Abstract:
:With the introduction of highly active antiretroviral therapy (HAART), HIV has become a chronic disease. As HIV-infected patients are aging, they are at increased risk for comorbid diseases. These non-AIDS related diseases account for a growing proportion of intensive care unit (ICU) admissions in HIV-infected patients in recent studies. HIV-infected patients still present to the ICU with HIV-related conditions such as Pneumocystis jirovecii pneumonia (PCP), but these conditions are becoming less common. Respiratory failure remains the most common indication for ICU admission. Immune reconstitution inflammatory response syndrome and toxicities related to HAART may also result in ICU admission. While ICU survival has improved since the earliest era of the HIV epidemic, hospital mortality for HIV-infected patients admitted to the ICU remains around 30%. Risk factors for ICU mortality include poor functional status, weight loss, more than one year between HIV diagnosis and ICU admission, lower serum albumin, higher severity of illness, need for mechanical ventilation, and respiratory failure-particularly if due to PCP and accompanied by pneumothorax. The impact of HAART on ICU outcomes is unclear. HAART administration in the ICU can be challenging due to limited delivery routes, concern for viral resistance and medication toxicities. There are no data to determine the safety or efficacy of HAART initiation in the ICU. Future studies are needed to address the role of age, associated comorbidities and impact of HAART on outcomes of HIV-infected patients admitted to the ICU.
journal_name
J Intensive Care Medjournal_title
Journal of intensive care medicineauthors
Akgün KM,Pisani M,Crothers Kdoi
10.1177/0885066610387996subject
Has Abstractpub_date
2011-05-01 00:00:00pages
151-64issue
3eissn
0885-0666issn
1525-1489pii
0885066610387996journal_volume
26pub_type
杂志文章,评审abstract:BACKGROUND:Agitation is common in the intensive care unit (ICU). Although antipsychotics are frequently used as first-line therapy, chlorpromazine has fallen out of favor due to risk of cardiovascular complications and severe hypotension. Although chlorpromazine is used anecdotally, there is a lack of data regarding it...
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abstract:RATIONALE:The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown. OBJECTIVES:To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis. METHODS:In a single-center phas...
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abstract:PURPOSE:Reintubation following unplanned extubation (UE) is often required and associated with increased morbidity; however, knowledge of risk factors leading to reintubation and subsequent outcomes in children is still lacking. We sought to determine the incidence, risk factors, and outcomes related to reintubation af...
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journal_title:Journal of intensive care medicine
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更新日期:2003-11-01 00:00:00
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更新日期:2020-12-01 00:00:00
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更新日期:1995-09-01 00:00:00
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更新日期:2019-10-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2020-10-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
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更新日期:2018-04-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
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更新日期:1991-03-01 00:00:00
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更新日期:2020-01-09 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2014-01-01 00:00:00
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更新日期:2019-11-28 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2020-04-01 00:00:00