Anti-urolithiatic activity of Salvia hispanica L. seeds in ethylene glycol induced urolithiasis rat's model.

Abstract:

:Urolithiasis is a disorder of kidneys in which stones formation occur due to the excessive deposition of minerals in the urinary tract. It affects 12% of the population worldwide. Salvia hispanica seeds are rich source of quercetin which has preventive role in renal stone formation. The study objective was to explore scientifically the anti-urolithiatic effect of Salvia hispanica seed's methanol extract using in vitro and in vivo urolithiasis models. For in-vitro study nucleation, growth and aggregation assays were performed. In vivo study was performed on rats and they were divided into six groups (n=6). Group-I was given vehicle only. Group-II was disease control, treated with 0.75% EG in drinking water which triggered urolithiasis. Groups-III received cystone (750 mg/kg, orally). Groups IV-VI were treated with extract at 100, 300 and 700 mg/kg doses orally once daily. Groups III-VI additionally received 0.75% EG in drinking water. In vitro study revealed concentration dependent increase in percentage inhibition of crystal's nucleation, growth and aggregation. In vivo study revealed anti-urolithiatic activity by lowering oxalate, calcium, phosphate, sodium and potassium levels in the urine and the serum uric acid, blood urea nitrogen, total proteins and total albumin. Salvia hispanica seeds are good alterative of allopathic anti-urolithiatic drugs to treat urolithiasis.

journal_name

An Acad Bras Cienc

authors

Saleem U,Ahmad N,Shah MA,Anwar F,Ahmad B

doi

10.1590/0001-3765202020200067

subject

Has Abstract

pub_date

2020-11-16 00:00:00

pages

e20200067

issue

4

eissn

0001-3765

issn

1678-2690

pii

S0001-37652020000700911

journal_volume

92

pub_type

杂志文章
  • Areas of natural occurrence of Melipona scutellaris Latreille, 1811 (Hymenoptera: Apidae) in the state of Bahia, Brazil.

    abstract::The bee Melipona scutellaris is considered the reared meliponine species with the largest distribution in the North and Northeast regions of Brazil, with records from the state of Rio Grande do Norte down to the state of Bahia. Considering the importance of this species in the generation of income for family agricultu...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000300010

    authors: Alves RM,Carvalho CA,Souza BA,Santos WS

    更新日期:2012-09-01 00:00:00

  • Antioxidant and antimicrobial potential of selected varieties of Piper betle L. (Betel leaf).

    abstract::Piper betle L., is an evergreen perennial creeper belonging to family Piperaceae and is known to possess numerous medicinal properties. Current study focuses on evaluating antioxidant and antimicrobial potential of betel leaf. For the present study, distilled water, hexane, acetone and ethanolic extracts of two variet...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180285

    authors: Sarma C,Rasane P,Kaur S,Singh J,Singh J,Gat Y,Garba U,Kaur D,Dhawan K

    更新日期:2018-10-01 00:00:00

  • Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination.

    abstract::Miconazole is reduced at mercury electrode above pH 6 involving organometallic compound formation, responsible for an anomalous polarographic behavior. The electrodic process presents a large contribution of the adsorption effects. The drug can be determined by cathodic stripping voltammetry from 8.0 x 10(-8) to 1, 5 ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652002000300005

    authors: Pereira FC,Stradiotto NR,Zanoni MV

    更新日期:2002-09-01 00:00:00

  • Effect of herbicides in the oxidative stress in crop winter species.

    abstract::Most herbicides applied in crop field, stay in the soil for a period, affecting next crop or even the plants using as green manure. Nowadays, the use of herbicides grow to increase productivity, mainly in the grain producing region north of Rio Grande do Sul state. The objective of this study was to evaluate the effec...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170482

    authors: Alves C,Costa E,Sofiatti JR,Forte CT,Winter FL,Holz CM,Kaizer RR,Galon L

    更新日期:2018-04-01 00:00:00

  • Modulation of diabetes and dyslipidemia in diabetic insulin-resistant rats by mangiferin: role of adiponectin and TNF-α.

    abstract::Mangiferin, present in Mangifera indica bark, was reported to produce hypoglycemic and antidiabetic activity in an animal model of genetic type 2 diabetes and in streptozotocin diabetic rats. Its effect on diabetic insulin-resistant animals has not been investigated. The current work aimed to explore the effect of man...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420140212

    authors: Saleh S,El-Maraghy N,Reda E,Barakat W

    更新日期:2014-12-01 00:00:00

  • Inhibition kinetics of digestive proteases for Anticarsia gemmatalis.

