D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice.

Abstract:

:D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic and hypolipidemic actions in diabetic rodents. Here, we investigated the actions of D-pinitol on adiposity, and in lipid and glycemic homeostasis in monosodium glutamate (MSG)-obese mice. Swiss mice received daily subcutaneous injections of MSG [(4g/kg of body weight (BW)] or saline [1.25g/kg BW; control (CTL)] during their first five days of life. From 90-120 day-old, half of the MSG and CTL groups received 50 mg D-pinitol/kg BW/day (MPIN and CPIN groups) or vehicle (saline; MSG and CTL groups) by gavage. MSG mice displayed higher abdominal adiposity and hepatic triglycerides (TG) deposition, and increased hepatic expression of lipogenic genes (SREBP-1c, ACC-1 and FASN), but downregulation in AMPKα mRNA. MSG mice also exhibited hyperinsulinemia, islet hypersecretion and hypertrophy, glucose intolerance and insulin resistance. D-pinitol did not change adiposity, glucose intolerance, insulin resistance, but increased hepatic triglycerides (TG) content in MPIN mice, which was associated with increases in gene expressions of SREBP-1c and FASN, but reduction in AMPKα. Furthermore, D-pinitol enhanced insulin secretion in MPIN and CPIN groups. Therefore, D-pinitol enhanced glucose-induced insulin secretion, which may account to enhances hepatic lipogenesis and TG deposition in MPIN mice.

journal_name

An Acad Bras Cienc

authors

Silva JÚnior JAD,Silva ACVFD,Figueiredo LS,Araujo TR,Freitas IN,Carneiro EM,Ribeiro ES,Ribeiro RA

doi

10.1590/0001-3765202020201382

subject

Has Abstract

pub_date

2020-11-20 00:00:00

pages

e20201382

issue

4

eissn

0001-3765

issn

1678-2690

pii

S0001-37652020000700809

journal_volume

92

pub_type

杂志文章
  • In vivo biocompatibility of silicon dioxide nanofilm used as antimicrobial agent on acrylic surface.

    abstract::the focus ofthis study was to testthe hypothesisthatthere would be no difference betweenthe biocompatibility of silicon dioxide nanofilms used as antimicrobial agents. Sixty male Wistar rats were divided into 4 groups (n=15): Group C (Control,Polyethylene), Group AR (Acrylic Resin), Group NP (Acrylic Resin coated with...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181120

    authors: Lacerda-Santos R,Lima ABL,Penha ESD,Santos AD,Carvalho FG,Pithon MM,Dantas AFM

    更新日期:2020-04-17 00:00:00

  • Games Applied to Children with Motor Impairment using the Myo Wearable Device.

    abstract::The characteristic of immersion, involvement and motivation have made serious games an important tool to be used in the medical field. However, there are people that, having some sort of physical disability, are not able to, or do not feel motivated to play. This work presents a strategy to support human- computer int...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190273

    authors: Fernandes FG,Cardoso A,Lopes RA

    更新日期:2020-02-17 00:00:00

  • Bacterial and Archaeal Communities Variability Associated with Upwelling and Anthropogenic Pressures in the Protection Area of Arraial do Cabo (Cabo Frio region - RJ).

    abstract::Upwelling systems contain a high diversity of pelagic microorganisms and their composition and activity are defined by factors like temperature and nutrient concentration. Denaturing gradient gel electrophoresis (DGGE) technique was used to verify the spatial and temporal genetic variability of Bacteria and Archaea in...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140098

    authors: Coelho-Souza SA,Araújo FV,Cury JC,Jesus HE,Pereira GC,Guimarães JR,Peixoto RS,Dávila AM,Rosado AS

    更新日期:2015-09-01 00:00:00

  • Administering ascorbic acid to rats undergoing ageing processes: effects on myosin-V immunoreactive myenteric neurons.

    abstract::During the ageing process the enteric nervous system undergoes morphofunctional changes, such as enteric neurodegeneration. Neuronal death can be attributed to increase radicals free, and ascorbic acid (AA), known antioxidant, could minimize damage cause by oxidative stress. The objective of this study is to analyse t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013005000002

    authors: Mello SA,Marese AC,Brancalhão RM,Zanoni JN,Natali MR

    更新日期:2013-03-01 00:00:00

  • The theorical-methodological construction of theses and dissertations and their epistemological problems.

    abstract::This essay discusses the problem of the lack of dialogue between theory/empirical reality in the construction of the theoretical structure of dissertations and doctorates in Human Sciences in Brazil; taking Geography as an example, Santos (2000) observed this problem, which persists at the national level. The proposal...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920171020

    authors: Gomes RD

    更新日期:2019-01-01 00:00:00

  • Germination responses of the invasive Calotropis procera (Ait.) R. Br. (Apocynaceae): comparisons with seeds from two ecosystems in Northeastern Brazil.

