Abstract:
PURPOSE:For International Neuroblastoma Staging System (INSS) stages III or IV neuroblastoma (intermediate or high risk), complete excision of the primary tumor is not always feasible. Most current studies on the treatment outcome of these patients have reported on the complete excision status. The aim of this study is to review the treatment outcome after the incomplete resection. METHODS:The medical records of 37 patients that underwent incomplete resection between January 1986 and December 2005 were reviewed retrospectively. Incomplete resection was assessed by review of the operative notes and postoperative computerized tomography. Age, gender, tumor location, INSS stage, N-myc gene copy number, pre- and postoperative therapy, and treatment outcome were reviewed. The treatment outcome was evaluated according to the postoperative treatment protocol in the high-risk group. RESULTS:Intermediate-risk patients were treated with conventional chemotherapy, isotretinoin (ITT) and interleukin-2 (IL-2). High-risk patients were treated with peripheral blood stem cell transplantation (PBSCT), ITT, and IL-2 (N = 11). Before the introduction of PBSCT, the high-risk patients were also treated with the conventional chemotherapy (N = 19). Intermediate-risk patients (N = 5) currently have no evidence of disease (NED). For the high-risk patients (N = 32), 19 patients were treated with chemotherapy alone; 15 patients died of their disease while four patients currently have an NED status. Eight of 11 patients that underwent PBSCT are currently alive. CONCLUSIONS:For intermediate risk, conventional chemotherapy appears to be acceptable treatment. However, for high-risk patients, every effort should be made to control residual disease including the use of myeloablative chemotherapy, differentiating agents and immune-modulating agents.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Moon SB,Park KW,Jung SE,Youn WJdoi
10.1007/s00383-009-2417-8subject
Has Abstractpub_date
2009-09-01 00:00:00pages
789-93issue
9eissn
0179-0358issn
1437-9813journal_volume
25pub_type
杂志文章abstract::A congenital diaphragmatic hernia (CDH) model was induced in pregnant rats following administration of 100 mg nitrofen. The fetuses were stored and fixed in Bouin's solution for 24 h after caesarean section at term. After fixation, the lungs were dissected out. Immunostaining of the CDH lungs and controls with rabbit ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00180080
更新日期:1996-08-01 00:00:00
abstract::Rhabdomyosarcoma (RMS) is the most common soft tissue tumour in children. This is the first time a facial RMS metastatic to the pancreas is reported. The patient was a 3-year-old boy with a symptomatic solitary pancreatic metastasis of a primary facial RMS, with already one relapse in a submental lymph node. Since thi...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2539-z
更新日期:2010-03-01 00:00:00
abstract::The most popular techniques for repairing large diaphragmatic defects involve the use of synthetic patches. We present an alternative approach using living tissue. We reviewed our cases of congenital diaphragmatic hernia (CDH) diagnosed within the first 24 h of life from 1991 to 2003. Toldt's fascia (TF) flap was used...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1267-7
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To investigate the safety and efficacy of mucous fistula refeeding (MFR) in low-birth-weight infants. METHODS:Between December 2006 and December 2018, medical records of low-birth-weight infants who underwent small bowel enterostomy formation in the neonatal period and subsequent stoma closure at our instituti...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-019-04533-x
更新日期:2019-10-01 00:00:00
abstract::Juvenile papillomatosis (JP) is a rare benign, proliferative breast tumor in children. We observed a 9-year-old girl with a large soft-tissue mass at the lower outer quadrant of the left breast. Ultrasonography showed an ill-defined, inhomogeneous mass with numerous small, hypoechoic areas. The tumor was completely ex...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000462
更新日期:2001-03-01 00:00:00
abstract::Fertility in patients treated for unilateral testicular torsion has been shown to be significantly reduced in all the reported series to date, implying that the present-day treatment requires further refinement in the form of adjunct pharmacotherapeutic intervention (Lomodex and MgSO(4)) in addition to scrotal explora...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1317-1
更新日期:2005-03-01 00:00:00
abstract::The incidence of gastroschisis appears to be rising in developed nations, with epidemiological studies indicating association with young maternal age and smoking. Is there an association between maternal smoking and the development of complicated gastroschisis? A retrospective population-based review of all cases of g...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-1926-6
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:Bone morphogenetic proteins (BMPs) are a group of growth factors that are implicated in intestinal growth, morphogenesis, differentiation, and homeostasis. The role of the BMP signaling cascade in stimulation of cell proliferation after massive small bowel resection is unknown. The purpose of this study was to ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3829-2
更新日期:2016-02-01 00:00:00
abstract::To determine which laser can be used for a vascular lesion, the different working mechanisms of the individual lasers must first be understood. The localization and diameter of the vessels to be treated define whether a certain laser is appropriate for that lesion. For teleangiectasias and port-wine stains the pulsed-...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00497797
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:The RAS association domain family protein 1 (RASSF1A) is known to be frequently inactivated by promoter hypermethylation in cancers. This study investigated the association of RASSF1A methylation with clinical outcomes in hepatoblastoma patients and whether it is correlated with the histological phenotype of he...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3371-z
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:The optimal management of simple hepatic cysts (SHCs) remains controversial. A retrospective review was carried out to evaluate the clinical presentation and surgical consideration of children with SHCs and outcome of management at our institution. METHODS:We performed a retrospective review of all patients di...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3509-7
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Intestinal adaptation in short bowel syndrome (SBS) consists of increased epithelial cells (ECs) proliferation as well as apoptosis. Angiotensin-converting enzyme (ACE) has been shown to regulate ECs apoptosis. In this study, we investigated the effect of ACE inhibition on intestinal adaptation after small b...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-012-3075-9
更新日期:2012-05-01 00:00:00