    abstract::Anticarsia gemmatalis Hübner, 1818 (Lepidoptera) is a major pest of soybean in the Brazil. It is known that the reduction of proteolytic activity by the ingestion of protease inhibitors reduces digestion and larval development of the insects. Control via inhibition of the digestive enzymes necessitates deeper knowledg...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020180477

    authors: Patarroyo-Vargas AM,Cordeiro G,Silva CRD,Silva CRD,Mendonça EG,Visôtto LE,Zanuncio JC,Campos WG,Oliveira MGA

    更新日期:2020-01-01 00:00:00

  • Bits and q-bits as versatility measures.

    abstract::Using Shannon information theory is a common strategy to measure any kind of variability in a signal or phenomenon. Some methods were developed to adapt information entropy measures to bird song data trying to emphasize its versatility aspect. This classical approach, using the concept of bit, produces interesting res...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652004000200035

    authors: Piqueira JR

    更新日期:2004-06-01 00:00:00

  • New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals.

    abstract::With the advance and popularization of molecular techniques, the identification of genetic mutations that cause diseases has increased dramatically. Thus, the number of laboratories available to investigate a given disorder and the number of subsequent diagnosis have increased over time. Although it is necessary to id...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/0001-3765201520140711

    authors: Velho RV,Sperb-Ludwig F,Schwartz IV

    更新日期:2015-08-01 00:00:00

  • Population structure and allometry of Podocnemis unifilis (Testudines, Podocnemididae) in a protected area upstream Belo Monte dam in Xingu River, Brazil.

    abstract::Amazon river turtles are increasingly threatened by habitat loss and alteration due to the Brazilian energy policy based on construction of hydroelectric dams, meanwhile, populational studies remain scarce. We described the population structure, and established body allometric relationships of Podocnemis unifilis in t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140321

    authors: Miorando PS,Giarrizzo T,Pezzuti JC

    更新日期:2015-10-01 00:00:00

  • Removal of synthetic sex hormones by hydrothermal carbonization.

    abstract::One of the most prominent fields of environmental chemistry is the study and the removal of micro-pollutants from aqueous matrices. Analytical techniques for their identification and quantification are becoming more sensitive and comprehensive and, as a result, an increasing number of drugs have been detected in envir...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170176

    authors: Morais RL,Santiago MF,Zang JW,Fonseca-Zang WA,Schimidt F

    更新日期:2018-04-01 00:00:00

  • Influence of land use changes on water chemistry in streams in the State of São Paulo, southeast Brazil.

    abstract::Streamwater is affected by several processes in the watershed including anthropogenic activities that result in changes in water quality as well as in the functioning of these stream ecosystems. Therefore, this work aims to evaluate the concentration of major ions (Ca(2+), Mg(2+), Na(+), K(+), NH4(+), NO3(-), NO2(-), ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000400007

    authors: Silva DM,Camargo PB,McDowell WH,Vieira I,Salomão MS,Martinelli LA

    更新日期:2012-12-01 00:00:00

  • Approaches to the mechanisms of song memorization and singing provide evidence for a procedural memory.

    abstract::There is growing evidence that, during song learning, birds do not only acquire 'what to sing' (the inventory of behavior), but also 'how to sing' (the singing program), including order-features of song sequencing. Common Nightingales Luscinia megarhynchos acquire such serial information by segmenting long strings of ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652004000200005

    authors: Hultsch H,Todt D

    更新日期:2004-06-01 00:00:00

  • Ecological affinities of Brazil and the southeastern United States of America. A study in comparative physiological ecology.

    abstract::Brazil and the southeastern United States have faunistic similarities and differences which are of fundamental interest to the environmental scientist. These similarities and differences provide natural experimental organisms and habitats which can provide answers to basic and applied questions. What are the lethal li...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Vernberg FJ,Vernberg WB

    更新日期:1976-01-01 00:00:00

  • Evaluation in vivo of biocompatibility of differents resin-modified cements for bonding orthodontic bands.

    abstract::The focus of this study was to test the hypothesis that there would be no difference between the biocompatibility of resin-modified glass ionomer cements. Sixty male Wistar rats were selected and divided into four groups: Control Group; Crosslink Group; RMO Group and Transbond Group. The materials were inserted into r...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170329

    authors: Mesquita JA,Lacerda-Santos R,Sampaio GAM,Godoy GP,Nonaka CFW,Alves PM

    更新日期:2017-01-01 00:00:00

  • Evaluation of the impact of pharmaceutical care for tuberculosis patients in a Secondary Referral Outpatient Clinic, Minas Gerais, Brazil.

