Effects of amygdala-hippocampal stimulation on synchronization.

abstract：PURPOSE:To evaluate the efficacy and safety of stiripentol as add-on therapy in Japanese patients with Dravet syndrome treated with clobazam (CLB) and valproate (VPA). METHODS:In this open-label study, patients aged 1-30 years entered a 4-week baseline phase, followed by a 4-week stiripentol dose-adjustment and 12-wee...

journal_title：Epilepsy research

authors： Inoue Y,Ohtsuka Y,STP-1 Study Group.

更新日期：2014-05-01 00:00:00

abstract：:Food intake triggers convulsions in fasted mice and rats treated with antimuscarinic drugs, scopolamine or atropine. Most of the drugs produced anticonvulsant efficacy in these convulsions have sedative effects. Thus, the present study was performed to evaluate the contribution of sedation in the suppression of convul...

journal_title：Epilepsy research

authors： Enginar N,Nurten A,Karamürsel Y,Zengin A,Baran E

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Activation of the neurokinin-1 (NK1) receptor by neuropeptide substance P (SP) induces and maintains epileptic activity in various experimental models of epilepsy. The primary objective of this study was to investigate whether neurobiological changes linked to NK1-SP receptor system are associated with hyperexc...

journal_title：Epilepsy research

authors： Danfors T,Åhs F,Appel L,Linnman C,Fredrikson M,Furmark T,Kumlien E

更新日期：2011-11-01 00:00:00

abstract：:Periodic lateralized epileptiform discharges (PLEDs) or lateralized periodic discharges (LPDs) are a well-known variant of pathological EEG activity. However, the mechanisms underpinning the appearance of this pattern are not completely understood. The heterogeneity of the features derived from LPDs patterns, and the ...

journal_title：Epilepsy research

authors： Chegodaev D,Pavlova NV,Pavlova P,Lvova O

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Diffusion tensor imaging (DTI) provides information about magnitude (diffusivity) and directionality (anisotropy, FA) of water diffusion. We explored the characteristics of pathology-proven cortical dysplasia (CD) in the posterior quadrant in a case series of three patients using DTI measures, to assess associa...

journal_title：Epilepsy research

authors： Diehl B,Tkach J,Piao Z,Ruggieri P,LaPresto E,Liu P,Fisher E,Bingaman W,Najm I

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Grammar is a core component of the language system, yet it is rarely assessed during the Wada (intracarotid amobarbital) test. It is hypothesized that adding grammar tests to the recovery phase of the Wada test will increase our ability to lateralize language function. METHOD:Sixteen individuals (nine fem...

journal_title：Epilepsy research

authors： Połczyńska M,Curtiss S,Walshaw P,Siddarth P,Benjamin C,Moseley BD,Vigil C,Jones M,Eliashiv D,Bookheimer S

更新日期：2014-12-01 00:00:00

abstract：:Four patients with complex partial seizure disorder whose positron emission tomography (PET) scans show sustained hyperperfusion of the epileptiform focus 12-24 h after a seizure episode are presented. Three of these patients underwent same day Fluorine-18 (18F) deoxyglucose (FDG) PET scans, which showed hypometabolis...

journal_title：Epilepsy research

authors： Tatlidil R

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Many new antiepileptic drugs (AEDs) have become available in recent years. Investigations of prescription patterns and exposure of AEDs to different patient groups are important regarding drug safety aspects. The aim of this study was to investigate the use of AEDs in epilepsy, with focus on exposure of AEDs...

journal_title：Epilepsy research

authors： Landmark CJ,Fossmark H,Larsson PG,Rytter E,Johannessen SI

更新日期：2011-06-01 00:00:00

abstract：:Sodium valproate is a drug widely used for the treatment of epilepsy and mood disorders. We studied the effect of valproate on cerebral energy metabolism by incubating rat brain slices with 5 mM [3-(13)C]glutamate in the absence and the presence of 1 mM valproate. Substrate removal and product formation were measured ...

journal_title：Epilepsy research

authors： El Hage M,Baverel G,Martin G

更新日期：2012-03-01 00:00:00

abstract：:Valproate (VPA) and vigabatrin (gamma-vinyl GABA, GVG) are two novel antiepileptic drugs with a presumed GABAergic mechanism of action. However, for VPA, this aspect has been extensively debated. The aim of the present study was to investigate whether treatment of cultured neurons with clinically relevant concentratio...

