Abstract：
:In contrast to adults, calcium carbonate gallstones are relatively common in children. Their pathogenesis is poorly understood. Cystic duct obstruction promotes calcium carbonate formation in bile and increases gallbladder mucin production. We tested the hypothesis that mucin producing epithelial cells would be increased in gallbladders of children with calcium carbonate gallstones. Archival gallbladder specimens from 20 consecutive children who had undergone elective cholecystectomy for cholelithiasis were examined. In each case, gallstone composition was determined by Fourier transform infrared microspectroscopy. Gallbladder specimens from six children who had undergone cholecystectomy for conditions other than cholelithiasis during the same period were used as controls. Multiple sections were examined in a blinded fashion and scored semiquantitatively for mucin production using two stains (alcian blue and periodic acid-Schiff). Increased mucin staining was observed in 50% or more epithelial cells in five gallbladder specimens from seven children with calcium carbonate stones, compared to 5 of 13 with other stone types (P = 0.17) and none of the control gallbladders (P = 0.02). Gallbladders containing calcium carbonate stones were significantly more likely than those containing other stone types or controls to contain epithelial cells with the greatest mucin content (P = 0.03). Gallbladders containing calcium carbonate stones were also more likely to show the ulcer-associated cell lineage. These results demonstrate an increase in mucin producing epithelial cells in gallbladders from children containing calcium carbonate stones. This supports the hypothesis that cystic duct obstruction leading to increased gallbladder mucin production may play a role in the development of calcium carbonate gallstones in children.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Sayers C,Wyatt J,Soloway RD,Taylor DR,Stringer MDdoi
10.1007/s00383-006-1867-5subject
Has Abstractpub_date
2007-03-01 00:00:00pages
219-23issue
3eissn
0179-0358issn
1437-9813journal_volume
23pub_type
杂志文章abstract：:Although delayed repair with preoperative stabilization using high-frequency oscillatory ventilation (HFOV) has been advocated in neonates with congenital diaphragmatic hernia (CDH), improved survival has not been reported. We compared survival between neonates undergoing delayed repair after prolonged stabilization f...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050398
更新日期：1998-10-01 00:00:00
abstract：:Fetal lambs with diaphragmatic herniae (CDH) created surgically at 73 days' gestation were subjected to three different forms of intrauterine correction: silastic patch correction of the diaphragmatic defect plus an abdominal patch at 101 days gestation; an intrathoracic "silo" at 101 days; and a tracheal "plug" obstr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00626057
更新日期：1996-10-01 00:00:00
abstract：:Controversy exists on the optimal age for elective resection of asymptomatic congenital pulmonary airway malformation. Current recommendations vary widely, highlighting the overall lack of consensus. A systematic search of Embase, MEDLINE, CINAL, and CENTRAL was conducted in January 2016. Identified citations were scr...