    abstract::Pharmaceutical care is a professional practice seeking the responsible provision of drug therapy by identifying, resolving, and preventing Drug-Related Problems (DRP). The study aims to describe and evaluate the impact of pharmaceutical care given to patients being treated for tuberculosis (TB). Study concurrent, long...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170301

    authors: Lopes ARV,Miranda SS,Ceccato MDGB,Silveira MR,Resende NH,Carvalho WS

    更新日期:2017-10-01 00:00:00

  • Sawdust Derivative for Environmental Application: Chemistry, Functionalization and Removal of textile dye from aqueous solution.

    abstract::The adsorption of Violet Remazol 5R (VR 5) on wood sawdust modified with succinic anhydride (SSA) as a function of contact time, pH, and initial dye concentrations was investigated using a batch technique under ambient conditions. The SSA obtained was confirmed by IR spectroscopy, thermogravimetry and 13C NMR, and deg...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620140656

    authors: Pinto TF,Bezerra CW,Silva DS,Silva EC Filho,Vieira AP,Airoldi C,Melo JC,Silva HA,Santana SA

    更新日期:2016-09-01 00:00:00

  • Consumption of Euterpe edulis fruit by wildlife: implications for conservation and management of the Southern Brazilian Atlantic Forest.

    abstract::This study aimed to measure the wildlife consumption of Euterpe edulis fruit and use this data to discuss management possibilities. To estimate infructescence fruit volume consumed, collectors were installed in fruit-bearing palms. To characterize consumption from the ground, samples were placed next to fruiting palms...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180537

    authors: Silva JZD,Reis MSD

    更新日期:2019-01-01 00:00:00

  • Plant Bugs Predators (Hemiptera: Heteroptera: Miridae) with References to Arthropods and Fungi in Brazil.

    abstract::The present study demonstrates 30 plant bugs species associated with 50 records of prey and six records of mycophagy for Brazil. The data were compiled from Schuh's Catalog, the literature, specimens deposited in entomology museums and exemplars from different regions of Brazil sent for identification. Some of the dat...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920181194

    authors: Nogueira BCF,Ferreira PSF,Coelho LA,Martins DS,Barcellos BD

    更新日期:2019-08-12 00:00:00

  • Short- and long-term memory: differential involvement of neurotransmitter systems and signal transduction cascades.

    abstract::Since William James (1890) first distinguished primary from secondary memory, equivalent to short- and long-term memory, respectively, it has been assumed that short-term memory processes are in charge of cognition while long-term memory is being consolidated. From those days a major question has been whether short-te...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652000000300009

    authors: Vianna MR,Izquierdo LA,Barros DM,Walz R,Medina JH,Izquierdo I

    更新日期:2000-09-01 00:00:00

  • Characterization, fractionation and mobility of trace elements in surface sediments of the Jequiezinho River, Bahia, Brazil.

    abstract::The Jequiezinho River is a temporary river. In the urban stretch it is impacted, with perennial flow coming from domestic sewage and rainwater. This study evaluated the geochemical distribution and potential mobility of some metals (Pb, Co, Ca, Cr, Mg, Cu, Fe, Mn, Ni and Zn) in sediments of the Jequiezinho River. Sedi...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190558

    authors: Silva DS,Cerqueira UMFM,Aguiar RM,Carneiro PLS,Bezerra MA

    更新日期:2020-11-27 00:00:00

  • New species of Myrmicium Westwood (Psedosiricidae = Myrmiciidae: Hymenoptera, Insecta) from the Early Cretaceous (Aptian) of the Araripe Basin, Brazil.

    abstract::This paper records the first occurrence of the genus Myrmicium Westwood, 1854 in the Cretaceous of Gondwana and describes it as a new species Myrmicium araripterum sp. nov, based on the most complete specimen of this genus yet known, which represents the largest specimen of the grade "Symphyta" ever found in the Crato...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020200479

    authors: Freitas LCB,Rasnitsyn AP,Moura GJB,Mendes M

    更新日期:2020-01-01 00:00:00

  • A new species of Tereancistrum (Monogenea, Dactylogyridae) from the gills of three Leporinus species (Characiformes, Anostomidae) and a revised description of Tereancistrum parvus.

