Management of aminoglycosides in the intensive care unit.

Abstract:

:Antibacterial resistance is increasing throughout the world, while the development of new agents is slowly progressing. In addition, the increasing prevalence of fluoroquinolone resistance may force many practitioners to choose an aminoglycoside agent in gram-negative regimens. Aminoglycosides are bactericidal agents with potent activity against gram-negative infections and activity against gram-positive infections when added to a cell wall active antimicrobial-based regimen. These agents may be dosed multiple times a day or consolidated as high-dose, extended-interval dosing to maximize pharmacokinetic and pharmacodynamic properties to achieve possible improved efficacy with reduced toxicity. Clinical application includes the treatment of bacteremia, endocarditis, health-care and nosocomial pneumonias, intra-abdominal infections, and others. Nephrotoxicity and ototoxicity are potential risks of aminoglycoside therapy that may be minimized with serum monitoring and short courses of therapy.

journal_name

J Intensive Care Med

authors

Radigan EA,Gilchrist NA,Miller MA

doi

10.1177/0885066610377968

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

327-42

issue

6

eissn

0885-0666

issn

1525-1489

pii

0885066610377968

journal_volume

25

pub_type

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