Effectiveness of Treatments and Diagnostic Tools and Declining Mortality in Patients With Severe Sepsis: A 12-Year Population-Based Cohort Study.

Abstract:

:Sepsis is a major cause of morbidity and mortality worldwide. With the advance of medical care, the mortality of sepsis has decreased in the past decades. Many treatments and diagnostic tools still lack supporting evidence. We conducted a retrospective population-based cohort study with propensity score matched subcohorts based on a prospectively collected national longitudinal health insurance database in Taiwan. Severe sepsis-associated hospital admissions from 2000 to 2011 based on International Classification of Diseases, Ninth Revision, Clinical Modification codes of infections and acute organ dysfunction were identified. To compare the effectiveness of treatment and diagnostic tool, propensity scores were generated to match the comparable control groups. During the 12-year period, 33 375 patients and 50 465 hospitalizations of severe sepsis were identified. The age-standardized 28-day in-hospital mortality decreased significantly from 21% in 2008 to 15% in 2011 with increasingly implemented treatment and diagnostic tool. After propensity score matching, procalcitonin (odds ratio [OR]: 0.70, 95% confidence interval [95% CI]: 0.61-0.81) and lactate testing (OR: 0.90, 95% CI: 0.84-0.97, respectively), transfusion of packed red blood cell (OR: 0.60, 95% CI: 0.52-0.69), albumin (OR: 0.72, 95% CI: 0.55-0.93), balanced crystalloid (OR: 0.29, 95% CI: 0.20-0.41), and use of dopamine (OR: 0.44, 95% CI: 0.39-0.49) were found to be significantly associated with lower mortality rate. However, inconsistent findings need to be further validated.

journal_name

J Intensive Care Med

authors

Chen KF,Tsai MY,Wu CC,Han ST

doi

10.1177/0885066619827270

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1418-1425

issue

12

eissn

0885-0666

issn

1525-1489

journal_volume

35

pub_type

杂志文章
  • Successful use of extracorporeal membrane oxygenation in an adult patient with toxic shock-induced heart failure.

    abstract::Cardiomyopathy secondary to toxic shock syndrome (TSS) is an uncommon but potentially life-threatening problem. We report the case of a 51-year-old male who presented with profound cardiogenic shock and multiorgan failure that could not be managed by conventional therapy with intravenous fluids, vasopressors and inotr...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066613517069

    authors: Gabel E,Gudzenko V,Cruz D,Ardehali A,Fink MP

    更新日期:2015-02-01 00:00:00

  • Management of aminoglycosides in the intensive care unit.

    abstract::Antibacterial resistance is increasing throughout the world, while the development of new agents is slowly progressing. In addition, the increasing prevalence of fluoroquinolone resistance may force many practitioners to choose an aminoglycoside agent in gram-negative regimens. Aminoglycosides are bactericidal agents ...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066610377968

    authors: Radigan EA,Gilchrist NA,Miller MA

    更新日期:2010-11-01 00:00:00

  • Hypogammaglobulinemia in pediatric ICU patients.

    abstract::The authors retrospectively review their experience with low immunoglobulin G (IgG) levels in a pediatric ICU population over a 12-month period. The total IgG level was below the normal for age in 14 of the 20 patients. The 14 patients with a low IgG level were younger and weighed less when compared with the 6 patient...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066603255905

    authors: Rehman S,Bytnar D,Berkenbosch JW,Tobias JD

    更新日期:2003-09-01 00:00:00

  • Predictors of Delayed Recognition of Critical Illness in Emergency Department Patients and Its Effect on Morbidity and Mortality.

    abstract:PURPOSE:Timely recognition of critical illness is associated with improved outcomes, but is dependent on accurate triage, which is affected by system factors such as workload and staffing. We sought to first study the effect of delayed recognition on patient outcomes after controlling for system factors and then to ide...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066620967901

    authors: Goel NN,Durst MS,Vargas-Torres C,Richardson LD,Mathews KS

    更新日期:2020-10-29 00:00:00

  • Serum Biomarkers for Risk Assessment of Intrahospital Transports in Mechanically Ventilated Neurosurgical Intensive Care Unit Patients.

    abstract:OBJECTIVE:Intrahospital transports (IHTs) of neurosurgical intensive care unit (NICU) patients can be hazardous. Increasing intracranial pressure (ICP) and/or decreasing cerebral perfusion pressure (CPP) as well as cardiopulmonary alterations are common complications of an IHTs, which can lead to secondary brain injury...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619891063

    authors: Bender M,Stein M,Kim SW,Uhl E,Schöller K

    更新日期:2019-11-28 00:00:00

  • Bi-level positive airway pressure ventilation in pediatric oncology patients with acute respiratory failure.

