The role of cortical bone and its microstructure in bone strength.

Abstract:

:Bone's mechanical competence and its fragility in particular depend to a certain extent on the structure and microstructure of the cortical bone compartment. Beyond bone mineral density (BMD) and bone mineral content, a variety of other features of cortical bone contribute to whole bone's resistance to fracture. Structural properties of cortical bone most commonly employed as surrogate for its mechanical competence include thickness of the cortex, cortical cross-sectional area and area moment of inertia. But microstructural properties such as cortical porosity, crystallinity or the presence of microcracks also contribute to bone's mechanical competence. Microcracks in particular not only weaken the cortical bone tissue but also provide an effective mechanism for energy dissipation. Bone is a damageable, viscoelastic composite and most of all a living material capable of self-repair and thus exhibits a complex repertoire of mechanical properties. This review provides an overview of a variety of features of cortical bone known to provide mechanical competence and how these features may be applied for fracture risk prediction.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Augat P,Schorlemmer S

doi

10.1093/ageing/afl081

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

ii27-ii31

eissn

0002-0729

issn

1468-2834

pii

35/suppl_2/ii27

journal_volume

35 Suppl 2

pub_type

杂志文章,评审
  • High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

    abstract:OBJECTIVE:to explore the relationship between blood lipids/lipoproteins and cognitive function in the Chinese oldest-old. DESIGN:multivariate statistical analysis using cross-sectional data. SETTING:community-based setting in longevity areas in China. SUBJECTS:eight hundred and thirty-six subjects aged 80 and older ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs033

    authors: Yin ZX,Shi XM,Kraus VB,Fitzgerald SM,Qian HZ,Xu JW,Zhai Y,Sereny MD,Zeng Y

    更新日期:2012-09-01 00:00:00

  • Sleep disordered breathing and cognitive function in a retirement village population.

    abstract::Sleep disordered breathing (SDB) may be associated with cognitive dysfunction in non-demented elderly people. A random sample of 96 retirement village residents were given both neuropsychological assessment and overnight sleep monitoring with a portable microprocessor based system (Vitalog PMS-8). Respiratory disturba...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/21.2.121

    authors: Hayward L,Mant A,Eyland A,Hewitt H,Purcell C,Turner J,Goode E,Le Count A,Pond D,Saunders N

    更新日期:1992-03-01 00:00:00

  • Fracture rates in Parkinson's disease compared with age- and gender-matched controls: a retrospective cohort study.

    abstract:INTRODUCTION:Patients with Parkinson's disease (PD) are not routinely prescribed bone-protecting medication despite the fact that they are known to be at risk of falling. We investigated whether subjects with PD were more at risk of fractures than other patient groups in order to establish whether preventative measures...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afh203

    authors: Genever RW,Downes TW,Medcalf P

    更新日期:2005-01-01 00:00:00

  • Refeeding syndrome.

    abstract:CASE REPORT:An elderly woman with poor nutritional intake developed profound hypophosphataemia and hypokalaemia following the institution of nasogastric feeding. DISCUSSION:Refeeding syndrome is well recognized in certain undernourished groups of patients, but may not be so well known to physicians looking after elder...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/31.1.65

    authors: Mallet M

    更新日期:2002-01-01 00:00:00

  • Medical therapy for the overactive bladder in the elderly.

    abstract::The overactive bladder is the commonest underlying bladder disorder causing urinary incontinence in elderly people. Management of the condition relies upon a holistic assessment of the problem, lifestyle adjustment, behavioural management and drug therapy. The majority of currently available drugs rely on their anti-m...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/31.4.241

    authors: Wagg A,Cohen M

    更新日期:2002-07-01 00:00:00

  • Inappropriate prescribing in the older population: need for new criteria.

    abstract::Inappropriate prescribing (IP) is a common and serious global healthcare problem in elderly people, leading to increased risk of adverse drug reactions (ADRs), polypharmacy being the main risk factor for both IP and ADRs. IP in older people is highly prevalent but preventable; hence screening tools for IP have been de...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afm189

    authors: O'Mahony D,Gallagher PF

    更新日期:2008-03-01 00:00:00

  • How empowering is hospital care for older people with advanced disease? Barriers and facilitators from a cross-national ethnography in England, Ireland and the USA.

