Abstract:
Background:overactive bladder (OAB) is a common condition in older persons. Antimuscarinic treatment remains the mainstay of treatment of OAB but clinicians have been reluctant to prescribe this to older patients. This study examined efficacy and safety information from patients >65 in fesoterodine trials to reaffirm efficacy and to explore the relationships between treatment emergent adverse events (TEAEs), coexisting medication and co-morbidity. Methods:data from 10 double-blind, placebo-controlled studies were analysed. A logistic regression analysis, where TEAE incidence was predicted by treatment, prior antimuscarinic treatment, number of coexisting medications, number of concomitant diseases and all possible combinations of two-way interaction terms with treatment was conducted. Results:of 4,040 patients who participated in trials; fesoterodine treatment was associated with statistically significant reductions in all disease-related and patient-reported outcomes compared to placebo. There was a significant increase in the likelihood of reporting a TEAE in association with the number of coexistent medications (odds ratio (OR) = 1.028, 95% CI: 1.0143-1.044, P < 0.003). The OR of having a TEAE with increase in the number of concomitant diseases was 1.058 (95% CI: 1.044-1.072, P < 0.0001). Central nervous system (CNS) events were few. Discussion:fesoterodine treatment led to clinically meaningful improvements across all included patient reported outcomes. The number of concomitant conditions had the greatest influence on the likelihood of an adverse event being reported. CNS TEAE were not associated with fesoterodine dose and were low across all categories of concomitant disease and coexisting medication.
journal_name
Age Ageingjournal_title
Age and ageingauthors
Wagg A,Arumi D,Herschorn S,Angulo Cuesta J,Haab F,Ntanios F,Carlsson M,Oelke Mdoi
10.1093/ageing/afw252subject
Has Abstractpub_date
2017-07-01 00:00:00pages
620-626issue
4eissn
0002-0729issn
1468-2834pii
afw252journal_volume
46pub_type
杂志文章相关文献
AGE AND AGEING文献大全abstract:BACKGROUND:delirium is under-recognised in comparison to other common and serious acute disorders. A 2006 survey of UK junior doctors (not undertaking specialist training) identified poor knowledge of the diagnostic criteria and treatment of delirium. We hypothesised that increased prominence accorded to delirium in th...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw066
更新日期:2016-07-01 00:00:00
abstract::The number of older people living with human immunodeficiency virus (HIV) in the UK is rising. Older people are at risk of acquiring HIV infection for a multitude of reasons. This, combined with effective HIV treatment which has significantly prolonged life expectancy, means that health care professionals working in t...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/afq009
更新日期:2010-05-01 00:00:00
abstract::Among 352 residents of a home for the elderly, who were fully mobile and devoid of most predisposing factors for bacteriuria, 19% of men and 27% of women had two positive cultures within two months. Positive conversion at one year among men and women negative at entry was 11% and 23% respectively, negative conversion ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/11.3.169
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:the relationship between proximity to death and the amount of care provided by general practitioners (GPs) is largely unknown. OBJECTIVE:to examine the influence of the proximity to death on the frequency and length of GP contacts in the oldest old. STUDY DESIGN:this population-based follow-up study includ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afs062
更新日期:2012-11-01 00:00:00
abstract::A study is reported of the religious beliefs, attitudes, and practice of old people in the West of Scotland, based on a questionnaire given to 501 people aged 65 years and over randomly selected from those living at home. Almost all had had a full range of religious instruction, and regarded their parents as religious...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/7.1.40
更新日期:1978-02-01 00:00:00
abstract::The disproportionately high suicide rate among the elderly is examined in this review. As opposed to younger age groups, a close association exists between suicide and parasuicide in old age. Factors associated with these events include a high incidence of depression, serious physical illness, as well as social factor...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/7.4.201
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Some patients may have medication-related risk factors only identified by home visits, but the extent to which those risk factors are associated with poor health outcomes remains unclear. OBJECTIVE:To determine the association between medication-related risk factors and poor patient health outcomes from obs...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afi202
更新日期:2005-11-01 00:00:00
abstract::High rates of mortality are an abiding feature of homes for the elderly. Almost a fifth (19.2%) of a cohort of 6947 residents died in the 12 months following initial assessment. Survival rates vary widely, however, for different groups within the residential population. Using data from a longitudinal study of 175 home...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/12.3.240
更新日期:1983-08-01 00:00:00
abstract::Joint geriatric/psychiatric wards are a potential solution to improving care of older patients with both psychiatric and medical illnesses in acute hospitals. A literature search using Medline, PsycINFO, Embase and CINAHL between 1980 and 2010 was carried out for information about joint wards for older people. Thirtee...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/afr080
更新日期:2011-09-01 00:00:00
abstract::Previous work has shown persistent elevations in plasma cortisol concentration following upper femur fracture in elderly people. To investigate this phenomenon further, we measured plasma cortisol and adrenocorticotrophin (ACTH) and performed overnight dexamethasone suppression tests in carefully characterized patient...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/19.5.304
更新日期:1990-09-01 00:00:00
abstract:Objective:to investigate a high-intensity functional exercise (HIFE) group in hospitalised older adults. Design:assessor-blinded, randomised-controlled trial. Setting:sub-acute wards at a metropolitan rehabilitation hospital. Participants:older adults ≥65 years (n = 468) able to stand with minimum assistance or less...