    abstract::The present study describes Tereancistrum flabellum n. sp. (Dactylogyridae, Ancyrocephalinae) from the gills of the anostomid fishes Leporinus friderici, Leporinus amblyrhynchus and Leporinus elongatus from two freshwater ecosystems in the south east of Brazil. This new species is mainly characterized by the morpholog...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160628

    authors: Zago AC,Yamada FH,Franceschini L,Bongiovani MF,Yamada POF,Silva RJD

    更新日期:2017-04-01 00:00:00

  • DNA damage and cytotoxicity in pathology laboratory technicians exposed to organic solvents.

    abstract::The aim of this study was to evaluate potential DNA damage and cytotoxicity in pathology laboratory technicians exposed to organic solvents, mainly xylene. Peripheral blood and buccal cells samples were collected from 18 technicians occupationally exposed to organic solvents and 11 non-exposed individuals. The technic...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150194

    authors: de Aquino T,Zenkner FF,Ellwanger JH,Prá D,Rieger A

    更新日期:2016-03-01 00:00:00

  • Scientists in the public sphere: Interactions of scientists and journalists in Brazil.

    abstract::In order to map scientists' views on media channels and explore their experiences interacting with journalists, the authors conducted a survey of about 1,000 Brazilian scientists. Results indicate that scientists have clear and high expectations about how journalists should act in reporting scientific information in t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150558

    authors: Massarani L,Peters HP

    更新日期:2016-06-07 00:00:00

  • Trade-off between reservoir yield and evaporation losses as a function of lake morphology in semi-arid Brazil.

    abstract::This study investigates the relationships between yield and evaporation as a function of lake morphology in semi-arid Brazil. First, a new methodology was proposed to classify the morphology of 40 reservoirs in the Ceará State, with storage capacities ranging from approximately 5 to 4500 hm3. Then, Monte Carlo simulat...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150124

    authors: Campos JN,Lima IE Neto,Studart TM,Nascimento LS

    更新日期:2016-05-31 00:00:00

  • Electrocyte physiology: I. Temperature dependence of membrane excitability.

    abstract::Some membrane characteristics of the isolated electrocyte of the Sachs organ are presented as function of temperature. Excitability curves are shown for electrocytes kept in standard saline at different temperatures. It is shown that rheobase varies directly with temperature. Apparently membrane resistance varies from...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Esquibel MA,Negreiros J,Gawryszewski LG

    更新日期:1980-09-01 00:00:00

  • Litter Size Reduction Induces Metabolic and Histological Adjustments in Dams throughout Lactation with Early Effects on Offspring.

    abstract::In the present study we analyzed morphological and metabolic alterations in dams nursing small litters and their consequences to offspring throughout lactation. Offspring sizes were adjusted to Small Litter (SL, 3 pups/ dam) and Normal Litter (NL, 9 pups/ dam). Body weight, food intake, white adipose tissue (WAT) cont...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920170971

    authors: Xavier JLP,Scomparin DX,Pontes CC,Ribeiro PR,Cordeiro MM,Marcondes JA,Mendonça FO,Silva MTD,Oliveira FB,Franco GCN,Grassiolli S

    更新日期:2019-03-21 00:00:00

  • Production, extraction and characterization of exopolysaccharides produced by the native Leuconostoc pseudomesenteroides R2 strain.

    abstract::The genus Leuconostoc belongs to a group of lactic acid bacteria usually isolated from fermented vegetables, which includes species involved in the production of exopolysaccharides (EPS). These biopolymers possess considerable commercial potential. Because of the wide variety of industrial applications of EPS, this st...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000200018

    authors: Paulo EM,Boffo EF,Branco A,Valente AM,Melo IS,Ferreira AG,Roque MR,Assis SA

    更新日期:2012-06-01 00:00:00

  • Assessment of scientific programs: a necessary procedure for Brazilian scientific policy--the Young Investigator Program of the State of São Paulo Research Foundation.

    abstract::Programs of Science and Technology research have grown significantly in Brazil over the last decades. Until the 1980s the so-called undirected programs, without specific goals and requiring only scientific merit, prevailed. The few programs with defined goals in this period were never objectively assessed. The same si...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652007000300014

    authors: Pian CA,Meneghini R

    更新日期:2007-09-01 00:00:00

  • Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation.

    abstract::Gabapentin has antihyperalgesic action, decreasing central sensitization in neuropathic pain models; this effect depends on the mobilization of endogenous pain control pathways. This study aims to investigate the contribution of the endocannabinoid system to the antihyperalgesic action of gabapentin. Mus musculus Swis...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020191155

    authors: Buffon AC,Javornik MA,Heymanns AC,Salm DC,Horewicz VV,Martins DF,Piovezan AP

    更新日期:2020-12-14 00:00:00