Abstract:
BACKGROUND:antipsychotics are widely used in assisted living (AL facilities). Even more, the prescription of these drugs is gradually increasing since the availability of second-generation atypical antipsychotics. More knowledge is needed on prescription reasons to understand this increasing prevalence. METHODS:cross-sectional analysis of 4,367 residents. Data were obtained from medical records assessed by geriatricians from the AL facility. A multiple logistic regression model (backward stepwise) was used to assess the independent associated factors with antipsychotic use. RESULTS:antipsychotic prescription was found in 1,203 (27.5%) of 4,367 residents. The independent associated factors with the use of antipsychotics were the presence of a psychiatric disorder [odds ratio, OR = 5.30 (4.42-6.35)], the age under 80 years [OR = 2.08 (1.62-2.68)], admission from another institution [OR = 1.49 (1.12-1.98)], treated dementia [OR = 1.84 (1.47-2.30)], the presence of neuropsychiatric symptoms (NPS): verbal outbursts [OR = 2.58 (1.96-3.39)], threatening behaviours or physical violence [OR = 2.13 (1.71-2.65)], and aimless wandering [OR = 1.55 (1.17-2.04)], the presence of cardiovascular disease [OR = 0.79 (0.65-0.96)] and the presence of cerebrovascular disease [OR = 0.77 (0.64-0.92)]. CONCLUSIONS:the study found that more than a quarter of the residents received antipsychotics. This study also highlighted the independent associated factors with antipsychotic prescription showing 'off-label' prescriptions in conditions such as dementia and certain NPS. The study findings suggest that improvements in the management of dementia and NPS in AL facilities are needed. Non-pharmacological alternatives should be enhanced and further developed viewing the high prevalence of antipsychotic prescription.
journal_name
Age Ageingjournal_title
Age and ageingauthors
Larrayadieu A,Abellan van Kan G,Piau A,Soto Martin M,Nourhashemi F,Rolland Y,Vellas Bdoi
10.1093/ageing/afr032subject
Has Abstractpub_date
2011-05-01 00:00:00pages
368-75issue
3eissn
0002-0729issn
1468-2834pii
afr032journal_volume
40pub_type
杂志文章相关文献
AGE AND AGEING文献大全abstract:OBJECTIVE:to investigate the associations between chronic health conditions, psychosocial and environmental factors and catastrophic decline in mobility among older people. DESIGN:longitudinal cohort. SETTING:national sample living in private households. PARTICIPANTS:nine hundred and ninety-nine adults aged > or = 6...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afl004
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:prevalence estimates for chronic diseases and associated risk factors are needed for priority setting and disease prevention strategies. The aim of this cross-sectional study was to estimate the self-reported and clinical prevalence of common chronic disorders in elderly men. STUDY DESIGN AND SETTING:a quest...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afr153
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION:a professional man sustained a residual, persisting, isolated impairment of short-term memory secondary to severe carbon monoxide poisoning. Informal, open trial of the cholinesterase inhibitor donepezil resulted in uncertain benefit. PROTOCOL:an N-of-1 randomized, double-blind controlled trial of donepez...
journal_title:Age and ageing
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ageing/31.4.307
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:avoidance of over anticoagulation in response to warfarin therapy would reduce risk of associated bleeding. SUBJECTS:two elderly patients with venous thromboembolism exhibited extreme anticoagulant response to warfarin. Both were noted to have variant CYP2C9 alleles, which reduce the metabolic capacity of c...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/32.2.226
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Female life expectancy in developed countries has increased by 30 years in the twentieth century. AIM:To determine if there has been an increase in reproductive longevity. METHODS:We analysed age-specific fertility data from birth statistics for the USA, Canada, Japan, France, Sweden, the UK and Australia....
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/29.1.75
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The European Stroke Database (ESDB) Project aims to develop a 'common clinical language' for stroke care by agreeing on terminology, definitions and clinical assessments. Each area of stroke assessment has a 'minimum dataset', which can be collected routinely and more detailed information can be added for pa...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/27.2.115
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:this study aimed to investigate the construct validity and responsiveness of performance-based and self-reported measures of strength, mobility and balance after hip fracture. DESIGN:secondary analysis of clinical trial data. SUBJECTS:a total of 148 older people undergoing hip fracture rehabilitation. MET...
journal_title:Age and ageing
pub_type: 杂志文章,随机对照试验
doi:10.1093/ageing/afs090
更新日期:2012-09-01 00:00:00
abstract::Clinical observations suggest an age-associated decline in skin perfusion but there are few quantitative in vivo data on skin perfusion at various ages. We studied skin perfusion of the dorsum of the foot by determining the capillary blood flow velocity (CBFV) expressed in millivolts (mV), using laser Doppler flowmetr...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/21.4.237
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVES:the purpose of this study was to evaluate the likelihood that the presence of certain medical conditions in older ambulatory patients are associated with the risk of developing a new pressure ulcer. DESIGN:a cohort study. SETTING AND SUBJECTS:a large outpatient record database from the United Kingdom calle...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/32.3.259
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:early mobilization after hip fracture (HF) is an important predictor of outcome, but knowledge of the consequences of not achieving the pre-fracture basic mobility status in acute hospital recovery is sparse. OBJECTIVE:we examined whether the regain of pre-fracture basic mobility status evaluated with the c...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afy185
更新日期:2019-03-01 00:00:00
abstract::The measurement of cutaneous pain threshold using the Neuromod Selectra Model 7750 Transcutaneous Neuronal Electrical Stimulator is described. Pain threshold, measured in 520 healthy volunteers aged 5-105 years, increased with age. Consistent values were obtained in 22 healthy volunteers on three successive days. Pain...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/18.4.241
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:to provide evidence for predictors of recovery in instrumental activities of daily living (IADLs) among disabled older people living in the community. DESIGN:MRC CFAS recruited a sample of 13,004 individuals aged 65 years and above from five communities in the UK. Participants underwent a baseline interview ...
