Pharmacologic Management of Delirium in the ICU: A Review of the Literature.

Abstract:

PURPOSE:Conflicting data exists on the pharmacologic management of intensive care unit (ICU) delirium. This review appraises the current evidence of pharmacologic management of ICU delirium. MATERIALS AND METHODS:A systematic literature search of MEDLINE and Embase was conducted to answer the population, intervention, comparison, and outcome (PICO) question of: "Does the use of a pharmacologic agent compared to standard of care or placebo improve ICU delirium in a critically ill patient population?" RESULTS:After application of the PICO question and the inclusion and exclusion criteria, 13 articles were included. Of these articles, 7 were prospective randomized controlled trials, 1 was a prospective nonrandomized controlled trial, and 5 were retrospective investigations. The included articles differed in the agents evaluated, primary outcome, and method of identifying delirium. CONCLUSION:The variability of outcomes illustrates the need for a large-scale investigation to further evaluate the role of pharmacologic management of ICU delirium.

journal_name

J Intensive Care Med

authors

Korenoski A,Li A,Kane-Gill SL,Seybert AL,Smithburger PL

doi

10.1177/0885066618805965

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

107-117

issue

2

eissn

0885-0666

issn

1525-1489

journal_volume

35

pub_type

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