Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study.


:Radiation-induced xerostomia can result in the rapid onset and progression of dental caries in head and neck cancer patients. Topically applied fluorides have been successfully used to inhibit the formation of dental caries in this population. However, because intensive daily self-application is required, compliance is an issue. The intraoral fluoride-releasing system (IFRS) containing a sodium fluoride core is a newly developed, sustained-release, passive drug delivery system that does not require patient involvement except for periodic replacement, thus reducing the effect of patient compliance on its effectiveness in dental caries prevention. Twenty-two head and neck cancer patients from U. T. M. D. Anderson Cancer Center, with radiation-induced xerostomia, were entered into a pilot study to contrast the daily home use of a 0.4% stannous fluoride-gel-containing tray (control group) to IFRS (study group) with respect to tolerability and adherence, and to obtain information on relative caries preventive efficacy. Participants were stratified on the basis of radiation exposure and randomly assigned to treatment with either IFRS or stannous fluoride gel. Patients in both groups were fitted with two IFRS retainers and also were instructed to use a 1100-ppm fluoride conventional sodium fluoride dentifrice twice daily. The study was conducted as a single-blinded, parallel-cell trial. Pre-existing carious lesions were restored prior to the beginning of the study. The efficacy variable was determined by the mean number of new or recurrent decayed surfaces. Patients were examined for caries 4, 8, 12, 24, 36, and 48 weeks after initiation of treatment. Reports of adverse reactions were based on information volunteered by patients and that were elicited during interviews. At baseline, the resting and stimulated salivary flow rates (g/5min) were significantly greater in the control group than in the study group (p<0.05). Patients in the control group had received significantly more radiation than those in the test group (68Gy vs. 60Gy; p=0.047). No marked differences in follow-up new and recurrent caries were found between the stannous fluoride gel control and IFRS groups during the study period. The rate of new or recurrent carious lesions in the group treated with the fluoride gel was slightly lower than in the IFRS group, based on carious lesions at the baseline examination (Poisson mean number of new or recurrent carious lesions for the control group=0.55 per year vs. 0.83 per year for the study group, p=0.705; odds ratio of the occurrence of any new or recurrent caries during follow-up for control group vs. the study group=0.80; p=0.781). This pilot study revealed that the IFRS was well-tolerated and safe in this study population associated with minimal complications during the duration of this study and was comparable in efficacy to a SnF(2) gel in preventing caries development. The IFRS provided similar rates of control for caries formation to a fluoride-gel-containing tray. The IFRS is designed to release a daily dose of 0.12mg of sodium fluoride, which can be evenly distributed throughout the oral cavity for a single application of 4 months. It would be more convenient than the daily home application of a tray of 0.4% stannous fluoride or 1.1% sodium fluoride gel, and avoids the problem of variable patient compliance.


Oral Oncol


Oral oncology


Chambers MS,Mellberg JR,Keene HJ,Bouwsma OJ,Garden AS,Sipos T,Fleming TJ




Has Abstract


2006-10-01 00:00:00














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    abstract::The epidemiological link between human papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied. The expression of p53 protein was evaluated by immunohistochemical analysis. The presence of HPV DNA was evaluated by polymerase chain reaction amplification and "in situ" hybridizati...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Cabanillas R,Rodrigo JP,Ferlito A,Rinaldo A,Fresno MF,Aguilar C,Alvarez ME,Suárez C

    更新日期:2007-04-01 00:00:00

  • Tumor necrosis factor α induces myofibroblast differentiation in human tongue cancer and promotes invasiveness and angiogenesis via secretion of stromal cell-derived factor-1.

    abstract:OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Zhou B,Zhuang XM,Wang YY,Lin ZY,Zhang DM,Fan S,Li JS,Chen WL

    更新日期:2015-12-01 00:00:00

  • Socio-economic factors and stage at presentation of head and neck cancer patients in Ottawa, Canada: a logistic regression analysis.

