Reduction of the DNA damages, Hepatoprotective Effect and Antioxidant Potential of the Coconut Water, ascorbic and Caffeic Acids in Oxidative Stress Mediated by Ethanol.

Abstract:

:Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLC-ESI+-MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective action of green dwarf coconut water, caffeic and ascorbic acids on the liver and serum of rats treated with ethanol. The results showed five polyphenols in the lyophilized coconut water spiked with standards: chlorogenic acid (0.18 µM), caffeic acid (1.1 µM), methyl caffeate (0.03 µM), quercetin (0.08 µM) and ferulic acid (0.02 µM) isomers. In the animals, the activity of the serum γ-glutamyltranspeptidase (γ-GT) was reduced to 1.8 I.U/L in the coconut water group, 3.6 I.U/L in the ascorbic acid group and 2.9 I.U/L in the caffeic acid groups, when compared with the ethanol group (5.1 I.U/L, p<0.05). Still in liver, the DNA analysis demonstrated a decrease of oxidized bases compared to ethanol group of 36.2% and 48.0% for pretreated and post treated coconut water group respectively, 42.5% for the caffeic acid group, and 34.5% for the ascorbic acid group. The ascorbic acid was efficient in inhibiting the thiobarbituric acid reactive substances (TBARS) in the liver by 16.5% in comparison with the ethanol group. These data indicate that the green dwarf coconut water, caffeic and ascorbic acids have antioxidant, hepatoprotective and reduced DNA damage properties, thus decreasing the oxidative stress induced by ethanol metabolism.

journal_name

An Acad Bras Cienc

authors

Bispo VS,Dantas LS,Chaves AB Filho,Pinto IFD,Silva RPD,Otsuka FAM,Santos RB,Santos AC,Trindade DJ,Matos HR

doi

10.1590/0001-3765201720160581

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

1095-1109

issue

2

eissn

0001-3765

issn

1678-2690

pii

S0001-37652017005009105

journal_volume

89

pub_type

杂志文章
  • Synthesis of new N-alkyl-2-mercapto-1-octylamines and respective disulfides.

    abstract::Four new N-alkyl-2-mercapto-1-octylamine hydrochlorides were synthesized via the reaction of 1,2-epithio-octane with corresponding amines following by conversion to the hydrochlorides. The disulfides were obtained by oxidation of the respective thiols. Upon biological assay of the products for activity against infecti...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Vieira Filho SA,Nelson DL,Piló-Veloso D

    更新日期:1986-12-01 00:00:00

  • Food restriction beginning at lactation interferes with the cellular dynamics of the mucosa and colonic myenteric innervation in adult rats.

    abstract::The effects of food restriction (FR) on the morphoquantitative aspects of the wall and myenteric neurons of the proximal colon in adult rats were analysed. FR was imposed by duplication of the experimental brood size in relation to the control brood during lactation. The FR group received a 50% reduction of food from ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420140163

    authors: Schoffen JP,Vicentini FA,Marcelino CG,Araújo EJ,Pedrosa MM,Natali MR

    更新日期:2014-12-01 00:00:00

  • Osteoderm microstructure of Riostegotherium yanei, the oldest Xenarthra.

    abstract::Abstract: Riostegotherium yanei from the Itaboraí Basin, Brazil, is the oldest known Xenarthra. This paper aims to describe the internal morphology of the osteoderms of Riostegotherium yanei from the perspective of histology and micro-CT approaches, expanding the available data on cingulate osteoderm microstructure. ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920181290

    authors: Bergqvist LP,Pereira PVLGC,Machado AS,Castro MC,Melki LB,Lopes RT

    更新日期:2019-09-02 00:00:00

  • New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals.

    abstract::With the advance and popularization of molecular techniques, the identification of genetic mutations that cause diseases has increased dramatically. Thus, the number of laboratories available to investigate a given disorder and the number of subsequent diagnosis have increased over time. Although it is necessary to id...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/0001-3765201520140711

    authors: Velho RV,Sperb-Ludwig F,Schwartz IV

    更新日期:2015-08-01 00:00:00

  • Interspecific variation in leaf pigments and nutrients of five tree species from a subtropical forest in southern Brazil.

