Litter Size Reduction Induces Metabolic and Histological Adjustments in Dams throughout Lactation with Early Effects on Offspring.

Abstract:

:In the present study we analyzed morphological and metabolic alterations in dams nursing small litters and their consequences to offspring throughout lactation. Offspring sizes were adjusted to Small Litter (SL, 3 pups/ dam) and Normal Litter (NL, 9 pups/ dam). Body weight, food intake, white adipose tissue (WAT) content, histological analysis of the pancreas, mammary gland (MG) and brown adipose tissue (BAT) as well as, plasma parameters and milk composition were measured in dams and pups on the 7th, 14th and 21st days of lactation. In general, SL-dams presented higher body weight and retroperitoneal fat content, elevated fat infiltration in BAT, reduced islets size and hyperglycemia throughout lactation in relation to NL-dams (p<0.05). Moreover, MG from SL-dams had reduced alveoli development and high adipocytes content, resulting in milk with elevated energetic value and fat content in relation to NL-dams (p<0.05). Maternal states influenced offspring anthropometric conditions during lactation, offspring-SL displayed higher body weight and growth, hyperglycemia, augmented lipid deposition in BAT and elevated islet. Thus, maternal histological and metabolic changes are due to modifications to nursing small litters and reinforce the importance of preserving maternal health during lactation avoiding early programming effects on offspring preventing metabolic consequences later in life.

journal_name

An Acad Bras Cienc

authors

Xavier JLP,Scomparin DX,Pontes CC,Ribeiro PR,Cordeiro MM,Marcondes JA,Mendonça FO,Silva MTD,Oliveira FB,Franco GCN,Grassiolli S

doi

10.1590/0001-3765201920170971

subject

Has Abstract

pub_date

2019-03-21 00:00:00

pages

e20170971

issue

1

eissn

0001-3765

issn

1678-2690

pii

S0001-37652019000100803

journal_volume

91

pub_type

杂志文章
  • Mercury concentrations in fish from the Itacaiúnas-Parauapebas River system, Carajás region, Amazon.

    abstract::This paper reports on total Hg concentrations in muscle tissue from 12 fish species collected in the Itacaiúnas and Parauapebas Rivers in the Carajás region, South Pará. It is found that carnivorous species present Hg concentrations higher than herbivorous and omnivorous species. Also, large carnivorous species presen...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Lacerda LD,Bidone ED,Guimarães AF,Pfeiffer WC

    更新日期:1994-01-01 00:00:00

  • Extremum Seeking-based Adaptive PID Control applied to Neuromuscular Electrical Stimulation.

    abstract::A multivariable deterministic extremum seeking (ES) is being evaluated to construct an adaptive Proportional-Integral-Derivative (PID) control law for the functional Neuromuscular Electrical Stimulation (NMES) of stroke patients. The developed scheme is applied to control the position of the patient's arm so that move...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180544

    authors: Roux-Oliveira T,Costa LR,Pino AV,Paz P

    更新日期:2019-02-14 00:00:00

  • In vivo biocompatibility of silicon dioxide nanofilm used as antimicrobial agent on acrylic surface.

    abstract::the focus ofthis study was to testthe hypothesisthatthere would be no difference betweenthe biocompatibility of silicon dioxide nanofilms used as antimicrobial agents. Sixty male Wistar rats were divided into 4 groups (n=15): Group C (Control,Polyethylene), Group AR (Acrylic Resin), Group NP (Acrylic Resin coated with...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181120

    authors: Lacerda-Santos R,Lima ABL,Penha ESD,Santos AD,Carvalho FG,Pithon MM,Dantas AFM

    更新日期:2020-04-17 00:00:00

  • Kinetic modelling of vitamin C losses in fresh citrus juices under different storage conditions.

    abstract::The degradation kinetics of vitamin C in different citrus juice types (tangerine, grapefruit, orange and lime) were investigated during four hours storage at temperatures of 4 and 25°C under different storage conditions in terms of light and oxygen presence. The loss of vitamin C at each sample followed the first-orde...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190328

    authors: NakilcioĞlu-TaŞ E,ÖtleŞ S

    更新日期:2020-06-12 00:00:00

  • Anatomical modifications of Butia capitata propagated under colored shade nets.

    abstract::The jelly palm plant [Butia capitata (Martius) Beccari] is a native palm of the Cerrado biome used for many purposes in northern Minas Gerais State, Brazil. Dormancy is common in palm seeds, resulting in slow and uneven germination that may take years to complete. Modification in the growth pattern, anatomical paramet...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170347

    authors: Costa BNS,Costa IJS,Souza GA,Santos DND,Silveira FAD,Melo ET,Martins AD,Pasqual M,Setotaw TA,Rodrigues FA

