Abstract:
INTRODUCTION:The endothelins are a family of small peptides with multiple roles in a variety of tissues. Signaling is mediated through two receptor subtypes, the endothelin A receptor (ET(A)) specific for Et-1 and the non-specific endothelin B receptor (ET(B)). OBJECTIVE:Our goal was to determine the location of immunoreactivity (IR) for ET(A) and ET(B) in developing and mature rat teeth as indicators of endothelin (Et) regulatory sites and to compare this to the Et-1 (ligand)-IR expression patterns. DESIGN:We used immunohistochemistry to study developing and mature rat molars and continuously developing incisors. RESULTS:We demonstrate ET(A), ET(B), and Et-1 expression patterns in teeth, for the first time. ET(A) was found in developing molar root pulp, pulpal vasculature, and preodontoblasts, and then persisted in odontoblasts or cellular cementocytes at the root apices of mature teeth. ET(B) was found at the molar (Hertwig's) root sheath during root formation and in molar ameloblasts, nerve fibers and odontoblasts of immature and mature teeth. In incisors, ET(B)-IR was associated with ameloblasts and the stem cell niche of the cervical loop while ET(A) was located in the substratum layer. Et-1 was found throughout the dental and periodontal tissues with higher concentrations associated with odontoblasts, nerves and incisor layers that expressed ET(B). CONCLUSION:The patterns of ET(A) and ET(B) in teeth differ from each other and from those of adjacent tissues suggesting multiple tooth-specific functions for endothelin during development and mature dental function.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Neuhaus SJ,Byers MRdoi
10.1016/j.archoralbio.2006.12.022subject
Has Abstractpub_date
2007-07-01 00:00:00pages
655-62issue
7eissn
0003-9969issn
1879-1506pii
S0003-9969(07)00025-8journal_volume
52pub_type
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(95)00046-r
更新日期:1995-09-01 00:00:00
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
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doi:10.1016/j.archoralbio.2006.02.008
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更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0003-9969(89)90149-0
更新日期:1989-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2013.11.010
更新日期:2014-02-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2013.07.003
更新日期:2013-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2015.05.011
更新日期:2015-09-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2013.12.003
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0003-9969(91)90116-c
更新日期:1991-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(83)90060-2
更新日期:1983-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2019.06.009
更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2010.03.006
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2009.05.005
更新日期:2009-08-01 00:00:00
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doi:10.1016/j.archoralbio.2005.09.003
更新日期:2006-04-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2007.11.009
更新日期:2008-04-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2007.04.011
更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2014.05.021
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2018.12.008
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2012.08.014
更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0003-9969(83)90113-9
更新日期:1983-01-01 00:00:00