Age and the rate of induction of aryl hydrocarbon hydroxylase in isolated peripheral blood monocytes.

Abstract:

:We have measured the rate of induction of the microsomal monooxygenase enzyme aryl hydrocarbon hydroxylase (AHH) in isolated peripheral blood monocytes from young and elderly donors. There was no effect of age on rate of induction. The mechanisms underlying impaired induction of drug metabolism in elderly people remain to be clarified.

journal_name

Age Ageing

journal_title

Age and ageing

authors

George G,Wynne H,Woodhouse K

doi

10.1093/ageing/20.6.421

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

421-3

issue

6

eissn

0002-0729

issn

1468-2834

journal_volume

20

pub_type

杂志文章
  • Lymphokine production in patients with Alzheimer's disease.

    abstract::The capacity of peripheral blood mononuclear cells (PBMC) isolated from patients with Alzheimer's disease to produce interleukin-1 and -2 (IL-1, IL-2) was compared to that of cells from age-matched controls and young healthy subjects. There was no difference in the production of both interleukins between patients and ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/18.1.21

    authors: Bessler H,Sirota P,Hart J,Djaldetti M

    更新日期:1989-01-01 00:00:00

  • Hospital use, institutionalisation and mortality associated with delirium.

    abstract:BACKGROUND:Delirium is a disorder affecting consciousness, which gives rise to core clinical features and associated symptoms. Older patients are particularly prone, owing to higher rates of pre-existing cognitive impairment, frailty, co-morbidity and polypharmacy. OBJECTIVES:The aim of this study was to investigate t...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afq052

    authors: Eeles EM,Hubbard RE,White SV,O'Mahony MS,Savva GM,Bayer AJ

    更新日期:2010-07-01 00:00:00

  • Predicting catastrophic decline in mobility among older people.

    abstract:OBJECTIVE:to investigate the associations between chronic health conditions, psychosocial and environmental factors and catastrophic decline in mobility among older people. DESIGN:longitudinal cohort. SETTING:national sample living in private households. PARTICIPANTS:nine hundred and ninety-nine adults aged > or = 6...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afl004

    authors: Ayis S,Gooberman-Hill R,Bowling A,Ebrahim S

    更新日期:2006-07-01 00:00:00

  • Occupational therapy compared with social work assessment for older people. An economic evaluation alongside the CAMELOT randomised controlled trial.

    abstract:OBJECTIVES:To compare costs and outcome of occupational therapy-led assessment with social worker-led assessment of older people, in terms of their independence and quality of life. DESIGN:Cost-effectiveness analysis alongside a randomised controlled trial. The analysis took viewpoints of health services and patients....

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/afh232

    authors: Flood C,Mugford M,Stewart S,Harvey I,Poland F,Lloyd-Smith W

    更新日期:2005-01-01 00:00:00

  • Investigation of ward fidelity to a multicomponent delirium prevention intervention during a multicentre, pragmatic, cluster randomised, controlled feasibility trial.

    abstract:BACKGROUND:delirium is a frequent complication of hospital admission for older people and can be reduced by multicomponent interventions, but implementation and delivery of such interventions is challenging. OBJECTIVE:to investigate fidelity to the prevention of delirium system of care within a multicentre, pragmatic,...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa042

    authors: Smith J,Green J,Siddiqi N,Inouye SK,Collinson M,Farrin A,Young J

    更新日期:2020-07-01 00:00:00

  • Fear of falling and its association with life-space mobility of older adults: a cross-sectional analysis using data from five international sites.

    abstract:Background:fear of falling (FOF) is a major health concern among community-dwelling older adults that could restrict mobility. Objective:to examine the association of FOF with life-space mobility (i.e. the spatial area a person moves through in daily life) of community-dwelling older adults from five diverse sites. M...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afw239

    authors: Auais M,Alvarado B,Guerra R,Curcio C,Freeman EE,Ylli A,Guralnik J,Deshpande N

