Abstract：
:Glicentin, the main component of enteroglucagon, has trophic effects on intestinal mucosa. It may also have an inhibitory effect on extraintestinal invasion of enteric bacteria. We have established an in vitro bioassay system for determining the effects of recombinant human glicentin on bacterial internalization by confluent enterocytes. An INT-407 cell line was serum-deprived for 2 days and was then treated on transwell filters for 24 h with a medium containing one of the following: glicentin 100 ng-1 microg/ml, glucagons-like peptide-2 (GLP-2) 1 microg/ml, 10% fetal bovine serum (FCS), or without any growth factors. Pure cultures of Salmonella enteritidis, Escherichia coli, and Enterococcus faecalis were introduced to the upper chambers of the filter units. Following 2 h of incubation the numbers of bacteria in the lower chambers were measured. Pretreatment of enterocytes with glicentin inhibited bacterial internalization compared to untreated or GLP-2 enterocytes. Glicentin was associated with inhibition of enterocyte internalization of enteric bacteria by a mechanism that might be related to the integrity of the enterocyte adhesive junctions and tight junctions and to the production of sIgA. Glicentin seems to have a function as a barrier-sustaining agent that inhibits extraintestinal invasion of enteric bacteria.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Chiba M,Sanada Y,Kawano S,Murofushi M,Okada I,Yoshizawa Y,Gomi A,Yatsuzuka M,Toki A,Hirai Ydoi
10.1007/s00383-007-1895-9subject
Has Abstractpub_date
2007-06-01 00:00:00pages
551-4issue
6eissn
0179-0358issn
1437-9813journal_volume
23pub_type
杂志文章abstract：PURPOSE:To study the gender assignment and hormonal treatment advocated for disorders of sexual differentiation (DSD). METHODS:A study was done on patients who were reviewed in the Pediatric Intersex Clinic to evaluate the pattern of gender assignment and hormonal treatment advocated. RESULTS AND CONCLUSION:The patie...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2232-7
更新日期：2008-10-01 00:00:00
abstract：INTRODUCTION:No protocol exists for prophylaxis or therapeutic management of peripherally inserted central catheter (PICC) related deep venous thrombosis (DVT) in children. Currently, very few patients are provided prophylaxis for DVT. In this study, we analyzed our current practice of PICC placement to identify the fr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3259-y
更新日期：2013-05-01 00:00:00
abstract：:Antral web is a rare cause of gastric-outlet obstruction. We report a case of gastric antral web with intermittent vomiting in a 10-year-old girl who received medical treatment for 6 months. The literature on this anomaly is reviewed with respect to differential diagnosis on the basis of upper gastrointestinal radiogr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003839900317
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:Lgr5+ intestinal epithelial stem cells (ISCs) crucial for intestinal epithelial regeneration are impaired during necrotizing enterocolitis. This study aims to investigate the influence of different stressors on intestinal epithelial injury and regeneration in vitro. METHODS:Intestinal epithelial cells (IEC-18)...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4183-3
更新日期：2018-02-01 00:00:00
abstract：:Multiple endocrine neoplasia (MEN) 2B is a hereditary syndrome including medullary thyroid carcinoma (MTC), pheochromocytoma, gastrointestinal (GI) disorders, marfanoid facies, and multiple ganglioneuromas. MTC is the major cause of mortality, and often appears during the 1st decade of life. RET proto-oncogene mutatio...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0824-1
更新日期：2002-09-01 00:00:00
abstract：:A 6-year-old girl presented with intractable constipation. On investigation, she was found to have an association of anorectal stenosis, anterior sacral defect, and anterior meningocoele (Currarino's triad). The meningocoele was excised and a Duhamel pull-through procedure performed after resection of a massively dist...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830050362
更新日期：1998-07-01 00:00:00
