Pregnancy decreases the frequency of spontaneous recurrent seizures in rats with kainic acid lesions of the hippocampus.

abstract：:Single photon emission computed tomography (SPECT) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. As yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. Sixty-three consecutive patients (...

journal_title：Epilepsy research

authors： Duncan S,Gillen G,Adams FG,Duncan R,Brodie MJ

更新日期：1992-10-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated in the pathogenesis of epilepsy and consequently as targets for anticonvulsant drugs. Consistent with this, broad-spectrum block of HCN-mediated current (Ih) reduces seizure susceptibility in a variety of epilepsy models. However, ...

journal_title：Epilepsy research

authors： Kharouf Q,Pinares-Garcia P,Romanelli MN,Reid CA

更新日期：2020-12-01 00:00:00

abstract：:This was an open-label study (N01281 [NCT00419393]) assessing the long-term safety of extended-release levetiracetam (LEV XR) in patients with partial-onset seizures (POS); the study was a follow-up to a double-blind, randomized, historical controlled, multicenter, conversion to monotherapy study (N01280 [NCT00419094]...

journal_title：Epilepsy research

authors： Chung S,Ceja H,Gawłowicz J,McShea C,Schiemann J,Lu S

更新日期：2016-02-01 00:00:00

abstract：:Glutamic acid decarboxylase autoantibodies (GADA) and anti-cardiolipin autoantibodies (ACA) have been detected in adult subjects with epilepsy, though the functional implications of these findings are a matter of debate. This study aimed to determine the prevalence of GADA and ACA and to investigate their clinical sig...

journal_title：Epilepsy research

authors： Veri K,Uibo O,Talvik T,Talvik I,Metsküla K,Napa A,Vaher U,Õiglane-Šlik E,Rein R,Kolk A,Traat A,Uibo R

更新日期：2013-07-01 00:00:00

abstract：:Studying infantile spasms is challenging because there are so many aspects of variation that introduce potential bias. These might relate to the many underlying etiologies, and variations in clinical semiology and electroencephalographic features that relate more to age or timing of investigation than to the underlyin...

journal_title：Epilepsy research

authors： Lux AL,Osborne JP

更新日期：2006-08-01 00:00:00

abstract：:The anticonvulsant activities of a noncompetitive (GYKI 52466) and a competitive (NBQX) AMPA/kainate antagonist were compared in the maximal electroshock (MES) seizure test and various chemoconvulsant models. Both antagonists were protective in the MES and pentylenetetrazol tests. GYKI 52466 was also protective agains...

journal_title：Epilepsy research

authors： Yamaguchi S,Donevan SD,Rogawski MA

更新日期：1993-07-01 00:00:00

abstract：:The epileptic baboon provides a natural model of idiopathic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). We sought to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) ba...

journal_title：Epilepsy research

authors： de la Garza MA,Poldiak D,Shade R,Salinas FS,Papanastassiou AM,Szabó CÁ

更新日期：2019-09-01 00:00:00

abstract：:Special issues are related to AED testing in several populations. Pharmacokinetics, pharmacodynamics and underlying neurochemistry and developing systems require specific testing in appropriate infants with refractory seizures. EEG monitoring is an essential part of seizure definition and recognition, making it a nece...

journal_title：Epilepsy research

authors： Pellock J

更新日期：2006-01-01 00:00:00

abstract：:Mutations in genes encoding ion channels in brain neurons have been identified in various epilepsy syndromes. In neuronal networks, "gain-of-function" of channels in excitatory neurotransmission could lead to hyper-excitation while "loss-of-function" in inhibitory transmission impairs neuronal inhibitory system, both ...

journal_title：Epilepsy research

authors： Hirose S

更新日期：2006-08-01 00:00:00

abstract：:The actions of adenosine in modulating amygdala kindling were examined using the stable adenosine analog 5'-N'-ethylcarboxamidoadenosine (NECA) and caffeine, an adenosine antagonist. Systemically administered NECA was found to significantly reduce the rate of postictal spiking and to significantly increase the duratio...