    abstract:Background:patient empowerment, through which patients become self-determining agents with some control over their health and healthcare, is a common theme across health policies globally. Most care for older people is in the acute setting, but there is little evidence to inform the delivery of empowering hospital care...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afw193

    authors: Selman LE,Daveson BA,Smith M,Johnston B,Ryan K,Morrison RS,Pannell C,McQuillan R,de Wolf-Linder S,Pantilat SZ,Klass L,Meier D,Normand C,Higginson IJ

    更新日期:2017-03-01 00:00:00

  • The natural history of delirium in older hospitalized patients: a syndrome of heterogeneity.

    abstract:OBJECTIVES:To determine the presentation, course and duration of delirium in hospitalized older people. DESIGN:Observational cohort study. SETTING:Inpatient surgical and medical wards at a university hospital. PARTICIPANTS:432 people over the age of 65. MEASUREMENTS:All participants were screened daily for confusio...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/26.3.169

    authors: Rudberg MA,Pompei P,Foreman MD,Ross RE,Cassel CK

    更新日期:1997-05-01 00:00:00

  • Institutionalization and the elderly: international comparisons.

    abstract::This paper is an exploratory attempt to examine international differences in the proportion of old people living in non-private households. The aim of the study was to provoke further discussion of the role which institutions play in the care of the elderly in various settings and to examine the effect of certain demo...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/13.3.129

    authors: Grundy E,Arie T

    更新日期:1984-05-01 00:00:00

  • Smoking cessation in late life is associated with increased risk of all-cause mortality amongst oldest old people: a community-based prospective cohort study.

    abstract:OBJECTIVE:we aimed to investigate the association of smoking cessation with risk of all-cause mortality amongst oldest old people (aged ≥ 80 years). DESIGN:this was a prospective cohort study. SETTING:the Chinese Longitudinal Healthy Longevity Survey, implemented in 23 provinces of China. PARTICIPANTS:a total of 28,...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa280

    authors: Wei Y,Lv Y,Zhou J,Gao X,Duan J,Zhao C,Yin Z,Kang Q,Wu B,Chen C,Mao C,Li J,Shi X

    更新日期:2021-01-23 00:00:00

  • Reduced survival with increasing plasma osmolality in elderly continuing-care patients.

    abstract::The results reported here are from a 2-year follow-up study of 58 elderly patients in a continuing-care unit. Most of these patients were in a hyperosmolar state at the time of entry (mean plasma osmolality 304 +/- 8 mOsmol/kg). The survival of those patients with the highest osmolality (greater than 308 mOsmol/kg) wa...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章

    doi:10.1093/ageing/19.1.68

    authors: O'Neill PA,Faragher EB,Davies I,Wears R,McLean KA,Fairweather DS

    更新日期:1990-01-01 00:00:00

  • New Horizons in orthostatic hypotension.

    abstract:Background:orthostatic hypotension (OH) is a common disabling condition associated with increased morbidity and mortality. Much of the evidence available is derived from younger populations with chronic neurological disease leading to uncertainty for the diagnosis and management of older people. Objective:to provide a...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afw211

    authors: Frith J,Parry SW

    更新日期:2017-03-01 00:00:00

  • Cognitive scores, even within the normal range, predict death and institutionalization.

    abstract:BACKGROUND:Dementia is a predictor of death and institutionalization. It is less clear if variations in cognition within the normal range predict adverse outcomes. OBJECTIVE:To determine if variation at the high end of cognitive test scores predicts mortality or institutionalization, independent of the effect of poten...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/31.5.373

    authors: St John PD,Montgomery PR,Kristjansson B,McDowell I

    更新日期:2002-09-01 00:00:00

  • A dose response relationship between accelerometer assessed daily steps and depressive symptoms in older adults: a two-year cohort study.

    abstract:OBJECTIVES:this study investigated the prospective associations of accelerometer assessed daily steps with subsequent depressive symptoms in older adults. METHODS:a 2-year prospective study was performed in the community. A total of 285 older adults ≥65 years (mean age = 74.5) attended the baseline assessment in 2012....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa162

    authors: Hsueh MC,Stubbs B,Lai YJ,Sun CK,Chen LJ,Ku PW

    更新日期:2020-09-25 00:00:00

  • Transcatheter aortic valve implantation: restoring the qualities of life in old age.