journal_title：Epilepsy research

authors： Gram L,Larsson OM,Johnsen AH,Schousboe A

更新日期：1988-03-01 00:00:00

abstract：:The experimental antiepileptic drug, levetiracetam (UCB L059), a piracetam analogue has been investigated in photosensitive patients in the "photosensitivity model", an early phase II study. A total of 12 patients (10 females, 2 males) with a mean age of 21.5 years (range 13-38) were investigated during a 3 day period...

journal_title：Epilepsy research

authors： Kasteleijn-Nolst Trenité DG,Marescaux C,Stodieck S,Edelbroek PM,Oosting J

更新日期：1996-11-01 00:00:00

abstract：:Opioid peptide release was monitored in the amygdala and hippocampus of freely moving rats following a single oral administration of gabapentin using microdialysis. Extracellular opioid peptide levels were elevated above basal levels in the amygdala within the first 60 (54%) and 90 min (68%) after gabapentin administr...

journal_title：Epilepsy research

authors： Rocha L,Ondarza-Rovira R,Maidment NT

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:The NTRK2 gene encodes a member of the neurotrophic tyrosine kinase receptor family known as TrkB. It is a membrane-associated receptor with signaling and cellular differentiation properties that has been involved in neuropsychiatric disorders, including epilepsy. We report here the frequencies of NTRK2 allel...

journal_title：Epilepsy research

authors： Torres CM,Siebert M,Bock H,Mota SM,Krammer BR,Duarte JÁ,Bragatti JA,Castan JU,de Castro LA,Saraiva-Pereira ML,Bianchin MM

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Tuberous sclerosis complex (TSC) is a multisystem genetic disorder affecting multiple organs, including the brain, and very often associated with epileptic activity. Language acquisition and development seems to be altered in a significant proportion of patients with TSC. In the present study, we used magn...

journal_title：Epilepsy research

authors： Gallagher A,Tanaka N,Suzuki N,Liu H,Thiele EA,Stufflebeam SM

更新日期：2013-03-01 00:00:00

abstract：:Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. In order to evaluate further the role of QUIN metabolism in genetic murine seizure models, the activities of its bi...

journal_title：Epilepsy research

authors： Eastman CL,Urbańska EM,Chapman AG,Schwarcz R

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:To identify consistent results of voxel-based morphometry (VBM) studies in unilateral refractory temporal lobe epilepsy (TLE). METHODS:Whole-brain VBM studies comparing refractory TLE patients with healthy controls (HC) were systematically searched in PubMed, ISI Web of Science, Embase, and Medline databases f...

journal_title：Epilepsy research

authors： Li J,Zhang Z,Shang H

更新日期：2012-02-01 00:00:00

abstract：:The Mongolian gerbil is known as an animal model that often exhibits spontaneous seizures that are characteristic of human epilepsy. Whereas there is much more information available relating this phenomenon to anatomical and electrophysiological characteristics of the hippocampal formation, the somatosensory cortex ha...

journal_title：Epilepsy research

authors： Kato M,Ito M,Seto-Ohshima A

更新日期：2000-07-01 00:00:00

abstract：:This paper reports the results of a 12-month prospective follow-up study on the effects of carbamazepine (CBZ) medication on serum sex and pituitary hormone concentrations in 21 male patients with recently diagnosed epilepsy. The results of the present study indicate that a change occurs in the androgen balance during...

journal_title：Epilepsy research

authors： Isojärvi JI,Pakarinen AJ,Myllylä VV

更新日期：1991-07-01 00:00:00

abstract：:Dietary supplements, herbal medicines, and other foods may affect the pharmacokinetics and/or pharmacodynamics of carbamazepine (CBZ), which may possibly lead to potential drug-drug/herb-drug interactions, as CBZ has a narrow therapeutic window. Sinapic acid (SA) is a bioactive phytoconstituent used as a dietary suppl...

journal_title：Epilepsy research

authors： Raish M,Ahmad A,Ansari MA,Alkharfy KM,Ahad A,Al-Jenoobi FI,Al-Mohizea AM,Khan A,Ali N