journal_title：Epilepsy research

authors： Whitcomb K,Lupica CR,Rosen JB,Berman RF

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVES:There is shortage of specialists for the diagnosis of children with epilepsy, especially in resource limited settings. Existing INCLEN (International Clinical Epidemiology Network) instrument was validated for children aged 2-9 years. The current study validated modifications of the same including wider symp...

journal_title：Epilepsy research

authors： Gulati S,Patel H,Chakrabarty B,Dubey R,Arora NK,Pandey RM,Paul VK,Ramesh K,Anand V,Meena A

更新日期：2017-02-01 00:00:00

abstract：:We have reported long-term clinical follow-up for two siblings with Lafora disease, a brother and sister, one of whom autopsied. Both siblings had repeated attacks of severe myoclonus, tonic and tonic-clonic convulsions, and intractable status epilepticus. The addition of orally administered zonisamide brought about s...

journal_title：Epilepsy research

authors： Yoshimura I,Kaneko S,Yoshimura N,Murakami T

更新日期：2001-09-01 00:00:00

abstract：:A freezing probe was placed on the skull of postnatal day (PN) 1 rats to induce formation of a cerebrocortical microsulcus. Experimental studies were performed on PN days 21-24. At that time point, Nissl-stained sections revealed the presence of a microsulcus similar to that described in human dysplastic cortex. Immun...

journal_title：Epilepsy research

authors： Hablitz JJ,DeFazio T

更新日期：1998-09-01 00:00:00

abstract：:Opioid peptide release was monitored in the amygdala and hippocampus of freely moving rats following a single oral administration of gabapentin using microdialysis. Extracellular opioid peptide levels were elevated above basal levels in the amygdala within the first 60 (54%) and 90 min (68%) after gabapentin administr...

journal_title：Epilepsy research

authors： Rocha L,Ondarza-Rovira R,Maidment NT

更新日期：1999-05-01 00:00:00

abstract：INTRODUCTION:Grammar is a core component of the language system, yet it is rarely assessed during the Wada (intracarotid amobarbital) test. It is hypothesized that adding grammar tests to the recovery phase of the Wada test will increase our ability to lateralize language function. METHOD:Sixteen individuals (nine fem...

journal_title：Epilepsy research

authors： Połczyńska M,Curtiss S,Walshaw P,Siddarth P,Benjamin C,Moseley BD,Vigil C,Jones M,Eliashiv D,Bookheimer S

更新日期：2014-12-01 00:00:00

abstract：:CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of phenytoin to its primary inactive metabolite, (S)-pHPPH, by these mu...

journal_title：Epilepsy research

authors： Rettie AE,Haining RL,Bajpai M,Levy RH

更新日期：1999-07-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenyl sulfone; DDS), an established anti-leprosy drug, showed anticonvulsive effects in the amygdaloid kindling model of epilepsy. Single doses of the drug in rats (6.25-12.5 mg/kg, i.p.) suppressed the kindled seizures in a dose-dependent manner without overt behavioral toxicity. With repeated...

journal_title：Epilepsy research

authors： Hamada K,Hiyoshi T,Kobayashi S,Ishida S,Yagi K,Seino M

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:EEG monitoring is important for the early detection of seizures during the course of critical illness. However, the logistics of real time EEG interpretation is challenging for the neurophysiology and critical care medicine teams. This study evaluated factors affecting the utility of digital trend analysis (...

journal_title：Epilepsy research

authors： Akman CI,Micic V,Thompson A,Riviello JJ Jr

更新日期：2011-01-01 00:00:00

abstract：:The present study investigated whether pharmacological stimulation of the GABAergic system can affect attention. The effects of vigabatrin, a novel antiepileptic drug, on the performance of rats in a 5-choice serial reaction time task assessing selective attention were studied. The effects of acute (100, 300, 500 and ...

journal_title：Epilepsy research

authors： Mazurkiewicz M,Sirviö J,Riekkinen P Sr

更新日期：1992-12-01 00:00:00

abstract：:Results of previous studies suggested that the brainstem participates in amygdaloid (AM) kindled seizure generalization and the positive transfer effect at the secondary site AM. This study was undertaken to define the role of the brainstem in the patterning of AM kindling, the maintenance of AM kindled seizure and th...

