ILAE classification of epilepsy syndromes.

abstract：OBJECTIVE:Lamotrigine (LTG) is approved for monotherapy following withdrawal from enzyme-inducing antiepileptic drugs. LTG is also frequently used in combination with sodium valproate (VPA), and withdrawal to monotherapy in this setting is also frequently desirable. Given the known pharmacokinetic interaction between t...

journal_title：Epilepsy research

authors： Gidal BE,Sheth R,Parnell J,Maloney K,Sale M

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Due to pharmacoresistant seizures and the underutilization of surgical treatments, a large number of temporal lobe epilepsy (TLE) patients experience seizures for years or decades. The goal of this study was to generate a predictive model of duration of disease with the least number of parameters possible in...

journal_title：Epilepsy research

authors： Morgan VL,Conrad BN,Abou-Khalil B,Rogers BP,Kang H

更新日期：2015-02-01 00:00:00

abstract：:Interpreting electrocorticography (ECoG) in the context of neuroimaging requires that multimodal information be integrated accurately. However, the implantation of ECoG electrodes can shift the brain impacting the spatial interpretation of electrode locations in the context of pre-implant imaging. We characterized the...

journal_title：Epilepsy research

authors： Foldes ST,Munter BT,Appavu BL,Kerrigan JF,Adelson PD

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Hippocampal sclerosis (HS) is the most common pathology in mesial temporal lobe epilepsy (MTLE). There are a few reports concerning prognosis in patients with MTLE-HS treated medically. The study was carried out to determine the clinical risk factors affecting prognosis. METHODS:We enrolled 287 patients with M...

journal_title：Epilepsy research

authors： Varoglu AO,Saygi S,Acemoglu H,Ciger A

更新日期：2009-08-01 00:00:00

abstract：:We analyzed 91 psychomotor seizures from 31 patients seizure free at least one year after temporal lobectomy (implying temporal lobe onset). Fifty symptoms were looked for in every seizure and their time of onset and ending noted. Statistical analysis was used to define symptom clusters and the order of appearance of ...

journal_title：Epilepsy research

authors： Kotagal P,Lüders HO,Williams G,Nichols TR,McPherson J

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To assess functional organization of the motor cortex in patients with Unverricht-Lundborg disease (EPM1A) using a combined neurophysiologic and imaging approach. METHODS:EPM1A patients underwent transcranial magnetic stimulation (TMS)-based cortical mapping of the motor hand area. Moreover, they performed n...

journal_title：Epilepsy research

authors： Rossi Sebastiano D,Visani E,Contarino VE,Panzica F,Duran D,D'Incerti L,Franceschetti S,Canafoglia L

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Activation of the neurokinin-1 (NK1) receptor by neuropeptide substance P (SP) induces and maintains epileptic activity in various experimental models of epilepsy. The primary objective of this study was to investigate whether neurobiological changes linked to NK1-SP receptor system are associated with hyperexc...

journal_title：Epilepsy research

authors： Danfors T,Åhs F,Appel L,Linnman C,Fredrikson M,Furmark T,Kumlien E

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur i...

journal_title：Epilepsy research

authors： Rozendaal YJ,van Luijtelaar G,Ossenblok PP

更新日期：2016-01-01 00:00:00

abstract：:The mechanisms of paradoxical aggravation of epileptic seizures induced by selected antiepileptic drugs (AEDs) remain unclear. The present study addressed this issue by determining the seizure-threshold doses of carbamazepine (CBZ) and phenytoin (PHT), as well the dose-dependent effects of CBZ, PHT, and carbonic anhyd...

journal_title：Epilepsy research

authors： Yamamura S,Hamaguchi T,Ohoyama K,Sugiura Y,Suzuki D,Kanehara S,Nakagawa M,Motomura E,Matsumoto T,Tanii H,Shiroyama T,Okada M

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:We studied the effect of fosphenytoin (FOS) pre-medication on the incidence and thresholds of after-discharges (ADs), seizures, and functional responses during electrical stimulation mapping (ESM). METHODS:As individualized by the attending epileptologist, FOS was given intravenously at 2 mg-phenytoin-equivale...

journal_title：Epilepsy research

authors： Arya R,Aungaroon G,Zea Vera A,Horn PS,Byars AW,Greiner HM,Mangano FT,Holland KD

