Distortion of the cortical motor map in patients with Unverricht-Lundborg disease: A combined TMS-MRI study.

abstract：:Temporal lobe epilepsy (TLE) is the most common type of epilepsy with about one third of TLE patients being refractory to antiepileptic drugs. Knowledge about the mechanisms underlying seizure activity is fundamental to the discovery of new drug targets. Brain Na(+),K(+)-ATPase activity contributes to the maintenance ...

journal_title：Epilepsy research

authors： Funck VR,Ribeiro LR,Pereira LM,de Oliveira CV,Grigoletto J,Fighera MR,Royes LF,Furian AF,Oliveira MS

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Valproate (VPA) administration may be associated with adverse metabolic effects, among is hyperammonemia, which could suggest metabolic abnormalities as carnitine deficiency. This study aimed to evaluate the risk frequency of hyperammonemia and abnormal carnitine levels in children receiving VPA who were otherw...

journal_title：Epilepsy research

authors： Hamed SA,Abdella MM

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate whether there may be a correlation between the anatomical variants of Circle of Willis (CoW) and presence/laterality of mesial temporal sclerosis (MTS). METHODS:We retrospectively identified the CoW variants on Wada angiograms in 71 patients with pathologically proven...

journal_title：Epilepsy research

authors： Kuyumcu G,Byrne RW,Dawe RJ,Kocak M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:To validate the Chinese version of the Generalized Anxiety Disorder-7 (GAD-7) in Chinese people with epilepsy (PWE). METHODS:A consecutive cohort of PWE from the West China Hospital was recruited. Each patient received a psychiatric evaluation comprising the Mini International Neuropsychiatric Interview (MIN...

journal_title：Epilepsy research

authors： Tong X,An D,McGonigal A,Park SP,Zhou D

更新日期：2016-02-01 00:00:00

abstract：:This study was carried out to evaluate Synthetic Aperture Magnetometry-kurtosis (SAM(g(2))), a spatially filtered source localization technique in magnetoencephalography (MEG), for identification of epileptogenic areas of focal cortical dysplasia (FCD). Three children with FCD were investigated to localize the ictal o...

journal_title：Epilepsy research

authors： Ishii R,Canuet L,Ochi A,Xiang J,Imai K,Chan D,Iwase M,Takeda M,Snead OC 3rd,Otsubo H

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To determine the relative bioavailability and tolerability of a topiramate (TPM) suspension after rectal administration. DESIGN/METHOD:Seven healthy men and five healthy non-pregnant women were enrolled. A 100 or 200 mg tablet of TPM was given orally and a 200 mg dose was given rectally in a randomized, open...

journal_title：Epilepsy research

authors： Conway JM,Birnbaum AK,Kriel RL,Cloyd JC

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To use proton Magnetic Resonance Spectroscopy (MRS) to measure in vivo temporal lobe GABA and glutamate plus glutamine (GLX) concentrations in patients with temporal lobe epilepsy (TLE) attributable to unilateral hippocampal sclerosis (HS) before and following anterior temporal lobe resection (ATLR). METHODS:W...

journal_title：Epilepsy research

authors： Simister RJ,McLean MA,Barker GJ,Duncan JS

更新日期：2009-02-01 00:00:00

abstract：:The subjects were 106 SMIDS with epilepsy. They were classified into four epileptic syndromes: (1) SE-MISF (34.0%), (2) SGE (25.5%), (3) SLRE (20.7%), and (4) epileptic discharge-free patients (EDFP) (19.8%). Clinical electroencephalographic studies elucidated the following result: (1) The seizure disappearance rate w...

journal_title：Epilepsy research

authors： Matsumoto A,Miyazaki S,Hayakawa C,Komori T,Nakamura M

更新日期：2007-12-01 00:00:00

abstract：:The efforts of the International League against Epilepsy (ILAE) to devise classifications of the epilepsies has greatly improved communication among epileptologists and influenced both basic and clinical research. Several classifications have been proposed since 1970; the most recent classification of epilepsy syndrom...

journal_title：Epilepsy research

authors： Engel J Jr

更新日期：2006-08-01 00:00:00

abstract：:Cranial MRI has been shown to be a safe procedure in patients with a vagus nerve stimulator (VNS), but body MRI may cause overheating of the stimulator lead. Here we report a case of a patient with an implanted vagus nerve stimulator who required a cervical spinal MRI due to a rapidly progressive paraparesis. The spin...