    abstract::Life history traits are considered key indicators of plant invasibility. Among them, the germination behavior of seeds is of major relevance because it is influenced by environmental factors of invaded ecosystem. Here, we investigated how seed traits and seed tolerance to environmental factors on seed germination of C...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013000300013

    authors: Leal LC,Meiado MV,Lopes AV,Leal IR

    更新日期:2013-09-01 00:00:00

  • Beyond diversity loss and climate change: Impacts of Amazon deforestation on infectious diseases and public health.

    abstract::Amazonian biodiversity is increasingly threatened due to the weakening of policies for combating deforestation, especially in Brazil. Loss of animal and plant species, many not yet known to science, is just one among many negative consequences of Amazon deforestation. Deforestation affects indigenous communities, rive...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/0001-3765202020191375

    authors: Ellwanger JH,Kulmann-Leal B,Kaminski VL,Valverde-Villegas JM,Veiga ABGD,Spilki FR,Fearnside PM,Caesar L,Giatti LL,Wallau GL,Almeida SEM,Borba MR,Hora VPD,Chies JAB

    更新日期:2020-04-17 00:00:00

  • Entropy Generation Minimization Analysis of Active Magnetic Regenerators.

    abstract::A performance assessment of active magnetocaloric regenerators using entropy generation minimization is presented. The model consists of the Brinkman-Forchheimer equation to describe the fluid flow and coupled energy equations for the fluid and solid phases. Entropy generation contributions due to axial heat conductio...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160427

    authors: Trevizoli PV,Barbosa JR

    更新日期:2017-05-01 00:00:00

  • Ultrastructure and pollen morphology of Bromeliaceae species from the Atlantic Rainforest in Southeastern Brazil.

    abstract::Pollen grain morphology of Bromeliaceae species collected in areas of the Atlantic Rainforest of southeastern Brazil was studied. The following species were analyzed: Aechmea bambusoides L.B.Sm. & Reitz, A. nudicaulis (L.) Griseb., A. ramosa Mart. ex Schult.f., Ananas bracteatus (Lindl.) Schult.f., Billbergia distachi...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620140715

    authors: Silva VJ,Ribeiro EM,Luizi-Ponzo AP,Faria AP

    更新日期:2016-01-01 00:00:00

  • Larval interactions between two aphidophagous coccinellids in sweet pepper.

    abstract::Antagonistic interactions among predators have the potential to dampen top-down impacts on a shared pest. Strong cannibalism by adults and larvae on eggs along with a stronger intraguild predation by Eriopis connexa on Cycloneda sanguinea (Coccinellidae) than vice versa had been documented. The intensity and direction...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181163

    authors: Rocca M,Rizzo E,Greco NM

    更新日期:2020-07-31 00:00:00

  • Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models.

    abstract::Cariniana rubra Miers (Lecythidaceae), popularly known as "jequitibá-vermelho'', is a large Brazilian tree whose bark is used in infusion and decoction for the treatment of inflammatory conditions. This study aims to assess the anti-inflammatory, antinociceptive, and antipyretic effects of Cariniana rubra methanolic s...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652011005000006

    authors: Santos EN,Lima JC,Noldin VF,Cechinel-Filho V,Rao VS,Lima EF,Schmeda-Hirschmann G,Sousa PT Jr,Martins DT

    更新日期:2011-06-01 00:00:00

  • New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals.

    abstract::With the advance and popularization of molecular techniques, the identification of genetic mutations that cause diseases has increased dramatically. Thus, the number of laboratories available to investigate a given disorder and the number of subsequent diagnosis have increased over time. Although it is necessary to id...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/0001-3765201520140711

    authors: Velho RV,Sperb-Ludwig F,Schwartz IV

    更新日期:2015-08-01 00:00:00

  • Centesimal composition and physical-chemistry analysis of the edible mushroom Lentinus strigosus occurring in the Brazilian Amazon.

    abstract::The centesimal composition and the physical and chemical analyses of Lentinus strigosus, an edible mushroom occurring in the Brazilian Amazon and produced in alternative substrates based on wood and agroindustrial residues, were evaluated. For this purpose, the C, N, pH, soluble solids, water activity, protein, lipids...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201399412

    authors: Sales-Campos C,Araujo LM,Minhoni MT,Andrade MC

    更新日期:2013-01-01 00:00:00

  • Potentially mobile of heavy metals on the surface sediments in tropical hyper-saline and positive estuaries.