    abstract::To determine if socio-economic status (SES) affects the stage at presentation of head and neck cancer (HNC) patients in Ottawa, Canada. To determine if the method of diagnosis affects the stage at presentation in these patients. We obtained data on SES, method of diagnosis, and stage at presentation for patients prese...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Johnson S,Corsten MJ,McDonald JT,Chun J

    更新日期:2010-05-01 00:00:00

  • Do we need a different staging system for tongue and gingivobuccal complex squamous cell cancers?

    abstract:OBJECTIVES:To determine the need for a separate staging system for gingivobuccal complex squamous cell cancers (GBCSCC) based on 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) data from one institution. PATIENTS AND METHODS:An Institutional Review Board (IRB)-approved...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Gupta P,Migliacci JC,Montero PH,Zanoni DK,Shah JP,Patel SG,Ganly I

    更新日期:2018-03-01 00:00:00

  • Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: potential to guide treatment? A systematic review.

    abstract::Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Bernstein JM,Homer JJ,West CM

    更新日期:2014-10-01 00:00:00

  • Cellular factors may enable squamous carcinoma cells to overcome TGF beta-mediated repression of CDK2 activity.

    abstract::Cell lines developed from head and neck squamous cell carcinomas exhibit variable responses to the negative regulatory effects of transforming growth factor beta (TGF beta) on cell growth. To analyse the effects of TGF beta on regulators of cell cycle progression, we characterised cell lines derived from head and neck...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lesaca EE,Ensley JF,Yeudall WA

    更新日期:1998-01-01 00:00:00

  • Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis.

    abstract:BACKGROUND:The use of transoral robotic surgery (TORS) and laser microsurgery (TLM) in the diagnosis and identification of the site of the unknown primary has become increasingly common. This systematic review and meta-analysis aims to assess the use and efficacy of TORS and TLM for this indication. METHOD:Systematic ...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析


    authors: Farooq S,Khandavilli S,Dretzke J,Moore D,Nankivell PC,Sharma N,Almeida JR,Winter SC,Simon C,Paleri V,De M,Siddiq S,Holsinger C,Ferris RL,Mehanna H

    更新日期:2019-04-01 00:00:00

  • Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells.

    abstract::The present study sought to determine the potential role of stress activated MAPK and phosphatidylinositol 3-kinase (PI3K) signaling pathways in mediating phenotypic switching between angiogenic and angiostatic elements among squamous cell carcinoma (SCC) cell lines. In particular, we investigated the effects of hypox...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Stewart J,Siavash H,Hebert C,Norris K,Nikitakis NG,Sauk JJ

    更新日期:2003-12-01 00:00:00

  • Exfoliative cytology of normal buccal mucosa to predict the relative risk of cancer in the upper aerodigestive tract using the MN-assay.

    abstract::The high frequency of second or third primary tumors was first explained by Slaughter et al. with the concept of field cancerisation. Another theory postulates micrometastatic lesions as a reason for this phenomenon. The micronuclei (MN)-assay was evaluated to provide evidence for the concept of field cancerisation an...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Bloching M,Hofmann A,Lautenschläger C,Berghaus A,Grummt T

    更新日期:2000-11-01 00:00:00

  • Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder?

    abstract::Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ficarra G,Prignano F,Romagnoli P

    更新日期:1997-09-01 00:00:00

  • HCV infection and the risk of head and neck cancer: A meta-analysis.

    abstract::Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection ...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Borsetto D,Fussey J,Fabris L,Bandolin L,Gaudioso P,Phillips V,Polesel J,Boscolo-Rizzo P

    更新日期:2020-06-26 00:00:00

  • Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.

    abstract::To understand the role of 70 kDa heat shock protein (HSP70) in the pathogenesis of oral cancer, its expression was studied in human normal, premalignant and malignant oral mucosa. Cell surface expression of HSP70 was assessed in oral tissue specimens by flow cytometric analysis using a mouse monoclonal antibody agains...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kaur J,Das SN,Srivastava A,Ralhan R

