Postnatal changes in enteric plexus axonal thickness.


PURPOSE:Chronological age has not always been an accurate predictor of gut motility in newborns. We hypothesized that the enteric plexus is immature at birth. We studied whole-mount preparations of the myenteric plexus in pigs from mid-point of gestation to adulthood. METHODS:Distal large bowel whole-mount preparations of the myenteric plexus were stained using ACHE histochemistry in five pigs from six different age groups (60 and 90 days gestation, newborn, 4 and 12 weeks old, and adult pigs). With the aid of light micrographs and Image J program the axonal diameter, distance between ganglia, neuronal size and neuronal nucleus size were measured. Statistical significance was measured using one-way ANOVA test. RESULTS:There was significant increase in axonal diameter and interganglionic distance, with increasing age in the myenteric plexus of rectum in pigs (P < 0.05). Neuronal cell size and nucleus size of the enteric neurons also increased with age, but was not statistically significant. CONCLUSION:This study shows for the first time that the axonal thickness in the enteric myenteric plexus undergoes striking changes during the first 12 weeks of life in piglets. Assessment of axonal thickness in rectal biopsies may be a valuable morphological feature in diagnosing functional intestinal obstruction in infants.


Pediatr Surg Int


Sri Paran T,Rolle U,Puri P




Has Abstract


2008-12-01 00:00:00












  • The vulnerable stomach in babies born with pure oesophageal atresia.

    abstract::Nine babies with pure oesophageal atresia were treated in our institution in the years 1979-1996. All received a feeding gastrostomy as their initial operation. After initiation of gastrostomy feeds seven (78%) developed gastric complications, including two posterior gastric perforations (one fatal). We propose that t...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Kimble RM,Harding JE,Kolbe A

    更新日期:1999-01-01 00:00:00

  • Is fecal diversion necessary during ileal pouch creation after initial subtotal colectomy in pediatric ulcerative colitis?

    abstract:BACKGROUND:Pediatric patients with medically refractory ulcerative colitis (UC) often undergo an initial subtotal colectomy end ileostomy (STC-I). The role of fecal diversion in the subsequent completion proctectomy/ileal-pouch anal anastomosis (CP-IPAA) remains controversial. METHODS:A multi-institutional retrospecti...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,多中心研究


    authors: Chen YJ,Grant R,Lindholm E,Lipskar A,Dolgin S,Khaitov S,Greenstein A

    更新日期:2019-04-01 00:00:00

  • Esophageal hiatal hernia after omphalocele repair.

    abstract::Esophageal hiatal hernias (EHH) are probably caused by congenital, traumatic, or iatrogenic factors, although the etiology remains unknown. EHHs may develop after abdominal wall closure for omphalocele or gastroschisis due to the increased intra-abdominal pressure, however, there have been few reports in the literatur...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Wang ZQ,Todani T,Watanabe Y,Toki A,Sato Y,Ogura K,Yamamoto S

    更新日期:1998-07-01 00:00:00

  • Influence of stress factors on intestinal epithelial injury and regeneration.

    abstract:PURPOSE:Lgr5+ intestinal epithelial stem cells (ISCs) crucial for intestinal epithelial regeneration are impaired during necrotizing enterocolitis. This study aims to investigate the influence of different stressors on intestinal epithelial injury and regeneration in vitro. METHODS:Intestinal epithelial cells (IEC-18)...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Lee C,Minich A,Li B,Miyake H,Seo S,Pierro A

    更新日期:2018-02-01 00:00:00

  • Minimally invasive surgery does not improve the outcome in a model of retroperitoneal murine neuroblastoma.

    abstract::Minimally invasive surgery (MIS) for cancer patients has become widely accepted in general surgery, however, it has not completely replaced the standard open operative procedures in pediatric oncology. The aim of this study was to evaluate the host relationship following MIS in a murine model of retroperitoneal neurob...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Iwanaka T,Arya G,Ziegler MM

    更新日期:1998-03-01 00:00:00

  • Ultrasound-guided percutaneous sclerotherapy of hydatid liver cysts in children.