    abstract::The purpose of this study was to analyze the seasonal variation in the nutrient and pigment content of leaves from five tree species - of which three are perennial (Cupania vernalis, Matayba elaeagnoides and Nectandra lanceolata) and two are deciduous (Cedrela fissilis and Jacaranda micrantha) - in an ecotone between ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620140605

    authors: Bündchen M,Boeger MR,Reissmann CB,Geronazzo KM

    更新日期:2016-01-01 00:00:00

  • A new species and new records of Leptogium (Ach.) Gray (Collemataceae, Peltigerales) from Rio Grande do Sul State with an identification key for the genus.

    abstract::Specimens of Leptogium collected in ten localities from the State of Rio Grande do Sul were studied. Sixteen species were found of 28 records mentioned to the state, which represents around 57% of the Leptogium diversity known for Rio Grande do Sul. Leptogium exaratum is proposed as a new species. Leptogium atlanticum...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180313

    authors: Kitaura MJ,Koch NM,Lucheta F,Käffer MI,Schmitt JL,Pedroso J,Martins SA,Rodrigues AS,Canêz LS

    更新日期:2019-02-14 00:00:00

  • Golden mussel Limnoperna fortunei (Bivalvia: Mytilidae) distribution in the main hydrographical basins of Uruguay: update and predictions.

    abstract::Limnoperna fortunei, an Asiatic rivers bivalve has become a worldwide problematic invasive species causing several water quality and macrofouling problems. In the Neotropical region it was first recorded in 1991 in the Rio de la Plata coast, Buenos Aires province. Since this, it showed a quick upstream invasion into t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652005000200004

    authors: Brugnoli E,Clemente J,Boccardi L,Borthagaray A,Scarabino F

    更新日期:2005-06-01 00:00:00

  • The influence of bromazepam on cortical power distribution.

    abstract::The EEG has been widely employed in the assessment of electrophysiological changes induced by distinct medications. Its sensibility in detecting alterations produced by a specific substance may be enhanced by methods of quantitative analyses (qEEG). The present study aimed at investigating the modulatory effects of br...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652008000200012

    authors: Sampaio I,Puga F,Veiga H,Cagy M,Piedade R,Ribeiro P

    更新日期:2008-06-01 00:00:00

  • Geologic conceptual model of the municipality of Sete Lagoas (MG, Brazil) and the surroundings.

    abstract::The study area is located in the state of Minas Gerais, Brazil, among the municipalities of Pedro Leopoldo, Matozinhos, and Sete Lagoas, with Velhas River as the eastern boundary. It is located in the São Francisco Craton, where carbonated argillo-arenaceous sediments are emplaced giving origin to the Bambuí Group, in...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140400

    authors: Galvão P,Hirata R,Cordeiro A,Barbati D,Peñaranda J

    更新日期:2016-03-01 00:00:00

  • The theorical-methodological construction of theses and dissertations and their epistemological problems.

    abstract::This essay discusses the problem of the lack of dialogue between theory/empirical reality in the construction of the theoretical structure of dissertations and doctorates in Human Sciences in Brazil; taking Geography as an example, Santos (2000) observed this problem, which persists at the national level. The proposal...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920171020

    authors: Gomes RD

    更新日期:2019-01-01 00:00:00

  • Identification of caffeic acid and rutin by UHPLC MS/MS and antioxidant activity of Commelina erecta Lineu. in cell culture.

    abstract::The Commelina erecta L. (C. erecta) also known as erva-de-santa-luzia is reported by local population to have medical properties against some pathological conditions. In this study, two extracts of C. erecta leaves (aqueous and ethanolic) were phytochemically analysed and evaluated for their in-vitro antioxidant activ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190491

    authors: Otsuka FAM,Santos RB,Chaves LF,Santos RS,Chaves Filho AB,Miyamoto S,Matos HR

    更新日期:2020-01-01 00:00:00

  • Feeding preference of Plutella xylostella for leaves treated with plant extracts.

    abstract::Plutella xylostella L. is one of the main agents to cause damages to plants of Brassica genus, provoking negative impacts in cultures. The use of botanical extracts in plants protection has been related in literature, however, their use in the species analyzed in this study is not yet reported. We assessed the effect ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150236

    authors: Couto IF,Fuchs ML,Pereira FF,Mauad M,Scalon SP,Dresch DM,Mussury RM

    更新日期:2016-01-01 00:00:00

  • Apis mellifera pollination improves agronomic productivity of anemophilous castor bean (Ricinus communis).

    abstract::Castor bean (Ricinus communis L.) is cultivated mainly for biodiesel production because of its oil-rich seeds; it is assumed to be an anemophylous species. But pollination deficit can lead to low productivity often attributed to other reasons. In this paper, we investigated pollination requirements, pollination mechan...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012005000057

    authors: Rizzardo RA,Milfont MO,Silva EM,Freitas BM

    更新日期:2012-12-01 00:00:00

  • The synergetic modulation of the excitability of central gray matter by a neuropeptide: two protocols using excitation waves in chick retina.

