The changing epidemiology of HIV-infected patients in the intensive care unit.

Abstract:

:With the introduction of highly active antiretroviral therapy (HAART), HIV has become a chronic disease. As HIV-infected patients are aging, they are at increased risk for comorbid diseases. These non-AIDS related diseases account for a growing proportion of intensive care unit (ICU) admissions in HIV-infected patients in recent studies. HIV-infected patients still present to the ICU with HIV-related conditions such as Pneumocystis jirovecii pneumonia (PCP), but these conditions are becoming less common. Respiratory failure remains the most common indication for ICU admission. Immune reconstitution inflammatory response syndrome and toxicities related to HAART may also result in ICU admission. While ICU survival has improved since the earliest era of the HIV epidemic, hospital mortality for HIV-infected patients admitted to the ICU remains around 30%. Risk factors for ICU mortality include poor functional status, weight loss, more than one year between HIV diagnosis and ICU admission, lower serum albumin, higher severity of illness, need for mechanical ventilation, and respiratory failure-particularly if due to PCP and accompanied by pneumothorax. The impact of HAART on ICU outcomes is unclear. HAART administration in the ICU can be challenging due to limited delivery routes, concern for viral resistance and medication toxicities. There are no data to determine the safety or efficacy of HAART initiation in the ICU. Future studies are needed to address the role of age, associated comorbidities and impact of HAART on outcomes of HIV-infected patients admitted to the ICU.

journal_name

J Intensive Care Med

authors

Akgün KM,Pisani M,Crothers K

doi

10.1177/0885066610387996

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

151-64

issue

3

eissn

0885-0666

issn

1525-1489

pii

0885066610387996

journal_volume

26

pub_type

杂志文章,评审
  • Safety and Effectiveness of Intravenous Chlorpromazine for Agitation in Critically Ill Patients.

    abstract:BACKGROUND:Agitation is common in the intensive care unit (ICU). Although antipsychotics are frequently used as first-line therapy, chlorpromazine has fallen out of favor due to risk of cardiovascular complications and severe hypotension. Although chlorpromazine is used anecdotally, there is a lack of data regarding it...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066618818787

    authors: Choi M,Barra ME,Newman K,Sin JH

    更新日期:2020-10-01 00:00:00

  • Antibiotic Use in the Intensive Care Unit: Optimization and De-Escalation.

    abstract::Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients, particularly those with severe sepsis and septic shoc...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066618762747

    authors: Campion M,Scully G

    更新日期:2018-12-01 00:00:00

  • Conservative Fluid Management After Sepsis Resuscitation: A Pilot Randomized Trial.

    abstract:RATIONALE:The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown. OBJECTIVES:To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis. METHODS:In a single-center phas...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066618823183

    authors: Semler MW,Janz DR,Casey JD,Self WH,Rice TW

    更新日期:2020-12-01 00:00:00

  • Heart transplantation.

    abstract::Although the number of available donor hearts severely limits the epidemiologic impact of heart transplantation on patients with heart failure, patients with end-stage heart failure unresponsive to medical management currently have no other viable alternatives. Destination therapy with a ventricular assist device is t...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066603259012

    authors: Poston RS,Griffith BP

    更新日期:2004-01-01 00:00:00

  • Resuscitation bundle compliance in severe sepsis and septic shock: improves survival, is better late than never.

    abstract:UNLABELLED:While clinicians' management of severe sepsis and septic shock has been positively influenced by a number of clinical research studies in the last decade, challenges remain regarding early hemodynamic optimization as envisioned in the Surviving Sepsis Campaign's (SSC) resuscitation bundle (RB). We examined t...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066610392499

    authors: Coba V,Whitmill M,Mooney R,Horst HM,Brandt MM,Digiovine B,Mlynarek M,McLellan B,Boleski G,Yang J,Conway W,Jordan J,(The Henry Ford Hospital Sepsis Collaborative Group).