journal_title：Pediatric surgery international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00383-017-4079-2
更新日期：2017-06-01 00:00:00
abstract：:A newborn case with cardiac rhabdomyoma is presented to discuss the differential diagnosis of mediastinal tumors around the heart in children. The diagnosis of rhabdomyoma can be suggested by modern visualization methods such as computerized tomography, magnetic resonance imaging and echocardiography. However, surgery...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1875-0
更新日期：2007-08-01 00:00:00
abstract：:It is unknown whether noncomplicated acute appendicitis cause bacterial translocation. In this study, we aimed to test development of the bacterial translocation in the patients who were operated for acute appendicitis. In this prospective study, 10 control patients who underwent elective operations because of other r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1899-5
更新日期：2007-06-01 00:00:00
abstract：:Congenital pyloric atresia (CPA) is a very rare condition that was first described by Calder in 1749. Commonly, CPA occurs as an isolated lesion, which has an excellent prognosis, but it can also be seen in association with other malformations, which can have a negative impact on the final outcome. The medical records...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1903-0
更新日期：2007-06-01 00:00:00
abstract：:Since January 2006, robotic assistance has been used for performing minimal invasive laparoscopic fundoplications in children. These patients were compared with those operated on with either the open surgical technique or the laparoscopic procedure. The first six children operated on with a fundoplication using the op...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1817-2
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is a gastrointestinal disease of complex etiology resulting in devastating systemic inflammation and often death in premature newborns. We previously demonstrated that formula feeding inhibits ileal expression of heat shock protein-70 (Hsp70), a critical stress protein within ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4211-3
更新日期：2018-03-01 00:00:00
abstract：:Recent studies of testicular descent suggest not only that the gubernaculum does not initially attach to the scrotum, but also that it must migrate from the groin. Two findings suggest that the gubernaculum may behave like an embryonic limb bud during this phase. First, the active growth centre is at the distal tip of...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-1907-9
更新日期：2007-07-01 00:00:00
abstract：INTRODUCTION:Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life. METHODS:From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal c...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3537-3
更新日期：2014-08-01 00:00:00
abstract：AIM:We assessed continence after scope-assisted anorectovaginoplasty (SARVP) for female anorectal malformation (FARM). METHODS:Five FARM cases were assessed; cases 1 and 2: cloacal malformation; case 3: urogenital sinus, and rectovestibular fistula (RF); case 4: RF, absent vagina, and sacral anomaly; case 5: covered c...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3141-3
更新日期：2012-09-01 00:00:00
abstract：:Spontaneous prenatal closure of gastroschisis (GS) is rare and usually associated with atresia of the midgut. We describe a case of GS diagnosed at 20 weeks' gestation that resolved spontaneously in utero. At delivery the infant had an ileus. A laparotomy with a jejunocolostomy was performed, but she died at 2 months ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-002-0815-2
更新日期：2002-09-01 00:00:00
abstract：AIM OF THE STUDY:The high morbidity and mortality in congenital diaphragmatic hernia (CDH) is attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PH). PH is characterized by increased pulmonary artery smooth muscle cell (SMC) proliferation, suppressed apoptosis as well as endothelial dysfunction. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3606-7
更新日期：2014-12-01 00:00:00
abstract：:To assess the important factors for successful primary closure in staged reconstruction of bladder exstrophy, 25 patients (18 males, 7 females) underwent primary bladder closure during the years 1993-1997. Twenty-one were more than 72 h old; all of these underwent bilateral posterior iliac osteotomies followed by prim...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050721
更新日期：2000-01-01 00:00:00
abstract：:A review of 100 consecutive cases of congenital diaphragmatic hernia (CDH) treated at our institute focusing on the efficacy of protocolized management (PM) was conducted. Of the 100 cases, 14 who became symptomatic more than 24 h after birth, and seven with fatal anomalies (four cardiac and three chromosomal) were ex...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1759-8
更新日期：2006-11-01 00:00:00
abstract：:Extensive loss of small bowel in all age groups has significant morbidity and mortality consequences. Despite the astonishing ability of the small bowel to compensate for an extensive loss, long-term parenteral nutrition and enteral nutrition, tailored to the need of the patients in relation to the missing intestinal ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-016-4043-6
更新日期：2017-04-01 00:00:00
abstract：:Hirschsprung disease (HSCR) is a fairly well understood congenital, genetically based functional obstruction due to the congenital absence of ganglion cells in the distal bowel. However, although over 90% of Hirschsprung cases conform to the normally accepted histological diagnostic criteria, it has become increasingl...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-016-4038-3
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:Thoracoscopic repair can be safely performed in most types of congenital esophageal atresia (EA), including in patients with long gap EA or very low birth weight. Accordingly, we performed single- or multistage thoracoscopic repair for various EA types. We aimed to report our therapeutic strategy for thoracosco...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04541-x
更新日期：2019-10-01 00:00:00
abstract：:Recent advances in culturing of intestinal stem cells and pluripotent stem cells have led to the development of intestinal organoids. These are self-organizing 3D structures, which recapitulate the characteristics and physiological features of in vivo intestinal epithelium. Intestinal organoids have allowed the develo...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-019-04581-3
更新日期：2020-01-01 00:00:00
abstract：:A 31-year-old man who died of metastatic adenocarcinoma of the sigmoid colon had undergone bilateral ureterosigmoidostomy for exstrophy of the bladder 20 years earlier. The patient never underwent a colonoscopy. Neoplastic transformation at the ureterosigmoid anastomosis must be considered as a possible severe complic...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050458
更新日期：1998-11-01 00:00:00
abstract：:Fertility in patients treated for unilateral testicular torsion has been shown to be significantly reduced in all the reported series to date, implying that the present-day treatment requires further refinement in the form of adjunct pharmacotherapeutic intervention (Lomodex and MgSO(4)) in addition to scrotal explora...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1317-1
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:Although the principles of the Ladd's procedure for intestinal malrotation in children have remained unchanged since its first description, in the era of minimally invasive surgery it is controversial whether laparoscopy is advantageous over open surgery. The aim of our study was to determine whether the surgic...