    abstract::The isolated chick retina provides an in vitro tissue model, in which two protocols were developed to verify the efficacy of a peptide in the excitability control of the central gray matter. In the first, extra-cellular potassium homeostasis is challenged at long intervals and in the second, a wave is trapped in a rin...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000100006

    authors: Lima VM,Piqueira JR,Hanke W

    更新日期:2009-03-01 00:00:00

  • New tools to study biophysical properties of single molecules and single cells.

    abstract::We present a review on two new tools to study biophysical properties of single molecules and single cells. A laser incident through a high numerical aperture microscope objective can trap small dielectric particles near the focus. This arrangement is named optical tweezers. This technique has the advantage to permit m...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652007000100003

    authors: Rocha MS,Mesquita ON

    更新日期:2007-03-01 00:00:00

  • Wollastonite to hinder growth of Aspergillus niger fungus on cotton textile.

    abstract::Effects of Aspergillus niger was investigated on the strength of cotton textile specimens impregnated with nano-wollastonite, and then compared with normal specimens. Cotton strips were cut and prepared in warp and wept directions according to the standard specifications ASTM D-5035. Results showed that incubation of ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170914

    authors: Taghiyari HR,Majidinajafabadi R,Vahidzadeh R

    更新日期:2018-09-01 00:00:00

  • Annual, seasonal and spatial abundance of the seabob shrimp Xiphopenaeus kroyeri (Decapoda, Penaeidae) off the Southeastern coast of Brazil.

    abstract::We investigated the influence of environmental factors in spatial and temporal distribution of the seabob shrimp Xiphopenaeus kroyeri in Santos Bay and São Vicente Estuary, state of São Paulo, Brazil. Monthly samples were obtained, from May 2008 through April 2010, from four locations in the estuary and four in the ba...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420130230

    authors: Heckler GS,Lopes M,Simões SM,Shimizu RM,Costa RC

    更新日期:2014-09-01 00:00:00

  • Reproductive success of South American terns (Sterna hirundinacea) from Cardos Islands, Florianópolis, SC, Brazil.

    abstract::Sterna hirundinacea (Lesson, 1831) is a migratory seabird that breeds in the Pacific Coast (from Peru to Chile) and along the Atlantic coast of South America from Espírito Santo (Brazil) to Terra del Fuego (Argentina). This paper describes the reproductive success of South American Terns on Cardos Island, Florianopoli...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012005000020

    authors: Fracasso HA,Branco JO

    更新日期:2012-06-01 00:00:00

  • Experimental validation of a bearing wear model using the directional response of the rotor-bearing system.

    abstract::The present work gives continuity in the analysis of the wear influence on cylindrical hydrodynamic bearings by presenting an experimental validation of the wear model previously proposed by the authors. This validation is carried on using the frequency response of the rotor-bearings system in directional coordinates....

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150414

    authors: Machado TH,Cavalca KL

    更新日期:2016-10-01 00:00:00

  • Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome.

    abstract::Investigation of hyperferritinemia in metabolic syndrome patients represents a diagnostic challenge, but it is essential for the identification of individuals with iron overload. Hepcidin negatively regulates iron absorption and release. An increase in hepcidin occurs when iron levels are sufficient or in inflammatory...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180286

    authors: Rauber MR,Pilger DA,Cecconello DK,Falcetta FS,Marcondes NA,Faulhaber GAM

    更新日期:2019-05-13 00:00:00

  • The complete amino acid sequence of the Vigna unguiculata (L.) Walp. seed trypsin and chymotrypsin inhibitor.

    abstract::The amino acid sequence of the "double-headed" trypsin and chymotrypsin inhibitor (BTCI), purified from the cowpea Vigna unguiculata (L.) Walp. cv "Seridó" was determined in our laboratory. Tryptic and chymotryptic peptides were sequenced by the Edman-Gray and Edman-Chang N-terminal manual method as well as the carbox...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Morhy L,Ventura MM

    更新日期:1987-01-01 00:00:00

  • Molecular characterization of Moenkhausia (Pisces: Characiformes) populations with different lateral line developmental levels.