    abstract::The aim of the study was to describe our experience with bi-level positive airway pressure (BiPAP) ventilation in oncology children with acute respiratory failure, hospitalized in a single tertiary pediatric tertiary center. This was a retrospective cohort study of all pediatric oncology patients in our center admitte...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066609344956

    authors: Schiller O,Schonfeld T,Yaniv I,Stein J,Kadmon G,Nahum E

    更新日期:2009-11-01 00:00:00

  • Use of methylene blue in sepsis: a systematic review.

    abstract::A systematic review of the literature was conducted to determine if the administration of methylene blue in humans improves hemodynamic status and/or outcome in patients with septic shock. Studies were identified from MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials database. The review included...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066606290671

    authors: Kwok ES,Howes D

    更新日期:2006-11-01 00:00:00

  • Patient origin is associated with duration of endotracheal intubation and PICU length of stay for children with status asthmaticus.

    abstract:OBJECTIVE:To describe intubation practices and duration of mechanical ventilation in children with status asthmaticus admitted from emergency departments (ERs) to pediatric intensive care units (PICUs). DESIGN:Retrospective cohort study using the Virtual PICU Performance System database (VPS, LLC) of children with sta...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066613476446

    authors: Shibata S,Khemani RG,Markovitz B

    更新日期:2014-05-01 00:00:00

  • Arterial Oxygenation in Traumatic Brain Injury-Relation to Cerebral Energy Metabolism, Autoregulation, and Clinical Outcome.

    abstract:BACKGROUND:Ischemic and hypoxic secondary brain insults are common and detrimental in traumatic brain injury (TBI). Treatment aims to maintain an adequate cerebral blood flow with sufficient arterial oxygen content. It has been suggested that arterial hyperoxia may be beneficial to the injured brain to compensate for c...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066620944097

    authors: Wettervik TS,Engquist H,Howells T,Lenell S,Rostami E,Hillered L,Enblad P,Lewén A

    更新日期:2020-07-27 00:00:00

  • Semiquantitative Power Doppler Ultrasound Score to Predict Acute Kidney Injury in Patients With Sepsis or Cardiac Failure: A Prospective Observational Study.

    abstract:BACKGROUND:Diagnosing acute kidney injury (AKI) stage 3 in critically ill patients may help physicians in making treatment decisions. This diagnosis relies chiefly on urinary output and serum creatinine, which may be of limited value. This study aimed to explore the diagnostic performance of renal resistive index (RRI)...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619887333

    authors: Zhi HJ,Zhao J,Nie S,Ma YJ,Cui XY,Zhang M,Li Y

    更新日期:2021-01-01 00:00:00

  • Characterization of Sepsis and Sepsis-Associated Encephalopathy.

    abstract:BACKGROUND:Sepsis and sepsis-associated encephalopathy (SAE) are common intensive care unit (ICU) diseases; the morbidity and mortality are high. The present study analyzed the sensitivity of different diagnostic criteria of sepsis 1.0 and 3.0, epidemiological characteristics of sepsis and SAE, and explored its risk fa...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066617719750

    authors: Feng Q,Ai YH,Gong H,Wu L,Ai ML,Deng SY,Huang L,Peng QY,Zhang LN

    更新日期:2019-11-01 00:00:00

  • Massive intravascular hemolysis from Clostridium perfringens septicemia: a review.

    abstract::We describe the case of a patient with hemolysis-associated Clostridium perfringens septicemia and review all similar cases published in the literature since 1990, with specific focus on the relationship between treatment strategy and survival. We searched PubMed for all published cases of C. perfringens-associated he...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066613498043

    authors: Simon TG,Bradley J,Jones A,Carino G

    更新日期:2014-11-01 00:00:00

  • Timing of Renal Replacement Therapy for Acute Kidney Injury.

    abstract::Acute kidney injury (AKI) is common in critically ill patients and associated with increased morbidity and mortality. With the increased use of renal replacement therapy (RRT) for severe AKI, the optimal time for initiation of RRT has become one of the most probed and debated topic in the field of nephrology and criti...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066618774257

    authors: Karakala N,Tolwani AJ

    更新日期:2019-02-01 00:00:00

  • A comparison of infusion volumes in the measurement of intra-abdominal pressure.

    abstract::Bladder pressure measurement through a foley catheter is the current standard in monitoring for intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Accurate pressure transduction requires a continuous fluid column with a small volume of transducing medium at the tip of the catheter. Infusing ex...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066609335730

    authors: Kimball EJ,Baraghoshi GK,Mone MC,Hansen HJ,Adams DM,Alder SC,Jackson P,Cannon P,Horn J,Wolfe TR

