Abstract:
:Whether intracardiac right-to-left shunt (RLS) is an independent risk factor for cerebrovascular accidents is disputed. In patients with RLS, venous thrombo-embolism (VTE) may predispose to paradoxical embolic events, among which stroke and transient ischemic attack (TIA). Whether genetic or acquired thrombophilia is associated with RLS is unclear. Thus, we compared prevalences of intra- and extracardiac intrapulmonary RLS and of atrial septal aneurysm (ASA) between 29 nondiabetic patients with cryptogenic stroke (n=17) or TIA (n=12) and 19 patients with VTE but without history of stroke/TIA, or autoimmune systemic disease or migraine. Carotid atherosclerosis was excluded in all patients. RLS and ASA were also evaluated in 30 healthy volunteers. We found that intracardiac RLS (31%) and ASA (21%) were detected in stroke/TIA patients and not in our selected VTE patients (both p<0.05); however, those prevalences were comparable to those detected in our controls (20% intracardiac RLS, 7% ASA, respectively, both p=NS). Within patients, thrombophilia was not associated with intracardiac RLS, but tended to be associated with ASA (83% in those with vs. 43% in those without ASA, p=0.08). In conclusions, intracardiac RLS may have a role in selected populations in the frame the multi-factorial pathogenesis of stroke/TIA of embolic origin. ASA appears to be an independent risk factor for stroke/TIA with possible interaction with thrombophilia.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Palmieri V,Tufano A,Carmen Bonito M,Martino S,Sabatella M,Di Minno G,Celentano Adoi
10.1016/j.ijcard.2007.06.072subject
Has Abstractpub_date
2008-10-30 00:00:00pages
99-102issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(07)01300-9journal_volume
130pub_type
信件abstract:AIMS:Suboptimal stent expansion correlates with adverse cardiac events. There is limited information regarding Absorb bioresorbable vascular scaffold (BVS) expansion characteristics. Optical coherence tomography (OCT) allows for high-resolution assessment of plaque morphology, composition and assessment of BVS expansio...
journal_title:International journal of cardiology
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.02.072
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2006-09-20 00:00:00
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pub_type: 杂志文章
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更新日期:2005-04-28 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2007-05-31 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.11.024
更新日期:2018-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-09-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-12-31 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:1997-12-19 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.08.024
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-15 00:00:00
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pub_type: 信件
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pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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