更新日期：2018-02-01 00:00:00

abstract：:Previous work showed that bilateral lesions made between the inferior and superior colliculi reduced the severity of audiogenic seizures in genetically epilepsy-prone rats (GEPR-9s), and indicated that the connections between these two structures are vital for the propagation of seizure activity. To determine the invo...

journal_title：Epilepsy research

authors： Ribak CE,Manio AL,Navetta MS,Gall CM

更新日期：1997-03-01 00:00:00

abstract：:Generalized seizures can induce both hypertension and hyperglycemia which may aggravate preexisting cerebral or medical conditions in patients. In vivo fluorescent imaging of regional cortical blood flow and brain intracellular pH (pHi) was performed in fasted New Zealand rabbits (n = 35) in which either mean arterial...

journal_title：Epilepsy research

authors： Tomlinson FH,Anderson RE,Meyer FB

更新日期：1993-02-01 00:00:00

abstract：:Overexpression of multidrug efflux transporters such as P-glycoprotein (Pgp; ABCB1) or multidrug resistance proteins (MRPs; ABCC) in the blood-brain barrier has recently been suggested to explain, at least in part, pharmacoresistance in epilepsy, which affects about 30% of all patients with this common brain disorder....

journal_title：Epilepsy research

authors： Potschka H,Baltes S,Löscher W

更新日期：2004-02-01 00:00:00

abstract：:We compared the relative sensitivity of two interictal PET techniques, bolus injection of [15O] labeled water for estimation of cerebral blood flow (H2(15)O CBF-PET), and 18F 2-deoxyglucose (18FDG-PET) for cerebral glucose metabolism (CMRglc), and T2-weighted magnetic resonance imaging, in 28 patients with medically i...

journal_title：Epilepsy research

authors： Leiderman DB,Balish M,Sato S,Kufta C,Reeves P,Gaillard WD,Theodore WH

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:Acetaminophen is one of the most commonly used analgesic and antipyretic drugs. It has been reported that acetaminophen has anticonvulsant effects in several animal models of seizure. An active metabolite of acetaminophen, AM404, inhibits the uptake of the endocannabinoid anandamide. However, the mechanism of...

journal_title：Epilepsy research

authors： Suemaru K,Yoshikawa M,Aso H,Watanabe M

更新日期：2018-09-01 00:00:00

abstract：:It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes. In patients, the onset of FS is likely due to the combined effect of temperature and i...

journal_title：Epilepsy research

authors： Warner TA,Liu Z,Macdonald RL,Kang JQ

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Recent ILAE classification defined focal cortical dysplasia (FCD) patients with accompanying epileptic lesions as a separate group. We investigated data of patients with sole FCD lesions regarding long-term seizure outcome and different characteristics of FCD type 1 and type 2 patients. METHODS:Eighty chi...

journal_title：Epilepsy research

authors： Isler C,Kucukyuruk B,Ozkara C,Gunduz A,Is M,Tanriverdi T,Comunoglu N,Oz B,Uzan M

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To study the different epilepsy syndromes that included epileptic spasms (ES) in clusters without hypsarrhythmia (WoH). METHODS:Between 2/1990 and 7/2013, we registered 48 patients with the electroclinical diagnostic criteria of ES in clusters WoH. RESULTS:We recognized two subgroups. In the first subgroup ...

journal_title：Epilepsy research

authors： Caraballo RH,Fortini S,Reyes G,Carpio Ruiz A,Sanchez Fuentes SV,Ramos B

更新日期：2016-07-01 00:00:00

abstract：:Resting motor threshold (rMT) assessed by means of Transcranial Magnetic Stimulation (TMS) is thought to reflect trans-synaptic excitability of cortico-spinal neurons. TMS studies reporting rMT in idiopathic generalized epilepsies (IGEs) yielded discrepant results, so that it is difficult to draw a definitive conclusi...

journal_title：Epilepsy research

authors： Brigo F,Storti M,Benedetti MD,Rossini F,Nardone R,Tezzon F,Fiaschi A,Bongiovanni LG,Manganotti P

更新日期：2012-08-01 00:00:00

abstract：:Mutations of the neuronal voltage-gated sodium channel alpha subunit type II (SCN2A) cause various epileptic syndromes, but have never been reported in association with acute encephalopathy. To validate the involvement of SCN2A mutations in acute encephalopathy, we screened 25 patients and found a novel missense mutat...