    更新日期:2011-09-01 00:00:00

  • Predicting Reintubation After Unplanned Extubations in Children: Art or Science?

    abstract:PURPOSE:Reintubation following unplanned extubation (UE) is often required and associated with increased morbidity; however, knowledge of risk factors leading to reintubation and subsequent outcomes in children is still lacking. We sought to determine the incidence, risk factors, and outcomes related to reintubation af...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066616675130

    authors: da Silva PSL,Reis ME,Fonseca TSM,Fonseca MCM

    更新日期:2018-08-01 00:00:00

  • Serum Lactate as an Independent Predictor of In-Hospital Mortality in Intensive Care Patients.

    abstract:PURPOSE:The aim of this study was to check if serum lactate was independently associated with mortality among critically ill patients. MATERIALS AND METHODS:This was a single-center, retrospective cohort study. All adult patients (>18 years of age) who had at least 1 measurement of lactate within 24 hours of admission...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619854355

    authors: Chebl RB,Tamim H,Dagher GA,Sadat M,Enezi FA,Arabi YM

    更新日期:2020-11-01 00:00:00

  • Efficacy and Safety of a Colistin Loading Dose, High-Dose Maintenance Regimen in Critically Ill Patients With Multidrug-Resistant Gram-Negative Pneumonia.

    abstract:INTRODUCTION:Emergence of multidrug-resistant (MDR) gram-negative (GN) pathogens and lack of novel antibiotics have increased the use of colistin, despite unknown optimal dosing. This study aimed to evaluate the safety and efficacy of a colistin loading dose, high-dose (LDHD) maintenance regimen in patients with MDR-GN...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066616646551

    authors: Elefritz JL,Bauer KA,Jones C,Mangino JE,Porter K,Murphy CV

    更新日期:2017-09-01 00:00:00

  • Six-Minute Walk Distance After Critical Illness: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND AND OBJECTIVES:Impaired physical functioning is common and long lasting after an intensive care unit (ICU) admission. The 6-minute walk test (6MWT) is a validated and widely used test of functional capacity. This systematic review synthesizes existing data in order to: (1) evaluate 6-minute walk distance (6M...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619885838

    authors: Parry SM,Nalamalapu SR,Nunna K,Rabiee A,Friedman LA,Colantuoni E,Needham DM,Dinglas VD

    更新日期:2019-11-05 00:00:00

  • A comparison of infusion volumes in the measurement of intra-abdominal pressure.

    abstract::Bladder pressure measurement through a foley catheter is the current standard in monitoring for intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Accurate pressure transduction requires a continuous fluid column with a small volume of transducing medium at the tip of the catheter. Infusing ex...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066609335730

    authors: Kimball EJ,Baraghoshi GK,Mone MC,Hansen HJ,Adams DM,Alder SC,Jackson P,Cannon P,Horn J,Wolfe TR

    更新日期:2009-07-01 00:00:00

  • Pharmacologic Management of Delirium in the ICU: A Review of the Literature.

    abstract:PURPOSE:Conflicting data exists on the pharmacologic management of intensive care unit (ICU) delirium. This review appraises the current evidence of pharmacologic management of ICU delirium. MATERIALS AND METHODS:A systematic literature search of MEDLINE and Embase was conducted to answer the population, intervention,...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066618805965

    authors: Korenoski A,Li A,Kane-Gill SL,Seybert AL,Smithburger PL

    更新日期:2020-02-01 00:00:00

  • Sudden cardiac death.

    abstract::Sudden cardiac death (SCD) due to ventricular tachyarrhythmias is a leading cause of death in the United States. This phenomenon is associated with coronary artery disease, valvular heart disease, nonischemic cardiomyopathies, congenital heart disease, primary electrical abnormalities, autonomic nervous system abnorma...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066603258140

    authors: Antezano ES,Hong M

    更新日期:2003-11-01 00:00:00

  • Effectiveness of Treatments and Diagnostic Tools and Declining Mortality in Patients With Severe Sepsis: A 12-Year Population-Based Cohort Study.

    abstract::Sepsis is a major cause of morbidity and mortality worldwide. With the advance of medical care, the mortality of sepsis has decreased in the past decades. Many treatments and diagnostic tools still lack supporting evidence. We conducted a retrospective population-based cohort study with propensity score matched subcoh...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619827270

    authors: Chen KF,Tsai MY,Wu CC,Han ST

    更新日期:2020-12-01 00:00:00

  • Septic arthritis in adults: clinical features, outcome, and intensive care requirements.

    abstract::A review of adults with septic arthritis was undertaken to evaluate outcome of treatment and intensive care requirements in a community-based teaching hospital. During an 80-month period (1986-1992), 38 cases of septic arthritis were identified. Underlying joint disease was present in 84% of patients. Mean age was 68 ...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/088506669501000507

    authors: Martens PB,Ho G Jr

    更新日期:1995-09-01 00:00:00

  • Novel Method of Atrial Fibrillation Case Identification and Burden Estimation Using the MIMIC-III Electronic Health Data Set.

    abstract:BACKGROUND:Atrial fibrillation (AF) portends poor prognoses in intensive care unit patients with sepsis. However, AF research is challenging: Previous studies demonstrate that International Classification of Disease (ICD) codes may underestimate the incidence of AF, but chart review is expensive and often not feasible....