abstract：PURPOSE:Ghrelin was recently reported to promote recovery from hepatic injury. We hypothesized that it could also be associated with clinical recovery of the transplanted liver from ischemia and reperfusion injury. Our aims were to investigate perioperative ghrelin changes following pediatric living donor liver transpl...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04463-8
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Three-dimensional (3D) imaging instead of two-dimensional (2D) computed tomography (CT) for diagnosis and preoperative planning in infants and young children with complex liver tumors is a promising technique for precision hepatectomy. METHODS:This study was a retrospective analysis of 26 infants and youn...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3864-7
更新日期：2016-04-01 00:00:00
abstract：:70 cases of gastroschisis (GS) were surgically treated at the Pediatric Surgical University Clinic, Münster, from 1984 through 1998. The defect occurred more frequently in males (44) than females (26). The average birth weight was 2,383 g and mean gestational age 36.8 weeks. 9 infants (12.9%) were delivered vaginally ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0799-y
更新日期：2002-09-01 00:00:00
abstract：INTRODUCTION:Hepatoportoenterostomy (HPE) with the Kasai procedure is the treatment of choice for biliary atresia (BA) as the initial surgery. However, the appropriate level of dissection level of the fibrous cone (FC) of the porta hepatis (PH) is frequently unclear, and the procedure sometimes results in unsuccessful ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3799-4
更新日期：2015-12-01 00:00:00
abstract：:Mortality rates in neonatal surgery have dropped markedly, illustrating the enormous progress made. Yet, new questions have arisen. To mention one, health care budgets have tightened. It follows that the effects of medical interventions should be weighted against their costs. As evidence was particularly sparse, we se...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-2045-0
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:Little is known of how children seek health information. This study evaluates online health information (OHI) seeking behaviours in adolescents undergoing major elective surgical procedures and compares responses within parent-child dyads. METHODS:With institutional approval, we prospectively surveyed parents ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04592-0
更新日期：2020-02-01 00:00:00
abstract：:Non-operative management of gastroschisis also known as plastic closure (PC) has been described as an alternative to conventional primary operative closure (POC) or staged silo closure (SSC). The aim of this study was to compare these techniques in neonates with gastroschisis. A retrospective review of neonates with g...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2153-5
更新日期：2008-07-01 00:00:00
abstract：INTRODUCTION:An experimental study was conducted to investigate the effects of erythropoietin on the acute phase of esophageal burn damage induced by sodium hydroxide. MATERIALS AND METHODS:A standard esophageal alkaline burn was produced by the application of 10% sodium hydroxide to the distal esophagus in an in vivo...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2480-1
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:For International Neuroblastoma Staging System (INSS) stages III or IV neuroblastoma (intermediate or high risk), complete excision of the primary tumor is not always feasible. Most current studies on the treatment outcome of these patients have reported on the complete excision status. The aim of this study is...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2417-8
更新日期：2009-09-01 00:00:00
abstract：AIM:Prepubertal testicular tumors are rare in children. We aim to present clinical and histological features of prepubertal testicular tumors through the analysis of the long-term experiences of a single medical center of China. MATERIALS AND METHODS:A total of 67 children (≤ 14 years) treated for testicular tumor at ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4366-6
更新日期：2018-12-01 00:00:00
abstract：:Recently, most studies reported magnesium as a N-methyl-D-aspartate receptor antagonist and its analgesic and perioperative anaesthetic effects have been discussed with central desensitization pathway. We investigated the effects of caudal ropivacaine plus magnesium and compared with ropivacaine alone on postoperative...