    更新日期:2009-07-01 00:00:00

  • Actigraphy to Measure Physical Activity in the Intensive Care Unit: A Systematic Review.

    abstract:OBJECTIVE:In the intensive care unit (ICU), prolonged inactivity is common, increasing patients' risk for adverse outcomes, including ICU-acquired weakness. Hence, interventions to minimize inactivity are gaining popularity, highlighting actigraphy, a measure of activity involving a wristwatch-like accelerometer, as a ...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619863654

    authors: Schwab KE,To AQ,Chang J,Ronish B,Needham DM,Martin JL,Kamdar BB

    更新日期:2020-11-01 00:00:00

  • Review of a large clinical series: intrahospital transport of critically ill patients: outcomes, timing, and patterns.

    abstract::The purpose of this study was to analyze the relationship of intrahospital transport patterns with patient throughput and outcomes in an oncological intensive care unit. We retrospectively reviewed all patients admitted to a closed medical-surgical intensive care unit at a cancer center between January 1, 2004 and Dec...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066608329946

    authors: Voigt LP,Pastores SM,Raoof ND,Thaler HT,Halpern NA

    更新日期:2009-03-01 00:00:00

  • The Association Between Admission Magnesium Concentrations and Lactic Acidosis in Critical Illness.

    abstract:INTRODUCTION:Although magnesium plays an important role in aerobic metabolism and magnesium deficiency is a common phenomenon in critical illness, the association between magnesium deficiency and lactic acidosis in the intensive care unit (ICU) has not been defined. METHODS:This was a retrospective, cross-sectional st...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066614530659

    authors: Moskowitz A,Lee J,Donnino MW,Mark R,Celi LA,Danziger J

    更新日期:2016-03-01 00:00:00

  • Practice Patterns in the Treatment of Patients With Severe Alcohol Withdrawal: A Multidisciplinary, Cross-Sectional Survey.

    abstract:PURPOSE:To characterize physicians' stated practices in the treatment of patients with severe acute alcohol withdrawal syndrome (sAAWS) and to use intravenous (IV) phenobarbital as an adjuvant treatment for sAAWS. METHODS:A multidisciplinary, cross-sectional, self-administered survey at 2 large academic centers specia...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619847119

    authors: Buell D,Filewod N,Ailon J,Burns KEA

    更新日期:2020-11-01 00:00:00

  • Effect of Compliance With a Nurse-Led Intensive Care Unit Checklist on Clinical Outcomes in Mechanically and Nonmechanically Ventilated Patients.

    abstract:BACKGROUND:Use of checklists brings about improvements in a variety of patient outcomes. Nevertheless, whether compliance with a nurse-led intensive care unit (ICU) checklist produces the same effect is currently unknown. METHODS:This is a retrospective analysis of data obtained during the implementation of a quality ...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066614533910

    authors: Al Ashry HS,Abuzaid AS,Walters RW,Modrykamien AM

    更新日期:2016-05-01 00:00:00

  • Pharmacologic Management of Delirium in the ICU: A Review of the Literature.

    abstract:PURPOSE:Conflicting data exists on the pharmacologic management of intensive care unit (ICU) delirium. This review appraises the current evidence of pharmacologic management of ICU delirium. MATERIALS AND METHODS:A systematic literature search of MEDLINE and Embase was conducted to answer the population, intervention,...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066618805965

    authors: Korenoski A,Li A,Kane-Gill SL,Seybert AL,Smithburger PL

    更新日期:2020-02-01 00:00:00

  • Risk of Mortality of Catheter-Related Bloodstream Infections Caused by Acinetobacter Species: Is Early Removal of the Catheters Associated With a Better Survival Outcome?

    abstract:PURPOSE:Bloodstream infections (BSIs) caused by Acinetobacter species have been extensively reported, however, which majorly focused on respiratory tract infections. The risk of mortality and the effect of early catheter removal on survival in catheter-related BSIs (CRBSIs) caused by Acinetobacter spp. remain unclear. ...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0885066616677710

    authors: Lee Y,Lee YT,Wang YC,Chen CT,Sun JR,Liu CP,Liu YM,Kuo SC,Chiu CH,Yang YS,Lin JC,Chen TL

    更新日期:2018-06-01 00:00:00

  • Effect of Interhospital ICU Relocation on Patient Physiology and Clinical Outcomes.

    abstract::Relocation of large numbers of critically ill patients between hospitals is sometimes necessary and the risks associated with relocation may be high. In the setting of adherence to an interhospital intensive care unit (ICU) relocation protocol, we aimed to determine whether the interhospital relocation of all ICU pati...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066617726754

    authors: Janz DR,Khan YA,Mooney JL,Semler MW,Rice TW,Johnson JL,deBoisblanc BP,ICU MOVE Investigators and the Pragmatic Critical Care Research Group.

