Abstract：
:Intracerebral hemorrhage (ICH) in patients with oral anticoagulation therapy is an increasingly prevalent problem in large part due to the aging population and the increased use of anticoagulants for patients at high risk of thrombosis. Warfarin has been virtually the only outpatient anticoagulant choice until fairly recently. The development of subcutaneously injected heparinoids, and more recently, of direct thrombin inhibitors, has made the treatment and prognostication of ICH in anticoagulated patients more difficult. In this review, we will review the current state of diagnosis, prognostication, and treatment for patients with this often-devastating type of bleeding. We will focus on warfarin therapy, because the preponderance of evidence comes from studies of warfarin treatment. Where there is evidence, we will contrast warfarin with some of the newer treatment modalities. We review the evidence of the 4 major reversal agents for warfarin, vitamin K, prothrombin complex concentrates, activated factor VII, and fresh frozen plasma as well as rational treatment choices. We offer possible treatments for the newer anticoagulants based on the limited evidence available. Finally, we review recommendations from the major societies and studies that support early and aggressive therapies in intensive care units with dedicated neurological specialists.
journal_name
J Intensive Care Medjournal_title
Journal of intensive care medicineauthors
da Silva IR,Provencio JJdoi
10.1177/0885066613488732subject
Has Abstractpub_date
2015-02-01 00:00:00pages
63-78issue
2eissn
0885-0666issn
1525-1489pii
0885066613488732journal_volume
30pub_type
杂志文章,评审abstract：PURPOSE:We previously developed a bedside model (I-TRACH), which used commonly obtained data at the time of intubation to predict the duration of mechanical ventilation (MV). We now sought to validate this in a prospective trial. METHODS:A prospective, observational study of 225 consecutive adult medical intensive car...
journal_title：Journal of intensive care medicine
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更新日期：2018-10-01 00:00:00
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doi：10.1177/088506669501000202
更新日期：1995-03-01 00:00:00
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journal_title：Journal of intensive care medicine
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journal_title：Journal of intensive care medicine
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更新日期：2015-07-01 00:00:00
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pub_type： 临床试验,杂志文章
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abstract：BACKGROUND:Use of checklists brings about improvements in a variety of patient outcomes. Nevertheless, whether compliance with a nurse-led intensive care unit (ICU) checklist produces the same effect is currently unknown. METHODS:This is a retrospective analysis of data obtained during the implementation of a quality ...
journal_title：Journal of intensive care medicine
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更新日期：2016-05-01 00:00:00
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更新日期：2014-03-01 00:00:00
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更新日期：2017-02-01 00:00:00
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更新日期：2012-05-01 00:00:00
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更新日期：2013-09-01 00:00:00
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更新日期：2011-05-01 00:00:00
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更新日期：2007-11-01 00:00:00
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journal_title：Journal of intensive care medicine
pub_type： 杂志文章
doi：10.1177/0885066610392516
更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2018-06-01 00:00:00
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journal_title：Journal of intensive care medicine
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更新日期：2018-08-01 00:00:00
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journal_title：Journal of intensive care medicine
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更新日期：2008-03-01 00:00:00