    abstract::Estuarine sediments represent important pools of trace metals, released from both anthropogenic and natural sources. Fluctuations in the water column physicochemical conditions, on the other hand, may transfer metals from solid to liquid compartment and resulting in contamination of the surrounding environment. The pr...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170110

    authors: Silva CARE,Fonseca EMD,Grotto BW,Souza FES,Baptista JA Neto

    更新日期:2017-10-01 00:00:00

  • The synergetic modulation of the excitability of central gray matter by a neuropeptide: two protocols using excitation waves in chick retina.

    abstract::The isolated chick retina provides an in vitro tissue model, in which two protocols were developed to verify the efficacy of a peptide in the excitability control of the central gray matter. In the first, extra-cellular potassium homeostasis is challenged at long intervals and in the second, a wave is trapped in a rin...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000100006

    authors: Lima VM,Piqueira JR,Hanke W

    更新日期:2009-03-01 00:00:00

  • Pseudophacopteron longicaudatum (Hemiptera) induces intralaminar leaf galls on Aspidosperma tomentosum (Apocynaceae): a qualitative and quantitative structural overview.

    abstract::The structural complexity of galls depends on species-specific interaction driven by the galling taxa. However, the host plant and environment stressors can impose limits on gall developmental patterns and impact the establishment of gall morphology. Herein, we employed qualitative and quantitative approaches in order...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181002

    authors: Oliveira DC,Martini VC,Moreira ASFP,Fuzaro L,GonÇalves LA

    更新日期:2020-10-19 00:00:00

  • Acritarchs of the Ediacaran Frecheirinha Formation, Ubajara Group, Northeastern Brazil.

    abstract::We report for the first time the occurrence of organic-walled microfossils in Ediacaran limestones and marls of the Frecheirinha Formation, Ubajara Group, and the first Precambrian acritarchs so far reported for northeastern Brazil. The assemblage of the Frecheirinha Formation represents a low-diversity microflora com...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140430

    authors: Chiglino L,Gaucher C,Sial AN,Ferreira VP

    更新日期:2015-04-01 00:00:00

  • Development of a real-time PCR assay for the detection of the golden mussel ( Limnoperna fortunei , Mytilidae) in environmental samples.

    abstract::The golden mussel, Limnoperna fortunei, is among the most devastating invasive species in freshwater habitats worldwide, leading to severe environmental disturbances and economic losses. Therefore, management efforts would be greatly improved by methods that efficiently detect and quantify the abundance of the golden ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160723

    authors: Pie MR,Ströher PR,Agostinis AO,Belmonte-Lopes R,Tadra-Sfeir MZ,Ostrensky A

    更新日期:2017-04-01 00:00:00

  • Splendid oddness: revisiting the curious trophic relationships of South American Pleistocene mammals and their abundance.

    abstract::The South American Pleistocene mammal fauna includes great-sized animals that have intrigued scientists for over two centuries. Here we intend to update the knowledge on its palaeoecology and provide new evidence regarding two approaches: energetics and population density and relative abundance of fossils per taxa. To...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420120010

    authors: Fariña RA,Czerwonogora A,di Giacomo M

    更新日期:2014-03-01 00:00:00

  • DNA damage in children and adolescents with cardiovascular disease risk factors.

    abstract::The risk of developing cardiovascular disease (CVD) is related to lifestyle (e.g. diet, physical activity and smoking) as well as to genetic factors. This study aimed at evaluating the association between CVD risk factors and DNA damage levels in children and adolescents. Anthropometry, diet and serum CVD risk factors...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012005000039

    authors: Kliemann M,Prá D,Müller LL,Hermes L,Horta JA,Reckziegel MB,Burgos MS,Maluf SW,Franke SI,Silva Jd

    更新日期:2012-09-01 00:00:00

  • Stonemeal of Amazon soils with sediments from reservoirs: a case study of remineralization of the Tucuruí degraded land for agroforest reclamation.

    abstract::This study suggests the employment of accumulated sediments in the reservoir of Tucuruí (Pará /Brazil) to remineralize the surrounding degraded soils. The approach was based on the principles of stonemeal technology. It suggests that the soil can be rejuvenated by crushed rocks rich in macro and micronutrients. Remova...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652013000100003

    authors: Theodoro SH,Leonardos OH,Rocha E,Macedo I,Rego KG

    更新日期:2013-03-01 00:00:00

  • Influence of tides and winds on fishing techniques and strategies in the Mamanguape River Estuary, Paraíba State, NE Brazil.

    abstract::This work was carried out in two small fishing communities, Barra de Mamanguape and Tramataia, Northeastern Brazil. The aim was to study these traditional fishermen's knowledge and perception about tide and wind classifications, as well as their fishing strategies and techniques. Our research methodology involved vari...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012005000046

    authors: Bezerra DM,Nascimento DM,Ferreira EN,Rocha PD,Mourão JS

    更新日期:2012-09-01 00:00:00

  • The exotic wasp Megastigmus transvaalensis (Hymenoptera: Torymidae): first record and damage on the Brazilian peppertree, Schinus terebinthifolius drupes, in São Paulo, Brazil.