    更新日期:2018-10-01 00:00:00

  • Growth and reproduction of the mangrove crab Goniopsis cruentata (Latreille, 1803) (Crustacea: Decapoda: Grapsidae) in southeastern Brazil.

    abstract::Goniopsis cruentata is a common semi-terrestrial crab in Brazilian mangroves and an important fishery resource for traditional communities in the northeastern Brazilian coast. Aiming to contribute to the knowledge about the species, this study evaluated the carapace width and weight growth curves, the relative growth ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520130387

    authors: Reis CR,Taddei FG,Cobo VJ

    更新日期:2015-04-01 00:00:00

  • Last millennium environmental changes and climate inferences in the Southeastern Atlantic forest, Brazil.

    abstract::This study presents paleoenvironmental data based on pollen, elemental and isotopic compositions of organic matter (TOC, N, δ(13)C and δ(15)N) and (14)C dating of 170 cm lake sediment record. Samplings have been made in Lagoa Grande at Parque Estadual Turístico do Alto Ribeira - PETAR, Southern São Paulo State, Southe...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652010000300019

    authors: Pessenda LC,Saia SE,Gouveia SE,Ledru MP,Sifeddine A,Amaral PG,Bendassolli JA

    更新日期:2010-09-01 00:00:00

  • New species of Myrmicium Westwood (Psedosiricidae = Myrmiciidae: Hymenoptera, Insecta) from the Early Cretaceous (Aptian) of the Araripe Basin, Brazil.

    abstract::This paper records the first occurrence of the genus Myrmicium Westwood, 1854 in the Cretaceous of Gondwana and describes it as a new species Myrmicium araripterum sp. nov, based on the most complete specimen of this genus yet known, which represents the largest specimen of the grade "Symphyta" ever found in the Crato...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020200479

    authors: Freitas LCB,Rasnitsyn AP,Moura GJB,Mendes M

    更新日期:2020-01-01 00:00:00

  • Identification of caffeic acid and rutin by UHPLC MS/MS and antioxidant activity of Commelina erecta Lineu. in cell culture.

    abstract::The Commelina erecta L. (C. erecta) also known as erva-de-santa-luzia is reported by local population to have medical properties against some pathological conditions. In this study, two extracts of C. erecta leaves (aqueous and ethanolic) were phytochemically analysed and evaluated for their in-vitro antioxidant activ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190491

    authors: Otsuka FAM,Santos RB,Chaves LF,Santos RS,Chaves Filho AB,Miyamoto S,Matos HR

    更新日期:2020-01-01 00:00:00

  • A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus.

    abstract::The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170240

    authors: Santos GFD,Takahashi JA

    更新日期:2017-01-01 00:00:00

  • High prevalence of unusual genotypes of Toxoplasma gondii infection in pork meat samples from Erechim, Southern Brazil.

    abstract::Toxoplasmosis is the most common cause of infectious uveitis in Brazil, with a higher frequency in the South of the country. We have collected samples from porcine tongue and diaphragm obtained in both large and small abattoirs and used molecular biological technique to determine the prevalence of infection and RFLP a...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652007000100013

    authors: Belfort-Neto R,Nussenblatt V,Rizzo L,Muccioli C,Silveira C,Nussenblatt R,Khan A,Sibley LD,Belfort R Jr

    更新日期:2007-03-01 00:00:00

  • The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1.

    abstract::The altered expression of the SOX2 transcription factor is associated with oncogenic or tumor suppressor functions in human cancers. This factor regulates the migration and invasion of different cancer cells. In this study we investigated the effect of constitutive SOX2 overexpression on the migration and adhesion cap...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140352

    authors: Drakulic D,Vicentic JM,Schwirtlich M,Tosic J,Krstic A,Klajn A,Stevanovic M

    更新日期:2015-03-01 00:00:00

  • D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice.

    abstract::D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic and hypolipidemic actions in diabetic rodents. Here, we investigated the actions of D-pinitol on adiposity, and in lipid and glycemic homeostasis in monosodium glutamate (MSG)-obese mice. Swiss mice received daily sub...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020201382

    authors: Silva JÚnior JAD,Silva ACVFD,Figueiredo LS,Araujo TR,Freitas IN,Carneiro EM,Ribeiro ES,Ribeiro RA

    更新日期:2020-11-20 00:00:00

  • Pond characteristics influence the intraspecific variation in the morphometry of the tadpoles of two species of Dendropsophus (Anura: Hylidae) from the Cerrado savanna of northeastern Brazil.

    abstract::Spatial variation in the environment may be an important source of morphological variation in many organisms. Tadpoles are valuable model organisms for studies of morphological variation, and in particular, the evaluation of the relationship between environmental and morphological variables. In heterogeneous environme...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181171

    authors: Lopes GN,Serra RTA,Piorski NM,Andrade GV

    更新日期:2020-11-02 00:00:00

  • The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro.

