Zingiber officinale formulation reduces hepatic injury and weight gain in rats fed an unhealthy diet.

Abstract:

:This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of lipid droplets deposited, compared to the group that received the cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver. The cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile, liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative stress and hepatic injury.

journal_name

An Acad Bras Cienc

authors

Leal DT,Fontes GG,Villa JKD,Freitas RB,Campos MG,Carvalho CA,Pizziolo VR,Diaz MAN

doi

10.1590/0001-3765201920180975

subject

Has Abstract

pub_date

2019-11-11 00:00:00

pages

e20180975

issue

4

eissn

0001-3765

issn

1678-2690

pii

S0001-37652019000700801

journal_volume

91

pub_type

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