journal_title:Age and ageing
pub_type: 杂志文章,随机对照试验
doi:10.1093/ageing/afw215
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To evaluate whether older patients with pyogenic liver abscess have distinctive presenting features or if their management differs from that of younger patients. DESIGN:Retrospective chart review of all cases occurring from 1982 to 1992. SETTING:A regional trauma centre and two large community hospitals. P...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/27.4.443
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:to develop a model to predict one- and three-year mortality in patients with dementia attending a hospital, through hospital admission or day/memory clinic. DESIGN:we constructed a cohort of dementia patients through data linkage of three Dutch national registers: the hospital discharge register (HDR), the p...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afaa007
更新日期:2020-04-27 00:00:00
abstract:OBJECTIVE:to review systematically the range of case definitions and methods used to measure falls in randomised controlled trials. DESIGN/METHODS:a Cochrane review of fall prevention interventions was used to identify fall definitions in published trials. Secondary searches of various databases were used to identify ...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/afi218
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:early mobilization after hip fracture (HF) is an important predictor of outcome, but knowledge of the consequences of not achieving the pre-fracture basic mobility status in acute hospital recovery is sparse. OBJECTIVE:we examined whether the regain of pre-fracture basic mobility status evaluated with the c...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afy185
更新日期:2019-03-01 00:00:00
abstract:Background:there is growing consensus around the importance of population level approaches which seek to improve public knowledge and awareness of dementia. Aim:to assess knowledge of the relationship between dementia and ageing, and of the risk and protective factors associated with it, among the general public in Ir...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afx082
更新日期:2017-09-01 00:00:00
abstract::Bone's mechanical competence and its fragility in particular depend to a certain extent on the structure and microstructure of the cortical bone compartment. Beyond bone mineral density (BMD) and bone mineral content, a variety of other features of cortical bone contribute to whole bone's resistance to fracture. Struc...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/afl081
更新日期:2006-09-01 00:00:00
abstract::Explicit criteria, such as the STOPP/START criteria, are increasingly used both in clinical practice and in research to identify potentially inappropriate prescribing in older people. In an article on the STOPP/START criteria version 2, O'Mahony et al have pointed out the advantages of developing computerised criteria...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw114
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:to examine the association of physical activity and cardio-respiratory fitness with dehydroepiandrosterone sulphate (DHEAS), insulin-like growth factor I (IGF-I) and testosterone in healthy elderly people. DESIGN:cross-sectional study. SETTING:university research department and department of geriatric medic...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/27.6.745
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Vitamin D deficiency is common in older people and may increase risk of falls and fracture. Hospital inpatients are at particular risk of falling. Previous studies suggest that vitamin D improves neuromuscular function and reduces falls. OBJECTIVE:To determine whether routine supplementation with vitamin D ...
journal_title:Age and ageing
pub_type: 杂志文章,随机对照试验
doi:10.1093/ageing/afm087
更新日期:2007-09-01 00:00:00
abstract::We evaluated the effect of impaired hearing and vision on balance in a sample of 977 elderly people residing in the community. Of the sample, 21% reported balance problems, 27% vision problems, and 30% hearing problems. The increased relative risk for balance problems was 1.7 for each 10-year age increment. Women were...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/18.1.31
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:to investigate the associations between chronic health conditions, psychosocial and environmental factors and catastrophic decline in mobility among older people. DESIGN:longitudinal cohort. SETTING:national sample living in private households. PARTICIPANTS:nine hundred and ninety-nine adults aged > or = 6...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afl004
更新日期:2006-07-01 00:00:00
abstract::A sample of 761 subjects 70 years and over was drawn from general-practice records of a rural township. Each subject was assessed and followed for 1 year to determine the incidence of and factors related to falls. The fall rate (number of falls per 100 person-years) increased from 47 for those aged 70-74 years to 121 ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/19.2.136
更新日期:1990-03-01 00:00:00
abstract:INTRODUCTION:care home residents have high healthcare needs not fully met by prevailing healthcare models. This study explored how healthcare configuration influences resource use. METHODS:a realist evaluation using qualitative and quantitative data from case studies of three UK health and social care economies select...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afx195
更新日期:2018-07-01 00:00:00
abstract::The DOMINO study compared domiciliary and hospital-based rehabilitation services for stroke patients after discharge from hospital, stratified by the hospital ward at discharge. No difference between the services had been found at 6 months, but home therapy was better than outpatient department therapy at improving ho...
journal_title:Age and ageing
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ageing/23.1.9
更新日期:1994-01-01 00:00:00
abstract::The results reported here are from a 2-year follow-up study of 58 elderly patients in a continuing-care unit. Most of these patients were in a hyperosmolar state at the time of entry (mean plasma osmolality 304 +/- 8 mOsmol/kg). The survival of those patients with the highest osmolality (greater than 308 mOsmol/kg) wa...
journal_title:Age and ageing
pub_type: 临床试验,杂志文章
doi:10.1093/ageing/19.1.68
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:residential aged care facility (RACF) resident numbers are increasing. Residents are frequently frail with substantial co-morbidity, functional and cognitive impairment with high susceptibility to acute illness. Despite living in facilities staffed by health professionals, a considerable proportion of reside...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/afu117
更新日期:2014-11-01 00:00:00
abstract:AIM:to establish age- and education-adjusted mean psychometric test scores of cognitively normal elderly Chinese people in Singapore. METHOD:155 community-living, cognitively intact elderly Chinese subjects, stratified according to age and education, were selected from the membership lists of senior citizens' clubs an...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/26.6.481
更新日期:1997-11-01 00:00:00
abstract::The change in mental and physical functioning over 5 years for 594 survivors of a community survey of the elderly is described. An increase in cognitive impairment, physical disability and incontinence over the period was found with increasing age. Women in the two oldest age groups had a significantly greater increas...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/18.2.77
更新日期:1989-03-01 00:00:00
abstract::Serological tests for syphilis were performed on 659 elderly patients admitted to hospital medical and psychiatric departments. Positive tests were found in 23 patients (3.5% of the sample), 17 women and 6 men. Six were subsequently discovered to have been treated previously for syphilis, and one other had radiologica...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/18.6.407
更新日期:1989-11-01 00:00:00