Synthesis of new N-alkyl-2-mercapto-1-octylamines and respective disulfides.

Abstract:

:Four new N-alkyl-2-mercapto-1-octylamine hydrochlorides were synthesized via the reaction of 1,2-epithio-octane with corresponding amines following by conversion to the hydrochlorides. The disulfides were obtained by oxidation of the respective thiols. Upon biological assay of the products for activity against infection by Schistosoma mansoni, only 2,2'-dithiobis(N-isobutyl-1-octylamine) exhibited activity.

journal_name

An Acad Bras Cienc

authors

Vieira Filho SA,Nelson DL,Piló-Veloso D

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

547-51

issue

4

eissn

0001-3765

issn

1678-2690

journal_volume

58

pub_type

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