Abstract:
:Heparin-induced thrombocytopenia requires immediate alternative anticoagulation to prevent or treat thromboembolic complications. Argatroban was approved based on multiple-center studies from the 1990s, but subsequent changes in prevailing awareness, diagnostic testing and therapeutic strategies for heparin-induced thrombocytopenia might affect results of argatroban therapy. Charts were retrospectively reviewed from patients administered argatroban for suspected heparin-induced thrombocytopenia over 22 months at a single large university hospital. Twenty-seven patients, most in intensive care units, received a median 0.5 microg/kg/min argatroban over a median 5.5 days. Patients had isolated heparin-induced thrombocytopenia (n = 10), had heparin-induced thrombocytopenia with thrombosis (n = 9), or lacked active heparin-induced thrombocytopenia (n = 8) on final analysis. New thromboses (14.8%), progression of preexisting thromboses (0%), amputation secondary to heparin-induced thrombocytopenia (0%), death (22.2%), bleeding requiring transfusion (3.7%), and any bleeding (22.2%) compared favorably with older multiple-center reports. Deaths occurred mainly with preexisting multiple-organ failure. In contemporary "real world" use, argatroban provides safe and effective anticoagulation, strengthening the mandate to initiate alternative anticoagulation whenever heparin-induced thrombocytopenia appears likely.
journal_name
J Intensive Care Medjournal_title
Journal of intensive care medicineauthors
Kodityal S,Nguyen PH,Kodityal A,Sherer J,Hursting MJ,Rice Ldoi
10.1177/0885066605284590subject
Has Abstractpub_date
2006-03-01 00:00:00pages
86-92issue
2eissn
0885-0666issn
1525-1489pii
21/2/86journal_volume
21pub_type
杂志文章abstract::Objectives: Standard management strategies for lowering intracranial pressure (ICP) in traumatic brain injury has been well-studied, but the use of lesser known interventions for ICP in subarachnoid hemorrhage (SAH) remains elusive. Searches were performed in PubMed and EBSCO Host to identify best available evidence f...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066618813073
更新日期:2020-03-01 00:00:00
abstract::We describe the case of a patient with hemolysis-associated Clostridium perfringens septicemia and review all similar cases published in the literature since 1990, with specific focus on the relationship between treatment strategy and survival. We searched PubMed for all published cases of C. perfringens-associated he...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066613498043
更新日期:2014-11-01 00:00:00
abstract::Hospital-acquired infections (HAIs) are common in intensive care unit (ICU) patients and are associated with increased morbidity and mortality. There has been an increasing effort to prevent HAIs, and infection control practices are paramount in avoiding these complications. In the last several years, numerous develop...
journal_title:Journal of intensive care medicine
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更新日期:2014-11-01 00:00:00
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journal_title:Journal of intensive care medicine
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doi:10.1177/0885066619866172
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:Conflicting data exists on the pharmacologic management of intensive care unit (ICU) delirium. This review appraises the current evidence of pharmacologic management of ICU delirium. MATERIALS AND METHODS:A systematic literature search of MEDLINE and Embase was conducted to answer the population, intervention,...
journal_title:Journal of intensive care medicine
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doi:10.1177/0885066618805965
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abstract:PURPOSE:Etomidate causes adrenal insufficiency. Yet in critically ill patients, it is controversial whether it increases mortality rates above that of comparator anesthetic induction agents. We postulated that etomidate would increase relative mortality rates correspondingly to the severity of illness as defined by SAP...
journal_title:Journal of intensive care medicine
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更新日期:2020-09-10 00:00:00
abstract:PURPOSE:The strategy used to improve effective checklist use in intensive care unit (ICU) setting is essential for checklist success. This study aimed to test the hypothesis that an electronic checklist could reduce ICU provider workload, errors, and time to checklist completion, as compared to a paper checklist. METH...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066614558015
更新日期:2016-03-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066610387996
更新日期:2011-05-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2004-03-01 00:00:00
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更新日期:2020-10-29 00:00:00
abstract:AIMS:To investigate the occurrence and etiology of fever at anytime during pediatric intensive care unit (PICU) admission, and to study its possible effects on clinical outcome in a heterogeneous population of critically ill children. METHODS:Retrospective, observational single center study, comprising 202 patients ag...
journal_title:Journal of intensive care medicine
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doi:10.1177/0885066609340631
更新日期:2009-09-01 00:00:00
abstract::Video laryngoscopy has demonstrated utility in airway management. For the present case series, we report the use of video laryngoscopy to evaluate the airway of critically ill, mechanically ventilated patients, as a means to reduce the risk of immediate postextubation stridor by assessing the degree of laryngeal edema...
journal_title:Journal of intensive care medicine
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doi:10.1177/0885066612437528
更新日期:2013-01-01 00:00:00
abstract::The whole-brain criterion of death provides that a person who has irreversibly lost all clinical functions of the brain is dead. Bedside brain death (BD) tests permit physicians to determine BD by showing that the whole-brain criterion of death has been fulfilled. In a nonsystematic literature review, we identified an...
journal_title:Journal of intensive care medicine
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更新日期:2020-08-01 00:00:00
abstract::Controlled donation after circulatory determination of death (cDCDD) concerns donation after withdrawal of life-sustaining therapy (W-LST). We examine the ethical issues raised by W-LST in the cDCDD context in the light of a review of cDCDD protocols and the ethical literature. Our analysis confirms that W-LST procedu...
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066618803062
更新日期:2020-10-01 00:00:00
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journal_title:Journal of intensive care medicine
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doi:10.1177/0885066606287039
更新日期:2006-05-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/088506669501000202
更新日期:1995-03-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2009-11-01 00:00:00
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更新日期:1991-03-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,meta分析
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更新日期:2019-08-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2015-05-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2020-10-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
abstract::Diabetes mellitus (DM) represents an enormous health care concern for the United States and other countries. According to the American Diabetes Association in 2007, there were more than 23 million Americans living with diabetes. This is a 13.5% increase from 2005, likely representing increases in Type II DM (DMII). Di...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2010-11-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00