Abstract:
BACKGROUND:In Marfan syndrome, the mitral valve prolapse, ranging from nonclassic to classic form on the basis of the leaflet thickness, is a common condition characterized by a highly variable structural abnormality. We investigated the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) I/D and angiotensin II type 1 receptor (AT1R) A1166C polymorphisms in influencing the susceptibility to classic or non-classic mitral valve prolapse in Marfan patients. METHODS:We studied 135 Marfan patients with mitral valve prolapse, diagnosed by echocardiography. AGT, ACE, and AT1R polymorphisms were identified by polymerase chain reaction-based restriction analysis. RESULTS:The frequency of the ACE D, but not AGT 235T and AT1R 1166C allele, was significantly higher in patients with classic mitral valve prolapse in comparison to that observed in the non-classic one (p=0.03). The percentage of subjects with the contemporaneous presence of ACE D and AGT 235T alleles was significantly higher in the classic mitral valve prolapse group in comparison to the non-classic one (79% vs. 55%, respectively; p=0.008). The concomitant presence of these two alleles was associated with increased susceptibility to the classic mitral valve prolapse (OR 3.02, p=0.016). CONCLUSIONS:Our findings show a possible role of ACE and AGT genes as predisposing factors to classic mitral valve prolapse in Marfan patients, thus suggesting a role of renin angiotensin system genes in modulating mitral valve abnormality, and the need for an interventional study with angiotensin II type 1 receptor antagonists, which considers the leaflet thickness progression in Marfan patients with MVP.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Fatini C,Attanasio M,Porciani C,Sticchi E,Padeletti L,Lapini I,Abbate R,Gensini GF,Pepe Gdoi
10.1016/j.ijcard.2006.12.015subject
Has Abstractpub_date
2008-01-24 00:00:00pages
293-7issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(07)00301-4journal_volume
123pub_type
杂志文章abstract::Three cases of myocardial infarction (MI) in women taking bromocriptine for milk suppression are presented. The incidents occurred in 1993 and 1994, the last only two weeks before the withdrawal of the drug from the American market as a drug suitable for ablactation. In one patient, the MI presented on the 12 day post...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(96)02789-1
更新日期:1996-12-13 00:00:00
abstract:AIMS:To analyse measures of clinical data, functional capacity, left ventricular function and neurohormonal activation for the ability to predict mortality and morbidity in patients after a hospitalisation for heart failure. METHODS:In a prospective study, patients 60 years or above with systolic heart failure NYHA II...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.07.015
更新日期:2006-04-28 00:00:00
abstract::Mongrel dogs of either sex with ligation of their left anterior descending coronary artery were employed for the present study to investigate the biochemical basis of the cardioprotective action of dilazep. Dilazep (0.2 mg/kg intravenous) was administered 20 minutes after coronary arterial occlusion. Ligation of the a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90244-1
更新日期:1989-05-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.07.106
更新日期:2015-12-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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abstract::Whether intracardiac right-to-left shunt (RLS) is an independent risk factor for cerebrovascular accidents is disputed. In patients with RLS, venous thrombo-embolism (VTE) may predispose to paradoxical embolic events, among which stroke and transient ischemic attack (TIA). Whether genetic or acquired thrombophilia is ...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-09-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2007-10-18 00:00:00
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journal_title:International journal of cardiology
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更新日期:2016-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-03-14 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2015-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.11.106
更新日期:2010-04-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2006-08-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-07-21 00:00:00
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更新日期:1991-05-01 00:00:00
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更新日期:1996-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 评论,信件
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更新日期:2010-07-09 00:00:00
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更新日期:1988-06-01 00:00:00
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journal_title:International journal of cardiology
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-03-18 00:00:00
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更新日期:2020-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:2007-09-14 00:00:00
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pub_type: 信件
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更新日期:2007-02-07 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-03-01 00:00:00
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pub_type: 信件
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更新日期:2010-10-29 00:00:00
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pub_type: 杂志文章
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更新日期:1989-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-04-01 00:00:00
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pub_type: 信件
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更新日期:2009-06-12 00:00:00