    更新日期:1998-03-01 00:00:00

  • Tubulopapillary hidradenoma-like tumor of the mandible: Two case reports of an underrecognized entity.

    abstract::Tubulopapillary hidradenoma-like tumor of the mandible is extremely rare, with only 3 cases published in the English-language literature. The clinicopathological characteristics and histogenesis of this tumor are unclear. Few pathologists and perhaps fewer clinicians are familiar with this entity, and it is likely und...

    journal_title:Oral oncology

    pub_type: 信件


    authors: Zeng M,Guo X,Chen X,Yang S

    更新日期:2020-01-01 00:00:00

  • Hypoxia modulates CCR7 expression in head and neck cancers.

    abstract:BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Basheer HA,Pakanavicius E,Cooper PA,Shnyder SD,Martin L,Hunter KD,Vinader V,Afarinkia K

    更新日期:2018-05-01 00:00:00

  • Numerical aberrations of chromosomes 8, 9, 11, and 17 in squamous cell carcinoma of the pharynx and larynx: a fluorescence in situ hybridization and DNA flow cytometric analysis of 50 cases.

    abstract::Squamous cell carcinoma of the pharynx and larynx (SCCPL) is a genetically complex disease and is frequently associated with nonrandom chromosomal alterations. Fifty primary SCC of the pharynx (oropharynx, n=11): see and hypopharynx, n=11) and larynx ( n=28) were examined for numerical aberrations of chromosomes 8, 9,...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Hardisson D,Alvarez-Marcos C,Salas-Bustamante A,Alonso-Guervós M,Sastre N,Sampedro A

    更新日期:2004-04-01 00:00:00

  • Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.

    abstract:OBJECTIVE:Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and charac...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kujiraoka S,Tsunematsu T,Sato Y,Yoshida M,Ishikawa A,Tohyama R,Tanaka M,Kobayashi Y,Kondo T,Ushio A,Otsuka K,Kurosawa M,Saito M,Yamada A,Arakaki R,Nagai H,Nikai H,Takeuchi K,Nagao T,Miyamoto Y,Ishimaru N,Kudo Y

    更新日期:2017-06-01 00:00:00

  • Safety of boneless reconstruction of the mandible with a CAD/CAM designed titanium device: The replica cohort study.

    abstract:OBJECTIVE:We evaluated the safety of REPLICA, a CAD/CAM-designed patient-specific titanium mandible, in patients with mandibular defects not suitable for reconstruction with traditional techniques. PATIENTS AND METHODS:We performed a cohort study with a composite primary outcome assigned at the end of a 1-year follow-...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Bedogni A,Bettini G,Bedogni G,Menapace G,Sandi A,Michelon F,Di Carlo R,Franco P,Saia G

    更新日期:2021-01-01 00:00:00

  • Prognostic value of DNA ploidy status in patients with oral leukoplakia.

    abstract::Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia. A cohort of 62 leukoplakia patients was studied and their biops...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Bremmer JF,Brakenhoff RH,Broeckaert MA,Beliën JA,Leemans CR,Bloemena E,van der Waal I,Braakhuis BJ

    更新日期:2011-10-01 00:00:00

  • Odontogenic carcinosarcoma: A systematic review.

    abstract::The aim of this study was to integrate the available data published on odontogenic carcinosarcoma into a comprehensive analysis of their features, treatment and recurrence. An electronic search with no publication date or language restriction was undertaken in March 2018 in the following databases: Medline Ovid, PubMe...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Schuch LF,de Arruda JAA,Silva LVO,Abreu LG,Silva TA,Mesquita RA

    更新日期:2018-10-01 00:00:00

  • Predictive factors for distant metastasis from oral and oropharyngeal squamous cell carcinoma.

    abstract::The presence of distant metastasis after the initial treatment of head and neck squamous cell carcinoma is not considered a common event and is associated with a poor outcome. The objective of this study was to investigate the prevalence and risk factors associated with the diagnosis of distant metastasis in oral and ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kowalski LP,Carvalho AL,Martins Priante AV,Magrin J

