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Dietary iron intake and risk of non-fatal acute myocardial infarction.

Abstract：

OBJECTIVE:The relation between several measures of body iron and atherosclerotic disease, particularly acute myocardial infarction (AMI), is debated. This is of specific interest since iron is frequently included in supplementation and fortification of foods. We assessed the relation between dietary iron intake and the risk of non-fatal AMI. DESIGN:Case-control study. The information was collected by interviewers using a food-frequency questionnaire tested for validity and reproducibility. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were obtained by multiple unconditional logistic regression models, including terms for energy and alcohol intake, as well as for sociodemographic factors, tobacco and other major recognised risk factors for AMI. SETTING:Milan, Italy, between 1995 and 1999. SUBJECTS:Cases were 507 patients, below age 79 years, with a first episode of non-fatal AMI, and controls were 478 patients admitted to hospital for a wide spectrum of acute conditions unrelated to known or potential AMI risk factors. RESULTS:Compared with patients in the lowest tertile of total iron intake, the OR was 0.48 (95% CI 0.29-0.82) for those in the highest tertile. The corresponding value for haem iron was 0.71 (95% CI 0.48-1.06), for non-haem, non-alcohol iron was 0.80 (95% CI 0.51-1.24) and for iron derived from alcoholic beverages was 0.60 (95% CI 0.40-0.90). Sex-specific OR for total iron intake were not heterogeneous. CONCLUSIONS:In this Italian population dietary iron intake was inversely related to AMI risk. This inverse association may depend on other nutrients present in the major sources of iron in the Italian diet.

journal_name

Public Health Nutr

journal_title

Public health nutrition

authors

Tavani A,Gallus S,Bosetti C,Parpinel M,Negri E,La Vecchia C

doi

10.1079/phn2005869

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

480-4

issue

4

eissn

1368-9800

issn

1475-2727

pii

S1368980006000814

journal_volume

9

pub_type

杂志文章

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