journal_title：Epilepsy research

authors： Kobayashi K,Ohzono H,Shinohara M,Saitoh M,Ohmori I,Ohtsuka Y,Mizuguchi M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Cryosurgery is an alternative technique for minimally invasive treatment of lesions. We have recently examined cryosurgery for epilepsy in animal models, and found that penicillin G (PG)-induced epileptiform discharges (EDs) mostly vanished after freezing. However, EDs were provoked again after insufficient ...

journal_title：Epilepsy research

authors： Tokiwa T,Zimin L,Inoue T,Nomura S,Suzuki M,Yamakawa T

更新日期：2018-07-01 00:00:00

abstract：AIM:Vitamin D (Vit D) has been considered as a neurosteroid and has a pivotal role in neuroprotection including epilepsy. Vit D regulator acts via a Vit D receptor (VDR). WAG/Rij rats have a genetically epileptic model of absence epilepsy with comorbidity of depression. The aim of the present study was to investigate t...

journal_title：Epilepsy research

authors： Aygun H,Ayyildiz M,Agar E

更新日期：2019-11-01 00:00:00

abstract：:In a selected group of temporal lobe epilepsy patients with seizures refractory to pharmacological treatment, pharmacological seizure control can be attained by surgical resection of the epileptic zone. We investigated to what extent pharmaco-resistance is reflected in a reduced response at the cellular level, in neur...

journal_title：Epilepsy research

authors： Vreugdenhil M,van Veelen CW,van Rijen PC,Lopes da Silva FH,Wadman WJ

更新日期：1998-09-01 00:00:00

abstract：:Treatment of epileptic patients with valproic acid (VPA) may be associated with substantial weight changes that may increase morbidity and impair adherence to the treatment regimen. VPA-induced weight gain seems to be associated with many metabolic disturbances; the most frequent are hyperinsulinemia and insulin resis...

journal_title：Epilepsy research

authors： Belcastro V,D'Egidio C,Striano P,Verrotti A

更新日期：2013-11-01 00:00:00

abstract：:A partially purified extract from American ginseng has been shown to have anticonvulsant activity. To identify the active components in this extract, the activities of the individual ginsenosides (Rb(1), Rb(3) and Rd), mixtures of the purified ginsenosides and a newly prepared Rb fraction were determined. One hour aft...

journal_title：Epilepsy research

authors： Lian XY,Zhang Z,Stringer JL

更新日期：2006-08-01 00:00:00

abstract：:Interictal blood flow single photon emission computed tomography (SPECT) has been considered to be of limited value in the investigation of patients with partial epilepsies. Newer SPECT technologies using brain dedicated multiple detector systems have not been fully evaluated. To study the usefulness of an optimized S...

journal_title：Epilepsy research

authors： Schmitz EB,Costa DC,Jackson GD,Moriarty J,Duncan JS,Trimble MR,Ell PJ

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:We retrospectively analyzed the seizure characteristics, EEG pattern, treatment, and outcome in a series of patients with self-limited epilepsy with centrotemporal spikes (SLECTS) who presented with unusual clinical manifestations. METHOD:A retrospective, descriptive, multicenter study was conducted evaluating...

journal_title：Epilepsy research

authors： Galicchio S,Espeche A,Cersosimo R,Chacon S,Gamboni B,Adi J,Fasulo L,Semprino M,Fortini S,Cachia P,Caraballo RH

更新日期：2021-01-01 00:00:00

abstract：:Fits of audiogenic seizures in rodents are considered as a model for generalized convulsive epilepsies in humans. The laminar distribution of the H3 histamine receptor binding densities was quantified in the motor cortex of two strains of rats with genetically determined generalized epilepsies, namely KM rats with aud...

journal_title：Epilepsy research

authors： Midzyanovskaya IS,Petrenko TE,Birioukova LM,Tuomisto LM

更新日期：2020-12-25 00:00:00

abstract：:The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. ...

journal_title：Epilepsy research

authors： Coppola G,Caliendo G,Veggiotti P,Romeo A,Tortorella G,De Marco P,Pascotto A

更新日期：2002-09-01 00:00:00

abstract：SUMMARY:Stereotactic radiofrequency amygdalohippocampectomy (AHE) has been reintroduced as an alternative treatment of mesial temporal lobe epilepsy. The aim of this study was to describe MRI changes after stereotactic AHE and to correlate the hippocampal and amygdalar volumes reduction with the clinical seizure outcom...

journal_title：Epilepsy research

authors： Malikova H,Vojtech Z,Liscak R,Prochazka T,Vymazal J,Vladyka V,Keller J,Kalina M

更新日期：2009-02-01 00:00:00