Abstract:
:The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around -30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder layers, as well as ulcer formation. Conversely, the CAPLIP group showed a smooth inflammatory reaction and hyperemia. In conclusion, the liposomes effectively protected the bladder against the irritative action of capsaicin.
journal_name
An Acad Bras Ciencjournal_title
Anais da Academia Brasileira de Cienciasauthors
Cirino LM,Vergne DM,Santana PF,Almeida ED,Costa LP,Albuquerque-Júnior RL,Lima-Verde IB,Padilha FF,Cardoso JCdoi
10.1590/0001-3765201620150309subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1539-47issue
3eissn
0001-3765issn
1678-2690pii
S0001-37652016005014102journal_volume
88pub_type
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journal_title:Anais da Academia Brasileira de Ciencias
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