Short- and long-term memory: differential involvement of neurotransmitter systems and signal transduction cascades.

Abstract:

:Since William James (1890) first distinguished primary from secondary memory, equivalent to short- and long-term memory, respectively, it has been assumed that short-term memory processes are in charge of cognition while long-term memory is being consolidated. From those days a major question has been whether short-term memory is merely a initial phase of long-term memory, or a separate phenomena. Recent experiments have shown that many treatments with specific molecular actions given into the hippocampus and related brain areas after one-trial avoidance learning can effectively cancel short-term memory without affecting long-term memory formation. This shows that short-term memory and long-term memory involve separate mechanisms and are independently processed. Other treatments, however, influence both memory types similarly, suggesting links between both at the receptor and at the post-receptor level, which should not be surprising as they both deal with nearly the same sensorimotor representations. This review examines recent advances in short- and long-term memory mechanisms based on the effect of intra-hippocampal infusion of drugs acting upon neurotransmitter and signal transduction systems on both memory types.

journal_name

An Acad Bras Cienc

authors

Vianna MR,Izquierdo LA,Barros DM,Walz R,Medina JH,Izquierdo I

doi

10.1590/s0001-37652000000300009

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

353-64

issue

3

eissn

0001-3765

issn

1678-2690

pii

S0001-37652000000300009

journal_volume

72

pub_type

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