Abstract:
:Neurologic complications of cancer are common and are frequently life-threatening events. Certain neurologic emergencies occur more frequently in the cancer population, specifically elevated intracranial pressure, epidural cord compression, status epilepticus, ischemic and hemorrhagic stroke, central nervous system infection, and treatment-associated neurologic dysfunction. These emergencies require early diagnosis and prompt treatment to ensure the best possible outcome and are best managed in the intensive care unit. This article reviews the presentation, pathophysiology, and management of the most common causes of acute neurologic decompensation in the patient with cancer.
journal_name
J Intensive Care Medjournal_title
Journal of intensive care medicineauthors
Lin AL,Avila EKdoi
10.1177/0885066615619582subject
Has Abstractpub_date
2017-02-01 00:00:00pages
99-115issue
2eissn
0885-0666issn
1525-1489pii
0885066615619582journal_volume
32pub_type
杂志文章,评审abstract:BACKGROUND:Insulin receptors (IRs) in the brain have unique molecular features and a characteristic pattern of distribution. Their possible functions extend beyond glucose utilization. In this systematic review, we explore the interactions between insulin and the brain and its implications for anesthesiologists, critic...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066615594341
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The invasive nature and potential complications associated with pulmonary artery (PA) catheters (PACs) have prompted the pursuit of less invasive monitoring options. Before implementing new hemodynamic monitoring technologies, it is important to determine the interchangeability of these modalities. This st...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066614530085
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Intracerebral hemorrhage (ICH) is a devastating and costly condition. Although the American Heart Association/American Stroke Association recommends admitting patients with ICH to a neurocritical care unit (NCCU), this strategy may accrue unnecessary cost for patients with relatively milder presentation. We ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066615578113
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE::To analyze the management and outcome of patients with refractory respiratory failure complicating severe Legionella pneumonia rescued with extracorporeal membrane oxygenation (ECMO) in our Center. DESIGN AND SETTING::Observational study of patients with refractory respiratory failure treated with ECMO in H...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066617700121
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:In the setting of the COVID pandemic, many patients falling ill with acute respiratory distress syndrome eventually require prone positioning for gas exchange. Traditionally, central venous catheters are inserted with patient in the supine or Trendelenburg position. However, when a patient cannot tolerate su...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066620959649
更新日期:2020-09-16 00:00:00
abstract:BACKGROUND:There is variation in the treatment of patients with severe alcohol withdrawal and a need for effective protocols. The purpose of this study was to evaluate the implementation of a symptom-triggered benzodiazepine protocol using the 5-item Brief Alcohol Withdrawal Scale (BAWS) for treatment of alcohol withdr...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066620952762
更新日期:2020-08-27 00:00:00
abstract:AIMS:To investigate the occurrence and etiology of fever at anytime during pediatric intensive care unit (PICU) admission, and to study its possible effects on clinical outcome in a heterogeneous population of critically ill children. METHODS:Retrospective, observational single center study, comprising 202 patients ag...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066609340631
更新日期:2009-09-01 00:00:00
abstract::Patients undergoing surgery for pituitary tumors represent a heterogeneous population each with unique clinical, biochemical, radiologic, pathologic, neurologic, and/or ophthalmologic considerations. The postoperative management of patients following pituitary surgery often occurs in the context of a dynamic state of ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066605275247
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To describe intubation practices and duration of mechanical ventilation in children with status asthmaticus admitted from emergency departments (ERs) to pediatric intensive care units (PICUs). DESIGN:Retrospective cohort study using the Virtual PICU Performance System database (VPS, LLC) of children with sta...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066613476446
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:Timely recognition of critical illness is associated with improved outcomes, but is dependent on accurate triage, which is affected by system factors such as workload and staffing. We sought to first study the effect of delayed recognition on patient outcomes after controlling for system factors and then to ide...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066620967901
更新日期:2020-10-29 00:00:00
abstract:BACKGROUND::Patients with septic shock by multidrug resistant (MDR) microorganism maybe considered a specific population of critical patients at very high risk of death in whom the effects of standard sepsis treatment has never been assessed. The objective of this retrospective analysis was to evaluate the risk factors...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066616688165
更新日期:2019-01-01 00:00:00
abstract::Hypercalcemia may be seen in a variety of clinical settings and often requires intensive management when serum calcium levels are dramatically elevated. All of the many etiologies of mild hypercalcemia can lead to severe hypercalcemia. Knowledge of the physiologic mechanisms involved in maintaining normocalcemia and b...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066613507530
更新日期:2015-07-01 00:00:00
abstract::Venous thromboembolism (VTE) is a major health concern associated with significant morbidity and mortality. Critically ill patients are at an increased risk of VTE compared to general medical patients due to unique risk factors: prolonged immobilization, invasive lines and devices, certain medications, and acquired th...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066618796486
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Morbidity associated with stress ulcer-related bleeding, the cost of medications, and the possible complications associated with stress ulcer prophylaxis are important considerations when prescribing prophylaxis. We prospectively studied the prescription patterns for stress ulcer prophylaxis in patients admi...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,多中心研究
