Abstract:
:In this Opinion article we describe a theory that the brain mechanisms underlying working memory for novel information include a buffer in parahippocampal cortices. Computational modeling indicates that mechanisms for maintaining novel information in working memory could differ from mechanisms for maintaining familiar information. Electrophysiological data suggest that the buffer for novel information depends on acetylcholine. Acetylcholine activates single-cell mechanisms that underlie persistent spiking of neurons in the absence of synaptic transmission, allowing maintenance of information without prior synaptic modification. fMRI studies and lesion studies suggest that parahippocampal regions mediate working memory for novel stimuli, and the effects of cholinergic blockade impair this function. These intrinsic mechanisms in parahippocampal cortices provide an important alternative to theories of working memory based on recurrent synaptic excitation.
journal_name
Trends Cogn Scijournal_title
Trends in cognitive sciencesauthors
Hasselmo ME,Stern CEdoi
10.1016/j.tics.2006.09.005subject
Has Abstractpub_date
2006-11-01 00:00:00pages
487-93issue
11eissn
1364-6613issn
1879-307Xpii
S1364-6613(06)00242-7journal_volume
10pub_type
杂志文章,评审abstract::Understanding the neurophysiological mechanisms of learning is important for both fundamental and clinical neuroscience. We present a neurophysiologically inspired framework for understanding cortical mechanisms of feedback-guided learning. This framework is based on dynamic changes in systems-level oscillatory synchr...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2011.10.004
更新日期:2011-12-01 00:00:00
abstract::Depression is characterized by distinct profiles of disturbance in ways autobiographical memories are represented, recalled, and maintained. We review four core domains of difficulty: systematic biases in favor of negative material; impoverished access and responses to positive memories; reduced access to the specific...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2014.06.010
更新日期:2014-11-01 00:00:00
abstract::Memory storage is not static - updating is often needed. When it comes to traumatic memories, forgetting may be desired. Two innovative studies recently demonstrated that fear memories can be weakened during sleep using odors associated with fear-learning episodes. New strategies along these lines should be carefully ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2013.10.003
更新日期:2014-01-01 00:00:00
abstract::The manner by which the human brain learns and recognizes stimuli is a matter of ongoing investigation. Through examination of meta-analyses of task-based functional MRI and resting state functional connectivity MRI, we identified a novel network strongly related to learning and memory. Activity within this network at...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2015.07.004
更新日期:2015-09-01 00:00:00
abstract::Heavy prenatal alcohol exposure can have lifelong, disabling effects on brain and cognition. Unlike animal studies, research on light-to-moderate drinking in humans demonstrates less consistent impact. Discussions of negative research findings in popular media underestimate potential adverse outcomes and complicate de...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2015.09.011
更新日期:2016-02-01 00:00:00
abstract::Political disputes ruin family reunions, scuttle policy initiatives, and spur violence and even terrorism. We summarize recent research indicating that the source of political differences can be found in biologically instantiated and often subthreshold predispositions as reflected in physiological, cognitive, and neur...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2013.12.010
更新日期:2014-03-01 00:00:00
abstract::Computational models of human collective behavior offer promise in providing quantitative and empirically verifiable accounts of how individual decisions lead to the emergence of group-level organizations. Agent-based models (ABMs) describe interactions among individual agents and their environment, and provide a proc...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2005.07.009
更新日期:2005-09-01 00:00:00
abstract::A new brain imaging study demonstrates that patients with autism have a strikingly different pattern of brain activity compared with control subjects. During cognitive tasks, cortical areas known as the "default state" network--areas that have been implicated in both self-referential processing and processing of socia...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2006.08.002
更新日期:2006-10-01 00:00:00
abstract::In this article we provide a unifying neural hypothesis on how individuals understand the actions and emotions of others. Our main claim is that the fundamental mechanism at the basis of the experiential understanding of others' actions is the activation of the mirror neuron system. A similar mechanism, but involving ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2004.07.002
更新日期:2004-09-01 00:00:00
abstract::Why do people sometimes seem to know things when they are tested in one way, while seeming unaware of this information when tested in a different way? Such task-dependent behaviors, or dissociations, often occur in infants and children, and in adults following brain damage. To explain these dissociations, researchers ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(00)01682-x
更新日期:2001-07-01 00:00:00
abstract::How does organized cognition arise from distributed brain activity? Recent analyses of fluid intelligence suggest a core process of cognitive focus and integration, organizing the components of a cognitive operation into the required computational structure. A cortical 'multiple-demand' (MD) system is closely linked t...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2020.06.012
更新日期:2020-10-01 00:00:00
abstract::Learning is usually thought to occur during episodes of studying, whereas retrieval of information on testing simply serves to assess what was learned. We review research that contradicts this traditional view by demonstrating that retrieval practice is actually a powerful mnemonic enhancer, often producing large gain...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2010.09.003
更新日期:2011-01-01 00:00:00
abstract::A new class of visuomotor neuron has been recently discovered in the monkey's premotor cortex: mirror neurons. These neurons respond both when a particular action is performed by the recorded monkey and when the same action, performed by another individual, is observed. Mirror neurons appear to form a cortical system ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(98)01262-5
更新日期:1998-12-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) noninvasively measures human brain activity at millimeter resolution. Scientists use different approaches to take advantage of the remarkable opportunities presented by fMRI. Here, we describe progress using the computational neuroimaging approach in human visual cortex, wh...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2015.03.009
