Abstract:
INTRODUCTION:Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy syndrome. Under appropriate antiepileptic drugs (AED) up to 85% of patients become seizure-free, but many may have a relapse after AED withdrawal. METHODS:We retrospectively studied 242 patients with JME at the Department of Neurology, Medical University Innsbruck, Austria (1975-2006). We analyzed age at seizure onset, age at last follow up, seizure types, photosensitivity, seizure outcome and neuroimaging findings; inclusion criterion was a medical treatment period of >2 years; exclusion criteria were traumatic or infectious brain injury before the onset of JME and/or gross structural pathology on neuroimaging. RESULTS:We identified 175 patients (111 women) with a median age at seizure onset of 15 years, (range 3-46) and a median age at follow-up (FU) of 38 years (range 14-87; median FU 8 years, range 2-38). Fourteen percent showed (24/175) photosensitivity on routine EEG. Seizure outcome: 62% (109/175) were seizure-free of myoclonic seizures (MS), generalized tonic clonic seizures (GTCS) and absence seizures (AS) for >1 year, and 53% (94/175) for >2 years, including 16 patients (9%) without AEDs. Thirty-one percent (54/175) were seizure-free between 2 and 5 years, 15% (26/175) between 6 and 10, and 8% (14/175) >10 years; 38% (66/175) were not seizure-free. Not seizure-free patients had more often MS, AS and GTCS within the first year of epilepsy than those who were seizure-free at last FU (11% vs. 3%, Chi(2)=4.679, df=1, p=0.043). Seizure-free patients had more often MS and GTCS as last seizure types in the year before becoming seizure-free (37% vs. 15%, p=0.003), whereas in not seizure-free group MS only and GTCS only persisted. CONCLUSIONS:JME does not always need lifelong treatment, as a substantial minority of patients remain seizure-free without AEDs. AS, MS and GTCS at onset of the disease are indicators of poor long-term seizure control.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Höfler J,Unterberger I,Dobesberger J,Kuchukhidze G,Walser G,Trinka Edoi
10.1016/j.eplepsyres.2014.09.008subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1817-24issue
10eissn
0920-1211issn
1872-6844pii
S0920-1211(14)00241-1journal_volume
108pub_type
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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abstract:STUDY OBJECTIVE:Non-convulsive seizures/status epilepticus occur in approximately 20% of comatose, non-cardiac arrest intensive care unit (ICU) patients, and are associated with increased mortality. The prevalence and clinical significance of seizures in comatose survivors of cardiac arrest undergoing therapeutic hypot...
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doi:10.1016/j.eplepsyres.2012.02.001
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pub_type: 杂志文章
doi:10.1016/0920-1211(92)90010-q
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pub_type: 杂志文章
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doi:10.1016/s0920-1211(99)00101-1
更新日期:2000-02-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2014.04.006
更新日期:2014-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-04-01 00:00:00
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更新日期:2013-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2018.10.013
更新日期:2019-01-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(96)00026-5
更新日期:1996-10-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/s0920-1211(98)00041-2
更新日期:1998-09-01 00:00:00
abstract::Levetiracetam is a novel antiepileptic drug with an unknown mechanism of action. To-date levetiracetam is not known to be associated with any clinically significant pharmacokinetic interaction. Similarly, levetiracetam has not been associated with any pharmacodynamic interactions. We present four patients with severe ...
journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/s0920-1211(01)00309-6
更新日期:2002-02-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2012.09.009
更新日期:2013-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2018.03.021
更新日期:2018-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2018.02.003
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00