Hyponatremic coma under oxcarbazepine therapy.

abstract：:The deletion of a sodium channel gene cluster located on chromosome 2q24.3 is associated with variable epilepsy phenotypes, including Dravet syndrome and migrating partial seizures of infancy. Although SCN1A is considered as the major contributor to the epilepsy phenotype, the role of other sodium channel genes that m...

journal_title：Epilepsy research

authors： Lim BC,Hwang H,Kim H,Chae JH,Choi J,Kim KJ,Hwang YS,Yum MS,Ko TS

更新日期：2015-01-01 00:00:00

abstract：:The new antiepileptic drug zonisamide was evaluated in a European multicenter parallel-group double-blind trial as add-on treatment for 139 patients with refractory partial epilepsy. During treatment with zonisamide complex partial seizures decreased by 27.7% compared to placebo (P < 0.05) and the median rate dropped ...

journal_title：Epilepsy research

authors： Schmidt D,Jacob R,Loiseau P,Deisenhammer E,Klinger D,Despland A,Egli M,Bauer G,Stenzel E,Blankenhorn V

更新日期：1993-05-01 00:00:00

abstract：:The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These...

journal_title：Epilepsy research

authors： Noh HS,Kang SS,Kim DW,Kim YH,Park CH,Han JY,Cho GJ,Choi WS

更新日期：2005-07-01 00:00:00

abstract：:It has been suggested that loss of the astrocytic water channel aquaporin-4 (AQP4) from perivascular endfeet in sclerotic hippocampi contributes to increased seizure propensity in human mesial temporal lobe epilepsy (MTLE). Whether this loss occurs prior to or as a consequence of epilepsy development remains to be res...

journal_title：Epilepsy research

authors： Alvestad S,Hammer J,Hoddevik EH,Skare Ø,Sonnewald U,Amiry-Moghaddam M,Ottersen OP

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate volumetric proton magnetic resonance spectroscopic imaging (MRSI) for localization of epileptogenic foci in neocortical epilepsy. METHODS:Twenty-five subjects reporting seizures considered to be of neocortical origin were recruited to take part in a 3-T MR study that inclu...

journal_title：Epilepsy research

authors： Maudsley AA,Domenig C,Ramsay RE,Bowen BC

更新日期：2010-02-01 00:00:00

abstract：:Four patients with complex partial seizure disorder whose positron emission tomography (PET) scans show sustained hyperperfusion of the epileptiform focus 12-24 h after a seizure episode are presented. Three of these patients underwent same day Fluorine-18 (18F) deoxyglucose (FDG) PET scans, which showed hypometabolis...

journal_title：Epilepsy research

authors： Tatlidil R

更新日期：2000-12-01 00:00:00

abstract：:A single-dose study of the beta-carboline, ZK 95962, on photosensitive generalized paroxysmal activity in the EEG was conducted in 6 patients with primary generalized epilepsy. Four of the patients were newly diagnosed and did not receive any antiepileptic drug or other medication during the study. Two were receiving ...

journal_title：Epilepsy research

authors： Møller A,Jensen LH,Skrumsager B,Blatt-Lyon B,Pedersen B,Dam M

更新日期：1990-03-01 00:00:00

abstract：:Status epilepticus (SE) is a common neurological and medical emergency. Despite the significant mortality associated with SE, no human data have been available regarding cardiovascular changes prior to death in patients with this condition. This study was conducted to measure hemodynamic trends in the 24 h prior to de...

journal_title：Epilepsy research

authors： Boggs JG,Marmarou A,Agnew JP,Morton LD,Towne AR,Waterhouse EJ,Pellock JM,DeLorenzo RJ

更新日期：1998-08-01 00:00:00

abstract：:Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative trea...

journal_title：Epilepsy research

authors： Dale T,Downs J,Olson H,Bergin AM,Smith S,Leonard H

更新日期：2019-03-01 00:00:00

abstract：:The monoamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability. In the present work, we have described the effects of serotonin (5-HT) depletion after the administration of 5,7-dihydroxytryptamine (5,7-D...