journal_title：Pediatric surgery international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00383-016-3974-2
更新日期：2016-12-01 00:00:00
abstract：:Desmoplastic small round cell tumour (DSRCT) is an extremely rare neoplasm. Adolescent males and young adults are most frequently affected. It is highly malignant, with only 29% of patients surviving up to 3 years. This paper documents two cases, one of which, at 4 years old, is the second youngest case documented. Ca...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1401-1
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:Cervicothoracic and apical thoracic neuroblastoma pose unique surgical challenges. We report our experience with the trapdoor anterior thoracotomy (TAT) approach to overcome these difficulties. METHODS:Retrospective review of our centre's neuroblastoma database was conducted. Patients who underwent TAT at our ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04692-2
更新日期：2020-08-01 00:00:00
abstract：:Gastroschisis closure is performed either primarily or after staged reduction of the prolapsed bowel. A technique for surgical closure of the abdominal wall defect is described which allows for an almost scarless appearance of the abdominal surface with preservation of a midline umbilicus. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2215-8
更新日期：2008-09-01 00:00:00
abstract：:Endoscopic management is the accepted form of treatment for posterior urethral valves (PUV). The Nd:YAG laser has been in clinical use for many decades, but has been used only sporadically for ablating PUV. In this study, PUV were diagnosed by micturating cystourethrogram (MCU). In the 9-month period beginning March 1...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050018
更新日期：2000-01-01 00:00:00
abstract：:Abdominal actinomycosis (AMC) is a rare infection in children. The appendix is the most common intra-abdominal organ involved. It presents as an undifferentiated mass, forming abscesses and fistulas in the right lower quadrant. The case of a 15-year-old girl with a AMC of the appendix detected by the pathologist after...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050515
更新日期：1999-01-01 00:00:00
abstract：:Reflux nephropathy (RN) is recognized as a major cause of end-stage renal failure in children and young adults. Inhibition of nitric oxide (NO) exacerbates and enhanced production ameliorates tubulointerstitial fibrosis (TIF) in experimental obstructive uropathy. NO is synthesised by NO synthase (NOS), three distinct ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0858-4
更新日期：2002-10-01 00:00:00
abstract：:Recurrent or chronic abdominal pain can be a challenging problem when conventional diagnostic studies fail to identify the cause. It is estimated that up to one-third of children suffer from abdominal pain, and in this population recurrent pain can be even more challenging. Although recurrent right lower quadrant (RLQ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1632-1
更新日期：2006-03-01 00:00:00
abstract：:The authors report two patients with extrahepatic portal hypertension and repeated massive bleeding from esophageal varices who underwent urgent distal splenorenal shunting (DSRS) after having proved refractory to medical treatment, endoscopic sclerotherapy, and ligation of esophageal varices. Their ages and weights w...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830100014
更新日期：2001-11-01 00:00:00