    更新日期:2005-05-01 00:00:00

  • Imaging of oral cavity cancer.

    abstract::Despite many advances in surgical techniques, technology, radiation therapy, and chemotherapy, survival rates for head and neck cancer (HNCa) have not improved significantly in decades, with many patients being diagnosed at advanced disease stages. Adequate assessment of oral cavity malignancies is critical for approp...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Rumboldt Z,Day TA,Michel M

    更新日期:2006-10-01 00:00:00

  • Complex midfacial defects: Is the extended Abbé flap the ideal solution to a tough problem?

    abstract:OBJECTIVES:The aim of this study was to investigate the role of the extended Abbé flap in the reconstruction of complex midfacial defects (upper lip, nasal base and medial cheek). We describe our personal experience with this method and present some interesting aspects from the relevant literature. MATERIALS AND METHO...

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    pub_type: 信件,多中心研究


    authors: Mantsopoulos K,Iro H,Constantinidis J

    更新日期:2020-01-01 00:00:00

  • Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells.

    abstract::Apicidin acts as a potent histone deacetylases (HDAC) inhibitor and the precise mechanism for its anti-tumor activity in human oral squamous cell carcinoma (OSCC) cells has not been examined. The aim of this study was to evaluate the anti-tumor efficacy of apicidin through apoptosis and autophagy in OSCC cells. Cells ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ahn MY,Ahn SG,Yoon JH

    更新日期:2011-11-01 00:00:00

  • Staging and prognosis in head and neck cancer.

    abstract::Head and neck malignant tumors are classified according to the TNM staging system. The TNM system is a universally accepted, widely used, staging method. Its goals are to help clinicians and researchers to choose from treatment options, to give patients an estimate of their prognosis and to compare results of treatmen...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: van der Schroeff MP,Baatenburg de Jong RJ

    更新日期:2009-04-01 00:00:00

  • Periodontitis and oral Cancer-A striking link.

    abstract::Oral squamous cell carcinoma (OSCC) has become a major public health problem in the worldwide for its increasing incidence and mortality, especially in younger trends. Risk factors for OSCC apart from alcohol and tobacco use, include poor oral hygiene, inflammation caused by inadequately fitting dentures and other rou...

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    pub_type: 信件


    authors: Karmakar S,Kar A,Thakur S,Rao VUS

    更新日期:2020-07-01 00:00:00

  • Elective neck dissection for salvage laryngectomy: A systematic review and meta-analysis.

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    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析


    authors: Lin C,Puram SV,Bulbul MG,Sethi RK,Rocco JW,Old MO,Kang SY

    更新日期:2019-09-01 00:00:00

  • Quantitative proteomic analysis of microdissected oral epithelium for cancer biomarker discovery.

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    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Xiao H,Langerman A,Zhang Y,Khalid O,Hu S,Cao CX,Lingen MW,Wong DTW

    更新日期:2015-11-01 00:00:00

  • Computed tomography evaluation after induction chemotherapy for T3 laryngeal cancer: Does response correlate with vocal cord mobility?

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    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Garcia GCTE,Gorphe P,Hartl D,Ammari S,Even C,Tao Y,Balleyguier C,Varoquaux A,Bidault F

    更新日期:2019-03-01 00:00:00

  • Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment.

    abstract:BACKGROUND:The 2017 National Comprehensive Cancer Network Clinical Practice Guidelines recommend surgical resection or definitive radiation therapy for early-stage oral cavity malignancies, and surgical resection or multimodality clinical trials for late-stage disease. Few studies have been conducted to identify predic...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Fujiwara RJT,Burtness B,Husain ZA,Judson BL,Bhatia A,Sasaki CT,Yarbrough WG,Mehra S

    更新日期:2017-08-01 00:00:00

  • miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis.

    abstract::MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSC...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lin SC,Liu CJ,Lin JA,Chiang WF,Hung PS,Chang KW

    更新日期:2010-03-01 00:00:00