更新日期：2019-07-01 00:00:00

abstract：:Basal and high potassium-stimulated release of endogenous amino acids was measured using brain dialysis in the hippocampus of urethane-anesthetized seizure-resistant (SR) and seizure-susceptible (SS) rats. Moreover, the tissue level of amino acids was determined in the hippocampus, sensorimotor cortex, cerebellum and ...

journal_title：Epilepsy research

authors： Lehmann A

更新日期：1989-03-01 00:00:00

abstract：:The postictal behavioral depression (PBD), characterized by behavioral immobility and unresponsiveness to environmental stimuli, observed after a stage 5 kindling seizure is opioid dependent. Morphine injection prolongs while naloxone and naltrexone (opioid antagonists) reduce or eliminate PBD. Opioids have clear rewa...

journal_title：Epilepsy research

authors： Paredes RG,Muzzi G,Aguirre E,Romero V

更新日期：2000-02-01 00:00:00

abstract：AIM:To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ). BACKGROUND:Individuals with epilepsy have increased risk factors for vascular disease, particu...

journal_title：Epilepsy research

authors： Keenan N,Sadlier LG,Wiltshire E

更新日期：2014-08-01 00:00:00

abstract：:Generic substitution of antiepileptic drugs (AEDs) is still a matter of controversy and concern among clinicians and patients. We aimed to assess intrasubject variation in plasma concentrations of lamotrigine (LTG), levetiracetam (LEV) and topiramate (TPM) after generic substitution compared with a stable brand-name d...

journal_title：Epilepsy research

authors： Contin M,Alberghini L,Candela C,Benini G,Riva R

更新日期：2016-05-01 00:00:00

abstract：:Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurologic inherited disease with heterogeneity. Autosomal dominant (AD) is the common inherited mode. There have been two loci mapped to 16 chromosome for PKD. However, no gene responsible for it has been identified so far. We collected 6 pedigrees from Chinese mainla...

journal_title：Epilepsy research

authors： Zhou J,Li G,Chen C,Liu D,Xiao B

更新日期：2008-08-01 00:00:00

abstract：:It has previously been suggested that abnormalities in cardiac repolarization (QTc lengthening and shortening) are more likely to accompany seizures with hypoxemia and may be involved in sudden unexpected death in epilepsy (SUDEP). Accordingly, we evaluated for associations between peri-ictal QTc changes and hypoxemia...

journal_title：Epilepsy research

authors： Moseley BD,Britton JW

更新日期：2014-07-01 00:00:00

abstract：:The epileptic baboon provides a natural model of idiopathic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). We sought to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) ba...

journal_title：Epilepsy research

authors： de la Garza MA,Poldiak D,Shade R,Salinas FS,Papanastassiou AM,Szabó CÁ

更新日期：2019-09-01 00:00:00

abstract：:Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ h...

journal_title：Epilepsy research

authors： Tabb K,Szot P,White SS,Liles LC,Weinshenker D

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Clobazam (CLB, 1,5-benzodiazepine, 1,5-BZP) has been reported to show unique antiepileptic action profile distinguishing from standard 1,4-BZPs. To further elucidate the action profile of CLB, its effects on the abnormal circling fits (ACFs) and generalized tonic-clonic convulsions (GTCs) in Ihara epileptic rat...

journal_title：Epilepsy research

authors： Miura Y,Amano S,Torii R,Ihara N

更新日期：2002-05-01 00:00:00

abstract：:The present study intends to identify factors that predict postoperative clinical outcome in patients with gangliogliomas (GG) and dysembryoplastic neuroepithelial tumors (DNT). We evaluated the medical records of 45 patients with GG and 13 patients with DNT, treated surgically between 1985 and 1995. We assessed sever...

journal_title：Epilepsy research

authors： Aronica E,Leenstra S,van Veelen CW,van Rijen PC,Hulsebos TJ,Tersmette AC,Yankaya B,Troost D

更新日期：2001-03-01 00:00:00

abstract：:Levetiracetam is a novel antiepileptic drug with an unknown mechanism of action. To-date levetiracetam is not known to be associated with any clinically significant pharmacokinetic interaction. Similarly, levetiracetam has not been associated with any pharmacodynamic interactions. We present four patients with severe ...

journal_title：Epilepsy research

authors： Sisodiya SM,Sander JW,Patsalos PN

更新日期：2002-02-01 00:00:00