    更新日期:2019-11-01 00:00:00

  • Multimodality Monitoring in Neurocritical Care: Decision-Making Utilizing Direct And Indirect Surrogate Markers.

    abstract::Substantial progress has been made to create innovative technology that can monitor the different physiological characteristics that precede the onset of secondary brain injury, with the ultimate goal of intervening prior to the onset of irreversible neurological damage. One of the goals of neurocritical care is to re...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066618788022

    authors: Al-Mufti F,Lander M,Smith B,Morris NA,Nuoman R,Gupta R,Lissauer ME,Gupta G,Lee K

    更新日期:2019-06-01 00:00:00

  • Accuracy of Ultrasonographic Measurements of Inferior Vena Cava to Determine Fluid Responsiveness: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVE:Fluid responsiveness is the ability to increase the cardiac output in response to a fluid challenge. Only about 50% of patients receiving fluid resuscitation for acute circulatory failure increase their stroke volume, but the other 50% may worsen their outcome. Therefore, predicting fluid responsiveness is ne...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,meta分析

    doi:10.1177/0885066617752308

    authors: Orso D,Paoli I,Piani T,Cilenti FL,Cristiani L,Guglielmo N

    更新日期:2020-04-01 00:00:00

  • Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages.

    abstract::The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a spectrum of symptoms ranging from mild to critical illness requiring intensive care unit (ICU) admission. Acute respiratory distress syndrome is a m...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066620951426

    authors: Ammar MA,Sacha GL,Welch SC,Bass SN,Kane-Gill SL,Duggal A,Ammar AA

    更新日期:2021-02-01 00:00:00

  • Fever during pediatric intensive care unit admission is independently associated with increased morbidity.

    abstract:AIMS:To investigate the occurrence and etiology of fever at anytime during pediatric intensive care unit (PICU) admission, and to study its possible effects on clinical outcome in a heterogeneous population of critically ill children. METHODS:Retrospective, observational single center study, comprising 202 patients ag...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066609340631

    authors: Gordijn MS,Plötz FB,Kneyber MC

    更新日期:2009-09-01 00:00:00

  • Controlled Donation After Circulatory Determination of Death.

    abstract::Controlled donation after circulatory determination of death (cDCDD) concerns donation after withdrawal of life-sustaining therapy (W-LST). We examine the ethical issues raised by W-LST in the cDCDD context in the light of a review of cDCDD protocols and the ethical literature. Our analysis confirms that W-LST procedu...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066615625628

    authors: Dalle Ave AL,Shaw DM

    更新日期:2017-03-01 00:00:00

  • Isolated shortness of breath in a woman with a history of Hodgkin lymphoma.

    abstract:BACKGROUND:Isolated shortness of breath in the patient with a history of a malignancy creates a diagnostic challenge and serves as a source of anxiety. Although cancer recurrence is typically the first concern of the patient and the clinician, toxicities of anticancer therapies must also be considered. METHODS:A case ...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066614538910

    authors: Clapham KR,Bhimani RD,Cooper JP,Stern TA

    更新日期:2015-05-01 00:00:00

  • A review of the fundamental principles and evidence base in the use of extracorporeal membrane oxygenation (ECMO) in critically ill adult patients.

    abstract::Extracorporeal membrane oxygenation (ECMO) comprises a commonly used method of extracorporeal life support. It has proven efficacy and is an accepted modality of care for isolated respiratory or cardiopulmonary failure in neonatal and pediatric populations. In adults, there are conflicting studies regarding its benefi...

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0885066610384061

    authors: Allen S,Holena D,McCunn M,Kohl B,Sarani B

    更新日期:2011-01-01 00:00:00

  • Novel Method of Atrial Fibrillation Case Identification and Burden Estimation Using the MIMIC-III Electronic Health Data Set.

    abstract:BACKGROUND:Atrial fibrillation (AF) portends poor prognoses in intensive care unit patients with sepsis. However, AF research is challenging: Previous studies demonstrate that International Classification of Disease (ICD) codes may underestimate the incidence of AF, but chart review is expensive and often not feasible....

    journal_title:Journal of intensive care medicine

    pub_type: 杂志文章

    doi:10.1177/0885066619866172

    authors: Ding EY,Albuquerque D,Winter M,Binici S,Piche J,Bashar SK,Chon K,Walkey AJ,McManus DD

    更新日期:2019-10-01 00:00:00