Abstract:
:Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement and atomic force microscopy (AFM). Furthermore, the blood compatibility of the fabricated nanocomposites evaluated through activated prothrombin time (APTT), partial thromboplastin time (PT) and hemolysis assay to determine the anticoagulant nature. The morphological results showed that the fabricated nanocomposites showed reduced fiber size (789 ± 143.106 nm) than the pristine control (890 ± 116.91 nm). The interaction between PU and megni oil was identified by the hydrogen bond formation evident in the FTIR. The incorporation of megni oil in the PU decreased the wettability behavior (113.3° ± 1.528) and improved the surface roughness (646 nm). Preliminary evaluation of blood compatibility assessments was carried out using APTT, PT and hemolysis assay revealed the enhanced antithrombogenicity nature of the fabricated nanocomposites than the PU. Hence, we conclude that the fabricated new nanocomposite membrane with desirable characteristics which might find potential application in the tissue engineering applications.
journal_name
An Acad Bras Ciencjournal_title
Anais da Academia Brasileira de Cienciasauthors
Jaganathan SK,Mani MP,Supriyanto Edoi
10.1590/0001-3765201920190018subject
Has Abstractpub_date
2019-06-19 00:00:00pages
e20190018issue
2eissn
0001-3765issn
1678-2690pii
S0001-37652019000300708journal_volume
91pub_type
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