doi:10.1177/0885066612453542
更新日期:2014-03-01 00:00:00
abstract:RATIONALE:The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown. OBJECTIVES:To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis. METHODS:In a single-center phas...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066618823183
更新日期:2020-12-01 00:00:00
abstract::Combined poisoning with calcium-channel blockers and beta-blockers is usually associated with severe heart failure. This report shows the effectiveness of emergency extracorporeal life support in treating life-threatening simultaneous propranolol and verapamil intoxication. A 15-year-old girl presented in cardiogenic ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066607307528
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Consensus guidelines support the use of low-molecular-weight heparin for venous thromboembolism (VTE) prophylaxis in high-risk trauma patients but do not recommend a specific regimen. The current study compared the effectiveness and safety of enoxaparin 40 mg once-daily versus enoxaparin 30 mg twice-daily fo...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066610384462
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Fluid responsiveness is the ability to increase the cardiac output in response to a fluid challenge. Only about 50% of patients receiving fluid resuscitation for acute circulatory failure increase their stroke volume, but the other 50% may worsen their outcome. Therefore, predicting fluid responsiveness is ne...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,meta分析
doi:10.1177/0885066617752308
更新日期:2020-04-01 00:00:00
abstract::Thrombolytic therapy has been established as a safe and effective therapeutic strategy in acute myocardial infarction (MI). Its efficacy is improved with early administration, although modest benefits can be demonstrated for up to 12 hours. Tissue plasminogen activator (TPA) appears to offer benefits over streptokinas...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/088506669501000202
更新日期:1995-03-01 00:00:00
abstract::The authors retrospectively review their experience with low immunoglobulin G (IgG) levels in a pediatric ICU population over a 12-month period. The total IgG level was below the normal for age in 14 of the 20 patients. The 14 patients with a low IgG level were younger and weighed less when compared with the 6 patient...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066603255905
更新日期:2003-09-01 00:00:00
abstract::The role of percutaneous transluminal coronary angioplasty (PTCA) in the management of acute myocardial infarction (AMI) has not yet been precisely defined. The longest experience with PTCA in this setting has been in patients who are not candidates for thrombolytic therapy and in patients in whom thrombolysis has fai...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/088506669501000402
更新日期:1995-07-01 00:00:00
abstract:PURPOSE:The strategy used to improve effective checklist use in intensive care unit (ICU) setting is essential for checklist success. This study aimed to test the hypothesis that an electronic checklist could reduce ICU provider workload, errors, and time to checklist completion, as compared to a paper checklist. METH...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066614558015
更新日期:2016-03-01 00:00:00
abstract::Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients, particularly those with severe sepsis and septic shoc...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066618762747
更新日期:2018-12-01 00:00:00
abstract::The objective of this article was to review the effects of acute intracranial lesions on myocardial function. The authors reviewed scientific and clinical literature retrieved from a computerized MEDLINE search from January 1965 through January 2002. Pertinent literature was referenced, including clinical and laborato...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066603251202
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:The process of controlled donation after circulatory death (cDCD) is strongly connected with the process of withdrawal of life-sustaining therapy. In addition to impacting cDCD success, actions comprising withdrawal of life-sustaining therapy have implications for quality of palliative care. We examined pilot...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066615571529
更新日期:2016-05-01 00:00:00
abstract::The brain reacts to injury or disease by cascades of cellular and molecular responses. Evidence suggests that immune-inflammatory processes are key elements in the physiopathological processes associated with brain injury or damage. Cytokines are among major mediators implicated in these processes. Cytokine responses ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066608318458
更新日期:2008-07-01 00:00:00
abstract::Antibacterial resistance is increasing throughout the world, while the development of new agents is slowly progressing. In addition, the increasing prevalence of fluoroquinolone resistance may force many practitioners to choose an aminoglycoside agent in gram-negative regimens. Aminoglycosides are bactericidal agents ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066610377968
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The efficacy of routinely obtained chest radiographs (CXRs) on admission to the intensive care unit (ICU) is largely unknown. The current study investigated the efficacy of routinely obtained admission CXRs and determined whether the value of this diagnostic test was dependent on patient categ...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066610366925
更新日期:2010-07-01 00:00:00
abstract::Primary and acquired abdominal pathology accounts for a significant proportion of sepsis and SIRS in the ICU population. Abdominal processes often present a difficult diagnostic dilemma in the truly critically ill patient who, due to hemodynamic instability or severe acute respiratory distress syndrome (ARDS) requirin...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章
doi:10.1177/0885066613492102
更新日期:2015-07-01 00:00:00
abstract::A systematic review of the literature was conducted to determine if the administration of methylene blue in humans improves hemodynamic status and/or outcome in patients with septic shock. Studies were identified from MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials database. The review included...
journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
doi:10.1177/0885066606290671
更新日期:2006-11-01 00:00:00