    abstract::To evaluate the efficacy of ultrasound (US) guided percutaneous sclerotherapy in the pediatric population, 14 hydatid liver cysts (HLC) in eight male patients whose ages ranged between 6 and 16 years (mean 9.9 years) were treated. The maximum diameter was 110 mm. Albendazole was administered orally to all patients for...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Kabaalioğlu A,Karaali K,Apaydin A,Melikoğlu M,Sindel T,Lüleci E

    更新日期:2000-01-01 00:00:00

  • Modified PATIO repair for urethrocutaneous fistula post-hypospadias repair: operative technique and outcomes.

    abstract:BACKGROUND:To describe a modification of PATIO repair for urethrocutaneous fistula repair and evaluate its outcome. METHODS:We studied 15 boys who underwent modified PATIO repair from Jan 2010 to Sept 2015. Parameters studied included age, type of hypospadias, age at first urethroplasty, hypospadias repair technique, ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Rathod K,Loyal J,More B,Rajimwale A

    更新日期:2017-01-01 00:00:00

  • Neonatal surgery in low- vs. high-volume institutions: a KID inpatient database outcomes and cost study after repair of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis.

    abstract:BACKGROUND/PURPOSE:The volume-outcome relationship and optimal surgical volumes for repair of congenital anomalies in neonates is unknown. METHODS:A retrospective study of infants who underwent diaphragmatic hernia (CDH), gastroschisis (GS), and esophageal atresia/tracheoesophageal fistula (EA/TEF) repair at US hospit...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Sømme S,Shahi N,McLeod L,Torok M,McManus B,Ziegler MM

    更新日期:2019-11-01 00:00:00

  • Pediatric Morgagni diaphragmatic hernia: a descriptive study.

    abstract:INTRODUCTION:The Morgagni hernia (MH) accounts for 3-4% of congenital diaphragmatic hernias. There is a paucity of data regarding this rare defect. The purpose of this study is to describe the characteristics of children with MH, surgical approaches for repair, and patient outcomes. METHODS:Pediatric patients (ages 0-...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Golden J,Barry WE,Jang G,Nguyen N,Bliss D

    更新日期:2017-07-01 00:00:00

  • Plasticity of the enteric nervous system in patients with intestinal neuronal dysplasia associated with Hirschsprung's disease: a report of three patients.

    abstract::Intestinal neuronal dysplasia is a controversial form of dysganglionosis that has been described both as an isolated disorder and in association with Hirschsprung's disease. It has been blamed for the bad outcome of bowel function in patients operated on for Hirschsprung's disease. According to various authors, intest...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Meyrat BJ,Laurini RN

    更新日期:2003-12-01 00:00:00

  • Radical soft tissue mobilization and reconstruction (Kelly procedure) for bladder extrophy [correction of exstrophy] repair in males: initial experience with nine cases.

    abstract:PURPOSE:to report the early experience with the Kelly procedure for the treatment of bladder exstrophy (BE) in males. MATERIALS AND METHODS:Nine boys with BE were treated at our institute. One had an untouched BE, four had epispadias after neonatal bladder closure, and four were secondary phalloplasties. Data on surgi...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Berrettini A,Castagnetti M,Rigamonti W

    更新日期:2009-05-01 00:00:00

  • Tethered cord in patients affected by anorectal malformations: a survey from the ARM-Net Consortium.

    abstract:PURPOSE:The goal of this study was to determine the degree of consensus in the management of spinal cord tethering (TC) in patients with anorectal malformation (ARM) in a large cohort of European pediatric centers. METHODS:A survey was sent to pediatric surgeons (one per center) members of the ARM-Net Consortium. RES...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,多中心研究


    authors: Fanjul M,Samuk I,Bagolan P,Leva E,Sloots C,Giné C,Aminoff D,Midrio P,ARM-Net Consortium.

    更新日期:2017-08-01 00:00:00

  • Intrathyroidal parathyroid carcinoma in a pediatric patient.

    abstract::Parathyroid carcinoma is unusual and its intrathyroidal variant is extremely rare. Therefore, few cases have been reported to describe a case of parathyroid carcinoma located inside the thyroid gland. The case corresponds to a 14-year-old girl who came to the office with a severe osteoarticular disease, depression, ca...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Herrera-Hernández AA,Aranda-Valderrama P,Díaz-Pérez JA,Herrera LP

    更新日期:2011-12-01 00:00:00

  • Postoperative decrease in plasma acyl ghrelin levels after pediatric living donor liver transplantation in association with hepatic damage due to ischemia and reperfusion injury.

