Abstract:
:Sepsis is a major cause of morbidity and mortality worldwide. With the advance of medical care, the mortality of sepsis has decreased in the past decades. Many treatments and diagnostic tools still lack supporting evidence. We conducted a retrospective population-based cohort study with propensity score matched subcohorts based on a prospectively collected national longitudinal health insurance database in Taiwan. Severe sepsis-associated hospital admissions from 2000 to 2011 based on International Classification of Diseases, Ninth Revision, Clinical Modification codes of infections and acute organ dysfunction were identified. To compare the effectiveness of treatment and diagnostic tool, propensity scores were generated to match the comparable control groups. During the 12-year period, 33 375 patients and 50 465 hospitalizations of severe sepsis were identified. The age-standardized 28-day in-hospital mortality decreased significantly from 21% in 2008 to 15% in 2011 with increasingly implemented treatment and diagnostic tool. After propensity score matching, procalcitonin (odds ratio [OR]: 0.70, 95% confidence interval [95% CI]: 0.61-0.81) and lactate testing (OR: 0.90, 95% CI: 0.84-0.97, respectively), transfusion of packed red blood cell (OR: 0.60, 95% CI: 0.52-0.69), albumin (OR: 0.72, 95% CI: 0.55-0.93), balanced crystalloid (OR: 0.29, 95% CI: 0.20-0.41), and use of dopamine (OR: 0.44, 95% CI: 0.39-0.49) were found to be significantly associated with lower mortality rate. However, inconsistent findings need to be further validated.
journal_name
J Intensive Care Medjournal_title
Journal of intensive care medicineauthors
Chen KF,Tsai MY,Wu CC,Han STdoi
10.1177/0885066619827270subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1418-1425issue
12eissn
0885-0666issn
1525-1489journal_volume
35pub_type
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journal_title:Journal of intensive care medicine
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journal_title:Journal of intensive care medicine
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journal_title:Journal of intensive care medicine
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journal_title:Journal of intensive care medicine
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更新日期:2014-11-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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更新日期:2009-07-01 00:00:00
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doi:10.1177/0885066619863654
更新日期:2020-11-01 00:00:00
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更新日期:2009-03-01 00:00:00
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journal_title:Journal of intensive care medicine
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doi:10.1177/0885066614530659
更新日期:2016-03-01 00:00:00
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journal_title:Journal of intensive care medicine
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更新日期:2020-11-01 00:00:00
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2019-06-01 00:00:00
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journal_title:Journal of intensive care medicine
pub_type: 杂志文章,meta分析
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更新日期:2020-04-01 00:00:00
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更新日期:2021-02-01 00:00:00
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更新日期:2009-09-01 00:00:00
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更新日期:2017-03-01 00:00:00
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00