    abstract::The genera Hemigrammus and Moenkhausia have been traditionally diagnosed mainly by the former having lateral line completely pored whereas the latter having a lateral line with a few pored scales. Those features have been used to diagnose species of both genera in the upper Paraná River floodplain. Specimens with the ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170493

    authors: Mota TFM,Fabrin TMC,Deprá GC,Gasques LS,Oliveira AV,Pavanelli CS,Prioli SMAP,Prioli AJ

    更新日期:2018-07-01 00:00:00

  • Fertility Life Table, Population Parameters and Biotic Potential of Helicoverpa gelotopoeon (Dyar) (Lepidoptera: Noctuidae).

    abstract::Helicoverpa gelotopoeon is an endemic pest of South America that affects soybean and other important crops. Life tables are a fundamental tool used to study insect populations, resulting in crucial information for integrated pest management programs. Therefore, the aim of this study was to evaluate the biotic potentia...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180318

    authors: Herrero MI,Dami LC,Fogliata SV,Casmuz AS,Gómez DRS,Gastaminza GA,Murúa MG

    更新日期:2018-10-01 00:00:00

  • Uncertainties Associated with Arithmetic Map Operations in GIS.

    abstract::Arithmetic map operations are very common procedures used in GIS to combine raster maps resulting in a new and improved raster map. It is essential that this new map be accompanied by an assessment of uncertainty. This paper shows how we can calculate the uncertainty of the resulting map after performing some arithmet...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170589

    authors: Yamamoto JK,Kikuda AT,Rampazzo GJ,Leite CBB

    更新日期:2018-08-01 00:00:00

  • Plant Bugs Predators (Hemiptera: Heteroptera: Miridae) with References to Arthropods and Fungi in Brazil.

    abstract::The present study demonstrates 30 plant bugs species associated with 50 records of prey and six records of mycophagy for Brazil. The data were compiled from Schuh's Catalog, the literature, specimens deposited in entomology museums and exemplars from different regions of Brazil sent for identification. Some of the dat...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920181194

    authors: Nogueira BCF,Ferreira PSF,Coelho LA,Martins DS,Barcellos BD

    更新日期:2019-08-12 00:00:00

  • First record of Spirocamallanus krameri (Nematoda: Camallanidae) in Brazil: Morphological review.

    abstract::This study aimed to describe the occurrence, morphology and prevalence of Spirocamallanus krameri, a parasite of Hoplerythrinus unitaeniatus collected in state of Pará, Brazil. The morphological and morphometric characteristics are consistent with the species S. krameri, by having a hexagonal mouth opening, 16 cephali...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020180721

    authors: Pinheiro RHS,Cardoso PJC,Monks S,Santos JN,Giese EG

    更新日期:2020-10-28 00:00:00

  • Assessment of the yield loss imparted by Orobanche aegyptiaca in tomato in Pakistan.

    abstract::Broomrapes (Orobanche sp.) are root holoparasitic plants causing severe damage to various families of horticultural crops. A Preliminary survey was carried in tomato fields infested with orobanche in Potohar plateau of Pakistan. Results indicated that each planting bed comprising10-12 tomato plants contained 7-8 paras...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180098

    authors: Ahmad T,Ahmad B,Tariq RMS,Syed MZ,Ahmad Z

    更新日期:2018-10-01 00:00:00

  • The use of Fluorescence Resonance Energy Transfer (FRET) peptides for measurement of clinically important proteolytic enzymes.

    abstract::Proteolytic enzymes have a fundamental role in many biological processes and are associated with multiple pathological conditions. Therefore, targeting these enzymes may be important for a better understanding of their function and development of therapeutic inhibitors. Fluorescence Resonance Energy Transfer (FRET) pe...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652009000300005

    authors: Carmona AK,Juliano MA,Juliano L

    更新日期:2009-09-01 00:00:00

  • Human Heat stress risk prediction in the Brazilian semiarid Region based on the Wet-Bulb Globe Temperature.

    abstract:OBJECTIVE:the aim of this study is to map thermal stress risks for human health at the São Francisco River Basin (SFRB) in the Semiarid region, for climatic scenarios RCP 4.5 and 8.5. METHODS:The heat stress conditions were defined by the Wet Bulb Globe Temperature (WBGT) indicator and by the average number of annual ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180748

    authors: Oliveira BFA,Silveira IH,Feitosa RC,Horta MAP,Junger WL,Hacon S

    更新日期:2019-10-07 00:00:00

  • A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus.

    abstract::The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170240

    authors: Santos GFD,Takahashi JA

    更新日期:2017-01-01 00:00:00