Abstract:
:Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on a series of events involving interactions of diverse parasite molecules with host components. Here we focus on the mechanisms of target cell invasion by metacyclic trypomastigotes (MT) and mammalian tissue culture trypomastigotes (TCT). During MT or TCT internalization, signal transduction pathways are activated both in the parasite and the target cell, leading to Ca2+ mobilization. For cell adhesion, MT engage surface glycoproteins, such as gp82 and gp35/50, which are Ca2+ signal-inducing molecules. In T. cruzi isolates that enter host cells in gp82-mediated manner, parasite protein tyrosine kinase as well as phospholipase C are activated, and Ca2+ is released from I P3-sensitive stores, whereas in T. cruzi isolates that attach to target cells mainly through gp35/50, the signaling pathway involving adenylate cyclase appears to be stimulated, with Ca2+ release from acidocalciosomes. In addition, T. cruzi isolate-dependent inhibitory signals, mediated by MT-specific gp90, may be triggered both in the host cell and the parasite. The repertoire of TCT molecules implicated in cell invasion includes surface glycoproteins of gp85 family, with members containing binding sites for laminin and cytokeratin 18, enzymes such as cruzipain, trans-sialidase, and an oligopeptidase B that generates a Ca2+-agonist from a precursor molecule.
journal_name
An Acad Bras Ciencjournal_title
Anais da Academia Brasileira de Cienciasauthors
Yoshida Ndoi
10.1590/s0001-37652006000100010subject
Has Abstractpub_date
2006-03-01 00:00:00pages
87-111issue
1eissn
0001-3765issn
1678-2690pii
S0001-37652006000100010journal_volume
78pub_type
杂志文章,评审abstract::Two major memory systems have been recognized over the years (Squire 1987): the declarative memory system, which is under the control of the hippocampus and related temporal lobe structures, and the procedural or habit memory system, which is under the control of the striatum and its connections. Most if not all learn...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章,评审
doi:10.1590/s0001-37652006000300011
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abstract::Current two-dimensional (2D) ultrasonic marker measurements are inherent with intra- and inter-observer variability limitations. The objective of this paper is to investigate the performance of conventional 2D ultrasonic marker measurements and proposed programmable interactive three-dimensional (3D) marker evaluation...
journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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abstract::Candida is a human fungal pathogen that causes a wide range of diseases. Candida albicans is the main etiologic agent in these diseases; however, infections can be caused by non-albicans Candida species. Virulence factors such as biofilm production, which protect the fungus from host immunity and anti-fungal drugs, ar...
journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/S0001-37652013000300019
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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journal_title:Anais da Academia Brasileira de Ciencias
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