Hypercalcemia in the Intensive Care Unit: A Review of Pathophysiology, Diagnosis, and Modern Therapy.

Abstract:

:Hypercalcemia may be seen in a variety of clinical settings and often requires intensive management when serum calcium levels are dramatically elevated. All of the many etiologies of mild hypercalcemia can lead to severe hypercalcemia. Knowledge of the physiologic mechanisms involved in maintaining normocalcemia and basic pathophysiology is essential for making a timely diagnosis and hence prompt institution of etiology-specific therapy. The development of new medications and critical reviews of traditional therapies have changed the treatment paradigm for severe hypercalcemia, calling for a more limited role for aggressive isotonic fluid administration and furosemide and an expanded role for calcitonin and the bisphosphonates. Experimental therapies such as denosumab show promise.

journal_name

J Intensive Care Med

authors

Maier JD,Levine SN

doi

10.1177/0885066613507530

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

235-52

issue

5

eissn

0885-0666

issn

1525-1489

pii

0885066613507530

journal_volume

30

pub_type

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