    abstract::This paper records the first report of Megastigmus transvaalensis Hussey (Hymenoptera: Torymidae) in Brazilian peppertree, Schinus terebinthifolius Raddi (Anacardiaceae) drupes in Sorocaba, state of São Paulo, Brazil. This wasp is an invasive species and was found damaging S. terebinthifolius drupes in urban areas (35...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140478

    authors: Ferreira-Filho PJ,Piña-Rodrigues FC,Silva JM,Guerreiro JC,Ghiotto TC,Piotrowski I,Dias LP,Wilcken CF,Zanuncio JC

    更新日期:2015-10-01 00:00:00

  • Production, extraction and characterization of exopolysaccharides produced by the native Leuconostoc pseudomesenteroides R2 strain.

    abstract::The genus Leuconostoc belongs to a group of lactic acid bacteria usually isolated from fermented vegetables, which includes species involved in the production of exopolysaccharides (EPS). These biopolymers possess considerable commercial potential. Because of the wide variety of industrial applications of EPS, this st...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000200018

    authors: Paulo EM,Boffo EF,Branco A,Valente AM,Melo IS,Ferreira AG,Roque MR,Assis SA

    更新日期:2012-06-01 00:00:00

  • Uncertainties Associated with Arithmetic Map Operations in GIS.

    abstract::Arithmetic map operations are very common procedures used in GIS to combine raster maps resulting in a new and improved raster map. It is essential that this new map be accompanied by an assessment of uncertainty. This paper shows how we can calculate the uncertainty of the resulting map after performing some arithmet...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170589

    authors: Yamamoto JK,Kikuda AT,Rampazzo GJ,Leite CBB

    更新日期:2018-08-01 00:00:00

  • Fundamental tone estimates for elliptic operators in divergence form and geometric applications.

    abstract::We establish a method for giving lower bounds for the fundamental tone of elliptic operators in divergence form in terms of the divergence of vector fields. We then apply this method to the Lr operator associated to immersed hypersurfaces with locally bounded (r + 1)-th mean curvature Hr + 1 of the space forms Nn+ 1(c...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652006000300001

    authors: Bessa GP,Jorge LP,Lima BP,Montenegro JF

    更新日期:2006-09-01 00:00:00

  • Molecular characterization of Moenkhausia (Pisces: Characiformes) populations with different lateral line developmental levels.

    abstract::The genera Hemigrammus and Moenkhausia have been traditionally diagnosed mainly by the former having lateral line completely pored whereas the latter having a lateral line with a few pored scales. Those features have been used to diagnose species of both genera in the upper Paraná River floodplain. Specimens with the ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170493

    authors: Mota TFM,Fabrin TMC,Deprá GC,Gasques LS,Oliveira AV,Pavanelli CS,Prioli SMAP,Prioli AJ

    更新日期:2018-07-01 00:00:00

  • Unenlagiinae revisited: dromaeosaurid theropods from South America.

    abstract::Over the past two decades, the record of South American unenlagiine dromaeosaurids was substantially increased both in quantity as well as in quality of specimens. Here is presented a summary review of the South American record for these theropods.Unenlagia comahuensis, Unenlagia paynemili, and Neuquenraptor argentinu...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652011000100009

    authors: Gianechini FA,Apesteguia S

    更新日期:2011-03-01 00:00:00

  • Approaches to the mechanisms of song memorization and singing provide evidence for a procedural memory.

    abstract::There is growing evidence that, during song learning, birds do not only acquire 'what to sing' (the inventory of behavior), but also 'how to sing' (the singing program), including order-features of song sequencing. Common Nightingales Luscinia megarhynchos acquire such serial information by segmenting long strings of ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652004000200005

    authors: Hultsch H,Todt D

    更新日期:2004-06-01 00:00:00

  • Chemical composition, antioxidant and antibacterial activities of essential oils from leaves and flowers of Eugenia klotzschiana Berg (Myrtaceae).

    abstract::Many essential oils (EOs) of different plant species possess interesting antimicrobial effects on buccal bacteria and antioxidant properties. Eugenia klotzschiana Berg (pêra-do-cerrado, in Portuguese) is a species of Myrtaceae with restricted distribution in the Cerrado. The essential oils were extracted through the h...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160652

    authors: Carneiro NS,Alves CCF,Alves JM,Egea MB,Martins CHG,Silva TS,Bretanha LC,Balleste MP,Micke GA,Silveira EV,Miranda MLD

    更新日期:2017-07-01 00:00:00