Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination.

Abstract:

:Miconazole is reduced at mercury electrode above pH 6 involving organometallic compound formation, responsible for an anomalous polarographic behavior. The electrodic process presents a large contribution of the adsorption effects. The drug can be determined by cathodic stripping voltammetry from 8.0 x 10(-8) to 1, 5 x 10(-6) molL-1 in Britton-Robinson buffer pH 8.0, when pre-accumulated for 30s at an accumulation potential of 0V. A relative standard deviation of 3.8% was obtained for ten measurements of 1.0 x 10(-7) molL-1 miconazole in B-R buffer pH 8.0 and a limit detection of 1, 7 x 10(-8) molL-1 was determined using 60s of deposition time and scan rate of 100 mVs-1. The proposed method is simple, precise and it was applied successfully for the determination of the miconazole in pure form and in commercial formulations, showing mean recoveries of 99.7-98.4%.

journal_name

An Acad Bras Cienc

authors

Pereira FC,Stradiotto NR,Zanoni MV

doi

10.1590/s0001-37652002000300005

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

425-32

issue

3

eissn

0001-3765

issn

1678-2690

pii

S0001-37652002000300005

journal_volume

74

pub_type

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