journal_title：Epilepsy research

authors： Hamada K,Wada JA

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To quantitatively analyze trajectory of movement in automatisms with temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE). METHODS:Twenty markers were attached to chosen body parts of patients, and 10 videos of seizures were recorded. The obtained videos were converted into digital matrices. Motor tr...

journal_title：Epilepsy research

authors： Yang X,Chen L,Liu Y,Zeng D,Tang Y,Yan B,Lin X,Liu L,Xu H,Zhou D

更新日期：2009-02-01 00:00:00

abstract：:Acute psychological disorders (APDs) are more common in epilepsy than in the general population, with estimates varying from 2 to 16% depending on the population of patients sampled. APD has traditionally been classified by seizure activity (ictal), the early post-ictal period (post-ictal) and unrelated to seizure act...

journal_title：Epilepsy research

authors： Cockerell OC,Moriarty J,Trimble M,Sander JW,Shorvon SD

更新日期：1996-10-01 00:00:00

abstract：:In this preliminary study, we evaluated the predictive ability of Correlation Dimension (CD) and Nonlinear Interdependence (NI) for seizures in pediatric myoclonic epilepsy patients. Scalp EEG recordings of eight diagnosed cases of myoclonic epilepsy were analyzed using Receiver Operating Curve (ROC) for discriminatin...

journal_title：Epilepsy research

authors： Kolarijani MAS,Amirsalari S,Haidari MR

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in order to inv...

journal_title：Epilepsy research

authors： Menezes Cordeiro I,von Ellenrieder N,Zazubovits N,Dubeau F,Gotman J,Frauscher B

更新日期：2015-07-01 00:00:00

abstract：:Kindling, in the classical sense, involves progressively increasing responsivity to the intermittent repetition of the same 1-s subthreshold electrical stimulation over time, with the amygdala being the area most frequently studied. Such repeated subthreshold stimulation is associated with: lowering of the after-disch...

journal_title：Epilepsy research

authors： Post RM

更新日期：2002-06-01 00:00:00

abstract：:Levetiracetam is a novel antiepileptic drug with an unknown mechanism of action. To-date levetiracetam is not known to be associated with any clinically significant pharmacokinetic interaction. Similarly, levetiracetam has not been associated with any pharmacodynamic interactions. We present four patients with severe ...

journal_title：Epilepsy research

authors： Sisodiya SM,Sander JW,Patsalos PN

更新日期：2002-02-01 00:00:00

abstract：:Benzodiazepines (BDZs) are GABA(A) receptor modulators with anxiolytic, hypnotic, and anticonvulsant properties. BDZs are understood to potentiate GABA(A) receptor function by increasing channel opening frequency, in contrast to barbiturates, which increase channel open duration. However, the in vitro evidence demonst...

journal_title：Epilepsy research

authors： Bianchi MT,Botzolakis EJ,Lagrange AH,Macdonald RL

更新日期：2009-08-01 00:00:00

abstract：:Post-stroke paroxysmal activity is a neurophysiological indicator of epileptogenesis and increase of seizure susceptibility, so treatments with neuroprotective activity and anti-paroxysmal activity can be more beneficial during post-ischemic period. The goal of this study was evaluation of levetiracetam (100 mg/kg, 7 ...

journal_title：Epilepsy research

authors： Litvinova SA,Kutepova IS,Voronina TA,Petrunina АА

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The aim of this study is to classify infantile cases with benign seizures into known epileptic syndromes, thereby facilitating discussion of clinical factors that could play an important role in diagnosis. SUBJECTS:Fifty-seven patients with afebrile seizures fulfilling all of the following criteria were enroll...

journal_title：Epilepsy research

authors： Tanabe T,Hara K,Kashiwagi M,Tamai H

更新日期：2006-08-01 00:00:00

abstract：:In a selected group of temporal lobe epilepsy patients with seizures refractory to pharmacological treatment, pharmacological seizure control can be attained by surgical resection of the epileptic zone. We investigated to what extent pharmaco-resistance is reflected in a reduced response at the cellular level, in neur...

journal_title：Epilepsy research

authors： Vreugdenhil M,van Veelen CW,van Rijen PC,Lopes da Silva FH,Wadman WJ

更新日期：1998-09-01 00:00:00