    abstract:PURPOSE:Ghrelin was recently reported to promote recovery from hepatic injury. We hypothesized that it could also be associated with clinical recovery of the transplanted liver from ischemia and reperfusion injury. Our aims were to investigate perioperative ghrelin changes following pediatric living donor liver transpl...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Zenitani M,Hosoda H,Kodama T,Saka R,Takama Y,Ueno T,Tazuke Y,Kangawa K,Oue T,Okuyama H

    更新日期:2019-06-01 00:00:00

  • Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung's disease.

    abstract::Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the in...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: O' Donnell AM,Puri P

    更新日期:2008-01-01 00:00:00

  • Long-term outcome of congenital cystic adenomatoid malformation.

    abstract::To determine the long-term outcome of congenital cystic adenomatoid malformation (CCAM), the records of all patients with CCAM treated in three Hungarian paediatric surgical centers between 1977 and 1996 were reviewed. Patients were followed for up to 20 years following diagnosis and treatment. In 20 patients CCAM was...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Pinter A,Kalman A,Karsza L,Verebely T,Szemledy F

    更新日期:1999-07-01 00:00:00

  • Bronchial foreign body: should bronchoscopy be performed in all patients with a choking crisis?

    abstract::The aspiration of a bronchial foreign body (FB) remains a common pediatric problem with serious and sometimes fatal sequelae. The diagnosis is often delayed or overlooked. With the aim of determining a reliable clinical and/or radiologic finding to indicate the requirement for bronchoscopy, 100 patients admitted to ou...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Fontoba JEB,Gutierrez C,Lluna J,Vila JJ,Poquet J,Ruiz-Company S

    更新日期:1997-03-21 00:00:00

  • Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow's milk protein allergy?

    abstract:BACKGROUND/PURPOSE:To determine the frequency and characteristics of suspected cow's milk protein allergy (CMPA) in infants with gastroschisis and response to change in milk. METHODS:A retrospective cohort study of 111 consecutive infants with gastroschisis. RESULTS:64 episodes suggesting non-IgE-mediated CMPA occurr...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Burge D,Drewett M,Hall N

    更新日期:2015-03-01 00:00:00

  • Semen analysis in post-pubertal patients with posterior urethral valves: a pilot study.

    abstract::The issues of sexual function and fertility are becoming relevant in patients with posterior urethral valves (PUV), as more of them reach adulthood. To evaluate the semen of post-pubertal patients with PUV as a determinant of future fertility, all such patients (age >16 years) attending the follow-up urology clinic of...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Puri A,Gaur KK,Kumar A,Bhatnagar V

    更新日期:2002-03-01 00:00:00

  • NKCC-1 and ENaC are down-regulated in nitrofen-induced hypoplastic lungs with congenital diaphragmatic hernia.

    abstract::Congenital diaphragmatic hernia (CDH) is accompanied by pulmonary hypoplasia and pulmonary hypertension. Fetal lung growth is dependent on the secretion of lung liquid, which normally is absorbed at partus. The ion channel NKCC-1 is involved in this secretory process, but has recently also been reported to be implicat...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Ringman A,Zelenina M,Eklöf AC,Aperia A,Frenckner B

    更新日期:2008-09-01 00:00:00

  • Postoperative abdominal evisceration in children: possible risk factors.

    abstract::Postoperative abdominal evisceration may lead to high morbidity and mortality. The purpose of the present study was to determine possible risk factors, morbidity and mortality associated with abdominal evisceration in children. A total of 3,591 children underwent abdominal exploration in our clinic between 1983 and 20...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Ciğdem MK,Onen A,Otçu S,Duran H

    更新日期:2006-08-01 00:00:00

  • Penetrating pharyngeal injuries in children: trivial trauma leading to devastating complications.

    abstract::Pharyngeal perforations are uncommon in children and are usually secondary to instrumentation or external penetrating injuries. A delay in management can lead to life-threatening complications such as retropharyngeal abscess, mediastinitis, and airway compromise. We report three children who had pharyngeal perforation...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Luqman Z,Khan MA,Nazir Z

    更新日期:2005-06-01 00:00:00

  • Differences in the characteristics and management of pyriform sinus fistula between neonates and young children.

