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A prospective study of serum sex hormones during carbamazepine therapy.

Abstract：

:This paper reports the results of a 12-month prospective follow-up study on the effects of carbamazepine (CBZ) medication on serum sex and pituitary hormone concentrations in 21 male patients with recently diagnosed epilepsy. The results of the present study indicate that a change occurs in the androgen balance during CBZ medication in male patients with epilepsy: a rise in serum sex hormone binding globulin levels results in decreased free androgen index values, and dehydroepiandrosterone sulfate serum levels decrease. Serum testosterone and free testosterone levels remain unchanged, but estradiol levels decrease. Serum basal prolactin (PRL) levels remain unchanged, but the PRL responses to thyrotropin-releasing hormone and metoclopramide increase slightly during the first year of CBZ medication. Basal and stimulated serum gonadotropin levels remain unchanged. The clinical consequences of these hormonal changes during CBZ medication call for further studies.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Isojärvi JI,Pakarinen AJ,Myllylä VV

doi

10.1016/0920-1211(91)90025-b

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

139-44

issue

2

eissn

0920-1211

issn

1872-6844

pii

0920-1211(91)90025-B

journal_volume

9

pub_type

杂志文章

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