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619866172

    authors: Ding EY,Albuquerque D,Winter M,Binici S,Piche J,Bashar SK,Chon K,Walkey AJ,McManus DD

    更新日期:2019-10-01 00:00:00

  • Midodrine as an Adjuvant to Intravenous Vasopressor Agents in Adults With Resolving Shock: Systematic Review and Meta-Analysis.

    abstract:PURPOSE:To evaluate the effects of midodrine in addition to intravenous vasopressor therapy on outcomes in adults recovering from shock. MATERIALS AND METHODS:PubMed, Scopus, Clinicaltrials.gov, and published abstracts were searched from inception to November 2018 for studies comparing outcomes in shock after midodrin...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619843279

    authors: Hammond DA,Smith MN,Peksa GD,Trivedi AP,Balk RA,Menich BE

    更新日期:2020-11-01 00:00:00

  • The Use of Cerebral NIRS Monitoring to Identify Acute Brain Injury in Patients With VA-ECMO.

    abstract::Acute brain injury (ABI) increases morbidity and mortality in patients with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Optimal neurologic monitoring methods have not been well-explicated. We studied the use of Near-infrared Spectroscopy (NIRS) to monitor cerebral regional oxygenation tissue saturatio...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066620966962

    authors: Hunt MF,Clark KT,Whitman G,Choi CW,Geocadin RG,Cho SM

    更新日期:2020-10-15 00:00:00

  • Exogenous Vasopressin-Induced Hyponatremia in Patients With Vasodilatory Shock: Two Case Reports and Literature Review.

    abstract::Vasopressin has gained wide support as an adjunct vasopressor in patients with septic shock. This agent exerts its vasoconstriction effects through smooth muscle V1 receptors and also has antidiuretic activity via renal V2 receptors. This interaction with the renal V2 receptors results in the integration of aquaporin ...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066613507410

    authors: Salazar M,Hu BB,Vazquez J,Wintz RL,Varon J

    更新日期:2015-07-01 00:00:00

  • Predictors of Outcome Post Cardiac Arrest.

    abstract::Early predictors of prognosis in comatose patients post cardiac arrest help inform decisions surrounding continuation or withdrawal of treatment and provide a framework on which to better inform relatives of the likely outcome. Markers defined prior to the widespread use of therapeutic hypothermia post arrest may no l...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066613511045

    authors: Bigham S,Bigham C,Martin D

    更新日期:2018-04-01 00:00:00

  • Noninvasive Ventilation in a Pediatric Trauma Center: A Cohort Study.

    abstract:OBJECTIVE:To determine whether non-invasive ventilation (NIV) can avoid the need for tracheal intubation and/or reduce the duration of invasive ventilation (IMV) in previously intubated patients admitted to the pediatric intensive care unit (PICU) and developing acute hypoxemic respiratory failure (AHRF) after major tr...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066620983744

    authors: Piastra M,De Bellis A,Morena TC,De Luca D,Pezza L,Pizza A,Genovese O,Mancino A,Picconi E,Conti G

    更新日期:2021-01-19 00:00:00

  • Controlled Donation After Circulatory Determination of Death.

    abstract::Controlled donation after circulatory determination of death (cDCDD) concerns donation after withdrawal of life-sustaining therapy (W-LST). We examine the ethical issues raised by W-LST in the cDCDD context in the light of a review of cDCDD protocols and the ethical literature. Our analysis confirms that W-LST procedu...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066615625628

    authors: Dalle Ave AL,Shaw DM

    更新日期:2017-03-01 00:00:00

  • After-Hours/Nighttime Transfers Out of the Intensive Care Unit and Patient Outcomes: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:We evaluated the effects of after-hours/nighttime patient transfers out of the ICU on patient outcomes, by performing a systematic review and meta-analysis (PROSPERO CRD 42017074082). DATA SOURCES:MEDLINE, PubMed, EMBASE, Google Scholar, CINAHL, and the Cochrane Library from 1987-November 2019. Conference abst...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066620984410

    authors: Moshynskyy AI,Mailman JF,Sy EJ

    更新日期:2020-12-28 00:00:00

  • Cardiac transplantation: a review for the intensivists.

