Hyponatremia in heart failure.

Abstract:

:Hyponatremia is one of the newer and emerging risk factors for an adverse prognosis in chronic heart failure. Why decreased serum sodium is associated with worse prognosis remains unclear. It may reflect worsening heart failure and the deleterious effects of activation of neurohormones. The mechanism of hyponatremia in heart failure also remains unclear. A relatively greater degree of free-water retention compared to sodium retention is probably the major mechanism. The treatment of significant hyponatremia in heart failure is difficult. The conventional treatments such as fluid restriction, infusion of hypertonic saline, and aggressive diuretic therapies are not usually effective. Vasopressin receptor antagonists have been shown to enhance aquaresis and correct hyponatremia. However, long-term beneficial effects of such treatments in chronic heart failure have not been documented.

journal_name

J Intensive Care Med

authors

Chatterjee K

doi

10.1177/0885066609344941

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

347-51

issue

6

eissn

0885-0666

issn

1525-1489

pii

0885066609344941

journal_volume

24

pub_type

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