Thyroid storm: an updated review.

Abstract:

:Thyroid storm, an endocrine emergency first described in 1926, remains a diagnostic and therapeutic challenge. No laboratory abnormalities are specific to thyroid storm, and the available scoring system is based on the clinical criteria. The exact mechanisms underlying the development of thyroid storm from uncomplicated hyperthyroidism are not well understood. A heightened response to thyroid hormone is often incriminated along with increased or abrupt availability of free hormones. Patients exhibit exaggerated signs and symptoms of hyperthyroidism and varying degrees of organ decompensation. Treatment should be initiated promptly targeting all steps of thyroid hormone formation, release, and action. Patients who fail medical therapy should be treated with therapeutic plasma exchange or thyroidectomy. The mortality of thyroid storm is currently reported at 10%. Patients who have survived thyroid storm should receive definite therapy for their underlying hyperthyroidism to avoid any recurrence of this potentially fatal condition.

journal_name

J Intensive Care Med

authors

Chiha M,Samarasinghe S,Kabaker AS

doi

10.1177/0885066613498053

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

131-40

issue

3

eissn

0885-0666

issn

1525-1489

pii

0885066613498053

journal_volume

30

pub_type

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