    abstract::Aged skin, featured with dryness and wrinkles, has received mounting attention due to its adverse influences on beauty. β-Sitosterol and vermicularin are two common active ingredients of Thamnolia vermicularis (Sw.) Ach., a traditional Chinese medicine, of which the anti-aging effect has been discovered. Their protect...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920181088

    authors: Haiyuan YU,Shen X,Liu D,Hong M,Lu Y

    更新日期:2019-12-02 00:00:00

  • New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals.

    abstract::With the advance and popularization of molecular techniques, the identification of genetic mutations that cause diseases has increased dramatically. Thus, the number of laboratories available to investigate a given disorder and the number of subsequent diagnosis have increased over time. Although it is necessary to id...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/0001-3765201520140711

    authors: Velho RV,Sperb-Ludwig F,Schwartz IV

    更新日期:2015-08-01 00:00:00

  • The synergetic modulation of the excitability of central gray matter by a neuropeptide: two protocols using excitation waves in chick retina.

    abstract::The isolated chick retina provides an in vitro tissue model, in which two protocols were developed to verify the efficacy of a peptide in the excitability control of the central gray matter. In the first, extra-cellular potassium homeostasis is challenged at long intervals and in the second, a wave is trapped in a rin...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000100006

    authors: Lima VM,Piqueira JR,Hanke W

    更新日期:2009-03-01 00:00:00

  • A new ascarid species in cynodont coprolite dated of 240 million years.

    abstract::Cynodonts represent the transition from reptiles to mammals. They are classified as synapsids, or tetrapod animals with mammalian characteristics. We present here the finding of helminth eggs in a coprolite identified as of cynodont origin dated of nearly 240 million years. Microscopy revealed the presence of very wel...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201320130036

    authors: Silva PA,Borba VH,Dutra JM,Leles D,da-Rosa AA,Ferreira LF,Araujo A

    更新日期:2014-03-01 00:00:00

  • Evaluation of hematology, general serum biochemistry, bone turnover markers and bone marrow cytology in a glucocorticoid treated ovariectomized sheep model for osteoporosis research.

    abstract::Osteoporosis is a metabolic disorder characterized by a loss of bone mass and structure and increasing the risk of fragility fractures, mostly among postmenopausal women. Sheep is a recognized large animal model for osteoporosis research. An experimental group of ewes (3-4 years old) was subjected to ovariectomy (OVX)...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020200435

    authors: Coelho CA,Bordelo JP,Camassa JA,Barros VA,Babo PS,Gomes ME,Reis RL,Azevedo JT,Requicha JF,FaÍsca P,Carvalho PP,Viegas CA,Dias IR

    更新日期:2020-12-07 00:00:00

  • Metabolic responses to dietary carbohydrate/lipids ratios in neotropical hybrid catfish (♂Pseudoplatystoma corruscans×♀Pseudoplatystoma fasciatum).

    abstract::The purpose of this study was to assess the effect of different carbohydrate and lipid (CHO/L) ratios on the performance and energy metabolism of hybrid catfish (♂Pseudoplatystoma corruscans × ♀ Pseudoplatystoma fasciatum). One hundred and sixty-eight fish (104.9±16.5 g BW) were distributed into 24 100-L tanks. The ex...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920190075

    authors: Okamura D,Fortes-Silva R,Paulino RR,Araújo FG,Costa DVD,Pereira RT,Rosa PV

    更新日期:2019-11-25 00:00:00

  • Histological modifications of the rat prostate following transection of somatic and autonomic nerves.

    abstract::It is known that hormones influence significantly the prostate tissue. However, we reported that mating induces an increase in androgen receptors, revealing a neural influence on the gland. These data suggested that somatic afferents (scrotal and genitofemoral nerves) and autonomic efferents (pelvic and hypogastric ne...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652010000200015

    authors: Diaz R,Garcia LI,Locia J,Silva M,Rodriguez S,Perez CA,Aranda-Abreu GE,Manzo J,Toledo R,Hernandez ME

    更新日期:2010-06-01 00:00:00

  • Modulation of diabetes and dyslipidemia in diabetic insulin-resistant rats by mangiferin: role of adiponectin and TNF-α.

    abstract::Mangiferin, present in Mangifera indica bark, was reported to produce hypoglycemic and antidiabetic activity in an animal model of genetic type 2 diabetes and in streptozotocin diabetic rats. Its effect on diabetic insulin-resistant animals has not been investigated. The current work aimed to explore the effect of man...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420140212

    authors: Saleh S,El-Maraghy N,Reda E,Barakat W

    更新日期:2014-12-01 00:00:00

  • An integrated approach clarifies the cryptic diversity in Hypostomus Lacépède 1803 from the Lower La Plata Basin.

