Abstract:
:Antibacterial resistance is increasing throughout the world, while the development of new agents is slowly progressing. In addition, the increasing prevalence of fluoroquinolone resistance may force many practitioners to choose an aminoglycoside agent in gram-negative regimens. Aminoglycosides are bactericidal agents with potent activity against gram-negative infections and activity against gram-positive infections when added to a cell wall active antimicrobial-based regimen. These agents may be dosed multiple times a day or consolidated as high-dose, extended-interval dosing to maximize pharmacokinetic and pharmacodynamic properties to achieve possible improved efficacy with reduced toxicity. Clinical application includes the treatment of bacteremia, endocarditis, health-care and nosocomial pneumonias, intra-abdominal infections, and others. Nephrotoxicity and ototoxicity are potential risks of aminoglycoside therapy that may be minimized with serum monitoring and short courses of therapy.
journal_name
J Intensive Care Medjournal_title
Journal of intensive care medicineauthors
Radigan EA,Gilchrist NA,Miller MAdoi
10.1177/0885066610377968subject
Has Abstractpub_date
2010-11-01 00:00:00pages
327-42issue
6eissn
0885-0666issn
1525-1489pii
0885066610377968journal_volume
25pub_type
杂志文章abstract::The role of percutaneous transluminal coronary angioplasty (PTCA) in the management of acute myocardial infarction (AMI) has not yet been precisely defined. The longest experience with PTCA in this setting has been in patients who are not candidates for thrombolytic therapy and in patients in whom thrombolysis has fai...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/088506669501000402
更新日期:1995-07-01 00:00:00
abstract:UNLABELLED:While clinicians' management of severe sepsis and septic shock has been positively influenced by a number of clinical research studies in the last decade, challenges remain regarding early hemodynamic optimization as envisioned in the Surviving Sepsis Campaign's (SSC) resuscitation bundle (RB). We examined t...
journal_title:Journal of intensive care medicine
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doi:10.1177/0885066610392499
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Consensus guidelines support the use of low-molecular-weight heparin for venous thromboembolism (VTE) prophylaxis in high-risk trauma patients but do not recommend a specific regimen. The current study compared the effectiveness and safety of enoxaparin 40 mg once-daily versus enoxaparin 30 mg twice-daily fo...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066610384462
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:The Surviving Sepsis Campaign guidelines recommend early goal-directed therapy (EGDT) for the resuscitation of patients with sepsis; however, the recent evidences quickly evolve and convey conflicting results. We performed a meta-analysis to evaluate the effect of EGDT on mortality in adults with severe se...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,meta分析
doi:10.1177/0885066616671710
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:Reintubation following unplanned extubation (UE) is often required and associated with increased morbidity; however, knowledge of risk factors leading to reintubation and subsequent outcomes in children is still lacking. We sought to determine the incidence, risk factors, and outcomes related to reintubation af...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066616675130
更新日期:2018-08-01 00:00:00
abstract::Sepsis is a major cause of morbidity and mortality worldwide. With the advance of medical care, the mortality of sepsis has decreased in the past decades. Many treatments and diagnostic tools still lack supporting evidence. We conducted a retrospective population-based cohort study with propensity score matched subcoh...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066619827270
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To determine whether non-invasive ventilation (NIV) can avoid the need for tracheal intubation and/or reduce the duration of invasive ventilation (IMV) in previously intubated patients admitted to the pediatric intensive care unit (PICU) and developing acute hypoxemic respiratory failure (AHRF) after major tr...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066620983744
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Use of checklists brings about improvements in a variety of patient outcomes. Nevertheless, whether compliance with a nurse-led intensive care unit (ICU) checklist produces the same effect is currently unknown. METHODS:This is a retrospective analysis of data obtained during the implementation of a quality ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066614533910
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Morbidity associated with stress ulcer-related bleeding, the cost of medications, and the possible complications associated with stress ulcer prophylaxis are important considerations when prescribing prophylaxis. We prospectively studied the prescription patterns for stress ulcer prophylaxis in patients admi...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,多中心研究
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更新日期:2014-03-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066618762747
更新日期:2018-12-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066618796486
更新日期:2019-11-01 00:00:00
abstract:RATIONALE:The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown. OBJECTIVES:To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis. METHODS:In a single-center phas...
journal_title:Journal of intensive care medicine
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doi:10.1177/0885066618823183
更新日期:2020-12-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066613507530
更新日期:2015-07-01 00:00:00
abstract::This was a retrospective observational study in a pediatric intensive care unit, in which 19 patients received levosimendan. There were no adverse events attributable to levosimendan and no instances where the clinical condition worsened after administration. Arterial lactate levels decreased significantly following l...
journal_title:Journal of intensive care medicine
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doi:10.1177/0885066606287039
更新日期:2006-05-01 00:00:00
abstract::Patients undergoing surgery for pituitary tumors represent a heterogeneous population each with unique clinical, biochemical, radiologic, pathologic, neurologic, and/or ophthalmologic considerations. The postoperative management of patients following pituitary surgery often occurs in the context of a dynamic state of ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066605275247
更新日期:2005-05-01 00:00:00
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journal_title:Journal of intensive care medicine
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doi:10.1177/0885066620917630
更新日期:2020-04-13 00:00:00
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journal_title:Journal of intensive care medicine
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doi:10.1177/0885066608329946
更新日期:2009-03-01 00:00:00
abstract::Extracorporeal membrane oxygenation (ECMO) comprises a commonly used method of extracorporeal life support. It has proven efficacy and is an accepted modality of care for isolated respiratory or cardiopulmonary failure in neonatal and pediatric populations. In adults, there are conflicting studies regarding its benefi...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066610384061
更新日期:2011-01-01 00:00:00
abstract::Thyroid storm, an endocrine emergency first described in 1926, remains a diagnostic and therapeutic challenge. No laboratory abnormalities are specific to thyroid storm, and the available scoring system is based on the clinical criteria. The exact mechanisms underlying the development of thyroid storm from uncomplicat...
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更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To characterize physicians' stated practices in the treatment of patients with severe acute alcohol withdrawal syndrome (sAAWS) and to use intravenous (IV) phenobarbital as an adjuvant treatment for sAAWS. METHODS:A multidisciplinary, cross-sectional, self-administered survey at 2 large academic centers specia...
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更新日期:2020-11-01 00:00:00
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更新日期:2016-03-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2003-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066614566794
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:We report the case of a 28-year-old patient with systemic lupus erythematosus (SLE) with rapid onset of dyspnea and hemoptysis found to have diffuse alveolar hemorrhage (DAH) with refractory hypoxemia successfully treated with venovenous extracorporeal membrane oxygenation (ECMO). The discussion includes cli...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Diagnosing acute kidney injury (AKI) stage 3 in critically ill patients may help physicians in making treatment decisions. This diagnosis relies chiefly on urinary output and serum creatinine, which may be of limited value. This study aimed to explore the diagnostic performance of renal resistive index (RRI)...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066619887333
更新日期:2021-01-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066613507410
更新日期:2015-07-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2006-03-01 00:00:00
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更新日期:2020-11-05 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章
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更新日期:2020-01-09 00:00:00