abstract::Intestinal neuronal dysplasia is a controversial form of dysganglionosis that has been described both as an isolated disorder and in association with Hirschsprung's disease. It has been blamed for the bad outcome of bowel function in patients operated on for Hirschsprung's disease. According to various authors, intest...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-1035-0
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The natural history of patients with antenatally diagnosed congenital cystic adenomatoid malformation of the lung (CCAM) is still fully unknown. In symptomatic patients with respiratory distress, an operation is performed during the neonatal period. However, in asymptomatic patients, the optimal timing of th...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2431-x
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Bicycling is a well-liked sporting activity in which many children participate, and bicycle accidents are one of the most common causes of abdominal injuries in children. We evaluated the characteristics and outcomes of abdominal injuries due to bicycle accidents in children. PATIENTS AND METHODS:This study wa...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3279-7
更新日期:2013-05-01 00:00:00
abstract::The authors report two patients with extrahepatic portal hypertension and repeated massive bleeding from esophageal varices who underwent urgent distal splenorenal shunting (DSRS) after having proved refractory to medical treatment, endoscopic sclerotherapy, and ligation of esophageal varices. Their ages and weights w...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830100014
更新日期:2001-11-01 00:00:00
abstract:PURPOSE:Sacrococcygeal teratoma (SCT) is the most common congenital neoplasm in neonates. We wished to assess the long-term functional outcome of children undergoing SCT resection. METHODS:Records of neonates diagnosed with SCT from two surgeons' practices, and operated on between 1970 and 2006, were retrospectively r...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2322-1
更新日期:2009-03-01 00:00:00
abstract::Inflammatory pseudotumors (IPT) are uncommon mass lesions arising most typically in the lungs of young adults. These tumors are so named because of the difficulty in distinguishing them preoperatively from malignant lesions. IPT are characterized histologically by localized fibrous proliferations with infiltration by ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830000518
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:Historically, the majority of patients with colonic atresia have been managed by ostomy creation at the time of initial operation; conversely, we have tended to treat the atresia with resection and anastomosis. The purpose of this study is to determine the rate of concomitant Hirschsprung's disease and to ident...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2401-3
更新日期:2009-07-01 00:00:00
abstract::With widespread use of antenatal ultrasound, an increasing number of urinary-tract lesions are being detected, and the clinician is called upon to make management decisions. Parenchymal lesions of the kidney pose a special challenge because of the associated risk of the occurrence of malignancy. A case of an antenatal...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0833-0
更新日期:2003-04-01 00:00:00
abstract::Reflux nephropathy (RN) is recognized as a major cause of end-stage renal failure in children and young adults. Inhibition of nitric oxide (NO) exacerbates and enhanced production ameliorates tubulointerstitial fibrosis (TIF) in experimental obstructive uropathy. NO is synthesised by NO synthase (NOS), three distinct ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0858-4
更新日期:2002-10-01 00:00:00
abstract::The association of Enterobius vermicularis infestation with acute appendicitis varies from 0.2-41.8% worldwide. Our purpose was to determine the significance of Enterobius-associated appendicitis by retrospective review of appendectomies performed during a 5-year period at a major children's hospital. The Surgical Pat...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-004-1151-5
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:Lgr5+ intestinal epithelial stem cells (ISCs) crucial for intestinal epithelial regeneration are impaired during necrotizing enterocolitis. This study aims to investigate the influence of different stressors on intestinal epithelial injury and regeneration in vitro. METHODS:Intestinal epithelial cells (IEC-18)...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4183-3
更新日期:2018-02-01 00:00:00
abstract::To assess the relation between continence and the manometric and endosonographic state of the anorectal segment after surgery for anorectal anomalies (ARA), 33 adolescents operated upon for ARA and 14 controls were examined. Seventeen patients had low and 16 intermediate or high ARA. Fecal continence was recorded, and...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01258715
更新日期:1997-09-01 00:00:00
abstract:AIM:Although liver abscess (LA) is prevalent worldwide, especially in developing countries, there is a paucity of data regarding the protocol for management of LA in children. The aim of this study was to analyze the outcome of a protocol-based management of pediatric LA from a single institution. MATERIALS AND METHOD...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-4009-8
更新日期:2017-02-01 00:00:00
abstract::Children with pyometrocolpos due to distal vaginal atresia may present as acutely ill, with severe obstructive uropathy and septicemia. In such patients the clinical course is markedly improved by urgent drainage of the infected cystic mass, and a temporary drainage procedure is required to allow local findings of inf...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1323-3
更新日期:2005-03-01 00:00:00
abstract::The majority of congenital diaphragmatic hernias (CDH) occur through the foramen of Bochdalek; herniation through the foramen of Morgagni (MH) is rare. Fifteen children (12 males and 3 females) with congenital MH (7 right, 3 left, 5 bilateral) were treated over a period of 15 years, comprising 11% of a total of 135 ch...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830100653
更新日期:2002-03-01 00:00:00
abstract::Coagulopathies associated with malignancies are not extremely rare, but are uncommonly associated with Wilms' tumour (WT). A 6-month-old female with a WT and an abnormal coagulation profile is reported. Due to the Coagulopathy and elevated D-dimers in the blood, surgery was deferred and chemotherapy was given, after w...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0853-9
更新日期:2003-06-01 00:00:00
abstract::Cystic teratoma of the pancreas is an extremely rare entity: only 11 cases have been described so far in the world literature. We report the 12th case, in a 4-month-old girl. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00183759
更新日期:1996-03-01 00:00:00
abstract:INTRODUCTION:We assessed the impact of intestinal transplantation on Japanese pediatric patients with intestinal failure with data from the Japanese intestinal transplant registry. METHODS:Standardized forms were sent to all known intestinal transplantation programs, requesting information on transplants performed bet...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3392-7
更新日期:2013-10-01 00:00:00