Abstract:
BACKGROUND:Vascular inflammation and endothelial dysfunction are evident in patients with chronic heart failure (CHF). We hypothesized that circulating peripheral blood mononuclear cells (PBMCs) may be activated and the resultant increased endothelial monocyte adhesion may be functionally and pathophysiologically relevant in CHF. In the present study, we investigated the clinical significance of the activity of PBMCs in patients with CHF. METHODS:PBMCs were isolated from 34 CHF patients, from 10 healthy volunteers (normal control group) and from 17 patients admitted for investigation of suspected coronary artery disease (disease control group). In each patient, the adhesiveness of PBMCs to cultured human aortic endothelial cells (HAECs) with or without tumor necrosis factor-alpha (TNF-alpha) stimulation was determined. Major adverse cardiac events (death, heart transplantation or hospitalization with worsening heart failure) were determined in the 34 CHF patients during a median follow-up period of 182 days. RESULTS:Compared with those from both control groups and from mild CHF patients, PBMCs isolated from severe CHF patients adhered more to the HAECs. The endothelial adhesiveness of PBMCs correlated positively with the circulating levels of CAMs and can supply prognostic information in CHF patients. The difference between event-free curves based on the median levels of endothelial-PBMC adhesion was significant (log rank test, p=0.0139). CONCLUSIONS:Endothelial adhesiveness of PBMCs is increased and correlated to clinical outcomes, and may be pathophysiologically relevant to the progression of CHF.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Yin WH,Chen JW,Young MS,Lin SJdoi
10.1016/j.ijcard.2006.11.012subject
Has Abstractpub_date
2007-10-18 00:00:00pages
276-83issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(06)01416-1journal_volume
121pub_type
杂志文章abstract:BACKGROUND:Sildenafil and bone marrow-derived endothelial progenitor cells (BMDEPCs) have been shown to ameliorate monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in the rat. We test whether combined sildenafil and BMDEPC treatment exerts additional protection against MCT-induced PAH in rats. METHODS...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.05.002
更新日期:2012-12-15 00:00:00
abstract:BACKGROUND:In this prospective study we determine the diagnostic value of coronary CT angiography (CTA) and calcium imaging in low to intermediate risk acute chest pain patients. METHODS:One hundred and eleven consecutive patients (57 ± 11 years, 71 males) presenting to the emergency department with chest pain suggest...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.04.099
更新日期:2013-08-20 00:00:00
abstract::We compared the basal coronary artery tone and the constrictive responses to acetylcholine (Ach) and ergonovine (Erg) among three groups of patients: 31 patients (group 1) with variant angina in whom spasm was provoked by low doses of acetylcholine (intracoronary 20 micrograms) or ergonovine (intravenous 50 micrograms...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1996-07-26 00:00:00
abstract::The accumulation of fluid in the pericardium in an amount sufficient to cause severe obstruction to blood inflow to the ventricles results in cardiac tamponade. In this condition, relief of intrapericardial pressure by pericardiocentesis usually dramatically improves cardiac output, and can be lifesaving. We report a ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/s0167-5273(97)02918-5
更新日期:1997-04-18 00:00:00
abstract:PURPOSE:Severe valve lesions require corrective interventions to avoid progression to heart failure (HF) and premature demise. We tested the hypothesis that despite operative risks, corrective valvular interventions will lead to significant improvements in overall cardiac pump function, especially before the onset of c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.03.177
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The stress-related cardiomyopathy (SRC) is a relatively novel cardiac syndrome characterized by peculiar transient left ventricular dysfunction, which accounts for approximately 1-3% of patients with symptoms that initially appear to be an acute coronary syndrome. To date, the true incidence and clinical sig...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2009.09.468
更新日期:2010-05-14 00:00:00
abstract::We describe a case of fatal reaction to angiocardiography following investigation of tetralogy of Fallot. This happening has occurred only once in 8300 procedures in our laboratory. It was due to cerebral edema. Although a recognized, but very rare, hazard following injection of contrast material, we found no way in o...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90127-5
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:This study sought to examine a possible relationship between the severity of aortic valve calcification (AVC), the distribution of AVC and the degree of aortic valve regurgitation (AR) after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS). METHODS:57 patients (22 men, 81 ± 5 y...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.03.004
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:The optimal treatment of patients undergoing percutaneous coronary interventions (PCI) for lesions located at coronary bifurcations is still debated. METHODS:Data on 5036 consecutive patients who underwent PCI on coronary bifurcation at 17 major coronary intervention centers between January 2012 and Decembe...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2018.11.139