journal_title：Epilepsy research

authors： Roebling R,Huch K,Kassubek J,Lerche H,Weber Y

更新日期：2009-04-01 00:00:00

abstract：:Benzodiazepines (BDZs) are GABA(A) receptor modulators with anxiolytic, hypnotic, and anticonvulsant properties. BDZs are understood to potentiate GABA(A) receptor function by increasing channel opening frequency, in contrast to barbiturates, which increase channel open duration. However, the in vitro evidence demonst...

journal_title：Epilepsy research

authors： Bianchi MT,Botzolakis EJ,Lagrange AH,Macdonald RL

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The aim of the present study is to verify whether patients with partial epilepsy receiving levetiracetam (LEV) as an add-on treatment show an improvement in cognitive function. METHODS:A neuropsychological battery of tests was administered to 35 patients with partial epilepsy before the assumption of LEV and a...

journal_title：Epilepsy research

authors： Piazzini A,Chifari R,Canevini MP,Turner K,Fontana SP,Canger R

更新日期：2006-03-01 00:00:00

abstract：:The ideal proof-of-principle study design provides a strong efficacy signal over the shortest duration, while exposing the fewest patients possible. Data from a large database (Pfizer Inc) which studied add-on pregabalin for the treatment of partial seizures was used to model how duration of baseline, post-randomizati...

journal_title：Epilepsy research

authors： French JA,Cabrera J,Emir B,Whalen E,Lu F

更新日期：2013-09-01 00:00:00

abstract：:Depression is a frequent psychiatric symptom in epilepsy and has been related to epilepsy of temporal origin, especially of left-sided foci. No study differentiated the precise localization of the epileptogenic lesion within the temporal lobe. Regarding this issue, we evaluated depression assessed by the Beck Depressi...

journal_title：Epilepsy research

authors： Quiske A,Helmstaedter C,Lux S,Elger CE

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:To evaluate diffusion tensor imaging (DTI) indices of (i) cortical tubers and (ii) normal-appearing subcortical white matter adjacent to cortical tubers within the epileptogenic zone and non-epileptogenic zone. METHODS:Twelve children with tuberous sclerosis complex underwent MRI, DTI and magnetoencephalograph...

journal_title：Epilepsy research

authors： Widjaja E,Simao G,Mahmoodabadi SZ,Ochi A,Snead OC,Rutka J,Otsubo H

更新日期：2010-05-01 00:00:00

abstract：:The development of epilepsy and a progressive increase in susceptibility to seizures may involve changes in inhibitory and excitatory systems from the beginning of the process. The present study was focused to analyze the opioid peptide changes induced by a chemical sub-convulsant stimulation. Experiments were carried...

journal_title：Epilepsy research

authors： Rocha L,Cano A,Cruz C,Omaña-Zapata I,Villalobos R,Maidment NT

更新日期：1999-11-01 00:00:00

abstract：:A partially purified extract from American ginseng has been shown to have anticonvulsant activity. To identify the active components in this extract, the activities of the individual ginsenosides (Rb(1), Rb(3) and Rd), mixtures of the purified ginsenosides and a newly prepared Rb fraction were determined. One hour aft...

journal_title：Epilepsy research

authors： Lian XY,Zhang Z,Stringer JL

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The stringent dichotomy between focal and generalized epilepsies has become a contentious issue, since neuropathological studies as well as structural and functional imaging data hypothesized the existence of focal brain abnormalities in patients with well-documented idiopathic generalized epilepsy. The aim of ...

journal_title：Epilepsy research

authors： Leutmezer F,Lurger S,Baumgartner C

更新日期：2002-08-01 00:00:00

abstract：:Single photon emission computed tomography (SPECT) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. As yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. Sixty-three consecutive patients (...

journal_title：Epilepsy research

authors： Duncan S,Gillen G,Adams FG,Duncan R,Brodie MJ

更新日期：1992-10-01 00:00:00

abstract：:Epilepsy affects about 1 % of the world population. Mesial temporal lobe epilepsy (mTLE) presents with seizures initiated in hippocampus and is the most frequent form of epilepsy. About 30 % of individuals with mTLE do not respond to conventional medications maintaining seizures and consequently new lesions on a daily...