journal_title：Epilepsy research

authors： Trindade-Filho EM,de Castro-Neto EF,de A Carvalho R,Lima E,Scorza FA,Amado D,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2008-12-01 00:00:00

abstract：:The present study examined whether the perceived behavioral problems of children with idiopathic epilepsy differed from those of healthy controls according to parent proxy-reports and which factors are associated with these problems. The parents of 106 children with idiopathic epilepsy and 305 healthy controls aged 6-...

journal_title：Epilepsy research

authors： Dafoulis V,Kalyva E

更新日期：2012-06-01 00:00:00

abstract：:Understanding the relationship between seizure frequency, seizure type and scores obtained from quality of life (QOL) measures is important if the incorporation of QOL measures into epilepsy clinical trials is to become standard practice. There is also a need to consider cross-cultural differences obtained from QOL me...

journal_title：Epilepsy research

authors： Baker GA,Gagnon D,McNulty P

更新日期：1998-05-01 00:00:00

abstract：:To study the risk of developing unprovoked seizures among patients with multiple sclerosis (MS) and systemic lupus erythematosus (SLE), we used 1885 new onset seizure cases, 15,080 controls and defined exposure as a hospital discharge diagnosis of MS or SLE. The odds ratio with 95% confidence interval was 3.7 (CI 1.2-...

journal_title：Epilepsy research

authors： Adelöw C,Andersson T,Ahlbom A,Tomson T

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. METHODS:Resting state fMR...

journal_title：Epilepsy research

authors： Zeng H,Ramos CG,Nair VA,Hu Y,Liao J,La C,Chen L,Gan Y,Wen F,Hermann B,Prabhakaran V

更新日期：2015-10-01 00:00:00

abstract：:Spreading depression (SD), a self-propagating wave of reversible cellular depolarization, is thought to play an important role in brain pathophysiology. SD and seizures are closely related events but little is known about involvement of SD in chronic epileptogenesis. Here we show that cortical SD is the first and high...

journal_title：Epilepsy research

authors： Vinogradova LV,Vinogradov VY,Kuznetsova GD

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication. METHODS:The database of the therapeutic drug monitoring service of a large neurological hospital was searched to ident...

journal_title：Epilepsy research

authors： Fattore C,Messina S,Battino D,Croci D,Mamoli D,Perucca E

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:We performed a retrospective study to investigate seizure, EEG, social and cognitive outcome in adult LGS subjects. METHODS:We retrospectively evaluated 27 LGS patients aged 40-59 years. We assessed in particular the evolution of different seizure types and EEG findings, as well as cognitive and social outcome...

journal_title：Epilepsy research

authors： Ferlazzo E,Nikanorova M,Italiano D,Bureau M,Dravet C,Calarese T,Viallat D,Kölmel M,Bramanti P,De Santi L,Genton P

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Valproate is used widely for the treatment of epilepsy but has been associated with hyperandrogenism, hyperinsulinemia, and dyslipidemia. The mechanism for these associations is unknown, but they have been hypothesized to be secondary to valproate-associated weight gain. This study was conducted to test the ...

journal_title：Epilepsy research

authors： Morrell MJ,Isojärvi J,Taylor AE,Dam M,Ayala R,Gomez G,O'Neill F,Tennis P,Messenheimer J

更新日期：2003-05-01 00:00:00

abstract：:To clarify the mechanisms of the antiepileptic activity of phenytoin (PHI), the effects of PHT on extracellular and total levels of monoamines (dopamine and serotonin), in rat striatum and hippocampus were studied. The plasma concentrations of PHT associated with therapeutic activity did not affect striatal and hippoc...

journal_title：Epilepsy research

authors： Okada M,Kawata Y,Kiryu K,Mizuno K,Wada K,Inomata H,Tasaki H,Kaneko S

更新日期：1997-09-01 00:00:00

abstract：:This prospective study examined the effects of the new antiepileptic drug (AED) gabapentin (GBP) compared to the standard AED carbamazepine (CBZ) and placebo (PLA) on eye movements, posture and finger force control in 12 healthy volunteers who received single doses of 600 mg GBP and 400 mg CBZ in a placebo-controlled,...

journal_title：Epilepsy research

authors： Noachtar S,von Maydell B,Fuhry L,Büttner U

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. METHODS:This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c a...

journal_title：Epilepsy research

authors： Hamed SA,Hamed EA,Hamdy R,Nabeshima T

更新日期：2007-05-01 00:00:00

abstract：:Recent years have witnessed an increased interest from pediatric neurologists, neuropediatricians, epileptologists and general neurologists in the use of the ketogenic diet (KD) for the management of refractory epilepsies, particularly in children and adolescents. This article summarizes current knowledge on various i...

journal_title：Epilepsy research

authors： Freeman J,Veggiotti P,Lanzi G,Tagliabue A,Perucca E,Institute of Neurology IRCCS C. Mondino Foundation.