    abstract::Transcatheter aortic valve implantation (TAVI) is a tremendous therapeutic advance for patients with severe aortic stenosis and high-surgical risk. Since TAVI-treated patients are elderly with multiple co-existing conditions, limited life expectancy and disproportionate health-care expenditures, the aspect of the heal...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afs110

    authors: Georgiadou P,Sbarouni E,Karavolias GK,Voudris V

    更新日期:2013-01-01 00:00:00

  • Predictors of depressive symptoms in older people--a survey of two general practice populations.

    abstract:BACKGROUND:Studies have shown strong associations between disability, social support and depressive symptoms in older people; but socio-economic effects are less clear and little is known about the role of health locus of control. OBJECTIVE:To examine the roles of physical health, disability, social support, socio-eco...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afg087

    authors: Harris T,Cook DG,Victor C,Rink E,Mann AH,Shah S,DeWilde S,Beighton C

    更新日期:2003-09-01 00:00:00

  • Duodenal ulcer disease in the elderly: a retrospective study.

    abstract::A retrospective study was performed of 163 patients aged 65 years and over with a diagnosis of duodenal ulceration admitted to one Health District over a period of six years. Eighty per cent of the patients were admitted with acute complications, 50% bled and 30% were perforated. A large proportion of these patients w...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/14.4.225

    authors: Watson RJ,Hooper TL,Ingram G

    更新日期:1985-07-01 00:00:00

  • Social isolation and loneliness as related to progression and reversion of frailty in the Survey of Health Aging Retirement in Europe (SHARE).

    abstract:BACKGROUND:Frailty was shown to be associated with psychosocial risk factors, but there are few longitudinal data. METHODS:We used data from waves 5 and 6 of the Survey of Health Aging Retirement in Europe (SHARE) to study the contribution of loneliness and social isolation to transitions towards frailty defined accor...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa168

    authors: Jarach CM,Tettamanti M,Nobili A,D'avanzo B

    更新日期:2021-01-08 00:00:00

  • Informant ratings of cognitive decline of elderly people: relationship to longitudinal change on cognitive tests

    abstract::Formal assessment of cognitive decline with cognitive tests can be difficult, requiring either two measurement points or a comparison of 'hold' with 'don't hold' tests. Informant-based assessment provides an alternative approach because informants can adopt a longitudinal perspective and directly rate cognitive change...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:

    authors: Jorm AF,Christensen H,Henderson AS,Jacomb PA,Korten AE,Mackinnon A

    更新日期:1996-03-01 00:00:00

  • The elimination half-life of benzodiazepines and fall risk: two prospective observational studies.

    abstract:BACKGROUND:the STOPP criteria advise against the use of long-acting benzodiazepines (LBs). OBJECTIVE:to study whether LBs are associated with a higher fall risk than short-acting benzodiazepines (SBs) (elimination half-life ≤ 10 h). METHODS:we used base-line data and prospective fall follow-up from the Longitudinal A...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft089

    authors: de Vries OJ,Peeters G,Elders P,Sonnenberg C,Muller M,Deeg DJ,Lips P

    更新日期:2013-11-01 00:00:00

  • Health-related quality of life and antihypertensive medication adherence among older adults.

    abstract:PURPOSE:health-related quality of life (HRQOL) is an important psycho-social characteristic which may impact an individual's ability to manage their chronic disease. We examined the association between HRQOL and antihypertensive medication adherence in older adults. METHODS:participants were part of a cohort study of ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afq040

    authors: Holt EW,Muntner P,Joyce CJ,Webber L,Krousel-Wood MA

    更新日期:2010-07-01 00:00:00

  • Reappraising 'the good death' for populations in the age of ageing.

    abstract::This is the second in an occasional series of paired commentaries in Age and Ageing, the Journal of the British Geriatrics Society and the Journal of the American Geriatrics Society (JAGS). The aim is to address issues of current significance and to foster dialogue and increased understanding between academics and cli...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afy008

    authors: Pollock K,Seymour J

    更新日期:2018-05-01 00:00:00

  • Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia.