journal_title:Age and ageing
pub_type: 杂志文章,多中心研究
doi:10.1093/ageing/afp128
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:to test the hypothesis as to whether persons newly discharged into the community following an acute stroke and assigned a stroke case manager would experience, compared to usual post-hospital care, better health-related quality of life (HRQL), fewer emergency room visits and less non-elective hospitalisation...
journal_title:Age and ageing
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/ageing/afm133
更新日期:2008-01-01 00:00:00
abstract:Background/Objective:studies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life. Methods:we studied 5,169 participants (mean age 76 years, 42.9% men) in the AGES-Reykja...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw219
更新日期:2017-03-01 00:00:00
abstract::We have measured the rate of induction of the microsomal monooxygenase enzyme aryl hydrocarbon hydroxylase (AHH) in isolated peripheral blood monocytes from young and elderly donors. There was no effect of age on rate of induction. The mechanisms underlying impaired induction of drug metabolism in elderly people remai...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/20.6.421
更新日期:1991-11-01 00:00:00
abstract:Background:overactive bladder (OAB) is a common condition in older persons. Antimuscarinic treatment remains the mainstay of treatment of OAB but clinicians have been reluctant to prescribe this to older patients. This study examined efficacy and safety information from patients >65 in fesoterodine trials to reaffirm e...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw252
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Obtaining well-founded estimates of the effect of demographic change on future health expenditures is a pressing issue in all developed countries. Thus far, expenditure projections have examined the effect of age on health care costs, but fail to account for the influence of remaining life expectancy on cost...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afh187
更新日期:2004-11-01 00:00:00
abstract::A 3-year prospective, controlled study of sports injuries in elderly athletes (over 60 years of age) treated at an outpatient sports clinic was carried out in order to determine the number, profile, and specific features of these injuries compared with those of young athletes (between 21 and 25 years). During the stud...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/18.4.263
更新日期:1989-07-01 00:00:00
abstract::Plasma and red-cell folate levels and dietary folate intake were monitored for about six months, including two months during which supplementary vitamin C was given, in 21 healthy elderly men and women living at home in the north of England. Although biochemical values were consistently low in some subjects, no clinic...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/9.4.241
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:Studies have raised concerns that medications with anticholinergic property have potential adverse effects on health outcomes. OBJECTIVES:The objective of this study is to examine the prospective relationships between total anticholinergic burden (ACB) from medications and mortality, and cardiovascular dise...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afu185
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:the relationship between proximity to death and the amount of care provided by general practitioners (GPs) is largely unknown. OBJECTIVE:to examine the influence of the proximity to death on the frequency and length of GP contacts in the oldest old. STUDY DESIGN:this population-based follow-up study includ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afs062
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:There is little evidence about the utilization of healthcare services and disease recognition in the older population, which was urged to self-isolate during the COVID-19 lockdowns. OBJECTIVES:We aimed to describe the utilization of physician consultations, specialist referrals, hospital admissions, and the...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afaa260
更新日期:2020-11-17 00:00:00
abstract::In a study of two representative population samples of 70-year-olds, one of which was followed up at 75 years of age, digitalis treatment was associated with oestrogen-like metabolic effects, indicated by changes in the composition of the plasma phospholipid fraction. Digitalis treatment, at least at these ages, is re...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/11.4.261
更新日期:1982-11-01 00:00:00
abstract::Investigation of 21 elderly women with a wide range of renal function showed that plasma creatinine concentrations above 100 mumol/l were associated with glomerular filtration rates (GFR) below 50 ml/min. Plasma 1,25-dihydroxyvitamin D concentrations and radio-calcium absorption were directly related to GFR and were l...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/13.1.14
更新日期:1984-01-01 00:00:00
abstract::In the UK, the General Medical Council's new guidance on confidentiality restates the professional duty for doctors to regard personal information revealed to them as confidential. Such information can be shared only with the patient's explicit consent--the exceptions to this are narrowly defined. We believe the guida...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/31.2.147
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:frequent emergency department (ED) attendance at the end of life disrupts care continuity and contradicts most patients' preference for home-based care. OBJECTIVE:to examine factors associated with frequent (≥3) end of life ED attendances among older people to identify opportunities to improve care. METHOD...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afz043
更新日期:2019-09-01 00:00:00
abstract::The DOMINO study compared domiciliary and hospital-based rehabilitation services for stroke patients after discharge from hospital, stratified by the hospital ward at discharge. No difference between the services had been found at 6 months, but home therapy was better than outpatient department therapy at improving ho...
journal_title:Age and ageing
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ageing/23.1.9
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:in older persons, anaemia is associated with a number of unfavourable outcomes. In approximately 30% of older persons with anaemia, the cause of the anaemia is unexplained. We assessed the clinical differences between subjects with explained and unexplained anaemia and investigated whether these subjects hav...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afs031
更新日期:2012-07-01 00:00:00
abstract::Many studies have shown the indigenous elderly population and Asian immigrants to be groups at particular risk of vitamin D deficiency and osteomalacia, but there are no data on the risks in elderly Asians. In this community-based study a group of elderly Asians was compared with control groups of elderly and young wh...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/24.2.103
更新日期:1995-03-01 00:00:00
abstract::Of 212 cases of peritonitis found in a retrospective study of geriatric inpatients, the most common causes were mesenteric infarction, malignancy, intestinal obstruction, perforated peptic ulcer, cholecystitis, diverticulitis and perforation of the urinary bladder. The diagnostic accuracy was 47%. Abdominal pain had b...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/20.2.90
更新日期:1991-03-01 00:00:00