更新日期：2006-02-01 00:00:00

abstract：:Assessing the functional reserve of key memory structures in the medial temporal lobes (MTL) of pre-surgical patients with intractable temporal lobe epilepsy (TLE) remains a challenge. Conventional functional MRI (fMRI) memory paradigms have yet to fully convince of their ability to confidently assess the risk of a po...

journal_title：Epilepsy research

authors： Bonnici HM,Sidhu M,Chadwick MJ,Duncan JS,Maguire EA

更新日期：2013-07-01 00:00:00

abstract：:Stroke is an important cause of symptomatic epilepsy especially in the elderly. Seizures in the setting of stroke will furthermore worsen the prognosis of stroke. Studies show that the frequency of seizures in stroke ranges between 2.3% and 14%. Typically early seizures are defined as those that occur within 14 days o...

journal_title：Epilepsy research

authors： Menon B,Shorvon SD

更新日期：2009-11-01 00:00:00

abstract：:To further elucidate the inheritance pattern and range of phenotypic manifestations of benign familial temporal lobe epilepsy (FTLE), we report a large family recently identified in southern Italy. There were 8 patients (4 men), ranging in age from 31 to 68 years in three generations. One affected patient was deceased...

journal_title：Epilepsy research

authors： Gambardella A,Messina D,Le Piane E,Oliveri RL,Annesi G,Zappia M,Andermann E,Quattrone A,Aguglia U

更新日期：2000-02-01 00:00:00

abstract：:Brain slices from adult rats that included ventral hippocampus and adjacent parahippocampal areas were studied at various sites for the appearance of epileptiform discharges as extracellular potassium ([K+]o) was systematically varied over the range of 3 mM to 10 mM. The development of evoked epileptiform discharges (...

journal_title：Epilepsy research

authors： Bear J,Lothman EW

更新日期：1993-03-01 00:00:00

abstract：:We hypothesized and found that the co-occurrence of migraine with aura (MA) with major depression (MD) or with suicide attempt (SA) increases the risk for developing unprovoked seizure more than these conditions alone. Number of conditions showed a linear relationship to seizure risk. This may reflect a new condition ...

journal_title：Epilepsy research

authors： Hesdorffer DC,Lúdvígsson P,Hauser WA,Olafsson E,Kjartansson O

更新日期：2007-07-01 00:00:00

abstract：:Changes in EEG synchronization, i.e., spatio-temporal correlation, with amygdala-hippocampal stimulation were studied in patients with temporal lobe epilepsy. Synchronization was evaluated for high frequency, 130 Hz, pseudo-monophasic or biphasic charge-balanced pulses. Desynchronization was most frequently induced by...

journal_title：Epilepsy research

authors： Tyrand R,Seeck M,Pollo C,Boëx C

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To study potential delays in epilepsy surgery in children with drug-resistant epilepsy (DRE) of early-onset. METHODS:Medical records were reviewed from 87 children with DRE and seizure onset before age 3 years who underwent epilepsy surgery between 2006 and 2015. Information was obtained about each child's e...

journal_title：Epilepsy research

authors： Prideaux L,Barton S,Maixner W,Harvey AS

更新日期：2018-07-01 00:00:00

abstract：:The present study aimed at investigating to what extent the regulation of excitability in cortical networks, as indicated by surface-negative slow cortical potentials (SCPs), is impaired in epileptic patients and to what extent training of SCP self-regulation by means of biofeedback and instrumental learning procedure...

journal_title：Epilepsy research

authors： Rockstroh B,Elbert T,Birbaumer N,Wolf P,Düchting-Röth A,Reker M,Daum I,Lutzenberger W,Dichgans J

更新日期：1993-01-01 00:00:00