    abstract:BACKGROUND:oropharyngeal dysphagia is a common condition among the elderly but not systematically explored. OBJECTIVE:to assess the prevalence and the prognostic significance of oropharyngeal dysphagia among elderly patients with pneumonia. DESIGN:a prospective cohort study. SETTING:an acute geriatric unit in a gene...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afp100

    authors: Cabre M,Serra-Prat M,Palomera E,Almirall J,Pallares R,Clavé P

    更新日期:2010-01-01 00:00:00

  • Four-year clinical results of transcatheter self-expanding Medtronic CoreValve implantation in high-risk patients with severe aortic stenosis.

    abstract:BACKGROUND:transcatheter aortic valve implantation (TAVI) has emerged as an alternative to surgical aortic valve replacement for patients with severe aortic stenosis considered inoperable or at high operative risk, but the long-term outcome remains unknown. HYPOTHESIS:we assessed the 4-year clinical and echocardiograp...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw038

    authors: Thomopoulou S,Vavuranakis M,Karyofyllis P,Kariori M,Karavolias G,Balanika M,Smyrli A,Stefopoulos C,Sbarouni E,Moldovan C,Khoury M,Stefanadis C,Voudris V

    更新日期:2016-05-01 00:00:00

  • Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.

    abstract:BACKGROUND/OBJECTIVES:to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. DESIGN:a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft191

    authors: Werner KB,Elmståhl S,Christensson A,Pihlsgård M

    更新日期:2014-05-01 00:00:00

  • Associated factors with antipsychotic use in assisted living facilities: a cross-sectional study of 4367 residents.

    abstract:BACKGROUND:antipsychotics are widely used in assisted living (AL facilities). Even more, the prescription of these drugs is gradually increasing since the availability of second-generation atypical antipsychotics. More knowledge is needed on prescription reasons to understand this increasing prevalence. METHODS:cross-...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afr032

    authors: Larrayadieu A,Abellan van Kan G,Piau A,Soto Martin M,Nourhashemi F,Rolland Y,Vellas B

    更新日期:2011-05-01 00:00:00

  • Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE.

    abstract:INTRODUCTION:Routine cognitive screening for in-patients aged ≥75 years is recommended, but there is uncertainty around how this should be operationalised. We therefore determined the feasibility and reliability of the Abbreviated mental test score (AMTS/10) and its relationship to subjective memory complaint, Montreal...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afv134

    authors: Pendlebury ST,Klaus SP,Mather M,de Brito M,Wharton RM

    更新日期:2015-11-01 00:00:00

  • The Short FES-I: a shortened version of the falls efficacy scale-international to assess fear of falling.

    abstract:BACKGROUND:the 16-item Falls Efficacy Scale-International (FES-I) has been shown to have excellent reliability and construct validity. However, for practical and clinical purposes, a shortened version of the FES-I would be useful. OBJECTIVE:to develop and validate a shortened version of FES-I while preserving good psy...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afm157

    authors: Kempen GI,Yardley L,van Haastregt JC,Zijlstra GA,Beyer N,Hauer K,Todd C

    更新日期:2008-01-01 00:00:00

  • Medication management at home: medication-related risk factors associated with poor health outcomes.

    abstract:BACKGROUND:Some patients may have medication-related risk factors only identified by home visits, but the extent to which those risk factors are associated with poor health outcomes remains unclear. OBJECTIVE:To determine the association between medication-related risk factors and poor patient health outcomes from obs...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afi202

    authors: Sorensen L,Stokes JA,Purdie DM,Woodward M,Roberts MS

    更新日期:2005-11-01 00:00:00

  • Gender and longitudinal changes in physical activities in later life.

    abstract:OBJECTIVES:to describe gender differences in levels of, and longitudinal changes in, habitual physical activity among older people. DESIGN:longitudinal study. PARTICIPANTS:sub-groups of survivors (with sample sizes dependent on the availability of complete datasets, ranging from 303-344) assessed on three occasions: ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/27.suppl_3.24

    authors: Bennett KM

    更新日期:1998-12-01 00:00:00