    abstract::Hypostomus commersoni Valenciennes 1836, Hypostomus cordovae (Günther 1880) and Hypostomus laplatae (Eigenmann 1907) have been little studied since their original descriptions. This study shows a comprehensive review of these species from the Lower La Plata Basin, including their taxonomic history, distribution, color...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180131

    authors: Cardoso YP,Brancolini F,Protogino L,Paracampo A,Bogan S,Posadas P,Montoya-Burgos JI

    更新日期:2019-01-01 00:00:00

  • Production of a bacteriophage, a phage tail-like bacteriocin and an antibiotic by Bacillus azotofixans.

    abstract::Twenty-two nitrogen-fixing Bacillus azotofixans strains were shown to produce an inhibition zone against themselves in plate assays. The B. azotofixans type strain P3L-5, chosen for further studies, produced inhibition zones against various Bacillus strains and other bacterial genera. This antibacterial substance was ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Seldin L,Penido EG

    更新日期:1990-03-01 00:00:00

  • Production of crispy bread snacks containing chicken meat and chicken meat powder.

    abstract::Chicken meat in two different forms (chicken meat and chicken meat powder) were added into white flour and whole wheat blend baguette bread formulations for protein enrichment and finally developing new and healthy snacks. The chicken meat and powder levels were 10% for white flour baguette, and 15% for whole wheat bl...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150059

    authors: Cakmak H,Altinel B,Kumcuoglu S,Kisla D,Tavman S

    更新日期:2016-10-01 00:00:00

  • Stimulation of mitochondrial Ca2+ efflux by NADP+ with maintenance of respiratory control.

    abstract::Experiments in this paper demonstrate that mitochondrial damage associated to NAD(P)+-induced Ca2+ efflux, is the consequence of inappropriate reaction conditions. The major findings are (i) Added oxaloacetate and acetoacetate readily oxidize NAD(P)H in intact rat liver mitochondria without causing swelling or membran...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Vercesi AE

    更新日期:1985-09-01 00:00:00

  • First Assessment of Carbon Stock in the Belowground Biomass of Brazilian Mangroves.

    abstract::Studies on belowground roots biomass have increasingly reported the importance of the contribution of this compartment in carbon stock maintenance in mangrove forests. To date, there are no estimates of this contribution in Brazilian mangrove forests, although the country has the second largest area of mangroves world...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160496

    authors: Santos DMC,Estrada GCD,Fernandez V,Estevam MRM,Souza BT,Soares MLG

    更新日期:2017-07-01 00:00:00

  • Density, abundance and extractive potential of the mangrove crab, Ucides cordatus (Linnaeus, 1763) (Brachyura, Ocypodidae): subsidies for fishery management.

    abstract::Ucides cordatus is a relevant fishery resource of Brazilian mangroves and requires legal normative to sustainable use based on stock assessment and management. This study evaluated some population parameters (structure, density, abundance, fishery potential and stock) of this crab species in Brazil Southeast (São Paul...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170090

    authors: Pinheiro MAA,Souza MR,Santos LCM,Fontes RFC

    更新日期:2018-04-01 00:00:00

  • First record of Dichelyne (Dichelyne) bonacii (Nematoda, Cucullanidae) parasitizing the intestine of two species of lutjanid fish (Perciformes, Lutjanidae) on the northeast Brazilian coast.

    abstract::Lutjanids are marine fish and commonly inhabit coral reefs, which have migratory habits and feed in a general way, due to these characteristics, are susceptible to infections by parasites, such as cuculanid nematodes. This work aimed to report for the first time, the occurrence of Dichelyne (Dichelyne) bonacii in Braz...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920190544

    authors: Alves AM,Calassans TAS,Freire JF,Souza GTRE,Takemoto RM,Melo CM,Jeraldo VLS,Madi RR

    更新日期:2019-12-02 00:00:00

  • Morphological and morphometric variations of Dicrocoelium rileyi (Digenea: Dicrocoelidae) parasitizing Tadarida brasiliensis (Chiroptera: Molosiidae) in Mexico.

    abstract::Fifty-five adult Dicrocoelium rileyi Macy, 1931 parasitizing Tadarida brasiliensis (Geoffroy, 1824) from Durango, Nuevo Leon, Puebla, Zacatecas and Mexico State were morphologically described and morphometrically analyzed. To evaluate the degree of variation among populations from the five localities, 27 morphometric ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180436

    authors: Falcón-Ordaz J,Octavio-Aguilar P,Estrella-Cruz I

    更新日期:2019-11-25 00:00:00