更新日期:2015-06-01 00:00:00
abstract::What makes us conscious? Many theories that attempt to answer this question have appeared recently in the context of widespread interest about consciousness in the cognitive neurosciences. Most of these proposals are formulated in terms of the information processing conducted by the brain. In this overview, we survey ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(00)01533-3
更新日期:2000-10-01 00:00:00
abstract::Perceptual learning can be defined as practice-induced improvement in the ability to perform specific perceptual tasks. We previously proposed the Reverse Hierarchy Theory as a unifying concept that links behavioral findings of visual learning with physiological and anatomical data. Essentially, it asserts that learni...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2004.08.011
更新日期:2004-10-01 00:00:00
abstract::Recent research using both naturalistic and experimental methods has found that the vast majority of young children's early language is organized around concrete, item-based linguistic schemas. From this beginning, children then construct more abstract and adult-like linguistic constructions, but only gradually and in...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(00)01462-5
更新日期:2000-04-01 00:00:00
abstract::Usage of the term 'theory of mind' (ToM) has exploded across fields ranging from developmental psychology to social neuroscience and psychiatry research. However, its meaning is often vague and inconsistent, its biological bases are a subject of debate, and the methods used to study it are highly heterogeneous. Most c...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2014.11.007
更新日期:2015-02-01 00:00:00
abstract::Sociality and cooperation are benefits to human cultures but may carry unexpected costs. We suggest that both the human experience of pain and the expression of distress may result from many causes not experienced as painful in our close primate relatives, because human ancestors motivated to ask for help survived in ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2014.08.002
更新日期:2014-12-01 00:00:00
abstract::When we move our eyes, we easily keep track of where relevant things are in the world. Recent proposals link this stability to the shifting of receptive fields of neurons in eye movement and attention control areas. Reports of 'spatiotopic' visual aftereffects have also been claimed to support this shifting connectivi...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2010.01.007
更新日期:2010-04-01 00:00:00
abstract::Behavioral analyses are a natural choice for understanding the wide-ranging behavioral consequences of racial stereotyping and prejudice. However, studies using neuroimaging and electrophysiological research have recently considered the neural mechanisms that underlie racial categorization and the activation and appli...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2009.10.002
更新日期:2009-12-01 00:00:00
abstract::Following groundbreaking work by linguists and cognitive scientists over the past thirty years, it is now generally accepted that sign languages of the deaf, such as ASL (American Sign Language) or BSL (British Sign Language), are structured and processed in a similar manner to spoken languages. The one striking diffe...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(02)00012-8
更新日期:2003-01-01 00:00:00
abstract::Categorization is a fundamental process whereby variable perceptual inputs are reduced progressively to a small number of equivalence classes, called 'categories'. How do theorists frame the categorization problem so that variable face, object and scene information is stabilized for higher-level processing? One approa...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/S1364-6613(97)01056-5
更新日期:1997-08-01 00:00:00
abstract::Decades of research have established two central roles of the hippocampus--memory consolidation and spatial navigation. Recently, a third function of the hippocampus has been proposed: simulating future events. However, claims that the neural patterns underlying simulation occur without prior experience have come unde...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2016.01.003
更新日期:2016-03-01 00:00:00
abstract::Despite normative declines in old age, healthy elderly typically report surprisingly high levels of well-being. It is not clear why this is so. A study by Brassen and colleagues suggests that one factor may be reduced responsiveness to regret. These findings highlight the role of emotion regulation in successful aging...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2012.06.007
更新日期:2012-08-01 00:00:00
abstract::A new study by Kano and colleagues shows that great apes use their own visual experience to attribute perceptions and beliefs to another agent. Their results suggest that the way apes understand behavior is more similar to human understanding than was previously thought, and may be driven by representations of mental ...
journal_title:Trends in cognitive sciences
pub_type: 评论,杂志文章
doi:10.1016/j.tics.2019.10.008
更新日期:2019-12-01 00:00:00
abstract::The study of social learning in robotics has been motivated by both scientific interest in the learning process and practical desires to produce machines that are useful, flexible, and easy to use. In this review, we introduce the social and task-oriented aspects of robot imitation. We focus on methodologies for addre...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(02)02016-8
更新日期:2002-11-01 00:00:00
abstract::On the basis of naturalistic observations of people conversing and laughing in pubs, a new study suggests that the 'grooming-at-a-distance' of laughter provides a three-fold increase in grooming group size, potentially explaining how hominins evolved social groups that are considerably larger than those of other prima...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2012.11.001
更新日期:2013-01-01 00:00:00
abstract::We describe two merging lines of empirical inquiry: entire false memories for autobiographical events and false confessions. A recent study showed that people can be led to remember, and confess to, perpetrating serious crimes that never occurred when confronted with suggestive interview tactics commonly used in polic...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2015.08.014
更新日期:2015-12-01 00:00:00
abstract::Young children exhibit several deficits in reasoning about their own and other people's mental states. We propose that these deficits, along with more subtle limitations in adults' social-cognitive reasoning, are all manifestations of the same cognitive bias. This is the 'curse of knowledge' - a tendency to be biased ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2004.04.011
更新日期:2004-06-01 00:00:00