journal_title：Pediatric surgery international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00383-006-1779-4
更新日期：2007-02-01 00:00:00
abstract：:The need for contralateral inguinal exploration in children during unilateral inguinal hernia repair remains controversial. We questioned whether an elective preoperative sonographic examination of the contralateral inguinal canal was accurate enough to prevent unnecessary exploration of the asymptotic side. Sonograph...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00180090
更新日期：1996-08-01 00:00:00
abstract：PURPOSE:Evaluate the management of hydrocephalus in pediatric patients in the Eastern Democratic Republic of Congo by a general surgeon. METHODS:Retrospective review of a single institution in the province of North Kivu. Patient charts and surgical notes were reviewed from 2003 to 2016. RESULTS:116 procedures were pe...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4238-0
更新日期：2018-04-01 00:00:00
abstract：:Three cases are reported of pyogenic (non-tuberculous) myositis involving the ilio-psoas and/or iliacus muscles in children presenting to John Hunter Hospital, Newcastle, Australia, in a 12-month period. In one, cultures grew Haemophilus influenzae type B and in the other two Staphylococcus aureus was isolated. Biopsy...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00183769
更新日期：1996-03-01 00:00:00
abstract：:We report the case of a female adolescent who had an ectopic ovary in the inguinal canal without an associated hernia, a unicornuate uterus, and ipsilateral renal agenesis. The incidental discovery of the ectopic ovary and other Mullerian anomalies, as well as the surgical correction that followed, highlights importan...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-014-3582-y
更新日期：2014-10-01 00:00:00
abstract：:The aim of this study was to determine whether barium enema reduction (BER) is safe and effective in patients with a long duration of intussusception. Over the last 17 years, 104 patients were admitted to our hospital with a diagnosis of intussusception. All except 1 with peritonitis underwent BER primarily. Of the 10...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050526
更新日期：1999-01-01 00:00:00
abstract：:To categorize variant persistent müllerian-duct derivatives (MDD) in males and determine their related clinical presentations for further management, five male patients with retained MDDs from abnormal müllerian remnants were studied. They comprised one patient with persistent müllerian-duct syndrome, one with transve...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0718-2
更新日期：2002-09-01 00:00:00
abstract：:Africa faces a triple burden of disease; HIV, tuberculosis and malaria. Despite this, its population is expected to double over the next 45 years. There is a dire shortage of medical specialists and many countries lack suitably qualified doctors to train medical specialists. Videoconferencing offers the opportunity to...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-2085-5
更新日期：2008-02-01 00:00:00
abstract：:In contrast to adults, calcium carbonate gallstones are relatively common in children. Their pathogenesis is poorly understood. Cystic duct obstruction promotes calcium carbonate formation in bile and increases gallbladder mucin production. We tested the hypothesis that mucin producing epithelial cells would be increa...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1867-5
更新日期：2007-03-01 00:00:00
abstract：:The use of a silo for temporary coverage of exposed viscera for newborns with gastroschisis has allowed gradual reduction of the externalized intestine into the abdominal cavity. However, there has not been an easy way to monitor blood perfusion to the intestine within the silo other than with visual examination. In a...
journal_title：Pediatric surgery international
pub_type： 临床试验,杂志文章
doi：10.1007/s00383-006-1726-4
更新日期：2006-09-01 00:00:00
abstract：:A neonate with a constellation of unusual congenital deformities associated with pulmonary agenesis is reported. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050603
更新日期：1999-07-01 00:00:00
abstract：:Biliary atresia (BA) is a common cause of infantile cholestasis. Disease progression leads to intra hepaticfibrosis, and thus to the development of PH and EV. Our objective has been to study the relationship between procollagen-III-peptide (PIIIP) and the severity of EV in children with BA after Kasai operation. Child...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830200007
更新日期：2002-01-01 00:00:00
abstract：PURPOSE:Chronological age has not always been an accurate predictor of gut motility in newborns. We hypothesized that the enteric plexus is immature at birth. We studied whole-mount preparations of the myenteric plexus in pigs from mid-point of gestation to adulthood. METHODS:Distal large bowel whole-mount preparation...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2265-y
更新日期：2008-12-01 00:00:00
abstract：:A case of extrahepatic biliary atresia (EBA) associated with trisomy 18 is presented. A 1-month-old boy was suspected to have Alagille syndrome with obstructive jaundice, a systolic heart murmur, growth retardation, and a small, pointed chin. However, surgery and chromosomal analysis revealed EBA associated with triso...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050536
更新日期：1999-01-01 00:00:00