更新日期:2019-05-15 00:00:00
abstract:BACKGROUND:Experimental studies demonstrate that higher intake of omega-3 fatty acids (n-3 FA) improves insulin sensitivity, however, we reported that n-3 FA 2g therapy, most commonly used dosage did not significantly improve insulin sensitivity despite reducing triglycerides by 21% in patients. Therefore, we investiga...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2014.07.075
更新日期:2014-10-20 00:00:00
abstract:BACKGROUND:P2Y12-ADP receptor blockade during percutaneous coronary intervention (PCI) is critical to prevent thrombotic events. In patients under chronic P2Y12 blockers, the use of additional loading dose (LD) before an elective PCI is debated. We aimed to investigate the rate of high on-treatment platelet reactivity ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.04.165
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:We were to evaluate the effect of Valsalva maneuver with comparison to preload reduction by nitroglycerin (NTG) to predict intraventricular obstruction (IVO) during dobutamine stress echocardiography (DSE) in patients with hypertension. METHODS:A total of 38 hypertensive patients (mean age 66.0±9.9 years; 3...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.03.069
更新日期:2010-10-29 00:00:00
abstract::Ischemic heart disease is the major cause of death, disability and lost productivity in the developed countries of the world. The evolution of cardiac care units has improved patient survival from myocardial infarctions, but requires a high-tech, very expensive treatment facility. Chest pain centers, located in emerge...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00160-6
更新日期:2000-01-15 00:00:00
abstract:BACKGROUND:Data regarding bioresorbable vascular scaffolds (BVS) use in coronary bifurcation lesions are limited. The aim of this study was to compare mid-term clinical outcomes of all-comer patients treated with BVS versus everolimus-eluting stents (EES) for bifurcation lesions. METHODS:A total of 351 non-left-main b...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.03.123
更新日期:2017-11-01 00:00:00
abstract::Directional coronary atherectomy has been applied to aorto-ostial lesions with higher success and lower complication rates than conventional balloon angioplasty. Aortic injuries have been reported with this technique, most resulting from the tip of the catheter. In this report, an aortic dissection caused by the shaft...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(96)02671-x
更新日期:1996-08-01 00:00:00
abstract::Diabetes and heart failure are very prevalent, and affect each other's incidence and severity. Novel therapies to reduce post-myocardial infarction (MI) remodeling that progresses into heart failure are urgently needed, especially in diabetic patients. Clinical studies have suggested that some oral anti-diabetic agent...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.10.005
更新日期:2013-11-30 00:00:00
abstract::The risk of surgical treatment of tetralogy of Fallot was analyzed with multivariate statistical techniques in a recent surgical series (1975-1983) of 159 corrected and 59 palliated patients. The overall mortality of correction was 12.6% and that of palliation was 15.3%. The significant and independent risk factors th...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90398-5
更新日期:1985-09-01 00:00:00
abstract::The concentration of calcitonin gene-related peptide in rat cardiovascular tissues was determined by a specific and sensitive radioimmunoassay and the distribution of its specific binding sites was assessed by radioligand binding studies. The binding of [125I]calcitonin gene-related peptide to cardiovascular membranes...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90313-0
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:The trends in the IHD mortality rates vary widely across countries, reflecting the heterogeneity in the variation of the exposure to the main risk factors and in the access to different management strategies among settings. We aimed to identify model-based patterns in the time trends in IHD mortality in 50 c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.11.004
更新日期:2014-01-01 00:00:00
abstract::Cannabis smoking is on the increase both in the United Kingdom and in the United States. For over three decades it has been known that cannabis has pathophysiological effects on the cardiovascular system, and previously an association with an increased risk of myocardial infarction has been reported. However, it is no...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2004.10.038
更新日期:2005-09-30 00:00:00
abstract::The journey of atherosclerosis begins with endothelial dysfunction and culminates into its most fearful destination producing ischemia, myocardial infarction and death. The excess cardiovascular disease morbidity and mortality in African-Americans is one of the major public health problems. In this review, we discuss ...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2008.10.007
更新日期:2009-02-20 00:00:00
abstract::In a press conference on Nov. 20, 2001 it was announced that the Multi-center Autonomic Defibrillator Implantation Trial II (MADIT II) was stopped early because of a 30% reduction in mortality in patients randomised to receive an implantable defibrillator device. The 4 year multi-centre trial of 1200 patients was term...