    更新日期:2017-05-01 00:00:00

  • Estimating total Barthel scores from just three items: the European Stroke Database 'minimum dataset' for assessing functional status at discharge from hospital.

    abstract:BACKGROUND:The European Stroke Database (ESDB) Project aims to develop a 'common clinical language' for stroke care by agreeing on terminology, definitions and clinical assessments. Each area of stroke assessment has a 'minimum dataset', which can be collected routinely and more detailed information can be added for pa...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/27.2.115

    authors: Ellul J,Watkins C,Barer D

    更新日期:1998-03-01 00:00:00

  • Effect of music-based multitask training on cognition and mood in older adults.

    abstract:BACKGROUND:in a secondary analysis of a randomised controlled trial, we investigated whether 6 months of music-based multitask training had beneficial effects on cognitive functioning and mood in older adults. METHODS:134 community-dwellers aged ≥65 years at increased risk for falling were randomly assigned to either ...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/aft163

    authors: Hars M,Herrmann FR,Gold G,Rizzoli R,Trombetti A

    更新日期:2014-03-01 00:00:00

  • Turnover of bacteriuria in old age.

    abstract::Among 352 residents of a home for the elderly, who were fully mobile and devoid of most predisposing factors for bacteriuria, 19% of men and 27% of women had two positive cultures within two months. Positive conversion at one year among men and women negative at entry was 11% and 23% respectively, negative conversion ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/11.3.169

    authors: Kasviki-Charvati P,Drolette-Kefakis B,Papanayiotou PC,Dontas AS

    更新日期:1982-08-01 00:00:00

  • What would make a definition of frailty successful?

    abstract::At present, frailty is defined variably. Some consensus on a definition is likely to emerge, but the basis for a successful definition needs to be explored. Here, a classic approach to validation is proposed: a successful definition of frailty should be multifactorial but must also manage the many factors in a way tha...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afi146

    authors: Rockwood K

    更新日期:2005-09-01 00:00:00

  • A re-validation of the Rivermead ADL scale for elderly patients with stroke.

    abstract::The Rivermead ADL scale was developed for assessing activities of daily living in stroke patients but was not validated for elderly subjects. This study was designed to validate the scale for patients aged over 64 years. A series of 150 stroke patients was assessed on the scale, of whom 103 were aged over 64 years. Th...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/19.1.19

    authors: Lincoln NB,Edmans JA

    更新日期:1990-01-01 00:00:00

  • Evidence for the validity of the Short-form 36 Questionnaire (SF-36) in an elderly population.

    abstract::The objective of this study was to determine whether the Short-form 36 Health Status Questionnaire (SF-36) is suitable for use in an elderly population. The SF-36 was administered by interview to a random sample of 827 adults from West Glamorgan. Among the 216 adults aged 65 and over the data were 98.8% complete. Evid...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.3.182

    authors: Lyons RA,Perry HM,Littlepage BN

    更新日期:1994-05-01 00:00:00

  • Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study.

    abstract:BACKGROUND:up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian a...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs150

    authors: Chalmers KA,Knuiman MW,Divitini ML,Bruce DG,Olynyk JK,Milward EA

    更新日期:2012-11-01 00:00:00

  • Safe working in a 7-day service. Experience of hip fracture care as documented by the UK National Hip Fracture Database.

    abstract:Objective:to describe differences in care and 30-day mortality of patients admitted with hip fracture on weekends (Saturday-Sunday) compared to weekdays (Monday-Friday), and their relationship to the organisation of care. Methods:data came from the National Hip Fracture Database (NHFD) linked to ONS mortality data on ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afy074

    authors: Neuburger J,Currie C,Wakeman R,Georghiou T,Boulton C,Johansen A,Tsang C,Wilson H,Cromwell DA,van der Meulen J

    更新日期:2018-09-01 00:00:00

  • A preliminary study of dietary aluminium intake and risk of Alzheimer's disease.