    abstract::Cardiac transplantation has now become accepted therapy for the treatment of end-stage heart disease in both children and adults, and literally thousands of patients are bearers of cardiac grafts. Because of these patients' susceptibility to infections, rejection, coronary disease, and malignancy, as well as to serio...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/088506669100600201

    authors: Perlroth MG

    更新日期:1991-03-01 00:00:00

  • Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study.

    abstract:BACKGROUND:Cognitive impairment after sepsis is an important clinical problem. Determinants of postseptic cognitive impairment are not well understood. We thus undertook a systems biology approach to exploring a possible role for apolipoprotein E (APOE) in postseptic cognitive impairment. DESIGN:Prospective, observati...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619897604

    authors: Brown SM,Beesley SJ,Stubben C,Wilson EL,Presson AP,Grissom C,Maguire C,Rondina MT,Hopkins RO

    更新日期:2020-01-09 00:00:00

  • Ethical challenges with deactivation of durable mechanical circulatory support at the end of life: left ventricular assist devices and total artificial hearts.

    abstract::Left ventricular assist devices (LVADs) and total artificial hearts (TAHs) are surgically implanted as permanent treatment of unrecoverable heart failure. Both LVADs and TAHs are durable mechanical circulatory support (MCS) devices that can prolong patient survival but also alter end-of-life trajectory. The permissibi...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066611432415

    authors: Rady MY,Verheijde JL

    更新日期:2014-01-01 00:00:00

  • Serum Biomarkers for Risk Assessment of Intrahospital Transports in Mechanically Ventilated Neurosurgical Intensive Care Unit Patients.

    abstract:OBJECTIVE:Intrahospital transports (IHTs) of neurosurgical intensive care unit (NICU) patients can be hazardous. Increasing intracranial pressure (ICP) and/or decreasing cerebral perfusion pressure (CPP) as well as cardiopulmonary alterations are common complications of an IHTs, which can lead to secondary brain injury...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619891063

    authors: Bender M,Stein M,Kim SW,Uhl E,Schöller K

    更新日期:2019-11-28 00:00:00

  • Successful use of extracorporeal membrane oxygenation in an adult patient with toxic shock-induced heart failure.

    abstract::Cardiomyopathy secondary to toxic shock syndrome (TSS) is an uncommon but potentially life-threatening problem. We report the case of a 51-year-old male who presented with profound cardiogenic shock and multiorgan failure that could not be managed by conventional therapy with intravenous fluids, vasopressors and inotr...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066613517069

    authors: Gabel E,Gudzenko V,Cruz D,Ardehali A,Fink MP

    更新日期:2015-02-01 00:00:00

  • Costs and Outcomes of Patients Admitted to the Intensive Care Unit With Cancer.

    abstract:INTRODUCTION:Cancer is associated with significant health-care expenditure, but few studies have examined the cost of patients with cancer in the intensive care unit (ICU). We aimed to describe the costs and outcomes of patients admitted to the ICU with cancer. METHODS:We conducted a retrospective cohort study of pati...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619899653

    authors: Zheng B,Reardon PM,Fernando SM,Webber C,Thavorn K,Thompson LH,Tanuseputro P,Munshi L,Kyeremanteng K

    更新日期:2021-02-01 00:00:00

  • Insulin and the Brain: A Sweet Relationship With Intensive Care.

    abstract:BACKGROUND:Insulin receptors (IRs) in the brain have unique molecular features and a characteristic pattern of distribution. Their possible functions extend beyond glucose utilization. In this systematic review, we explore the interactions between insulin and the brain and its implications for anesthesiologists, critic...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066615594341

    authors: Bilotta F,Lauretta MP,Tewari A,Haque M,Hara N,Uchino H,Rosa G

    更新日期:2017-01-01 00:00:00

  • Accuracy of Ultrasonographic Measurements of Inferior Vena Cava to Determine Fluid Responsiveness: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVE:Fluid responsiveness is the ability to increase the cardiac output in response to a fluid challenge. Only about 50% of patients receiving fluid resuscitation for acute circulatory failure increase their stroke volume, but the other 50% may worsen their outcome. Therefore, predicting fluid responsiveness is ne...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,meta分析

    doi:10.1177/0885066617752308

    authors: Orso D,Paoli I,Piani T,Cilenti FL,Cristiani L,Guglielmo N

    更新日期:2020-04-01 00:00:00