journal_title:International journal of cardiology
pub_type: 社论
doi:
更新日期:2002-01-01 00:00:00
abstract::We determined whether vaso-vagal syncope during sheath removal after percutaneous coronary intervention leads to a higher incidence of major adverse cardiac events including acute stent thrombosis, in 611 patients who participated in our previous trial assessing the impact of intravenous sedation and local anaesthesia...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.02.059
更新日期:2008-07-04 00:00:00
abstract::Calcium channel blockers (CCBs) have several properties which may have beneficial effects on the development of atherosclerosis. These include inhibition of vascular smooth muscle cell (SMC) proliferation and migration; inhibition of calcium influx into the vascular wall; reduction of extracellular matrix synthesis; p...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/s0167-5273(97)00236-2
更新日期:1997-12-31 00:00:00
abstract:OBJECTIVE:To study the joint prevalence of elevated blood pressure and raised total cholesterol in adult individuals and to estimate the multifactorial cardiovascular risk associated with this clustering. MATERIAL AND METHODS:Data were obtained through pooling of databases from large cross-sectional representative pop...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.08.037
更新日期:2006-06-16 00:00:00
abstract:BACKGROUND:The glycoprotein IIb/IIIa antagonists (GPAs) represent a new class of drugs to prevent platelet aggregation in the acute treatment of non-ST-elevation acute coronary syndromes (NSTE-ACS). Systematic reviews have identified serious limitations in published cost-effectiveness analyses, including a lack of UK-s...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.08.042
更新日期:2005-04-20 00:00:00
abstract:BACKGROUND:Inflammation and oxidative stress play a crucial role in the pathogenesis of cardiac sarcoidosis (SAR). We investigated whether urinary (U) 8-hydroxy-2'-deoxyguanosine (8-OHdG)--an oxidative DNA damage marker--was related to SAR inflammatory activity. METHODS:U-8-OHdG levels were measured in 31 SAR patients...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.04.144
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Since reported evidence is both scarce and controversial, the objective of this study is to determine the risk factors involved in the prognosis of older patients with heart failure (HF) receiving home healthcare from primary care professionals. METHODS:Retrospective cohort community study was carried out...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.01.170
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:The rapid adoption of percutaneous transluminal coronary angioplasty (PTCA) in Korea is provoking a widespread concern about possible overuse of this procedure with inappropriate indications. This study aimed to assess the rate of appropriate application of PTCA in Korea and investigate factors affecting thi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.03.028
更新日期:2004-06-01 00:00:00
abstract::We would like to present and discuss the dilemma of an unusual right coronary artery anomaly in two cases. Double right coronary artery or a high take off of a large right ventricular branch are two diagnostic possibilities that may provide difficulty in differentiating such an unusual orientation of coronary arteries...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/s0167-5273(01)00595-2
更新日期:2002-01-01 00:00:00