the left hemisphere (LH), five in the right hemisphere (RH), and one was insufficiently lateralized. We included only patients who were LH-dominant on the standard test in the encoding phase of the Wada test. In the recovery phase of Wada testing the participants underwent evaluation with a standard language and a new test of grammar, the CYCLE-N. Ten patients underwent bilateral injections, six unilateral (one RH, five LH). RESULTS:As expected, injection in the LH decreased language performance to a greater extent than injection to the RH on both tests. However, the CYCLE-N produced more profound language deficits in the injected LH compared to the RH (p=0.01), whereas the standard tests did not cause such pronounced differences (p=0.2). CONCLUSION:The results suggest that the standard tests did not significantly differentiate the effects of the injections and the CYCLE-N, for the most part, did. Our results are of particular relevance to patients who are too obtunded to speak in the encoding phase. In sum, the CYCLE-N may be helpful in assessing hemispheric dominance for language.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Połczyńska M,Curtiss S,Walshaw P,Siddarth P,Benjamin C,Moseley BD,Vigil C,Jones M,Eliashiv D,Bookheimer Sdoi
10.1016/j.eplepsyres.2014.09.014subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1864-73issue
10eissn
0920-1211issn
1872-6844pii
S0920-1211(14)00247-2journal_volume
108pub_type
杂志文章abstract:INTRODUCTION:Epilepsy surgery is an effective treatment for refractory focal epilepsy. Risks of surgery need to be considered when advising individuals of treatment options. We describe the frequency and nature of physical adverse events associated with epilepsy surgery in a single center. MATERIAL AND METHODS:We revi...
journal_title:Epilepsy research
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更新日期:2017-05-01 00:00:00
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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更新日期:2012-08-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-05-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章
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更新日期:1996-06-01 00:00:00
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更新日期:1994-10-01 00:00:00
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更新日期:1988-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2009.11.014
更新日期:2010-02-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::Outbred rats are widely used in biomedical research studies. The genotypic variation, different housing and handling conditions during development, and gender of used rats can be expected to cause variations in behavior and epileptogenesis. We tested the hypothesis that adult female Wistar rats from different breeders...
journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2010.12.012
更新日期:2011-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(93)90043-7
更新日期:1993-03-01 00:00:00
abstract::Benign childhood epilepsy with occipital paroxysms is classified among childhood benign partial epilepsies. The absence of neurological and neuropsychological deficits has long been considered as a prerequisite for a diagnosis of benign childhood partial epilepsy. Much evidence has been reported in literature in the l...
journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2005.03.004
更新日期:2005-05-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2014.09.011
更新日期:2014-12-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-06-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2016.05.003
更新日期:2016-08-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2013.06.018
更新日期:2013-10-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章,评审
doi:10.1016/s0920-1211(99)00046-7
更新日期:1999-09-01 00:00:00