Abstract:
OBJECTIVE:To estimate the impact of foetal nutritional status on cardiovascular risk among children with the Foetal Nutritional Status Index (FNSI), calculated by dividing the child's birth weight (BW, kg) by the mother's height (m2). DESIGN:Cross-sectional survey analysis. SETTING:A sample of children from the US Third National Health and Nutrition Examination Survey. SUBJECTS:A total of 3109 children who were 5-11 years of age and had data on BW and mother's height. Non-fasting blood samples were included. RESULTS:Overall, the FNSI was positively associated with BW and negatively associated with mother's height (P<0.0001). Within sex-specific quintiles of FNSI (third quintile as reference) adjusted for potential confounding variables, cardiovascular risk factors tended to be 'higher' in the lower quintiles for males while the opposite was true for females. Multivariate logistic regression analyses indicated that the odds for males in quintile 1 was 2.4 for having a low level of high-density lipoprotein cholesterol (P<0.01) and 2.1 for having a cluster of cardiovascular risk factors (P=0.01); for females, the odds of having a cluster of cardiovascular risk factors was approximately two times higher for those in the first and fifth quintiles, who also had a significantly higher prevalence of central obesity. CONCLUSIONS:The FNSI may be a potential proxy indicator of foetal nutritional status and it may be used to test specific hypotheses of whether foetal nutrition restriction or overnutrition programmes future cardiovascular risk.
journal_name
Public Health Nutrjournal_title
Public health nutritionauthors
Liu J,Sempos Cdoi
10.1017/S136898000768389Xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
1067-75issue
10eissn
1368-9800issn
1475-2727pii
S136898000768389Xjournal_volume
10pub_type
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journal_title:Public health nutrition
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pub_type: 杂志文章,多中心研究
doi:10.1017/S1368980010001266
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-08-01 00:00:00
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更新日期:2015-07-01 00:00:00
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doi:10.1017/S1368980013000359
更新日期:2014-04-01 00:00:00
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doi:10.1017/S1368980007000341
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/S1368980011003041
更新日期:2012-06-01 00:00:00
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doi:10.1017/S1368980020003250
更新日期:2020-10-15 00:00:00
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pub_type: 杂志文章
doi:10.1017/S1368980012004600
更新日期:2014-01-01 00:00:00
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doi:10.1017/S1368980007246762
更新日期:2007-02-01 00:00:00
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更新日期:2013-12-01 00:00:00
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更新日期:2019-10-01 00:00:00
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更新日期:2014-04-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980017002646
更新日期:2018-02-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980010000650
更新日期:2010-09-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章,评审
doi:10.1017/S1368980007000602
更新日期:2007-10-01 00:00:00
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更新日期:2009-07-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章,评审
doi:10.1079/phn2005935
更新日期:2006-02-01 00:00:00