journal_title：Epilepsy research

authors： Miranda DM,Rosa DV,Costa BS,Nicolau NF,Magno LAV,de Paula JJ,Romano-Silva MA

更新日期：2020-10-01 00:00:00

abstract：:Food intake triggers convulsions in fasted mice and rats treated with antimuscarinic drugs, scopolamine or atropine. Most of the drugs produced anticonvulsant efficacy in these convulsions have sedative effects. Thus, the present study was performed to evaluate the contribution of sedation in the suppression of convul...

journal_title：Epilepsy research

authors： Enginar N,Nurten A,Karamürsel Y,Zengin A,Baran E

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Idiopathic epilepsy (IE) is a syndrome that comprises epilepsy only, with no underlying structural brain lesion or other neurological signs or symptoms. Numerous studies have shown that genetic factors play an important role in IE. IE is a common disease in the Chinese Han population. However, the genetic ep...

journal_title：Epilepsy research

authors： Li M,Heng X,Tao R,Liu J,Zhang L,Sun X,Wang L,Wu Q,Che F,Xue F

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:EEG monitoring is important for the early detection of seizures during the course of critical illness. However, the logistics of real time EEG interpretation is challenging for the neurophysiology and critical care medicine teams. This study evaluated factors affecting the utility of digital trend analysis (...

journal_title：Epilepsy research

authors： Akman CI,Micic V,Thompson A,Riviello JJ Jr

更新日期：2011-01-01 00:00:00

abstract：:Understanding the relationship between seizure frequency, seizure type and scores obtained from quality of life (QOL) measures is important if the incorporation of QOL measures into epilepsy clinical trials is to become standard practice. There is also a need to consider cross-cultural differences obtained from QOL me...

journal_title：Epilepsy research

authors： Baker GA,Gagnon D,McNulty P

更新日期：1998-05-01 00:00:00

abstract：:We aim to investigate structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity (PS). Sixty JME patients, 19 (32%) of whom were photosensitive, were submitted to 1.5T magnetic resonance voxel-based morphometry (VBM). The control group (CTL) consisted of 30 sex-matched healthy v...

journal_title：Epilepsy research

authors： Lin K,Jackowski AP,Carrete H Jr,de Araújo Filho GM,Silva HH,Guaranha MS,Guilhoto LM,Bressan RA,Yacubian EM

更新日期：2009-10-01 00:00:00

abstract：:Triheptanoin, the triglyceride of heptanoate, is used to treat certain hereditary metabolic diseases in USA because of its anaplerotic potential. In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant. Here we investigated the effects of triheptanoin feeding in C3H and...

journal_title：Epilepsy research

authors： Thomas NK,Willis S,Sweetman L,Borges K

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of stiripentol as add-on therapy in Japanese patients with Dravet syndrome treated with clobazam (CLB) and valproate (VPA). METHODS:In this open-label study, patients aged 1-30 years entered a 4-week baseline phase, followed by a 4-week stiripentol dose-adjustment and 12-wee...

journal_title：Epilepsy research

authors： Inoue Y,Ohtsuka Y,STP-1 Study Group.

更新日期：2014-05-01 00:00:00

abstract：:Periventricular nodular heterotopia (PVNH) is a neuronal migrational disorder often associated with pharmacoresistant epilepsy (PRE). Resective surgery for PVNH is limited by its deep location, and the overlying eloquent cortex or white matter. Stereotactic MR guided laser interstitial thermal therapy (MRgLITT) has re...

journal_title：Epilepsy research

authors： Esquenazi Y,Kalamangalam GP,Slater JD,Knowlton RC,Friedman E,Morris SA,Shetty A,Gowda A,Tandon N

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway activato...

journal_title：Epilepsy research

authors： Singh N,Vijayanti S,Saha L,Bhatia A,Banerjee D,Chakrabarti A

更新日期：2018-07-01 00:00:00

abstract：:Mutations in genes encoding ion channels in brain neurons have been identified in various epilepsy syndromes. In neuronal networks, "gain-of-function" of channels in excitatory neurotransmission could lead to hyper-excitation while "loss-of-function" in inhibitory transmission impairs neuronal inhibitory system, both ...

journal_title：Epilepsy research

authors： Hirose S

更新日期：2006-08-01 00:00:00