    abstract:BACKGROUND:epidemiological studies of Alzheimer's disease and aluminium intake have focused on aluminium in drinking water. There have been no studies investigating the relation between the disease and the consumption of foods containing large amounts of aluminium additives. OBJECTIVES:to conduct a pilot study to dete...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/28.2.205

    authors: Rogers MA,Simon DG

    更新日期:1999-03-01 00:00:00

  • Persistent pain is a risk factor for frailty: a systematic review and meta-analysis from prospective longitudinal studies.

    abstract:Background:pain is prevalent in frail older adults; however, the association of pain and frailty has not been evaluated yet by a systematic assessment of prospective longitudinal studies. Objective:we aimed to assess the association of persistent pain as a risk factor for frailty incidence, using data from longitudina...

    journal_title:Age and ageing

    pub_type: 杂志文章,meta分析

    doi:10.1093/ageing/afy104

    authors: Saraiva MD,Suzuki GS,Lin SM,de Andrade DC,Jacob-Filho W,Suemoto CK

    更新日期:2018-11-01 00:00:00

  • Improving the recording of the clinical assessment of stroke patients using a clerking pro forma.

    abstract::In this study we examine whether the introduction of a clerking pro forma improves the completeness of the recording of the management of stroke patients and we review methodological issues important in this type of audit. We prospectively identified 244 consecutive stroke patients before and after the introduction of...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/24.1.43

    authors: Davenport RJ,Dennis MS,Warlow CP

    更新日期:1995-01-01 00:00:00

  • Effects of a physiotherapist-led stroke training programme for nurses.

    abstract:AIM:to assess the effects of a physiotherapist-led stroke training programme for nurses working in a rehabilitation ward on clinical practice and patient outcome. METHOD:before and after group comparison with outcome assessment by observational and quantitative methods. Non-participant observation before and after the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/28.6.567

    authors: Forster A,Dowswell G,Young J,Sheard J,Wright P,Bagley P

    更新日期:1999-10-01 00:00:00

  • Resting energy expenditure in relation to energy intake in patients with Alzheimer's disease, multi-infarct dementia and in control women.

    abstract::Energy intake and resting energy expenditure in relation to body composition were studied in female patients with Alzheimer's disease, multi-infarct dementia and in home-living non-demented elderly women. Patients with Alzheimer's disease tended to have lower body weight and higher energy intake (p = NS) than control ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/22.2.132

    authors: Niskanen L,Piirainen M,Koljonen M,Uusitupa M

    更新日期:1993-03-01 00:00:00

  • Trends in hip fracture incidence and mortality in Chinese population from Hong Kong 2001-09.

    abstract:BACKGROUND:there is a suggestion that while the age-adjusted incidence of hip fracture in the West may be declining, the incidence may be rising in Asia. OBJECTIVE:this study examines the incidence and post-fracture mortality from 2001 to 2009 among the population aged 65 years and over. METHODS:hip fracture incidenc...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs177

    authors: Chau PH,Wong M,Lee A,Ling M,Woo J

    更新日期:2013-03-01 00:00:00

  • Home from home: residents' opinions of nursing homes and long-stay wards.

    abstract:OBJECTIVE:To compare the levels of satisfaction expressed by residents of nursing homes with those of patients in geriatric long-stay wards. DESIGN:A structured satisfaction questionnaire containing 37 closed and two open questions was used to elicit responses from residents of nursing homes in the former South West T...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/27.2.199

    authors: Higgs PF,MacDonald LD,MacDonald JS,Ward MC

    更新日期:1998-03-01 00:00:00

  • How empowering is hospital care for older people with advanced disease? Barriers and facilitators from a cross-national ethnography in England, Ireland and the USA.

    abstract:Background:patient empowerment, through which patients become self-determining agents with some control over their health and healthcare, is a common theme across health policies globally. Most care for older people is in the acute setting, but there is little evidence to inform the delivery of empowering hospital care...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afw193

    authors: Selman LE,Daveson BA,Smith M,Johnston B,Ryan K,Morrison RS,Pannell C,McQuillan R,de Wolf-Linder S,Pantilat SZ,Klass L,Meier D,Normand C,Higginson IJ