    abstract:PURPOSE:Pyriform sinus fistula (PSF), which originates from the third or fourth branchial pouch remnant, is relatively rare. In young children and adults, it is characterized by lateral neck infections and suppurative thyroiditis, while neonatal PSF presents as a large cervical cystic mass and causes respiratory distre...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Amano H,Uchida H,Sato K,Kawashima H,Tanaka Y,Takazawa S,Jimbo T

    更新日期:2012-01-01 00:00:00

  • Redo transanal endorectal pull-through: a preliminary study.

    abstract::The aim of this study is to evaluate the safety and efficacy of the redo transanal endorectal pull-through (TEPT) for patients with persistent symptoms after pull-through for Hirschsprung's disease (HD). Seven children were included in the study, their ages ranged from 2.5 to 6 years (four males and three females). Th...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Gobran TA,Ezzat A,Hassan ME,O'Neill J

    更新日期:2007-02-01 00:00:00

  • The effect of phospholipids and fatty acids on tight-junction permeability and bacterial translocation.

    abstract::The activity of phospholipase A2 (PLA2) is elevated in the intestinal epithelia of patients with inflammatory bowel disease (IBD). We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resu...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Sawai T,Drongowski RA,Lampman RW,Coran AG,Harmon CM

    更新日期:2001-05-01 00:00:00

  • Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair.

    abstract::Fetal skin wounds heal scarlessly while adult wounds scar. Fetal wound healing occurs in a physiologically hypoxic environment whereas in adult wound healing, cells have to acutely adapt to hypoxia caused by locally impaired blood supply. We examined the expression of hypoxia-inducible factor 1 (HIF-1), a potent trans...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Scheid A,Wenger RH,Christina H,Camenisch I,Ferenc A,Stauffer UG,Gassmann M,Meuli M

    更新日期:2000-01-01 00:00:00

  • Pathophysiology, prevention, treatment, and outcomes of intestinal failure-associated liver disease.

    abstract:BACKGROUND:Intestinal failure-associated liver disease (IFALD) remains a serious problem in the treatment of infants with nutritional problems and short bowel syndrome. METHODS:A review of the recent literature from 2010 to 2016, concentrating on articles related to the pathophysiology of IFALD and to outcomes of nove...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审


    authors: Al-Shahwani NH,Sigalet DL

    更新日期:2017-04-01 00:00:00

  • Outcome of submucosal injection of different sclerosing materials for rectal prolapse in children.

    abstract::Parasitic infestations, mainly enterobiasis and amoebiasis, and poor toilet training practices are commonly associated with rectal prolapse in developing countries. Injection sclerotherapy is one of the commonly used modalities for treating partial rectal prolapse in children. Various materials are available for such ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Fahmy MA,Ezzelarab S

    更新日期:2004-05-01 00:00:00

  • Defect-diaphragmatic ratio: a new parameter for assessment of defect size in neonates with congenital diaphragmatic hernia.

    abstract:AIM:The aim of our study is to introduce a new objective method of perioperative evaluation of the size of diaphragmatic defect to enable comparison of results among various centres and methods used for diaphragmatic reconstruction. MATERIALS AND METHODS:Prospective observational study of neonates with congenital diap...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Rygl M,Kuklova P,Zemkova D,Slaby K,Pycha K,Stranak Z,Melichar J,Snajdauf J

    更新日期:2012-10-01 00:00:00

  • Comparison of diagnostic imaging modalities for the evaluation of pancreatic duct injury in children: a multi-institutional analysis from the Pancreatic Trauma Study Group.

    abstract:PURPOSE:Determining the integrity of the pancreatic duct is important in high-grade pancreatic trauma to guide decision making for operative vs non-operative management. Computed tomography (CT) is generally an inadequate study for this purpose, and magnetic resonance cholangiopancreatography (MRCP) is sometimes obtain...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,多中心研究


    authors: Rosenfeld EH,Vogel A,Russell RT,Maizlin I,Klinkner DB,Polites S,Gaines B,Leeper C,Anthony S,Waddell M,St Peter S,Juang D,Thakkar R,Drews J,Behrens B,Jafri M,Burd RS,Beaudin M,Carmant L,Falcone RA Jr,Moody S,Naik

    更新日期:2018-09-01 00:00:00