    更新日期:2017-03-01 00:00:00

  • Use of antipsychotics among nonagenarian residents in long-term institutional care in Finland.

    abstract:BACKGROUND:There is a paucity of information about the use of antipsychotic medication in long-term care, especially among the oldest-old residents. OBJECTIVE:To analyse the factors associated with the use of antipsychotic medication among nonagenarian residents in long-term institutional care. DESIGN:A retrospective...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afl065

    authors: Alanen HM,Finne-Soveri H,Noro A,Leinonen E

    更新日期:2006-09-01 00:00:00

  • Older people in accident and emergency departments.

    abstract::Older people attend accident and emergency departments more frequently than younger people. However, most assessments indicate that this higher level of use is appropriate and is the result of more serious injury and illness among this population. Older patients discharged from accident and emergency departments are f...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/30.suppl_3.3

    authors: Burns E

    更新日期:2001-08-01 00:00:00

  • Faecal incontinence in residential homes for the elderly: prevalence, aetiology and management.

    abstract::Faecal incontinence occurring at least once weekly was found in 10.3% of residents in 30 residential homes for the elderly. Fifty-two randomly-selected incontinent residents were prescribed treatment and the outcome was compared with 30 incontinent residents acting as controls. The vast majority of all incontinent res...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章

    doi:10.1093/ageing/15.1.41

    authors: Tobin GW,Brocklehurst JC

    更新日期:1986-01-01 00:00:00

  • Duodenal ulcer disease in the elderly: a retrospective study.

    abstract::A retrospective study was performed of 163 patients aged 65 years and over with a diagnosis of duodenal ulceration admitted to one Health District over a period of six years. Eighty per cent of the patients were admitted with acute complications, 50% bled and 30% were perforated. A large proportion of these patients w...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/14.4.225

    authors: Watson RJ,Hooper TL,Ingram G

    更新日期:1985-07-01 00:00:00

  • Priorities for the professional development of registered nurses in nursing homes: a Delphi study.

    abstract:Objective:To establish a consensus on the care and professional development needs of registered nurses (RNs) employed by UK care homes. Design:Two-stage, online modified Delphi study. Setting and Participants:A panel (n = 352) of individuals with experience, expertise or interest in care home nursing: (i) care home n...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw160

    authors: Cooper E,Spilsbury K,McCaughan D,Thompson C,Butterworth T,Hanratty B

    更新日期:2017-01-08 00:00:00

  • Rectus sheath haematoma in elderly patients: a diagnostic challenge.

    abstract:CASE REPORTS:We report three cases of rectus sheath haematoma in elderly women. This condition is commonly misdiagnosed at any age but is an even more elusive diagnosis in elderly patients. CONCLUSION:It is important to consider rectus sheath haematoma in older patients with an abdominal or pelvic mass or spontaneous ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/27.4.512

    authors: Bene J,Lassman D,Solomon SA

    更新日期:1998-07-01 00:00:00

  • The effect of white matter low attenuation on cognitive performance in dementia of the Alzheimer type.

    abstract::The effect of leukoaraiosis or white matter low attenuation (WMLA) on cognitive function is not fully understood. We compared the neuropsychological performance of 37 Alzheimer's disease patients with WMLA on CT brain scans with a similar group of 31 Alzheimer's disease patients with no evidence of white matter lesion...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/25.6.443

    authors: Amar K,Bucks RS,Lewis T,Scott M,Wilcock GK

    更新日期:1996-11-01 00:00:00

  • Upper gastro-intestinal endoscopy for Chinese elderly in an acute geriatric unit: a review.

    abstract::From December 1982 to August 1983, a total of 242 oesophago-gastro-duodenoscopies were performed for 208 elderly patients in the Geriatric Unit, Princess Margaret Hospital, Hong Kong. These were done as part of an investigatory procedure in the Geriatric Unit, the first of its kind in Hong Kong. In the 9-month survey,...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/13.5.285

    authors: Lee YC,Tam HC

    更新日期:1984-09-01 00:00:00